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公开(公告)号：KR100818274B1
公开(公告)日：2008-04-01
申请号：KR1020060085373
申请日：2006-09-05
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: B01L3/502715 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L2200/14 , B01L2300/0806 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K2099/0084 , F16K2099/0086 , G01N35/00069 , Y10T436/11 , Y10T436/25375 , Y10T436/2575
Abstract: 본 발명은 미세유동 시스템 제어장치 및 제어방법에 관한 것이다. 본 발명에 따른 미세유동 시스템을 제어하는 장치는 상기 미세유동 시스템의 전체 동작을 제어하는 중앙 제어부; 상기 중앙 제어부의 제1 제어신호에 따라 상기 회전판을 회전시키고, 상기 회전을 통해 발생한 원심력을 이용하여 샘플 유체를 흐르게 하는 회전수단을 제어하는 회전수단 제어부; 상기 중앙 제어부의 제2 제어신호에 따라 상기 미세유동 구조물 상의 소정의 위치로 이동하는 이동수단의 위치를 제어하는 위치 제어부; 및 상기 중앙 제어부의 제3 제어신호에 따라 상기 미세유동 구조물 상의 소정의 위치에 전자기파를 조사하는 외부 에너지원의 에너지를 제어하는 외부 에너지원 제어부를 포함함으로써, 소형의 휴대용 미세유동 시스템을 효과적으로 제어할 수 있다.
미세유동 장치, 미세유동 시스템, 회전수단, 이동수단, 밸브-
公开(公告)号：KR1020080028193A
公开(公告)日：2008-03-31
申请号：KR1020060093674
申请日：2006-09-26
Applicant: 삼성전자주식회사
CPC classification number: A61L2/238 , A61L2/084 , A61L2/085 , A61L2/232 , A61L2202/11
Abstract: A method of sterilizing an object comprising gold nano-rod and home electronic products employing the same method are provided to perform sterilization efficiently by using light that is not harmful to a human. A method of sterilizing an object comprising gold nano-rod includes irradiating light having a wavelength that is absorbed by the gold nano-rod to the gold nano-rod, and includes the steps of: applying gold nano-rod to a material in a solid phase to be sterilized; and irradiating light having a wavelength that is absorbed by the gold nano-rod to the material in a solid phage coated with the gold nano-rod. The gold nano-rod is contained in the material in a solid phase that can be permeated by the light. The material in a solid phase consists of silicone, metal, glass or polymer.
Abstract translation: 提供使用相同方法对包含金纳米棒和家用电子产品的物体进行灭菌的方法，以通过使用对人体无害的光来有效地进行灭菌。 对包含金纳米棒的物体进行灭菌的方法包括将具有由金纳米棒吸收的波长的光照射到金纳米棒上，并且包括以下步骤：将金纳米棒施加到固体中的材料 待灭菌阶段; 并将具有由金纳米棒吸收的波长的光照射到涂覆有金纳米棒的固体噬菌体中的材料。 金纳米棒包含在可被光透过的固相中的材料中。 固相中的材料由硅酮，金属，玻璃或聚合物组成。
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公开(公告)号：KR100813271B1
公开(公告)日：2008-03-13
申请号：KR1020060110544
申请日：2006-11-09
Applicant: 삼성전자주식회사
Abstract: A method for destructing cell or virus and amplifying nucleic acids is provided to increase the destruction efficiency of the cell or virus and perform PCR efficiently without elimination of gold nanorod, thereby performing the destruction of the cell or virus and the amplification of the nucleic acids efficiently in a single chamber. A method for destructing cell or virus and amplifying nucleic acids continuously in a single microchamber comprises the steps of: (a) injecting a solution including cell or virus and gold nanorod into the microchamber; (b) applying pulse laser or continuous wave laser to the gold nanorod to destruct the cell or virus; and (c) adding a PCR mixture to the microchamber and then performing PCR thereon. An apparatus for performing destruction of cell or virus and amplification of nucleic acids comprises: a chamber for destructing cell or virus which receives a sample including cell or virus and gold nanorod through a sample inlet; a laser generating portion which is attached to the chamber to supply laser; and a heating portion and a cooling portion for heating and cooling the chamber. Further, a length of the gold nanorod is 10-500 nm.
Abstract translation: 提供破坏细胞或病毒和扩增核酸的方法以增加细胞或病毒的破坏效率，并且有效地进行PCR而不消除金纳米棒，从而有效地进行细胞或病毒的破坏和核酸的扩增 在一个单一的房间。 用于破坏细胞或病毒并在单个微室中连续扩增核酸的方法包括以下步骤：（a）将包含细胞或病毒和金纳米棒的溶液注射到微室中; （b）向金纳米棒施加脉冲激光或连续波激光以破坏细胞或病毒; 和（c）向微室中加入PCR混合物，然后在其上进行PCR。 用于破坏细胞或病毒和扩增核酸的装置包括：用于破坏细胞或病毒的室，其通过样品入口接收包含细胞或病毒的样品和金纳米棒; 激光产生部，其附接到所述室以提供激光; 以及用于加热和冷却腔室的加热部分和冷却部分。 此外，金纳米棒的长度为10-500nm。
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公开(公告)号：KR1020080022027A
公开(公告)日：2008-03-10
申请号：KR1020070003401
申请日：2007-01-11
Applicant: 삼성전자주식회사
CPC classification number: G01N33/54326 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/0647 , B01L2300/0806 , B01L2300/0867 , B01L2300/1861 , B01L2400/0409 , B01L2400/0633 , B01L2400/0677 , B01L2400/0688 , G01N33/54366 , Y10T436/25375
Abstract: A centrifugal microfluidic device is provided to detect a target protein conveniently by moving a biological sample according to the centrifugal force when a biological sample is introduced into a microfluidic structure, and subjecting the biological sample to a series of procedures. A centrifugal microfluidic device for detecting a target protein comprises: a rotation body(100); a microfluidic structure(103) which is positioned in the rotation body, contains a plurality of chambers(11, 14, 18), a plurality of channels(21, 182, 183) for connecting the chambers, a plurality of valves for controlling the fluid, located in the channels, and transports the fluid by using the centrifugal force generated by the rotation of rotation body; beads(M1) which are located in the microfluidic structure and contain a capture probe having a specific affinity to a target protein on the surface; and a detection probe which is located in the microfluidic structure, has a specific affinity to the target protein and contains a material required for optical signal expression, wherein the valves include a capillary valve, a hydrophobic valve, a mechanical valve and a phase-change valve.
Abstract translation: 提供了一种离心微流体装置，用于通过在将生物样品引入微流体结构中时根据离心力移动生物样品，方便地检测靶蛋白，并对生物样品进行一系列操作。 用于检测靶蛋白的离心微流体装置包括：旋转体（100）; 定位在旋转体中的微流体结构（103）包含多个腔室（11,14,18），用于连接腔室的多个通道（21,182,183），多个用于控制 流体，位于通道中，并通过使用由旋转体的旋转产生的离心力来输送流体; 珠粒（M1），其位于微流体结构中并且包含与表面上的靶蛋白特异性亲和力的捕获探针; 位于微流体结构中的检测探针对靶蛋白具有特异性亲和性，并含有光信号表达所需的材料，其中，阀包括毛细管阀，疏水阀，机械阀和相变 阀。
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公开(公告)号：KR1020080022018A
公开(公告)日：2008-03-10
申请号：KR1020060085373
申请日：2006-09-05
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: B01L3/502715 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L2200/14 , B01L2300/0806 , B01L2300/1861 , B01L2400/0409 , B01L2400/0677 , F16K99/0001 , F16K99/0032 , F16K2099/0084 , F16K2099/0086 , G01N35/00069 , Y10T436/11 , Y10T436/25375 , Y10T436/2575 , B01L2300/0803
Abstract: An apparatus for controlling the microfluidic system is provided to isolate DNA of a target cell in a biological sample within a short time, simplify the DNA extraction operation, reduce the amount of sample required for DNA extraction, and efficiently control the microfluidic system. An apparatus for controlling the microfluidic system containing a microfluidic device including a microfluidic structure in a rotation plate comprises: a central control portion(700) for controlling the total operation of the microfluidic system; a rotation means control portion(710) for rotating the rotation plate according to the first control signal of the central controlling portion and controlling the rotation means permitting the flow of sample fluid by using the centrifugal force generated by the rotation; a position controlling portion(720) for controlling the position of mobile means moving to a certain position on the microfluidic structure according to the second control signal of the central control portion; and an external energy source control portion(730) for controlling energy of the external energy source irradiating the energy to a certain position on the microfluidic structure according to the third control signal of the central control portion, wherein the apparatus further comprises a detecting means control portion(740) for controlling the detecting means to output the signal detected by the detecting means for detecting the optical information on the sample fluid reaction and a certain wavelength information emitted from a certain position in the microfluidic device. Further, the energy is an electromagnetic wave.
Abstract translation: 提供了一种用于控制微流体系统的装置，以在短时间内分离生物样品中靶细胞的DNA，简化DNA提取操作，减少DNA提取所需的样品量，并有效控制微流体系统。 一种用于控制微流体系统的装置，其包括在旋转板中包括微流体结构的微流体装置，包括：用于控制微流体系统的总操作的中央控制部分（700） 用于根据中央控制部分的第一控制信号旋转旋转板的旋转装置控制部分（710），并且通过使用旋转产生的离心力来控制允许样品流体流动的旋转装置; 位置控制部分（720），用于根据中央控制部分的第二控制信号控制移动装置移动到微流体结构上的某个位置的位置; 和外部能量源控制部分（730），用于根据中央控制部分的第三控制信号，控制将能量照射到微流体结构上的特定位置的外部能量源的能量，其中所述装置还包括检测装置控制 部分（740），用于控制检测装置输出由检测装置检测的信号，用于检测关于样品流体反应的光学信息和从微流体装置中的某个位置发射的特定波长信息。 此外，能量是电磁波。
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Patent Agency Ranking
公开(公告)号：KR100790904B1
公开(公告)日：2008-01-04
申请号：KR1020070007645
申请日：2007-01-24
Applicant: 삼성전자주식회사
Abstract: A method for mixing at least two kinds of fluids in a microfluid treating substrate is provided to allow two of more different fluids to be mixed in a short time without increasing the size of a microfluid treating substrate or adding an additional member such as a magnet. A method for mixing at least two kinds of fluids comprises the steps of: introducing at least two kinds of fluids sequentially into a mixing chamber(15) of a microfluid treating substrate(10); and rotating the substrate clockwise and counter clockwise alternately until the fluids are mixed with each other, wherein any one direction of the clockwise direction and the counter clockwise direction is converted into the other direction before the vortex formed in the mixing chamber by the rotation along the former direction disappears.
Abstract translation: 提供了一种用于混合微流体处理基板中的至少两种流体的方法，以允许两个更多不同的流体在短时间内混合，而不增加微流体处理基板的尺寸或添加诸如磁体的附加构件。 用于混合至少两种流体的方法包括以下步骤：将至少两种流体依次引入到微流体处理基板（10）的混合室（15）中。 并顺时针和逆时针方向旋转基板，直到流体彼此混合，其中沿着顺时针方向和逆时针方向的任何一个方向被转换成在混合室中形成的涡流之前的另一个方向， 以前的方向消失。
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47.发明公开마이크로어레이용 기판, 그 마이크로어레이용 기판을이용하여 생분자를 분석하는 방법, 및 그 마이크로어레이용기판을 포함하는 랩온어칩 失效微晶基板，使用微晶基板分析生物分子的方法和包括微晶基板的实验室片
公开(公告)号：KR1020070073579A
公开(公告)日：2007-07-10
申请号：KR1020060107934
申请日：2006-11-02
Applicant: 삼성전자주식회사
CPC classification number: B01J19/0046 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00583
Abstract: A microarray substrate is provided to improve the fixation of a probe biomolecule on a substrate, decrease a non-specific binding of a protein to a target biomolecule on the substrate, and simultaneously perform the lysis process, PCR reaction, and hybridization of the probe and the target biomolecule. In addition, a method for analyzing a biomolecule using the same and a lab-on-a-chip comprising the same are provided. The microarray substrate is characterized in that a group represented by the formula(1) or (2) is fixed on a solid substrate. The method for analyzing a biomolecule comprises the steps of: (a) preparing a microarray substrate by fixing a group of the formula(1) or (2) on a solid substrate; (b) fixing a probe biomolecule on the microarray substrate under a first pH to prepare a microarray; (c) attaching a target biomolecule on the area other than the probe area of the microarray under the first pH; (d) under a second pH, after eluting the coupled target biomolecule, amplifying it; and (e) hybridizing the probe biomolecule on the microarray prepared by the step(b) with the target biomolecule. The lab-on-a-chip comprises the microarray substrate.
Abstract translation: 提供微阵列底物以改善探针生物分子在底物上的固定，降低蛋白质与底物上目标生物分子的非特异性结合，同时进行裂解过程，PCR反应和探针和 目标生物分子。 此外，提供了一种用于分析其使用的生物分子的方法和包含该生物分子的实验室。 微阵列基板的特征在于，由式（1）或（2）表示的基团固定在固体基材上。 分析生物分子的方法包括以下步骤：（a）通过将式（1）或（2）的基团固定在固体基质上来制备微阵列基底; （b）在第一pH下将探针生物分子固定在微阵列基底上以制备微阵列; （c）在第一pH下将目标生物分子附着在微阵列的探针区域以外的区域上; （d）在第二个pH下，洗脱偶联的目标生物分子后进行放大; 和（e）将由步骤（b）制备的微阵列上的探针生物分子与目标生物分子杂交。 芯片实验室包括微阵列基片。
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48.发明公开신규한 ｐＨ 의존성 이온 교환물질, 그가 고정화되어 있는고체 기판, 및 상기 물질 및 고체 기판을 이용하여 핵산을분리하는 방법 失效新型PH依赖离子交换材料，固体表面上的材料的固体基材和使用该材料和固体基材分离核酸的方法
公开(公告)号：KR1020060119634A
公开(公告)日：2006-11-24
申请号：KR1020050042782
申请日：2005-05-21
Applicant: 삼성전자주식회사
Inventor： 박종면
CPC classification number: B01J41/14 , B01D15/361 , B01D15/388 , B01J39/20 , C12Q1/6806 , C12Q2527/125 , C12Q2527/119 , C12Q2523/308
Abstract: Provided are a pH dependent ion exchange material which has high bonds to nucleic acid at first pH, releases nucleic acid with high rate at second pH, and has low bonds to protein, a solid substrate having the ion exchange material immobilized thereon, and a method for isolating nucleic acid by using the ion exchange material and the solid substrate. The pH dependent ion exchange material has carboxyl, amine groups, and polyethylene oxide moiety for isolating nucleic acid which comprise at least two monomers selected from the group consisting of the formulas M0, M1, M2, M3, and M4(the monomers are bonded with each other), and has at least one monomer selected from the group consisting of M1 and M2, and at least one monomers selected from the group consisting of M3 and M4. In the formulas, A is a base selected from -NH(CH2)nNH2(n is an integer of 1-10) and -NH(CH2)nY(n is an integer of 1-10, Y is an aromatic base in which at least one of cyclic elements are nitrogen), B is -(CH2CHO)nOR2(n is 1-20, R2 is an C1-C10 alkyl group or protecting group), R3 is a C1-C10 alkyl group. The ion exchange material has a polymerization degree of 2-30,000.
Abstract translation: 提供了一种pH依赖性离子交换材料，其在第一pH下与核酸具有高键，在第二pH下以高速率释放核酸，并且与蛋白质具有低键，固定有固定有离子交换材料的固体基质， 用于通过使用离子交换材料和固体基质来分离核酸。 pH依赖性离子交换材料具有羧基，胺基和聚环氧乙烷部分，用于分离核酸，其包含至少两种选自式M0，M1，M2，M3和M4的单体（单体与 并且具有至少一种选自M1和M2的单体和至少一种选自M3和M4的单体。 在式中，A为选自-NH（CH 2）n NH 2（n为1-10的整数）和-NH（CH 2）n Y（n为1-10的整数）的碱，Y为芳基， 环状元素中的至少一个为氮），B为 - （CH 2 CHO）nOR2（n为1-20，R2为C1-C10烷基或保护基），R3为C1-C10烷基。 离子交换材料的聚合度为2-30,000。
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公开(公告)号：KR1020060060929A
公开(公告)日：2006-06-07
申请号：KR1020040099743
申请日：2004-12-01
Applicant: 삼성전자주식회사
IPC: C09K5/14
CPC classification number: B01L7/00 , B01L3/5027 , B01L3/508 , B01L2300/1877 , C12M47/06
Abstract: 본 발명은 CaO 100 중량 %에 대하여 MgCl
2 또는 MgSO
4 5 내지 7 중량 % 및 NaOH 5 내지 7 중량 %를 포함하는 고상의 물질로서, 황산을 가하여 열을 발생시키는 발열 물질, 그를 이용한 세포 용해 방법 및 장치를 제공한다.
발열 반응, 세포 용해-
公开(公告)号：KR100580644B1
公开(公告)日：2006-05-16
申请号：KR1020040009942
申请日：2004-02-16
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: C12Q1/6837 , B01J2219/00387 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , C40B60/14 , G01N33/54393
Abstract: 본 발명은 수소 결합 공여능을 갖는 제1 관능기를 표면에 갖는 고체 기판 상에서 수소 결합 수용능을 갖는 화합물과 수소 결합 공여능을 갖는 제2 관능기로 관능기화된 생물분자의 혼합물을 반응시켜, 상기 생물분자를 비공유 결합에 의하여 상기 기판 상에 고정화하는 단계를 포함하는, 생물분자를 고체기판상에 고정화하는 방법 및 그에 의하여 제조된 마이크로어레이를 제공한다.
비공유결합, 폴리에틸렌글리콜, 마이크로어레이
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