公开(公告)号：WO2014012163A1

公开(公告)日：2014-01-23

申请号：PCT/CA2013/000631

申请日：2013-07-15

Applicant: UNIVERSITY OF WESTERN ONTARIO ,  CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION

Inventor： BAX, Jeffrey ,  FENSTER, Aaron

IPC: G01B5/004 ,  A61B19/00 ,  B25J11/00 ,  B25J19/02 ,  G01C9/00

CPC classification number: G01D5/14 ,  A61B5/055 ,  A61B6/032 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/0858 ,  A61B8/4218 ,  A61B8/4263 ,  A61B8/466 ,  A61B8/483 ,  A61B34/20 ,  A61B34/30 ,  A61B90/11 ,  A61B2034/2059 ,  A61B2090/378 ,  G01B5/004 ,  G01D5/26

Abstract: A mechanical tracking system comprises a first set of linkage arms, a second set of linkage arms, a pair of shafts connected at first end to one arm of the first set of linkage arms and at a second end to one arms of said second set of the linkage arms, wherein each arm of the second set of linkage arms is oriented out of phase with a respective arm of the first set of linkage arms, an attachment shaft positioned adjacent to the first set of linkage arms to accommodate a tool, and a sensor arrangement configured lo sense the orientation and position of the attachment shaft.

Abstract translation: 机械跟踪系统包括第一组联动臂，第二组联动臂，一对轴，其在第一端连接到第一组联动臂的一个臂，并且在第二端连接到所述第二组连杆的一个臂 所述连杆臂，其中所述第二组连杆臂的每个臂与所述第一组连杆臂的相应臂定向成异相;附接轴，其定位成与所述第一组连杆臂相邻以容纳工具;以及 配置的传感器布置使得感测附接轴的取向和位置。

公开(公告)号：WO2011068831A3

公开(公告)日：2011-10-06

申请号：PCT/US2010058498

申请日：2010-12-01

Applicant: TECHNOLOGY COMMERCIALIZATION CORP

Inventor： GANELIN BORIS ,  KENWORTHY MICHAEL W

IPC: E21B15/02 ,  E21B17/01

CPC classification number: E21B17/203 ,  E21B17/01 ,  F16L11/133 ,  F16L11/22 ,  F16L41/03

Abstract: Disclosed is a tubing system for transporting a gas-liquid flow from a well to a production platform or processing facility. It includes a dual pathway section between the well and the production point having a first tubing portion and a second tubing portion. The second tubing portion includes a plurality of parallel channels so as to divide the multi-phase flow into a plurality of flows through individual channels. This is done to reduce flow slippage of the lower viscosity portion of the flow, which may lead to inefficiencies in flow characteristics, and often, undesirable cyclical variations in pressure and fluid volume. This is especially useful in inclined portions of the petroleum flow pipe system and along hilly terrain. The first round tubing portion is used for transporting the gas-liquid flow as well as for maintenance purposes, such as for pigging, fishing or coiled tubing operations.

Abstract translation: 公开了一种用于将气液流从井输送到生产平台或处理设施的管道系统。 它包括井和生产点之间的双通道部分，其具有第一管部分和第二管部分。 第二管道部分包括多个平行通道，以便将多相流分成通过各个通道的多个流。 这样做是为了减少流动的较低粘度部分的流动滑动，这可能导致流动特性的低效率，并且通常会导致压力和流体体积的不希望的周期性变化。 这在石油管道系统的倾斜部分和丘陵地带尤其有用。 第一圆管部分用于输送气液流动以及用于维护目的，例如用于清管，捕鱼或连续油管作业。

公开(公告)号：WO2011068831A2

公开(公告)日：2011-06-09

申请号：PCT/US2010/058498

申请日：2010-12-01

Applicant: TECHNOLOGY COMMERCIALIZATION CORP.

Inventor： GANELIN, Boris ,  KENWORTHY, Michael, W.

CPC classification number: E21B17/203 ,  E21B17/01 ,  F16L11/133 ,  F16L11/22 ,  F16L41/03

Abstract: Disclosed is a tubing system for transporting a gas-liquid flow from a well to a production platform or processing facility. It includes a dual pathway section between the well and the production point having a first tubing portion and a second tubing portion. The second tubing portion includes a plurality of parallel channels so as to divide the multi-phase flow into a plurality of flows through individual channels. This is done to reduce flow slippage of the lower viscosity portion of the flow, which may lead to inefficiencies in flow characteristics, and often, undesirable cyclical variations in pressure and fluid volume. This is especially useful in inclined portions of the petroleum flow pipe system and along hilly terrain. The first round tubing portion is used for transporting the gas-liquid flow as well as for maintenance purposes, such as for pigging, fishing or coiled tubing operations.

Abstract translation: 公开了一种用于将气体 - 液体流从井输送到生产平台或处理设施的管道系统。 它包括井和生产点之间的双通道部分，其具有第一管部分和第二管部分。 第二管道部分包括多个并行通道，以便将多相流分成多个通过各个通道的流。 这是为了减少流动的较低粘度部分的流动滑移，这可能导致流动特性的低效率，并且通常是压力和流体体积的不期望的周期性变化。 这在石油流管系统的倾斜部分和丘陵地带特别有用。 第一圆管部分用于输送气液流以及用于维护目的，例如用于清管，钓鱼或连续油管操作。

公开(公告)号：WO2010052580A3

公开(公告)日：2010-05-14

申请号：PCT/IB2009/007601

申请日：2009-11-10

Applicant: KATHOLIEKE UNIVERSITEIT LEUVENK, K.U. LEUVEN R&D ,  REGENTS OF THE UNIVERSITY OF MINNESOTA, OFFICE FOR TECHNOLOGY COMMERCIALIZATION ,  VERFAILLIE, Catherine ,  SCHOEMANS, Helene ,  SNOECKX, Rikkert

Inventor： VERFAILLIE, Catherine ,  SCHOEMANS, Helene ,  SNOECKX, Rikkert

IPC: C12N5/0789

Abstract: The invention is related to methods for culturing stem cells, more particularly hematopoietic stem cells (HSC). The invention relates to methods for HSC expansion and the use of factors to increase the retention and/or expansion of KLS cells in vitro. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other things, for treatment of disorders or diseases (e.g. leukemia). The invention also relates to the development of small molecules that may increase HSC self renewal in vitro and in vivo.

公开(公告)号：WO2008094801A4

公开(公告)日：2009-01-22

申请号：PCT/US2008051806

申请日：2008-01-23

Applicant: TECHNOLOGY COMMERCIALIZATION

Inventor： GANELIN BORIS ,  KENWORTHY MICHAEL W

IPC: F04D29/041

CPC classification number: F01D3/00 ,  F01D11/02 ,  F04D29/0416 ,  F04D29/046 ,  F04D29/0513 ,  F04D29/056 ,  F05D2240/52 ,  F05D2240/53

Abstract: A method and apparatus to reduce the axial thrust in rotary machines such as compressors, centrifugal pumps, turbines, etc. includes providing additional peripheral restrictive means (7) attached at the peripheral portion of the disk forming the subdividing means (4) on the side facing the rotating rotor (2). An additional ring element at the periphery of the subdividing means forms additional radial (11) and axial restrictive means (15). Such peripheral restrictive means (7, 11 and 15) function as sealing dams, which combined with the outward flow induced by the rotating impeller, form self-pressurizing hydrodynamic bearings in the axial and radial planes, improving rotordynamic stability. Additionally, a stationary ring element in the center of the cavity forms a seal with the rotor, reducing leakage to suction.

Abstract translation: 一种用于减小诸如压缩机，离心泵，涡轮机等旋转机械中的轴向推力的方法和装置包括提供附加在盘的周边部分处的附加的外围限制装置（7），所述外围限制装置形成在侧面上的细分装置（4） 面向旋转转子（2）。 在分割装置的周边处的另外的环形元件形成附加的径向（11）和轴向限制装置（15）。 这种外围限制装置（7,11和15）用作密封坝，其结合由旋转叶轮引起的向外流动，在轴向和径向平面中形成自加压流体动力轴承，从而提高转动动力学稳定性。 另外，空腔中心的固定环元件与转子形成密封，减少了泄漏到吸力。

公开(公告)号：WO2008038160A2

公开(公告)日：2008-04-03

申请号：PCT/IB2007/004218

申请日：2007-06-21

Applicant: TECHNOLOGY COMMERCIALIZATION CORP.

CPC classification number: A61K31/351

Abstract: A substance with sedative effect comprises a therapeutically effective amount of a gamma- pyrone such as comenic acid, meconic acid, 5-methoxy-gamma-pyrone-2-carboxylic acid, and alike in a pharmaceutically acceptable carrier. When administered at a daily dosage of between 0.05 mg to about 10,000 mg of active ingredient per unit dose of a patient, the substance can be used to treat various disorders of a nervous system such as pain, insomnia, anxiety, neurosis, depression, as well as withdrawal symptoms experienced by drug addiction patients, especially for patients addicted to opiate-based drugs. The substance can be delivered in a number of ways of systemic administration of a pharmaceutical agent including oral, parenteral, transdermal, and transmucosal administration. For drug addicted patients, the preferred method of administration involves a subcutaneous implant providing a continuous release of an active ingredient at an effective daily rate over the entire treatment period ranging from 5 to 30 days, and preferably from 13 to 20 days.

Abstract translation: 具有镇静作用的物质在药学上可接受的载体中包含治疗有效量的γ-吡喃酮，例如康宁酸，麦康酸，5-甲氧基-γ-吡喃酮-2-羧酸。 当以每单位剂量的患者的0.05mg至约10,000mg活性成分的日剂量施用时，该物质可用于治疗神经系统的各种疾病，例如疼痛，失眠，焦虑，神经症，抑郁症，如 以及吸毒成瘾患者的戒断症状，​​特别是对于以鸦片类为主的药物成瘾的患者。 物质可以以多种方式递送，包括口服，胃肠外，透皮和经粘膜给药的药物的全身给药。 对于吸毒成瘾患者，优选的给药方法包括皮下植入物，其在5至30天，优选13至20天的整个治疗期间以有效的每日速率持续释放活性成分。

公开(公告)号：WO2007109228A1

公开(公告)日：2007-09-27

申请号：PCT/US2007/006809

申请日：2007-03-19

Applicant: NATIONAL INSTITUTES OF HEALTH ,  UNIVERSITY OF MARYLAND OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  GOMEZ, Romel, Del Rosario ,  KHAN, Javed ,  PANDANA, Herman ,  ASCHENBACH, Konrad ,  FUHRER, Michael ,  WEI, Jun

Inventor： GOMEZ, Romel, Del Rosario ,  KHAN, Javed ,  PANDANA, Herman ,  ASCHENBACH, Konrad ,  FUHRER, Michael ,  WEI, Jun

IPC: C12Q1/68

CPC classification number: G01N33/5438 ,  B82Y15/00 ,  B82Y30/00 ,  Y10S977/702 ,  Y10S977/92 ,  Y10S977/938

Abstract: A microarray apparatus is provided which contains at least one chip having source and drain electrodes positioned on an array of carbon nanotube transistors which allows for electronic detection of nucleic acid hybridizations, thereby affording both increased sensitivity and the capability of miniaturization.

Abstract translation: 提供一种微阵列装置，其包含至少一个芯片，其具有位于碳纳米管晶体管阵列上的源极和漏极，其允许电子检测核酸杂交，从而提供增加的灵敏度和小型化的能力。

公开(公告)号：WO2004000038A1

公开(公告)日：2003-12-31

申请号：PCT/US2003/018831

申请日：2003-06-13

Applicant: TECHNOLOGY COMMERCIALIZATION CORP.

Inventor： SOBOL, Constantin, V. ,  SOBOL, Yuzefa, T.

IPC: A23K3/03

CPC classification number: A23C9/133 ,  A23L7/104 ,  A23L19/20 ,  A23L33/135 ,  A23L33/17 ,  A61K35/74 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  Y02A50/401 ,  Y02A50/406 ,  Y02A50/471 ,  Y02A50/473

Abstract: A method of producing a hydrolyzed fermented medium containing microorganisms such as bacteria or yeast and the products of their metabolism in high concentration, the method includes providing at least one solid plant product reduced to small pieces and mixed with sugar and a biocompatible liquid such as milk for fermentation at a temperature of between 35 and 58 degrees C until the acidity of the medium reaches the range of 300 to 900 in Terner degrees. In an alternative embodiment, the medium is prepared by mixing in predetermined amounts of sprouted grains, biocompatible liquid inoculated with at least one of a variety of non-pathogenic microorganisms, vegetables, fruits, berries, high protein products, herbs, sugar, and a chemical element such as potassium. The mixture is then fermented at a selected temperature for a specified length of time to reach high acidity and high concentration of products of bacterial metabolism. A liquid phase is separated from a solid sediment phase and can be used to treat a wide variety of diseases including HIV/AIDS, viral infections, cardiovascular diseases, Alzheimer's and others as well as for other applications.

Abstract translation: 一种生产含有细菌或酵母等微生物及其高代谢产物的水解发酵培养基的方法，该方法包括提供至少一种还原成小片的固体植物产品，并与糖和生物相容性液体如牛奶混合 在35至58摄氏度的温度下进行发酵，直到培养基的酸度达到Terner度的300至900的范围。 在另一个实施方案中，通过将预定量的发芽谷物，接种有多种非病原微生物，蔬菜，水果，浆果，高蛋白质产品，草药，糖和至少一种的非生物相容性液体 化学元素如钾。 然后将混合物在选定温度下发酵一段特定的时间以达到高酸度和高浓度的细菌代谢产物。 液相从固体沉淀相分离，可用于治疗各种疾病，包括艾滋病毒/艾滋病，病毒感染，心血管疾病，阿尔茨海默氏症等，以及其他应用。

公开(公告)号：WO2019018371A1

公开(公告)日：2019-01-24

申请号：PCT/US2018/042451

申请日：2018-07-17

Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  DUKE UNIVERSITY

Inventor： FRANK, Barnett, Samuel ,  PADUA, Darin, Anthony ,  MAZZOLENI, Michael, Joseph ,  MANN, Brian, Patrick

IPC: A61B5/11 ,  A61B5/00 ,  A61B5/024 ,  A61B5/1455

Abstract: A system for assessing lower extremity movement quality includes one or more user sensors, at least one processor, and a movement evaluator implemented using the at least one processor. The movement evaluator is configured, by virtue of appropriate programming, for receiving movement data from the one or more user sensors during a user's performance of a movement task; extracting one or more movement features from the movement data, each movement feature characterizing a respective aspect of a movement pattern of the user's performance that is associated with lower extremity injury risk; and classifying the movement pattern into a classified risk category for lower extremity injury for the user based on the one or more movement features.

公开(公告)号：WO2018067811A1

公开(公告)日：2018-04-12

申请号：PCT/US2017/055331

申请日：2017-10-05

Applicant: CHILDREN'S HOSPITAL MEDICAL CENTER, CENTER FOR TECHNOLOGY COMMERCIALIZATION ,  UNIVERSITY OF CINCINNATI ,  IBANEZ, Jose Peiro ,  TATU, Rigwed ,  LIN, Chia-Ying

Inventor： IBANEZ, Jose Peiro ,  TATU, Rigwed ,  LIN, Chia-Ying

IPC: A61B17/03 ,  A61F2/02 ,  A61F2/82

Abstract: A patch of material is configured to be applied to human tissue. The patch includes a film comprising poly(L-lactide) and poly(ℇ-caprolactone). The film is configured to self-deploy between a first position and a second position in response to a temperature. The film is applied to the human tissue when the patch of material is in the second position, in which the film has a planar configuration.

Abstract translation:

一块材料被配置为应用于人体组织。 贴片包括包含聚（L-丙交酯）和聚（ε-己内酯）的膜。 该膜被配置为响应于温度而在第一位置和第二位置之间自行展开。 当材料片处于第二位置时，薄膜应用于人体组织，其中薄膜具有平面结构。