公开(公告)号：US20230058044A1

公开(公告)日：2023-02-23

申请号：US17779704

申请日：2020-11-25

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  ICHILOV TECH LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Vered PADLER-KARAVANI ,  Yafit ATIYA-NASAGI ,  Ron AMON ,  Anat GLOBERSON LEVIN ,  Tova WAKS ,  Moran RAWET-SLOBODKIN ,  Lihi NINIO MANY ,  Zelig ESHHAR

IPC: A61K35/17 ,  C07K14/725 ,  C07K14/705 ,  C07K14/735 ,  C12N5/0783

Abstract: The present invention discloses chimeric antigen receptors that specifically recognize and bind to SLe A carbohydrate antigen with high specificity and selectivity. The invention further provides lymphocytic cells, such as T cells, comprising said CARs, compositions comprising said cells or CARs as well as uses thereof.

公开(公告)号：US11576251B2

公开(公告)日：2023-02-07

申请号：US17255519

申请日：2019-06-24

Applicant: Ecole Polytechnique ,  Ecole Nationale Supérieure de Techniques Avancées ,  Centre National de La Recherche Scientifique ,  Yeda Research and Development Co. Ltd.

Inventor： Cédric Thaury ,  Slava Smartsev

IPC: H05H1/54 ,  H01S3/00

Abstract: A reflective optical system (100) comprising at least one reflective aspheric surface (1) of focal length f0 and optical axis (Z), the surface being configured so that an incident laser beam (2) propagating along an axis (Z′) is focused along the optical axis (Z) with a FWHM ((Full Width at Half Maximum) of the intensity of the reflected beam along the optical axis (Z) being larger, preferably by a factor of at least 10, than the FWHM of the intensity of a focused beam reflected by a parabola having same focal length f0 and same optical axis (Z), receiving same beam.

公开(公告)号：US11555178B2

公开(公告)日：2023-01-17

申请号：US16478477

申请日：2018-01-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair Reisner ,  Esther Bachar-Lustig ,  Shlomit Reich-Zeliger

IPC: C12N5/0783 ,  A61P35/02 ,  A61P35/04 ,  A61P35/00 ,  A61K35/17 ,  C07K14/725 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C12N5/00 ,  A61K38/00

Abstract: An isolated cytotoxic T-lymphocyte (CTL), said CTL being a tolerance inducing cell and substantially depleted of alloreactivity, and wherein said CTL does not comprise a central memory T-lymphocyte (Tcm) phenotype, the CTL being transduced to express a cell surface receptor comprising a T cell receptor signaling module, is disclosed. Methods of generating same and using same are also disclosed.

公开(公告)号：US11541008B2

公开(公告)日：2023-01-03

申请号：US16809816

申请日：2020-03-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Yechezkel Barenholtz ,  Avi Schroeder

IPC: A61K9/127 ,  A61L27/50

Abstract: The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature Tm of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.

公开(公告)号：US11540725B2

公开(公告)日：2023-01-03

申请号：US16334037

申请日：2017-09-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon Harmelin ,  Vyacheslav Kalchenko ,  Guillaume Molodij

IPC: A61B5/02 ,  G06T7/593 ,  G06T7/246 ,  G06T5/00 ,  G06T5/20 ,  A61B5/00 ,  G06T7/55

Abstract: There is provided a computer implemented method for generating a three dimensional (3D) image based of fluorescent illumination, comprising: receiving in parallel by each of at least three imaging sensors positioned at a respective parallax towards an object having a plurality of regions with fluorescent illumination therein, a respective sequence of a plurality of images including fluorescent illumination of the plurality of regions, each of the plurality of images separated by an interval of time; analyzing the respective sequences, to create a volume-dataset indicative of the depth of each respective region of the plurality of regions; and generating a 3D image according to the volume-dataset.

公开(公告)号：US20220364175A1

公开(公告)日：2022-11-17

申请号：US17846157

申请日：2022-06-22

Applicant: Yeda Research and Development Co. Ltd. ,  UCL Business Ltd

Inventor： Eran HORNSTEIN ,  Iddo MAGEN ,  Nancy-Sarah YACOVZADA ,  Jonathan ROHRER ,  Pietro FRATTA

IPC: C12Q1/6883 ,  G01N33/68

Abstract: A method of diagnosing Frontotemporal dementia (FTD) in a subject in need thereof is provided. The method comprising detecting a level of at least one micro RNA (miR) selected from the group consisting of hsa-miR-361-5p, hsa-miR-629-5p, hsa-miR-628-3p, hsa-miR-379-5p, hsa-miR-1-3p, hsa-miR-26a-5p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-142-5p and hsa-miR-340-5p in a biological sample of the subject, wherein when said level of said at least one micro RNA (miR) is higher than that in a control sample, it is indicative of FTD.

公开(公告)号：US11471504B2

公开(公告)日：2022-10-18

申请号：US16633175

申请日：2018-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena Samuels ,  Rand Arafeh ,  Karen Flores ,  Rony Seger ,  Ehud Wainstein

IPC: A61K38/10 ,  A61P35/00 ,  A61K31/4184 ,  A61K31/519

Abstract: An article of manufacture is disclosed which comprises: (i) a peptide agent which is capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus; and (ii) a MEK inhibitor. Uses thereof are also disclosed.

公开(公告)号：US20220307008A1

公开(公告)日：2022-09-29

申请号：US17619722

申请日：2020-06-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Ido YOFE ,  Diego JAITIN ,  Yonatan KATZENELENBOGEN ,  Mami LENNIKOV ,  Assaf WEINER ,  Hadas KEREN-SHAUL

IPC: C12N15/10 ,  C12Q1/6806 ,  C12N15/11

Abstract: A method of permeabilizing a cell is disclosed. Kits for permeabilizing cells and analysing RNA contents are also disclosed.

公开(公告)号：US20220306710A1

公开(公告)日：2022-09-29

申请号：US17748212

申请日：2022-05-19

Applicant: Yeda Research and Development Co. Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Ruth ARNON ,  Ruth MARON ,  Gad ARMONY ,  Michael Menachem TSOORY ,  Meir WILCHEK ,  Dan FRENKEL

IPC: C07K14/47 ,  A61K9/00 ,  A61P25/28

Abstract: A method of treating Alzheimer's Disease (AD) is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which prevents the binding of amyloid precursor protein (APP) to Tau protein.

公开(公告)号：US11446413B2

公开(公告)日：2022-09-20

申请号：US15109822

申请日：2015-01-06

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  MOR RESEARCH APPLICATIONS LTD.

Inventor： Reshef Tenne ,  David Zbaida ,  Racheli Ron ,  Ilan Kafka ,  Ilan Leibovitch

IPC: A61L29/14 ,  A61L31/08 ,  A61L29/10 ,  A61L31/14 ,  A61L29/18 ,  A61L31/18

Abstract: A new approach is presented to reduce encrustation of catheters by the application of nanoparticles. It is demonstrated that the negatively surface charged nanoparticles produce coating films comprised of long-range domains in which the nanoparticles are self-assembled into a mosaic-like order, showing a relatively small tendency to agglomerate.