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    BREATH SAMPLER
    41.
    发明专利
    BREATH SAMPLER 未知

    公开(公告)号：NL2021637B1

    公开(公告)日：2020-05-07

    申请号：NL2021637

    申请日：2018-09-14

    Applicant: STICHTING KATHOLIEKE UNIV

    Inventor： MARINUS ISAÄK DE JONGE ,  CORNELIS HUBERTUS VAN DEN KIEBOOM

    IPC: A61B5/08 ,  A61B5/091 ,  A61B5/097

    Abstract: A breath sampler (100) for collecting a breath sample from a patient is disclosed. The breath sampler comprises a non-rebreather unit comprising a first conduit (110) having a sample inlet (130) and a one-way outlet valve (160) downstream of the sample inlet (130). An air inlet (140) is disposed between the sample inlet and the one-way outlet valve and is closed by a one-way inlet valve. The breath sampler also comprises a sample delivery unit comprising a second conduit (120) defining a second portion ofthe internal breath flow pathway, the second conduit being in fluid communication with the first conduit at an upstream end via the one-way outlet valve (160). An air diverter (170) is arranged to divide the second conduit into an upstream portion upstream of the air diverter (170) and a downstream portion downstream of the air diverter and is configured to divert the breath sample into a sample collection chamber comprising a liquid capture interface.

    Ensayo de hemostasis basado en la quimioluminiscencia
    43.
    发明专利
    Ensayo de hemostasis basado en la quimioluminiscencia 未知

    公开(公告)号：ES2729800T3

    公开(公告)日：2019-11-06

    申请号：ES17158368

    申请日：2011-12-14

    Applicant: STICHTING KATHOLIEKE UNIV

    Inventor： VAN HEERDE WAANDER LAURENS ,  BLAAUW RICHARD HENDRIK

    IPC: C12Q1/56 ,  C12Q1/66

    Abstract: Método para determinar in vitro la generación de un factor hemostático en una muestra de ensayo que comprende determinar la cantidad de dicho factor hemostático generado usando un sustrato quimioluminiscente que es específico para dicho factor hemostático, donde una molécula luminiscente es liberada de dicho sustrato quimioluminiscente por dicho factor hemostático, donde dicha molécula luminiscente se convierte posteriormente para producir un cuanto de luz detectable, donde dicho factor hemostático es la plasmina y donde el sustrato quimioluminiscente es un sustrato seleccionado del grupo que consiste en: - CH3O-(CH2CH2O)n-acetil-Phe-Arg-aminoluciferina donde n está en el intervalo de 2-5; - CH3O-(CH2CH2O)2-acetil-Phe-Arg-aminoluciferina; - CH3O-(CH2CH2O)4-acetil-Phe-Arg-aminoluciferina; - piroGlu-Phe-Lys-aminoluciferina; y, - una sal de un sustrato de los anteriores, preferiblemente la sal de TFA.

    RNA PROFILING FOR INDIVIDUALIZED DIET AND TREATMENT ADVICE
    45.
    发明专利
    RNA PROFILING FOR INDIVIDUALIZED DIET AND TREATMENT ADVICE 未知

    公开(公告)号：CA3055463A1

    公开(公告)日：2018-09-13

    申请号：CA3055463

    申请日：2018-03-07

    Applicant: STICHTING KATHOLIEKE UNIV

    Inventor： LEENDERS WILHELMUS PETRUS JOHANNES

    IPC: C12Q1/68

    Abstract: The present invention relates to the field of medicine and molecular diagnostics. In particular, it relates to a novel RNA next generation sequencing-based profiling assay allowing simultaneous detection of transcripts and alternative splice variants thereof and mutations therein, from genes involved in disease. including genes involved in metabolism, resulting in an advice for personalized treatment with drugs targeting disease-associated molecular aberrations in combination with dietary compounds, food supplements or inhibitors of metabolism.

    COMBINATION VACCINE FOR STREPTOCOCCUS
    46.
    发明专利
    COMBINATION VACCINE FOR STREPTOCOCCUS 未知

    公开(公告)号：CA2790984C

    公开(公告)日：2018-07-17

    申请号：CA2790984

    申请日：2010-02-23

    Applicant: STICHTING KATHOLIEKE UNIV

    Inventor： HERMANS PETER WILHELMUS MARIA

    IPC: A61K39/09 ,  A61P31/04 ,  C07K14/315

    Abstract: The invention relates to the use of a combination of SP1298 and SP2205 proteins or functional fragments thereof or homologous proteins or protein fragments thereof of S. pneumoniae for preventing or treating a S. pneumoniae infection, their use for the preparation of a vaccine for the preventive treatment of a S. pneumoniae infection, compositions comprising said proteins of S. pneumoniae or functional fragments thereof, vaccines comprising said proteins or functional fragment thereof, and to a method for in vivo immune protection.

    Selective cell penetrating peptides.
    50.
    发明专利
    Selective cell penetrating peptides. 未知

    公开(公告)号：NL2016207B1

    公开(公告)日：2017-08-21

    申请号：NL2016207

    申请日：2016-02-02

    Applicant: STICHTING KATHOLIEKE UNIV

    Inventor： SASKIA ANNERIE BODE ,  HARMEN DOLSTRA ,  DENNIS WILHELMUS PETRUS MARIA LÖWIK ,  JAN CORNELIS MARIA VAN HEST

    IPC: A61P35/02 ,  C07K7/06

    Abstract: The present invention founded on the finding that the cellular uptake capacity of the cell penetrating peptides (CPPs) can be modulated, by introducing at least one modified positively charged amino acid residue, which is modified in that that positive charge is (a) absent, (b) located at least one atom more distant from the backbone of the CPP, (c) located at least one atom less distant from the backbone of the CPP, or (d) linked to the backbone of the CPP via a modified linking moiety. This finding has been put to practice in the various aspects of the present invention. A first aspect concerns a method for selectively targeting a cell of interest, comprising (i) providing a modified CPP according to the invention, and (ii) contacting the modified CPP with a cell of interest. A second aspect concerns a method for screening for selective uptake of modified CPPs by a cell of interest, comprising (i) providing a modified CPP according to the invention, (ii) contacting the modified CPP with a sample comprising the cell of interest and at least one additional cell, (iii) determining the uptake of the modified CPP by the cell of interest and the at least one additional cell, (iv) comparing the uptake by the cell of interest with the uptake by the at least one additional cell. Furthermore, the modified CPPs are disclosed, as well as compositions comprising the modified CPP and their use for the treatment, prevention, delay, diagnosis, or detection of cancer.

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