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公开(公告)号：KR101839582B1
公开(公告)日：2018-03-16
申请号：KR1020160086002
申请日：2016-07-07
Applicant: 동국대학교 산학협력단
IPC: A23L1/30 , A61K36/899 , C12N5/071
Abstract: 본발명은왕겨추출물을포함하는세포활성화용조성물및 이의세포활성화방법에관한것으로, 본발명의조성물은천연물로유래된오르토규산을포함하며, 체내에서세포및 장기에독성을유발시키지않아생체적합성이우수하며, 건강보조식품또는조직치료를위한보조수단으로유용하게이용될수 있다.
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公开(公告)号：KR101768795B1
公开(公告)日：2017-08-18
申请号：KR1020160003582
申请日：2016-01-12
Applicant: 동국대학교 산학협력단
IPC: C12N13/00 , C12N5/0793 , A61K35/30
Abstract: 본발명은중간엽줄기세포또는성체줄기세포에 1 내지 500mT 의전자기장강도와 1000 내지 6000Hz 의주파수를갖는맥동형전자기장을처리하여, 상기중간엽줄기세포또는성체줄기세포를신경세포로분화시키는방법에관한것이다.
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公开(公告)号：KR1020140058777A
公开(公告)日：2014-05-15
申请号：KR1020120124770
申请日：2012-11-06
Applicant: 동국대학교 산학협력단
CPC classification number: C04B33/04 , A23K20/28 , A23L29/015 , A61K35/02 , C04B33/131 , C05F7/00
Abstract: The present invention relates to an artificial terra tiavausta composition manufactured by adding sodium, potassium, and calcium components to loess. In addition, the present invention relates to a method for manufacturing artificial terra tiavausta which comprises the steps of: (i) obtaining a mixed composition by adding sodium, potassium, and calcium components to loess; (ii) obtaining a melted material by heating the mixed composition; (iii) pulverizing after cooling the melted material at room temperature; (iv) manufacturing the pulverized material into a nanocolloid form; (v) collecting an extract by filtering after adding diatomite to the nanocolloid; and (vi) neutralizing the filtered extract using acid.
Abstract translation: 本发明涉及通过将钠，钾和钙成分加入到黄土中制造的人造天竺葵组合物。 另外，本发明涉及一种制造人造天竺葵的方法，包括以下步骤：（i）通过向黄土中加入钠，钾和钙成分得到混合组合物; （ii）通过加热混合组合物获得熔融材料; （iii）在室温下冷却熔融材料后粉碎; （iv）将粉碎的材料制成纳米胶体形式; （v）在将硅藻土加入到纳米胶体中之后通过过滤收集提取物; 和（vi）使用酸中和过滤的提取物。
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公开(公告)号：KR1020130099633A
公开(公告)日：2013-09-06
申请号：KR1020120021285
申请日：2012-02-29
Applicant: 동국대학교 산학협력단 , 서울대학교산학협력단
Abstract: PURPOSE: A method for differentiating adult stem cells into schwann cells is provided to effectively differentiate adult stem cells into schwann cells without an expensive differentiation medium. CONSTITUTION: A method for differentiating adult stem cells into schwann cells using an electromagnetic field comprises the steps positioning the adult stem cells in the electromagnetic field at a frequency of 1-200 Hz; and culturing the adult stem cells. The intensity of the electromagnetic field is 0.5-2 mT. The culturing comprises the steps of: culturing the adult stem cells in an alpha-MEM medium containing beta-mercaptoethanol for 12-36 hours; culturing the adult stem cells in an alpha-MEM medium containing trans-retinoic acid for 60-82 hours; and culturing the adult stem cells in an alpha-MEM medium containing forskolin for 7-14 days.
Abstract translation: 目的：提供一种将成体干细胞分化为雪旺氏细胞的方法，以有效地将成体干细胞分化成施旺细胞，而不需要昂贵的分化培养基。 构成：使用电磁场将成体干细胞分化成雪旺氏细胞的方法包括以1-200Hz的频率将成体干细胞定位在电磁场中的步骤; 并培养成体干细胞。 电磁场强度为0.5-2 mT。 培养包括以下步骤：在含有β-巯基乙醇的α-MEM培养基中培养12-36小时的成体干细胞; 在含有反式视黄酸的α-MEM培养基中培养成体干细胞60-82小时; 并在含有毛喉素的α-MEM培养基中培养成体干细胞7-14天。
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公开(公告)号：KR1020130090512A
公开(公告)日：2013-08-14
申请号：KR1020120011717
申请日：2012-02-06
Applicant: 동국대학교 산학협력단
IPC: C12N5/079 , C12N5/0735 , C12N5/074 , C12N5/02
CPC classification number: C12N5/0618 , C12N2500/44 , C12N2501/33 , C12N2501/39 , C12N2501/999 , C12N2506/1346 , C12N2506/1384
Abstract: PURPOSE: A composition for inducing the differentiation into neural cells is provided to regenerate and resuscitate neural cells by transplanting mesenechymal stem cells to treat incurable neural diseases as the mesenechymal stem cells are differentiated into neural cells after the mesenechymal stem cells are transplanted into the area of lesion. CONSTITUTION: A method for differentiating stem cells into neural cells comprises the steps of: culturing stem cells; and differentiating the cultured stem cells into neural cells by treating the cultured stem cells with culture additive including lipoic acid, albumin, hydrocortisone, and insulin. The stem cells are one or more kinds selected from a group consisting of embryonic stem cells, adult stem cells, induced pluripotent stem cells, embryonic germ cells, embryonic tumor cells, neural stem cells, and mesenechymal stem cells. The stem cells are separated from one or more kinds selected from a group consisting of bone marrow, cord blood, and fat tissue. A composition for inducing the differentiation into neural cells includes lipoic ace, albumin, hydrocortisone, and insulin.
Abstract translation: 目的：提供一种用于诱导分化为神经细胞的组合物，通过移植间充质干细胞来治疗不可治愈的神经疾病来再生和复苏神经细胞，因为在将髓系间干细胞移植到 病变。 构成：将干细胞分化成神经细胞的方法包括以下步骤：培养干细胞; 并通过用包括硫辛酸，白蛋白，氢化可的松和胰岛素的培养添加剂处理培养的干细胞，将培养的干细胞分化成神经细胞。 所述干细胞是选自胚胎干细胞，成体干细胞，诱导多能干细胞，胚胎生殖细胞，胚胎肿瘤细胞，神经干细胞和髓系间干细胞的一种或多种。 将干细胞从选自骨髓，脐带血和脂肪组织中的一种或多种分离。 用于诱导分化成神经细胞的组合物包括硫辛酸，白蛋白，氢化可的松和胰岛素。
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Patent Agency Ranking46.发明授权미세유체 기반의 조직 배양시 저산소 조건의 구현을 위한 세포 내 용존산소농도 제어장치 및 이를 이용한 세포 내 용존산소농도 제어방법 有权氧化浓度控制装置及用于产生基于微流体组织培养的超临界状态的方法
公开(公告)号：KR101294521B1
公开(公告)日：2013-08-07
申请号：KR1020120015365
申请日：2012-02-15
Applicant: 서울대학교산학협력단 , 동국대학교 산학협력단
Abstract: PURPOSE: An apparatus for controlling the concentration of dissolved oxygen in cells and a method for controlling the concentration of dissolved oxygen in cells using the same are provided to simplify and miniaturize the apparatus because additional devices for injecting mixed gas are unnecessary. CONSTITUTION: An apparatus for controlling the concentration of dissolved oxygen in cells comprises: a first channel (110) which provides a space for cell culture; a second channel (120) which is placed at one side of the first channel; an intermediate membrane which is placed between the first and second channels and divides for enabling oxygen to pass through the first and second channels; and an oxygen absorbent supply unit which supplies an oxygen absorbent to the second channel for discharging intracellular dissolved oxygen of the first channel to the second channel through the intermediate membrane. A method for controlling the dissolved oxygen in cells using the apparatus comprises the steps of: culturing the cells in the first channel; and supplying the oxygen absorbent to the second channel and reducing oxygen partial pressure of the first channel.
Abstract translation: 目的：提供一种用于控制细胞中溶解氧浓度的装置以及使用该装置控制细胞中溶解氧浓度的方法，以便简化和小型化装置，因为不需要额外的注入混合气体的装置。 构成：用于控制细胞中溶解氧浓度的装置包括：提供细胞培养空间的第一通道（110） 第二通道（120），其设置在所述第一通道的一侧; 中间膜，其被放置在第一通道和第二通道之间，并分开以使氧能够通过第一和第二通道; 以及氧吸收剂供给单元，其向第二通道供给氧吸收剂，用于通过中间膜将第一通道的细胞内溶解氧排出到第二通道。 使用该装置控制细胞中的溶解氧的方法包括以下步骤：在第一通道中培养细胞; 以及将氧吸收剂供应到第二通道并降低第一通道的氧分压。
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公开(公告)号：KR1020130085249A
公开(公告)日：2013-07-29
申请号：KR1020120006280
申请日：2012-01-19
Applicant: 동국대학교 산학협력단
Abstract: PURPOSE: A sound wave concentration through the ultrasound modulation, a directionality providing apparatus, and a method are provided to transceiver the desired sound wave to the desired direction, thereby minimizing the surrounding effect. CONSTITUTION: A sound wave concentration through the ultrasound modulation and a directionality providing apparatus (100) comprise a sound wave signal generator (110), an ultrasound wave generator (120), a signal controller (130), a modulator (140), an amplifier (150), and an ultrasound wave converter (170). The sound wave signal generator generates a sound wave signal. The ultrasound wave generator generates an ultrasound signal. The signal controller decides the size and frequency of the sound wave signal or the ultrasound signal. The modulator modulates the sound wave signal and the ultrasound signal into the predetermined modulated electric signal. The amplifier amplifies the modulated electric signal. The ultrasound wave converter converts the signal which is amplified by the amplifier into the modulated ultrasound signal. [Reference numerals] (110) Sound wave signal generator; (120) Ultrasound wave generator; (130) Signal controller; (140) Modulator; (150) Amplifier; (160) Reception unit; (170) Ultrasound wave converter; (AA) Medium
Abstract translation: 目的：提供通过超声波调制的声波浓度，方向性提供装置和方法，以将期望的声波收发到期望的方向，从而最小化周围的效果。 构成：通过超声波调制的声波浓度和指向性提供装置（100）包括声波信号发生器（110），超声波发生器（120），信号控制器（130），调制器（140）， 放大器（150）和超声波转换器（170）。 声波信号发生器产生声波信号。 超声波发生器产生超声信号。 信号控制器决定声波信号或超声信号的大小和频率。 调制器将声波信号和超声信号调制成预定的调制电信号。 放大器放大调制电信号。 超声波转换器将由放大器放大的信号转换成调制超声信号。 （附图标记）（110）声波信号发生器; （120）超声波发生器; （130）信号控制器; （140）调制器; （150）放大器; （160）接待单位; （170）超声波转换器; （AA）中
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公开(公告)号：KR1020120137794A
公开(公告)日：2012-12-24
申请号：KR1020110056854
申请日：2011-06-13
Applicant: 동국대학교 산학협력단
Abstract: PURPOSE: A method for preparing a Hippophae rhamnoides L. seed extract with antioxidative and antibacterial activities is provided to effectively remove lipid and materials with low solubility without sedimentation. CONSTITUTION: A method for preparing a Hippophae rhamnoides L. seed extract comprises: a step of pulverizing Hippophae rhamnoides L. seeds and extracting with C1-C4 alcohol to prepare an alcohol extract; a step of adding diatomite to the alcohol extract and concentrating by reduced pressure to prepare concentrate; and a step of adding 1-50%(w/v) of diatomite to the concentrate and storing at -20 ~ 5 Deg.C. for 30 minutes to 20 hours. An antibacterial composition contains the Hippophae rhamnoides L. seed extract as an active ingredient.
Abstract translation: 目的：提供具有抗氧化和抗菌活性的沙棘种子提取物的制备方法，可有效去除脂质和低溶解度物质，无沉淀。 构成：一种沙棘种子提取物的制备方法，其特征在于，包括：将沙棘种子粉碎并用C1-C4醇提取以制备醇提取物的步骤; 将硅藻土添加到醇提取物中并通过减压浓缩以制备浓缩物的步骤; 并向浓缩物中加入1-50％（w / v）的硅藻土并保存在-20〜5℃的步骤。 30分钟至20小时。 抗菌组合物含有沙棘种子提取物作为活性成分。
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公开(公告)号：KR101210984B1
公开(公告)日：2012-12-11
申请号：KR1020100101652
申请日：2010-10-19
Applicant: 동국대학교 산학협력단
IPC: C12N13/00 , C12N5/0775 , C12N5/079
CPC classification number: C12N5/0619 , C12N5/0618 , C12N13/00 , C12N2506/1346 , C12N2506/1353 , C12N2506/1361 , C12N2506/1369 , C12N2506/1384 , C12N2529/00
Abstract: 본발명은중간엽줄기세포의분화방법에관한것이다. 보다구체적으로는, 저주파의음파를중간엽줄기세포에처리하여, 중간엽줄기세포를신경세포로분화시키는방법에관한것이다. 본발명에의한분화방법은성장인자추가에따른고비용의신경분화유도배지가아닌저가의배지에서도분화를유도할수 있으며, 본발명에의해분화된신경세포는뇌신경질환치료에유용하게사용될수 있다.
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公开(公告)号：KR1020110134252A
公开(公告)日：2011-12-14
申请号：KR1020100101651
申请日：2010-10-19
Applicant: 동국대학교 산학협력단
IPC: C12N13/00 , C12N5/079 , C12N5/0775 , A61K35/30
CPC classification number: C12N5/0619 , C12N5/0618 , C12N13/00 , C12N2506/1346 , C12N2506/1353 , C12N2506/1361 , C12N2506/1369 , C12N2506/1384 , C12N2529/00
Abstract: PURPOSE: A method for differentiating mesenchymal stem cells or dental pulp stem cells is provided to induce differentiation in a cheap medium and to treat nerve diseases. CONSTITUTION: A method for differentiating mesenchymal stem cells or adult stem cells into neural cells comprises a step of treating electric field to the stem cells at 1-1000Hz. The neural cells include astrocytes and oligodendrocytes. The mesenchymal stem cells are derived from bone marrow, adipose, or umbilical cord. The adult stem cells are dental pulp stem cells.
Abstract translation: 目的：提供一种分化间充质干细胞或牙髓干细胞的方法，以便在廉价的培养基中诱导分化并治疗神经疾病。 构成：将间充质干细胞或成体干细胞分化成神经细胞的方法包括在1-1000Hz处理干细胞的电场的步骤。 神经细胞包括星形胶质细胞和少突胶质细胞。 间充质干细胞衍生自骨髓，脂肪或脐带。 成体干细胞是牙髓干细胞。
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