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公开(公告)号：KR101637478B1
公开(公告)日：2016-07-08
申请号：KR1020140097518
申请日：2014-07-30
Applicant: 서울대학교산학협력단
IPC: H01M8/04
Abstract: 본발명은, 냉시동운전조건에서공기극과연료극의역할을바꾸어교차운전하는냉시동운전모드를설정횟수동안실시함으로써, 상기공기극측의수분의결빙을방지하거나생성된얼음의표면결합력을약화시켜얼음의분리가쉽게이루어지도록함으로써, 냉시동문제를해결할수 있다. 또한, 냉시동운전모드로전환시공기극내의산소를소모시키고공기극내의잔류질소를통해연료극을퍼지함으로써, 수소와산소의직접반응을방지할수 있다. 또한, 히터등의설치가불필요하여추가적인전력소요가없으면서냉시동문제를해결할수 있는이점이있다. 또한, 냉시동으로인한운전중단이없어지므로전력생산효율이향상될수 있다.
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公开(公告)号：KR1020160015503A
公开(公告)日：2016-02-15
申请号：KR1020140097518
申请日：2014-07-30
Applicant: 서울대학교산학협력단
IPC: H01M8/04
CPC classification number: H01M8/04223 , H01M8/04089 , H01M8/04231 , H01M8/04253 , H01M8/04298 , H01M8/04753
Abstract: 본발명은, 냉시동운전조건에서공기극과연료극의역할을바꾸어교차운전하는냉시동운전모드를설정횟수동안실시함으로써, 상기공기극측의수분의결빙을방지하거나생성된얼음의표면결합력을약화시켜얼음의분리가쉽게이루어지도록함으로써, 냉시동문제를해결할수 있다. 또한, 냉시동운전모드로전환시공기극내의산소를소모시키고공기극내의잔류질소를통해연료극을퍼지함으로써, 수소와산소의직접반응을방지할수 있다. 또한, 히터등의설치가불필요하여추가적인전력소요가없으면서냉시동문제를해결할수 있는이점이있다. 또한, 냉시동으로인한운전중단이없어지므로전력생산효율이향상될수 있다.
Abstract translation: 燃料电池系统及其控制方法技术领域本发明涉及燃料电池系统及其控制方法。 本发明可以通过执行冷启动驱动模式设定次数来解决冷启动问题，其中阴极和燃料电极在冷起动驱动条件下的作用改变，并且容易地分开 通过防止阴极的水分冻结并削弱表面粘合强度。 此外，当冷启动驱动模式改变时，通过消耗阴极中的空气并且将燃料电极通过剩余的氮扩散来防止氧气和氢气的直接反应。 此外，由于不需要安装加热器等，因此可以解决冷启动问题而不需要额外的电力成本。 此外，通过通过冷启动去除操作停止，可以提高发电效率。
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公开(公告)号：KR1020130112151A
公开(公告)日：2013-10-14
申请号：KR1020120034318
申请日：2012-04-03
Applicant: 서울대학교산학협력단
IPC: A01K67/027 , C12N15/36 , C12N15/85 , G01N33/15
CPC classification number: A01K67/027 , A01K2217/20 , C12N15/113 , C12N15/85 , G01N33/15
Abstract: PURPOSE: A transformed animal which reveals a preS1 W4P variation protein of a hepatitis B virus and a use thereof are provided to valuably use for investigation of pathogenesis of a liver disorder which is sex-specific as a liver-disordered animal model and to valuably use a liver disease medicine for screening. CONSTITUTION: A non-human transformed animal which has been through transformation with an HBV dielectric contains a W4P preS1 gene to reveal a W4P preS1 variation protein of hepatitis B virus (HBV). A dielectric HBV dielectric is an A type or a C type. The HBV dielectric has a base sequence from 1433 to 4674 among the base sequence of a sequence number 1. The HBV dielectric has a base sequence from 1448 to 4694 among the base sequence of a sequence number 2. The transformed non-human animal is a liver disease model which reveals over-expression of an HBs antigen and an HBe antigen protein.
Abstract translation: 目的：揭示乙型肝炎病毒的PreS1 W4P变异蛋白的转化动物及其用途，有助于调查作为肝脏无序动物模型的性别特异性的肝脏疾病的发病机制，并有价值地使用 一种用于筛查的肝病药物。 构成：已经通过HBV电介质转化的非人转化动物含有W4P preS1基因，以揭示乙型肝炎病毒（HBV）的W4P preS1变异蛋白。 电介质HBV电介质是A型或C型。 HBV电介质在序列号1的碱基序列中具有1433至4674的碱基序列。HBV电介质在序列号2的碱基序列中具有1448至4694的碱基序列。转化的非人动物是 揭示HBs抗原和HBe抗原蛋白过度表达的肝脏疾病模型。
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公开(公告)号：KR101291668B1
公开(公告)日：2013-08-01
申请号：KR1020110037147
申请日：2011-04-21
Applicant: 서울대학교산학협력단
CPC classification number: C12N15/74
Abstract: 본 발명은 서열목록 제1서열의 뉴클레오타이드 서열을 가지는 미코박테리아(
mycobacteria )-유래된 복제가능(replicable) DNA 핵산분자, 이를 이용하여 제작된 미코박테리아(
mycobacteria )-대장균(
Escherichia coli )용 셔틀 벡터, 그리고 이로 형질전환된 세포를 제공한다. 본 발명의 플라스미드(약 18 kb)는 미코박테리아에서 유래되었으며, 16개의 ORFs(open reading frames), 복제 개시점(replication region; oriM이라 명명) 및 복제에 필수적인 렙-유사 단백질(Rep-like protein)을 포함한다. 따라서, 본 발명의 플라스미드는 이를 이용한 유전자 연구/전달 시스템으로서 이용될 수 있을 뿐 아니라, DNA 또는 재조합 단백질을 효율적으로 전달함으로써 면역치료제로서 적용될 수 있다.-
公开(公告)号：KR1020130036883A
公开(公告)日：2013-04-15
申请号：KR1020110101094
申请日：2011-10-05
Applicant: 서울대학교산학협력단
Inventor： 김범준
CPC classification number: G01N33/6893 , C12Q1/025 , C12Q1/706 , G01N33/6854
Abstract: PURPOSE: S-antigenic protein of H B V false negative infection inducing endoplasmic reticulum stress and use thereof are provided to provide reagent composition of up-regulation of nitric oxide synthase. CONSTITUTION: A reagent composition of inducing endoplasmic reticulum stress comprises more than one Hepatitis B virus mutant S-antigen protein of first sequence to third sequence of rank list. Endoplasmic reticulum stress of the reagent composition for inducing endoplasmic reticulum stress emits Ca^2+ into cells.
Abstract translation: 目的：提供H B V的S-抗原蛋白，诱导内质网应激的假阴性感染及其使用，以提供一氧化氮合酶上调的试剂组成。 构成：诱导内质网应激的试剂组合包含第一序列至第三序列的多于一种乙型肝炎病毒突变S抗原蛋白。 用于诱导内质网应激的试剂组合物的内质网应激将Ca ^ 2 +释放到细胞中。
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Patent Agency Ranking
公开(公告)号：KR101248427B1
公开(公告)日：2013-03-28
申请号：KR1020100085955
申请日：2010-09-02
Applicant: 서울대학교산학협력단
IPC: C12Q1/68 , C12N15/11 , G01N33/576
Abstract: 본 발명은 B형 간염에서 유래된 간질환 환자에 특이적인 HBV로부터 유래된 변이된 코어 항원 유전자 또는 단백질을 검출하여, HBe 항원 음성 만성 B형 간염 및 이로부터 유래된 간질환을 진단할 수 있는 진단용 키트에 관한 것이다. 본 발명의 HBe 항원 음성 만성 B형 간염 진단용 키트를 사용할 경우, HBe 항원 음성 만성 B형 간염에 특이적인 변이된 HBV 코어 항원 유전자 또는 단백질을 용이하게 검출할 수 있으므로, 변이된 코어 항원 유전자 또는 단백질을 포함하는 HBV에 의하여 발병되는 HBe 항원 음성 만성 B형 간염 및 이로부터 유래된 간질환을 조기에 효과적으로 진단할 수 있을 것이다.
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公开(公告)号：KR1020120125753A
公开(公告)日：2012-11-19
申请号：KR1020110043380
申请日：2011-05-09
Applicant: 서울대학교산학협력단
CPC classification number: C12N15/74 , C07K14/35 , C12N15/115 , C12N2310/16 , C12Q1/689 , C12Q2600/158
Abstract: PURPOSE: A mycobacteria-derived DNA mismatch repair DNA nucleic acid molecule is provided to enhance resistance to UV and macrophage. CONSTITUTION: A mycobacteria-derived DNA mismatch repair DNA nucleic acid molecule has a nucleotide sequence of sequence number 1 or 2. The gene expression regulatory sequence with UV resistance contains the promoter containing a nucleotide sequence of sequence number 3. A recombinant vector contains an expression target-coding nucleotide sequence and a promoter operatively linked to the nucleotide sequence. The expression target-coding nucleotide sequence is a DNA mismatch repair protein-encoding nucleotide sequence of sequence number 1 or 2. The recombinant vector additionally contains a selection marker. A method for detecting mycobacteria other than tuberculosis(MOTT) comprises: a step of preparing a sample containing the nucleic acid molecule; and a step of detecting MutS4A or MutS4B from a sample.
Abstract translation: 目的：提供分枝杆菌衍生的DNA错配修复DNA核酸分子，以增强对紫外线和巨噬细胞的抗性。 构成：分枝杆菌衍生的DNA错配修复DNA核酸分子具有序列号1或2的核苷酸序列。具有抗紫外线性的基因表达调控序列含有含有序列号3的核苷酸序列的启动子。重组载体含有表达 靶标编码核苷酸序列和与该核苷酸序列有效连接的启动子。 表达靶编码核苷酸序列是序列号1或2的DNA错配修复蛋白编码核苷酸序列。重组载体另外含有选择标记。 一种检测除结核分枝杆菌（MOTT）以外的分枝杆菌的方法，包括：制备含有核酸分子的样品的步骤; 以及从样品中检测MutS4A或MutS4B的步骤。
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公开(公告)号：KR1020120022382A
公开(公告)日：2012-03-12
申请号：KR1020100085942
申请日：2010-09-02
Applicant: 서울대학교산학협력단
IPC: C12Q1/68 , C12N15/11 , G01N33/576
CPC classification number: C12Q1/6883 , G01N33/5761 , G01N33/6854
Abstract: PURPOSE: A kit for diagnosing HBe antigen-negative chronic hepatitis type B and liver diseases is provided to easily detect HBV-specific mutated HBV S antigen gene or protein. CONSTITUTION: A kit for detecting HBe antigen-negative chronic hepatitis type B contains a primer of sequence numbers 1-4. The kit contains: a DNA probe having base sequences of sequence numbers 11-18, which specifically binds to a gene encoding 100th amino acid of L110I S antigen protein; a linker which contains oligo(dT)15, -(CH2)6-, and amine group in order and is connected to thymine region at 5' terminal of the DNA probe; and a solid substrate having aldehyde which is attached on the surface, in which an amine group of an electric linker is connected to the aldehyde group by Schiff's base reaction.
Abstract translation: 目的：提供用于诊断HBe抗原阴性慢性乙型肝炎和肝脏疾病的试剂盒，用于容易地检测HBV特异性突变HBV S抗原基因或蛋白质。 构成：用于检测HBe抗原阴性慢性乙型肝炎的试剂盒含有序列号1-4的引物。 试剂盒包含：具有序列号11-18的碱基序列的DNA探针，其具体结合编码L110I S抗原蛋白的第100个氨基酸的基因; 包含寡聚（dT）15， - （CH 2）6 - 和胺基的连接体，并连接到DNA探针的5'末端的胸腺嘧啶区; 和具有醛的固体基质，其上附着有表面，其中电接头的胺基通过席夫碱反应与醛基连接。
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公开(公告)号：KR1020100041998A
公开(公告)日：2010-04-23
申请号：KR1020080101091
申请日：2008-10-15
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A mutated S antigen protein relating to HBV occult infection is provided to early diagnose HBV occult infection and to effectively treat hepatitis type B. CONSTITUTION: A mutated S antigen protein of HBV(hepatitis B virus) contains 1-30 mutants of which one amino acid is substituted in an amino acid of sequence number 1. The HBV mutant is directly related to HBV occult infection. A mutated S antigen gene is used for diagnosing HBV occult infection.
Abstract translation: 目的：提供与HBV隐匿感染相关的突变S抗原蛋白，以早期诊断HBV隐匿感染并有效治疗乙型肝炎。构成：HBV（乙型肝炎病毒）突变的S抗原蛋白含有1-30个突变体，其中一个 氨基酸在序列1的氨基酸中被取代。HBV突变体与HBV隐匿感染直接相关。 突变的S抗原基因用于诊断HBV隐匿感染。
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