公开(公告)号：US20190203253A1

公开(公告)日：2019-07-04

申请号：US16312410

申请日：2017-07-05

Applicant: University of Saskatchewan ,  SASKATCHEWAN CANCER AGENCY

Inventor： Franco Joseph Vizeacoumar ,  Andrew Freywald ,  James Mathew Paul ,  Frederick Sagayaraj Vizeacoumar

IPC: C12Q1/02 ,  A61P35/00 ,  A61K31/506 ,  C12Q1/686

CPC classification number: C12Q1/025 ,  A61K31/506 ,  A61P35/00 ,  C12Q1/686 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/158 ,  C40B30/06 ,  G01N33/57484 ,  G01N2333/715 ,  G01N2500/10 ,  G01N2800/52 ,  G01N2800/60

Abstract: Methods for identifying a subject with a cancer eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, are provided. The methods comprise testing a biological sample from the subject for a deficiency in EPHB6 receptor levels, wherein the subject is eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, if EPHB6 receptor levels in the biological sample are deficient.

公开(公告)号：US10213770B2

公开(公告)日：2019-02-26

申请号：US13667333

申请日：2012-11-02

Applicant: University of Saskatchewan

Inventor： Reza Abbaslou ,  Ajay Dalai

IPC: B01J23/887 ,  B82Y30/00 ,  B01J37/02 ,  B01J21/18 ,  B01J23/881 ,  B01J35/00 ,  B01J35/10 ,  C10G2/00

Abstract: The present application includes iron catalysts promoted with Mo, K and optionally Cu on a multi-walled carbon nanotube (MWCNT) support for high molecular weight hydrocarbon synthesis from synthesis gas.

公开(公告)号：US10212912B2

公开(公告)日：2019-02-26

申请号：US14766065

申请日：2013-02-05

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Vladimir Vujanovic ,  James J. Germida

IPC: A01H17/00 ,  A01N63/02 ,  A01N63/04 ,  B09C1/10 ,  A01N63/00 ,  C12R1/80 ,  C12R1/465 ,  C12R1/645

Abstract: The present disclosure provides novel endophyte strains or cultures thereof that have a symbiotic relationship with plants. The present disclosure further provides methods of improving seed vitality, biotic and abiotic stress resistance, plant health and yield under both stressed and unstressed environmental conditions, comprising inoculating a seed with the novel endophyte strains and cultivating a plant therefrom.

公开(公告)号：US10059971B2

公开(公告)日：2018-08-28

申请号：US15438291

申请日：2017-02-21

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA ,  UNIVERSITY OF SASKATCHEWAN

Inventor： Jonathan E. Page ,  Steve Gagne

IPC: C12N15/82 ,  C12P17/06 ,  C12P7/42 ,  C12P7/22 ,  C12N15/52 ,  C12N15/70

CPC classification number: C12P17/06 ,  C12N9/1025 ,  C12N15/52 ,  C12N15/70 ,  C12N15/8243 ,  C12P7/22 ,  C12P7/42 ,  C12Y203/01206 ,  C12Y404/01026 ,  Y02P20/52

Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.

公开(公告)号：US09809620B2

公开(公告)日：2017-11-07

申请号：US14265136

申请日：2014-04-29

Applicant: University of Saskatchewan

Inventor： Kristen Marciniuk ,  Ryan Taschuk ,  Scott Napper ,  Andrew Potter ,  Neil Cashman

IPC: A61K39/00 ,  C07K14/47 ,  C07K7/06 ,  C07K7/08 ,  C07K16/28 ,  C07K16/18 ,  C07K14/00 ,  C07K16/44 ,  G01N33/68 ,  C07K14/285

CPC classification number: C07K7/06 ,  A61K39/0007 ,  A61K2039/55566 ,  A61K2039/6037 ,  C07K14/001 ,  C07K14/285 ,  C07K14/47 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2760/20134 ,  G01N33/6854 ,  G01N33/6896 ,  G01N2333/001 ,  G01N2800/24 ,  G01N2800/2828

Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.

公开(公告)号：US20170151323A1

公开(公告)日：2017-06-01

申请号：US15218748

申请日：2016-07-25

Applicant: University of Saskatchewan

Inventor： Yan Zhou ,  Aleksandar Masic

IPC: A61K39/145 ,  C12N7/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/544 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/16121 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16162 ,  C12N2760/16171 ,  C12N2799/025

Abstract: Recombinant, chimeric porcine influenza viruses are disclosed that include hemagglutinin segments from more than one influenza virus subtype. Also described are methods of producing the recombinant influenza viruses, immunogenic compositions comprising the recombinant influenza viruses, methods of stimulating an immune response against influenza virus, and methods of treating and preventing influenza virus infection.

公开(公告)号：US09464015B2

公开(公告)日：2016-10-11

申请号：US14769112

申请日：2014-03-06

Applicant: University of Saskatchewan

Inventor： Ajay Kumar Dalai ,  Rajesh Vishnudev Sharma ,  Pardeep Kumar

IPC: C07C29/60 ,  B01J23/00 ,  B01J23/86 ,  B01J37/03 ,  B01J37/18 ,  B01J38/12 ,  B01J23/94 ,  B01J35/00 ,  B01J35/10

CPC classification number: C07C29/60 ,  B01J23/002 ,  B01J23/868 ,  B01J23/94 ,  B01J35/002 ,  B01J35/006 ,  B01J35/0066 ,  B01J35/1014 ,  B01J35/1038 ,  B01J35/1061 ,  B01J37/03 ,  B01J37/18 ,  B01J38/12 ,  B01J2523/00 ,  Y02P20/584 ,  C07C31/205 ,  B01J2523/17 ,  B01J2523/27 ,  B01J2523/48 ,  B01J2523/67

Abstract: A process for the hydrogenolysis of glycerol to produce propylene glycol as the major product comprising contacting the glycerol with hydrogen in the presence of a heterogeneous catalyst under conditions for the formation of propylene glycol is disclosed. In particular, propylene glycol is formed with a selectivity of greater than about 90%.

Abstract translation: 公开了一种用于甘油氢解生产丙二醇作为主要产物的方法，包括在形成丙二醇的条件下，在非均相催化剂存在下使甘油与氢气接触。 特别地，形成大于约90％的选择性的丙二醇。

公开(公告)号：US09408908B2

公开(公告)日：2016-08-09

申请号：US13768694

申请日：2013-02-15

Applicant: University of Saskatchewan ,  The University of British Columbia ,  Dalhousie University ,  International Vaccine Institute

Inventor： Sylvia van den Hurk ,  Volker Gerdts ,  Andrew Potter ,  Lorne Babiuk ,  Robert Hancock ,  Scott Halperin ,  Jennifer Kovacs-Nolan ,  George Mutwiri ,  Song Lee ,  Mi-Na Kweon ,  Jason Kindrachuk ,  Melissa Elliott

IPC: A61K39/39 ,  A61K39/12 ,  A61K47/30 ,  A61K45/06 ,  A61K39/155 ,  C07K7/08 ,  A61K39/02 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K39/099 ,  A61K39/12 ,  A61K39/155 ,  A61K45/06 ,  A61K47/30 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/6093 ,  C07K7/08 ,  C12N2760/18534

Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.

公开(公告)号：US20160158333A1

公开(公告)日：2016-06-09

申请号：US14907681

申请日：2014-07-25

Applicant: Aaron P. WHITE ,  Sumundu R. PERERA ,  Shirley LAM ,  Deanna L. GIBSON ,  UNIVERSITY OF SASKATCHEWAN

Inventor： Aaron P. White ,  Sumundu R. Perera ,  Shirley Lam ,  Deanna L. Gibson

IPC: A61K39/112 ,  C12P19/04 ,  G01N33/68 ,  A61K39/40

CPC classification number: A61K39/0275 ,  A61K39/40 ,  C07K16/1235 ,  C12P19/04 ,  G01N33/56916 ,  G01N33/6854 ,  G01N2333/255 ,  G01N2469/20 ,  Y02A50/482

Abstract: Methods of purifying O-Ag capsules from an S. enterica NTS serovar, wherein the O-Ag capsule is substantially free of co-expressed cellulose and LPS, are described, as are immunogenic compositions comprising the O-Ag capsules and methods for treating, preventing and diagnosing Salmonella infections. Also described are constructs and methods for producing S. enterica NTS serovar mutants which over-express the O-Ag capsule.

Abstract translation: 还描述了从含有O-Ag胶囊的免疫原性组合物和含有O-Ag胶囊的方法来纯化来自肠杆菌NTS血清型的O-Ag胶囊的方法，其中所述O-Ag胶囊基本上不含共表达的纤维素和LPS， 预防和诊断沙门氏菌感染。 还描述了用于产生过表达O-Ag胶囊的肠炎沙门氏菌NTS血清型突变体的构建体和方法。

公开(公告)号：US20160120186A1

公开(公告)日：2016-05-05

申请号：US14894318

申请日：2014-05-29

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Andrew A. Olkowski ,  Bernard Laarveld ,  Karen K. Tanino

IPC: A01N59/20 ,  A01N59/16 ,  A01N59/00

CPC classification number: A01N59/20 ,  A01C1/02 ,  A01N59/00 ,  A01N59/16 ,  A01N25/00 ,  A01N25/08 ,  A01N25/22

Abstract: The present application pertains to compositions for enhancing or controlling the germination of seeds. The compositions comprise i) a transition metal catalyst such as nanoparticulate catalyst bearing one or more transition metals, a carbon nanotube impregnated with Fe, Cu, Mo, Rh or Co, or a transition metal salt (FeSO4, CuSO4 or a cobalt salt) and ii) an oxidant such as hydrogen peroxide. The composition may further comprise a buffer. Methods of enhancing or controlling the germination of seeds using the composition are also disclosed.

Abstract translation: 本申请涉及用于增强或控制种子萌发的组合物。 组合物包括i）过渡金属催化剂，例如载有一种或多种过渡金属的纳米颗粒催化剂，浸渍有Fe，Cu，Mo，Rh或Co的碳纳米管，或过渡金属盐（FeSO 4，CuSO 4或钴盐）和 ii）氧化剂如过氧化氢。 组合物还可以包含缓冲剂。 还公开了使用该组合物增强或控制种子发芽的方法。