公开(公告)号：KR1020170125278A

公开(公告)日：2017-11-14

申请号：KR1020160055771

申请日：2016-05-04

Applicant: 삼성전자주식회사 ,  사회복지법인 삼성생명공익재단

Inventor： 손대순 ,  박동현 ,  정종석 ,  박웅양

IPC: G06F19/22 ,  G06F19/18 ,  C12Q1/68

CPC classification number: C12Q1/68 ,  G06F19/18 ,  G06F19/22

Abstract: 단일뉴클레오티드변이검출표지의신뢰도를정확하게결정하는방법및 장치에관한것으로, 유전체의표적자리를중심으로리드의뎁스에기초하여 QC점수를산출함으로써, 변이검출표지의신뢰도를결정할수 있다.

Abstract translation: 本发明涉及用于准确确定单核苷酸突变检测标签的可靠性的方法和装置，通过基于基因组目标位置周围的引导深度计算QC分数，可以确定突变检测标签的可靠性。

公开(公告)号：KR1020150027938A

公开(公告)日：2015-03-13

申请号：KR1020130106308

申请日：2013-09-04

Applicant: 삼성전자주식회사

Inventor： 손대순 ,  안태진 ,  이은진 ,  정종석

IPC: G06F19/00 ,  G06F17/10

CPC classification number: G06F17/18 ,  G06F19/20

Abstract: 피검체들에 대한 마이크로어레이 데이터들을 분석하는 방법 및 장치는, 상기 마이크로어레이 데이터들을 이용하여 부트스트랩(bootstrap) 데이터 세트들을 생성하고, 생성된 부트스트랩 데이터 세트들 각각에 대응되는 예측 모델들을 이용하여 경험적 검정력(empirical power)을 산출함으로써 목표 검정력을 만족하는 최소의 표본수를 탐색한다.

Abstract translation: 本发明涉及用于分析实验对象的微阵列数据的方法和装置。 该方法使用微阵列数据生成引导数据集，并通过使用与生成的引导数据集相对应的预测模型计算经验功率来搜索满足目标经验力的最小采样数。

公开(公告)号：KR100846511B1

公开(公告)日：2008-07-17

申请号：KR1020060135548

申请日：2006-12-27

Applicant: 삼성전자주식회사

Inventor： 오지영 ,  허남 ,  백상현 ,  정종석

IPC: C12Q1/68 ,  C12N15/10

CPC classification number: C12Q1/689 ,  C12Q2600/16 ,  Y02A50/451

Abstract: 본 발명은 9 종의 호흡기 질환을 야기시키는 박테리아의 표적 서열을 증폭시킬 수 있는 프라이머 세트, 9종의 박테리아의 표적 서열에 특이적으로 혼성화하는 프로브 세트, 상기 프로브 세트가 고정화되어 있는 마이크로어레이 및 상기 프로브 세트를 이용하여 9종의 박테리아의 존재를 검출하는 방법을 제공한다.
프라이머, 프로브, 23S rRNA

公开(公告)号：KR1020080029726A

公开(公告)日：2008-04-03

申请号：KR1020070007628

申请日：2007-01-24

Applicant: 삼성전자주식회사

Inventor： 오지영 ,  이연수 ,  백상현 ,  김병철 ,  김숙영 ,  박경희 ,  이정남 ,  정종석 ,  김아기 ,  이묘용 ,  안태진

IPC: C12Q1/68

CPC classification number: C12Q1/689 ,  C12Q2600/16 ,  C12Q1/6837

Abstract: A primer set is provided to amplify a resistance donating gene from antibiotics resistant bacteria. A probe set is provided to be specifically coupled to a target sequence existing in a PCR product amplified by the primer set, thereby being used for detecting at least one bacteria with the antibiotics resistance. A microarray is provided to be used for detecting the bacteria with antibiotics resistance. An oligonucleotide primer set for amplifying at least one selected from the group consisting of aataph, ant, aph, CMY1, CMY2, CTX1, CTX2, DHA, IMP, OXA, PER, SHV, TEM, VIM, ermA, ermB, ermC, mef, mecA, Spn pbp2b, Pae gyrA, Sau gyrA, Sau parC, Sau parE, vanA, and vanB is selected from the group consisting of: an oligonucleotide set including at least one oligonucleotide selected from oligonucleotides consisting of more than 10 consecutive nucleotide fragments in SEQ ID : NOs. 1 and 2; SEQ ID : NOs. 3 and 4; SEQ ID : NOs. 5 and 6; SEQ ID : NOs. 7 and 8; SEQ ID : NOs. 9 and 10; SEQ ID : NOs. 11 and 12; SEQ ID : NOs. 13 and 14; SEQ ID : NOs. 15 and 16; SEQ ID : NOs. 17 and 18; SEQ ID : NOs. 19 and 20; SEQ ID : NOs. 21 and 22; SEQ ID : NOs. 23 and 24; SEQ ID : NOs. 25 and 26; SEQ ID : NOs. 27 and 28; SEQ ID : NOs. 29 and 30; SEQ ID : NOs. 31 and 32; SEQ ID : NOs. 33 and 34; SEQ ID : NOs. 35 and 36; SEQ ID : NOs. 37 and 38; SEQ ID : NOs. 39 and 40; SEQ ID : NOs. 41 and 42; SEQ ID : NOs. 43 and 44; SEQ ID : NOs. 45 and 46; SEQ ID : NOs. 47 and 48; SEQ ID : NOs. 49 and 50; and SEQ ID : NOs. 51 and 52. A method for detecting the presence of bacteria having resistance against at least one antibiotics selected from the group consisting of aminoglycoside, beta-lactam, erythromycin, methicillin, vancomycin and quinolone-based antibiotics comprises the steps of: (a) contacting a sample with at least one oligonucleotide probe or oligonucleotide probe set to hybridize a target sequence in the sample with a probe sequence; and (b) detecting the hybridization degree between the probe and the target sequence in the sample. A kit for detecting the existence of the antibiotics resistant bacteria comprises the primer set and an instruction manual.

Abstract translation: 提供了一个引物组来扩增来自抗生素抗性细菌的抗性供体基因。 提供探针组以特异性偶联于存在于由引物组扩增的PCR产物中的靶序列，从而用于检测至少一种具有抗生素抗性的细菌。 提供微阵列用于检测抗生素抗性的细菌。 用于扩增选自由aataph，ant，aph，CMY1，CMY2，CTX1，CTX2，DHA，IMP，OXA，PER，SHV，TEM，VIM，ermA，ermB，ermC，mef中的至少一种的寡核苷酸引物组 ，mecA，Spn pbp2b，Pae gyrA，Sau gyrA，Sau parC，Sau parE，vanA和vanB选自：包含至少一种寡核苷酸组的寡核苷酸组，所述寡核苷酸组选自寡核苷酸，所述寡核苷酸由超过10个连续核苷酸片段组成， SEQ ID：NO。 1和2; SEQ ID：NO。 3和4; SEQ ID：NO。 5和6; SEQ ID：NO。 7和8; SEQ ID：NO。 9和10; SEQ ID：NO。 11和12; SEQ ID：NO。 13和14; SEQ ID：NO。 15和16; SEQ ID：NO。 17和18; SEQ ID：NO。 19和20; SEQ ID：NO。 21和22; SEQ ID：NO。 23和24; SEQ ID：NO。 25和26; SEQ ID：NO。 27和28; SEQ ID：NO。 29和30; SEQ ID：NO。 31和32; SEQ ID：NO。 33和34; SEQ ID：NO。 35和36; SEQ ID：NO。 37和38; SEQ ID：NO。 39和40; SEQ ID：NO。 41和42; SEQ ID：NO。 43和44; SEQ ID：NO。 45和46; SEQ ID：NO。 47和48; SEQ ID：NO。 49和50; 和SEQ ID NO： 一种用于检测对至少一种选自氨基糖苷，β-内酰胺，红霉素，甲氧西林，万古霉素和喹诺酮类抗生素的抗生素具有抗性的细菌的存在的方法包括以下步骤：（a） 设置有至少一个寡核苷酸探针或寡核苷酸探针的样品与样品中的靶序列与探针序列杂交; 和（b）检测样品中探针与目标序列之间的杂交度。 用于检测抗生素抗性细菌存在的试剂盒包括引物组和使用说明书。

公开(公告)号：KR1020080029102A

公开(公告)日：2008-04-03

申请号：KR1020060094673

申请日：2006-09-28

Applicant: 삼성전자주식회사

Inventor： 오지영 ,  백상현 ,  박경희 ,  이정남 ,  정종석 ,  김아기

IPC: C12Q1/68

CPC classification number: C12Q1/689 ,  C12Q2600/16 ,  Y02A50/451 ,  C12Q1/6837 ,  C12Q1/6876 ,  C12Q2563/107

Abstract: A primer set is provided to amplify a target sequence from bacteria causing 12 kinds of respiratory diseases. A probe set is provided to be specifically hybridized into the target sequence existing in a PCR product amplified by the primer set, thereby detecting at least one bacteria inducing the 12 kinds of the respiratory diseases. A detecting method is provided to detect the bacteria causing the respiratory diseases efficiently with high specificity. An oligonucleotide primer set for specifically amplifying at least one target sequence among Acinetobacter baumannii adeB gene, Bordetella pertussis Tcf gene, Chlamydophila pneumoniae Omp gene, Enterobacter aerogenes tsx gene, Enterobacter cloacae rpoS gene, Escherichia coli uspA gene, Klebsiella pneumoniae Wab gene, Legionella pneumophila Mip gene, Moraxella catarrhalis cop gene, Mycoplasma pneumoniae P1 gene, Pseudomonas aeruginosa ETA gene and Streptococcus pneumoniae lytA gene is selected from the group consisting of: an oligonucleotide set including at least one oligonucleotide selected from oligonucleotides consisting of more than 10 consecutive nucleotide fragments in SEQ ID : NOs. 1 and 2; SEQ ID : NOs. 3 and 4; SEQ ID : NOs. 5 and 6; SEQ ID : NOs. 7 and 8; SEQ ID : NOs. 9 and 10; SEQ ID : NOs. 11 and 12; SEQ ID : NOs. 13 and 14; SEQ ID : NOs. 15 and 16; SEQ ID : NOs. 17 and 18; SEQ ID : NOs. 19 and 20; SEQ ID : NOs. 21 and 22; and SEQ ID : NOs. 23 and 24. A method for detecting the presence of at least one bacteria among 12 bacteria inducing respiratory diseases consisting of Acinetobacter baumannii, Bordetella pertussis, Chlamydophila pneumoniae, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Legionella pneumophila, Moraxella catarrhalis, Mycoplasma pneumoniae, Pseudomonas aeruginosa, and Streptococcus pneumoniae comprises the steps of: (a) contacting a sample with at least one oligonucleotide probe or oligonucleotide probe set to hybridize a target sequence in the sample with a probe sequence; and (b) detecting the hybridization degree between the probe and the target sequence in the sample. A kit for detecting the existence of the 12 respiratory diseases inducing bacteria comprises the primer set and an instruction manual.

Abstract translation: 提供引物组以扩增来自引起12种呼吸道疾病的细菌的靶序列。 提供探针组，以特异性杂交到由引物组扩增的PCR产物中存在的靶序列中，从而检测至少一种诱导12种呼吸道疾病的细菌。 提供检测方法，以高特异性有效地检测引起呼吸道疾病的细菌。 用于特异性扩增鲍曼不动杆菌adeB基因，百日咳杆菌Tcf基因，肺炎衣原体Omp基因，产气肠杆菌tsx基因，阴沟肠杆菌rpoS基因，大肠杆菌uspA基因，肺炎克雷伯杆菌Wab基因，嗜肺军团杆菌中的至少一个靶序列的寡核苷酸引物组 Mip基因，卡他莫拉菌属基因，肺炎支原体P1基因，绿脓假单胞菌ETA基因和肺炎链球菌lytA基因选自：包含至少一种寡核苷酸组的寡核苷酸组，所述寡核苷酸组选自寡核苷酸，所述寡核苷酸由超过10个连续核苷酸片段组成 SEQ ID：NO。 1和2; SEQ ID：NO。 3和4; SEQ ID：NO。 5和6; SEQ ID：NO。 7和8; SEQ ID：NO。 9和10; SEQ ID：NO。 11和12; SEQ ID：NO。 13和14; SEQ ID：NO。 15和16; SEQ ID：NO。 17和18; SEQ ID：NO。 19和20; SEQ ID：NO。 21和22; 和SEQ ID NO： 一种用于检测12种细菌中存在至少一种细菌的方法，所述细菌诱导由鲍氏不动杆菌，百日咳博德特氏菌，肺炎衣原体，产气肠杆菌，阴沟肠杆菌，大肠杆菌，肺炎克雷伯杆菌，嗜肺军团菌，卡他莫拉菌， 肺炎支原体，绿脓假单胞菌和肺炎链球菌包括以下步骤：（a）将样品与至少一种寡核苷酸探针或寡核苷酸探针接触，将样品中的靶序列与探针序列杂交; 和（b）检测样品中探针与目标序列之间的杂交度。 用于检测12种呼吸道疾病诱导细菌存在的试剂盒包括引物组和使用说明书。

公开(公告)号：KR1020080009960A

公开(公告)日：2008-01-30

申请号：KR1020060069797

申请日：2006-07-25

Applicant: 삼성전자주식회사

Inventor： 정종석 ,  황규연 ,  심저영

IPC: G01N33/48 ,  G01N33/50

CPC classification number: B81C1/00206 ,  B01J19/0046 ,  B01J2219/00387 ,  B01J2219/0043 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00711 ,  B01J2219/00722 ,  B81B2201/06 ,  B82Y30/00 ,  C40B50/18

Abstract: A method for preparing a patterned spot microarray is provided to decrease the size of the patterned spot by coating a photocatalytic material such as TiO2. A method for preparing a patterned spot microarray comprises the steps of: (a) coating a photo-catalytic material such as TiO2, ZnO, SnO2, SrTiO3, WO3, B2O3, and Fe2O3 on a substrate to form a photocatalytic layer; (b) coating a functional group able to be bound to a bio-molecule on the photocatalytic layer to from an organic thin-film layer; (c) spotting the bio-molecule on the organic thin film layer; and (d) placing a photo-mask on the spot of the bio-molecule and applying light to the photo-mask to pattern the fixed spot, wherein the functional group is amine, carboxyl, epoxy, or sulfur and the substrate is glass, silicone wafer, fused silica, gold, silver, copper, platinum, polystyrene, poly(methylacrylate) or polycarbonate. A microarray substrate comprises a photocatalytic layer formed by coating a photocatalytic material on a substrate and an organic thin film layer formed by coating a material having a functional group able to be bound to a bio-molecule on the photocatalytic layer.

Abstract translation: 提供了一种制备图案斑点微阵列的方法，通过涂覆诸如TiO 2的光催化材料来减小图案化斑点的尺寸。 一种制备图案斑点微阵列的方法包括以下步骤：（a）在基底上涂覆TiO 2，ZnO，SnO 2，SrTiO 3，WO 3，B 2 O 3和Fe 2 O 3等光催化材料以形成光催化层; （b）在有机薄膜层上涂覆能够结合到光催化层上的生物分子的官能团; （c）在有机薄膜层上检测生物分子; 和（d）将光掩模放置在生物分子的位置上并向光掩模施加光以对固定点进行图案化，其中该官能团是胺，羧基，环氧基或硫，并且该基底是玻璃， 硅胶片，熔融石英，金，银，铜，铂，聚苯乙烯，聚（甲基丙烯酸酯）或聚碳酸酯。 微阵列基板包括通过在基板上涂布光催化材料形成的光催化层和通过涂布具有能够结合到光催化层上的生物分子的官能团的材料而形成的有机薄膜层。

公开(公告)号：KR1020080016131A

公开(公告)日：2008-02-21

申请号：KR1020060077826

申请日：2006-08-17

Applicant: 삼성전자주식회사

Inventor： 안태진 ,  오지영 ,  이정남 ,  정종석

IPC: C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q1/6837 ,  C12Q1/689 ,  Y10T436/145555 ,  C12Q2521/501 ,  C12Q2525/161 ,  C12Q2525/185 ,  G06F19/20

Abstract: A method for designing a probe is provided to obtain the probe which is able to detect rapidly and accurately existence of a target sequence in a reaction sample including the target sequence and many non-target sequences. And a method for detecting a target sequence is provided to be able to detect rapidly and accurately existence of the target sequence in the reaction sample. A method for designing a probe for detecting a target sequence comprises the steps of: (a) selecting a position in a target sequence different from a non-target sequence which has the highest sequence homology to the target sequence to be detected as a standard position; (b) selecting a first probe design area for all probes having a certain length designed in a certain area in the target sequence including the standard position; (c) selecting a position in the target sequence different from the non-target sequence as a probe selection position; (d) selecting a complete match probe including the probe selection position at the center position and consisting of a completely hybridizable sequence; and (e) selecting an intentional mis-match probe which is longer than the complete match probe, includes the probe selection position at the first position and a nucleotide, unable to be hybridized with the target sequence, and consists of a sequence which is completely hybridizable with the target sequence except the second position. A method for detecting a target sequence using the probe designed by the method above comprises the steps of: (a) providing a reaction sample to detect the existence of the target sequence to the complete match probe and the intentional mis-match probe; and (b) identifying the hybridization between the probes and the target sequence.

Abstract translation: 提供了一种用于设计探针的方法，以获得能够快速且准确地检测包含目标序列和许多非靶序列的反应样品中靶序列存在的探针。 并且提供了用于检测靶序列的方法，以能够快速准确地检测反应样品中靶序列的存在。 一种用于设计用于检测目标序列的探针的方法，包括以下步骤：（a）选择与要检测的目标序列具有最高序列同源性的非目标序列的目标序列中的位置作为标准位置 ; （b）为包括标准位置的目标序列中的某一区域中设计的具有一定长度的所有探针选择第一探针设计区域; （c）选择与非目标序列不同的目标序列中的位置作为探针选择位置; （d）选择包括在中心位置的探针选择位置并由完全可混合的序列组成的完整匹配探针; 和（e）选择比完全匹配探针更长的故意错配探针，包括在第一位置的探针选择位置和不能与靶序列杂交的核苷酸，并且由完全匹配的序列组成 可与第二位置之外的目标序列杂交。 使用由上述方法设计的探针检测靶序列的方法包括以下步骤：（a）提供反应样品以检测目标序列存在于完全匹配探针和有意误配对探针; 和（b）鉴定探针与目标序列之间的杂交。

公开(公告)号：KR100612877B1

公开(公告)日：2006-08-14

申请号：KR1020040099743

申请日：2004-12-01

Applicant: 삼성전자주식회사

Inventor： 백상현 ,  박종면 ,  이정남 ,  정종석

IPC: C09K5/14

CPC classification number: B01L7/00 ,  B01L3/5027 ,  B01L3/508 ,  B01L2300/1877 ,  C12M47/06

Abstract: 본 발명은 CaO 100 중량 %에 대하여 MgCl
2 또는 MgSO
4 5 내지 7 중량 % 및 NaOH 5 내지 7 중량 %를 포함하는 고상의 물질로서, 황산을 가하여 열을 발생시키는 발열 물질, 그를 이용한 세포 용해 방법 및 장치를 제공한다.
발열 반응, 세포 용해

公开(公告)号：KR1020140023607A

公开(公告)日：2014-02-27

申请号：KR1020120089667

申请日：2012-08-16

Applicant: 삼성전자주식회사

Inventor： 손대순 ,  안태진 ,  이은진 ,  정종석

IPC: G06F19/10

CPC classification number: G06F19/10 ,  G06F19/18

Abstract: A method of analyzing personalized multi-omics data comprises the steps of: acquiring a plurality of biological data groups containing different types of genome data from an individual's gene sample; estimating indices indicating a degree of genetic abnormalities in each of the different types of genomic data for each of the plurality of biological data groups; and generating a combined index which evaluates the degree of genetic abnormalities for the entire biological data groups by using an analysis algorithm for generalizing the estimated indices. [Reference numerals] (10) Apparatus for analyzing personalized multi-omics data; (100) Data obtaining unit; (200) Index estimating unit; (300) Combined index generating unit; (310) Index standardizing unit; (320) Combined index calculating unit

Abstract translation: 一种分析个性化多元素数据的方法包括以下步骤：从个体的基因样品获取含有不同类型的基因组数据的多个生物数据组; 估计指示所述多个生物数据组中的每一个的不同类型的基因组数据的遗传异常程度的指标; 并且通过使用用于推广估计指数的分析算法来生成整个生物数据组的遗传异常程度的综合指数。 （附图标记）（10）用于分析个性化多音乐数据的装置; （100）数据获取单元; （200）指标估计单位; （300）组合指标生成单元; （310）指标标准化单位; （320）组合指标计算单位

公开(公告)号：KR1020130125617A

公开(公告)日：2013-11-19

申请号：KR1020120049275

申请日：2012-05-09

Applicant: 삼성전자주식회사

Inventor： 정종석 ,  안태진 ,  손대순 ,  이은진

IPC: G06F19/10 ,  C12Q1/68

CPC classification number: G06F17/18 ,  G06F19/18 ,  G06F19/22

Abstract: A method and an apparatus for analyzing the genetic information of abnormal tissue obtains sequence data from each gene sample of abnormal tissue and normal tissue, analyzes the sequence data corresponding to the abnormal tissue and the normal tissue in the gene sample of abnormal tissue by using the obtained sequence data, decides the contamination rate of the gene sample of the abnormal tissue by the gene sample of normal tissue by using the analyzed result. [Reference numerals] (10) Genetic information analyzing device;(110) Data obtaining unit;(120) Gene analyzing unit;(130) Contamination ratio determining unit;(20) Gene sequencing device

Abstract translation: 用于分析异常组织的遗传信息的方法和装置从异常组织和正常组织的每个基因样品获得序列数据，通过使用异源组织的基因样品中的异常组织和正常组织分析对应的序列数据 获得的序列数据，通过使用分析结果来确定正常组织的基因样品的异常组织的基因样品的污染率。 （10）遗传信息分析装置;（110）数据获取单元;（120）基因分析单元;（130）污染比例确定单元;（20）基因测序装置