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公开(公告)号：KR1020110018401A
公开(公告)日：2011-02-23
申请号：KR1020110003713
申请日：2011-01-13
Applicant: 충남대학교산학협력단 , 연세대학교 산학협력단
CPC classification number: G01N33/6893 , C07K14/47 , C12Q1/6883 , G01N33/5302
Abstract: PURPOSE: A biomarker used in serological diagnosis for Crohn's disease is provided to specifically react to serum from a patient with Crohn's disease. CONSTITUTION: A marker for diagnosing Crohn's disease is derived from Mycobacterium avium subsp. Paratuberculosis and contains PhoS2-2(Periplasmic phosphate-binding lipoprotein 2-2). A composition for diagnosing Crohn's disease contains the marker. The composition is fixed on a carrier or support to enhance rapidity and convenience of diagnosis. The support comprises a sphere type(bead), cylindrical type(test tube or well inside), and flat type(sheet, test strip). A kit for diagnosing Crohn's disease contains the marker.
Abstract translation: 目的：提供用于克罗恩病血清学诊断的生物标志物，用于与克罗恩病患者的血清特异性反应。 构成：诊断克罗恩病的标记源自鸟分枝杆菌（Mycobacterium avium subsp。 结核分枝杆菌包含PhoS2-2（磷脂结合脂蛋白2-2）。 用于诊断克罗恩病的组合物含有标记物。 该组合物固定在载体或载体上以增强诊断的快速性和便利性。 支撑体包括球形（胎圈），圆柱型（试管或井内）和平型（片，试纸）。 用于诊断克罗恩病的试剂盒含有标记物。
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公开(公告)号：KR1020110017897A
公开(公告)日：2011-02-22
申请号：KR1020110003719
申请日：2011-01-13
Applicant: 충남대학교산학협력단 , 연세대학교 산학협력단
Abstract: PURPOSE: A biomarker for serological diagnosis for Crohn's disease is provided to specifically react in serum from Crohn's disease without reaction on other similar diseases. CONSTITUTION: A marker for diagnosing Crohn's diseases is derived from Mycobacterium avium subsp. Paratuberculosis and contains LprG(probable conserve lipoprotein LprG). The marker additionally contains antigen such as FbpC1(Fibronectin binding protein C1), FadB1(Fatty oxidation protein B1), Gap(Glyceraldehyde 3-phosphate dehydrogenase), Tpi(Triosephosphate isomeras), Tal(Transaldorase), aconitate hydratase, ArgJ(Arginine biosynthesis bifunctional protein), FbpB(Fibronectin binding protein B), HisG(Histidine synthesis protein G), Wag31(Conserved hypothetical protein), Mdh(Malate dehydrogenase), LppZ(Putative lipoprotein), FecB(Probable FeIIIdicitrate-binding periplasmic lipoprotein), GabD2(Putative succinate-semialdehyde dehydrogenase(NADP+) dependant), or superoxide dismutase.
Abstract translation: 目的：提供克罗恩病血清学诊断的生物标志物，在克罗恩病的血清中特异性反应，而不会对其他类似疾病产生反应。 构成：用于诊断克罗恩病的标记源自鸟分枝杆菌（Mycobacterium avium subsp。 结核分枝杆菌并含有LprG（可能保存脂蛋白LprG）。 标记物还含有抗原如FbpC1（纤连蛋白结合蛋白C1），FadB1（脂肪氧化蛋白B1），Gap（Glyceraldehyde 3-phosphate dehydrogenase），Tpi（Triosephosphate isomeras），Tal（Transaldorase），aconitate hydratase，ArgJ（精氨酸生物合成 双功能蛋白），FbpB（纤连蛋白结合蛋白B），HisG（组氨酸合成蛋白G），Wag31（保守假想蛋白），Mdh（苹果酸脱氢酶），LppZ（推定性脂蛋白），FecB（可能的FeIIIdicitrate结合周质脂蛋白） （推定的琥珀酸 - 半醛脱氢酶（NADP +）依赖）或超氧化物歧化酶。
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公开(公告)号：KR1020100033868A
公开(公告)日：2010-03-31
申请号：KR1020080092934
申请日：2008-09-22
Applicant: 충남대학교산학협력단 , 연세대학교 산학협력단
Abstract: PURPOSE: A method for screening a marker for diagnosing tuberculosis is provided to diagnose progression of tuberculosis and predict prognosis. CONSTITUTION: A method for screening a marker for diagnosing tuberculosis progression comprises a step of detecting an antigen derived from tubercular bacillus expressed in serum from blood at active phase, latent phase, and reactive phase. A used animal is mouse. The active phase is from after infection to before tuberculosis. The latent phase is from after treating tuberculosis to before administration immuno suppressant. The detection is performed through 2-dimensional electrophoresis, immunoblot, and LC-ESI-MS(liquid chromatography-electrospray ionization-mass spectrometry). A specific antigen to serum at active phase is KatG or Adenylate kinase. An antigen specific to serum at latent phase is KatG, Malate synthase G, GroEL, Cytidylate kinase or CFP-10. An antigen specific to serum at reactive phase is KatG, PstS3, Enoyl-CoA hydratase, Adenylate kinase, Cytidylate kinase or CFP-10.
Abstract translation: 目的：提供筛选结核病诊断标记物的方法，以诊断结核病的进展并预测预后。 构成：用于筛选用于诊断结核病进展的标志物的方法包括检测来自活动期，潜伏期和反应期的血液中来自结节性芽孢杆菌的血清中的抗原的步骤。 用过的动物是老鼠。 活动期是从感染后到结核病之前。 潜伏期来自治疗结核病后至给药免疫抑制剂。 通过2维电泳，免疫印迹和LC-ESI-MS（液相色谱 - 电喷雾离子化 - 质谱）进行检测。 活性期血清的特异性抗原是KatG或腺苷酸激酶。 潜伏期血清特异性抗原为KatG，苹果酸合酶G，GroEL，胞苷酸激酶或CFP-10。 活性期血清特异性抗原为KatG，PstS3，Enoyl-CoA水合酶，腺苷酸激酶，胞苷酸激酶或CFP-10。
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44.发明授权Rv2299c 또는 Rv2299c와 ESAT-6 융합한 단백질을 포함하는 수지상 세포의 성숙화 촉진용 조성물 有权促进树突细胞成熟的组合物，其包含Rv2299c或与Rv2299c和ESAT-6融合的蛋白质
公开(公告)号：KR101749165B1
公开(公告)日：2017-06-23
申请号：KR1020160070517
申请日：2016-06-07
Applicant: 충남대학교산학협력단 , 연세대학교 산학협력단
IPC: C12N5/0784 , C07K14/35 , A61K38/16
CPC classification number: A61K38/16 , C07K14/35 , C12N5/0639 , A61K38/164 , C07K2319/00 , C12N2501/998
Abstract: 본발명은수지상세포성숙화유도조성물및 수지상세포를성숙시키는방법에관한것이다. 더욱구체적으로는결핵균(M. tuberculosis) 유래의 Rv2299c 또는 Rv2299c 와 ESAT-6를융합한단백질을유효성분으로포함하는수지상세포성숙화유도조성물및 이를이용하여미성숙수지상세포를수지상세포로분화시키는방법에관한것이다. 본발명의방법에의하여수지상세포에의한신체의면역반응을증강시킬수 있다.
Abstract translation: 本发明涉及树突细胞成熟诱导组合物和用于成熟树突细胞的方法。 更具体地说，它使用它们，包括ESAT-6的融合蛋白作为活性成分的树突囚禁涉及euroneun结核分枝杆菌（结核分枝杆菌），或Rv2299c和的树突状细胞成熟的起源和来源的组合物的未成熟树突状细胞的Rv2299c分化的方法 。 通过本发明的方法可以增强树突细胞对身体的免疫反应。
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公开(公告)号：KR101290230B1
公开(公告)日：2013-07-30
申请号：KR1020110010165
申请日：2011-02-01
Applicant: 충남대학교산학협력단
Abstract: 본 발명은 수지상 세포 암 치료제에 관한 것이다. 더욱 구체적으로는 결핵균의 Rv0652를 아쥬반트로 이용한 수지상 세포 암 치료제에 관한 것이다. 본 발명의 결핵균의 Rv0652를 아쥬반트로 이용한 수지상 세포 암 치료제는 종양의 성장을 효과적으로 억제시킨다.
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Patent Agency Ranking
公开(公告)号：KR1020130039061A
公开(公告)日：2013-04-19
申请号：KR1020110103498
申请日：2011-10-11
Applicant: 충남대학교산학협력단
IPC: C12N5/0784 , C12N1/38 , C07K14/195
Abstract: PURPOSE: A method for maturing dendritic cells is provided to promote differentiation of immature dendritic cells using Mycobacterium tuberculosis Rv2299c, to effectively mature the dendriric cells, and to effectively enhance immune response. CONSTITUTION: A composition for inducing maturation of dendritic cells contains 1-5 microgram/ml of Rv2299c protein derived from Mycobacterium tuberculosis as an active ingredient. A method for inducing maturation of immature dendritic cells comprises: a step of treating Rv2299c to the immature dendritic cells; and a step of culturing the treated dendritic cells for 12-36 hours. The maturation of the immature dendritic cells indicates enhancement of TNF-alpha, IL-12p70, IL-6, and IL-1beta.
Abstract translation: 目的：提供成熟树突状细胞的方法，以促进使用结核分枝杆菌Rv2299c的未成熟树突状细胞的分化，以有效地成熟树突状细胞，并有效增强免疫应答。 构成：用于诱导树突细胞成熟的组合物含有1-5微克/ ml来自结核分枝杆菌的Rv2299c蛋白作为活性成分。 用于诱导未成熟树突状细胞成熟的方法包括：将Rv2299c处理至未成熟树突状细胞的步骤; 以及培养经处理的树突状细胞12-36小时的步骤。 未成熟树突细胞的成熟表明TNF-α，IL-12p70，IL-6和IL-1beta的增强。
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47.发明公开마이코박테리움 파라튜버큘로시스의 ＭＡＰ１９４８ 단백질을 이용한 수지상 세포의 성숙방법 有权使用MYCOBACTERIUM PARATUBERCULOSIS MAP1948的感染细胞的成熟方法
公开(公告)号：KR1020130037884A
公开(公告)日：2013-04-17
申请号：KR1020110102394
申请日：2011-10-07
Applicant: 충남대학교산학협력단
IPC: C12N5/0784 , C12N1/38 , C07K14/35
Abstract: PURPOSE: A method for maturing dendritic cells using Mycobacterium paratuberculosis MAP1948 is provided to promote the differentiation of immature dendritic cells and to effectively mature the dendritic cells. CONSTITUTION: A method for maturing dendritic cells using Mycobacterium paratuberculosis MAP1948 comprises: a step of treating immature resin cells with MAP1948; and a step of culturing the cell for 12-36 hours. The immature resin cells are matured through the increase of IL-6, IL-1beta, and IFN-gamma generation.
Abstract translation: 目的：提供使用分枝杆菌MAP1948成熟树突状细胞的方法，以促进未成熟树突状细胞的分化并有效地成熟树突状细胞。 构成：使用分枝杆菌MAP1948成熟树突状细胞的方法包括：用MAP1948处理未成熟树脂细胞的步骤; 以及培养细胞12-36小时的步骤。 未成熟树脂细胞通过增加IL-6，IL-1β和IFN-γ产生而成熟。
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公开(公告)号：KR101082816B1
公开(公告)日：2011-11-11
申请号：KR1020110095102
申请日：2011-09-21
Applicant: 충남대학교산학협력단
IPC: G01N33/569 , G01N33/68
Abstract: 본발명은비결핵항산균중 하나인감염진단용조성물및진단용키트,진단에대한정보를제공하는방법에관한것이다. 보다구체적으로본 발명은수퍼옥사이드디스뮤타제(superoxide dismutase) 또는카탈라아제(catalase)를포함하는진단용조성물, 키트, 진단에대한정보를제공하는방법에관한것이며, 항산균감염증중에서특히고병원성인만을특이적으로진단할수 있다.
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公开(公告)号：KR101052350B1
公开(公告)日：2011-07-27
申请号：KR1020100009747
申请日：2010-02-02
Applicant: 충남대학교산학협력단 , 부산대학교 산학협력단
IPC: C07K14/35 , C12N5/0784
Abstract: PURPOSE: A method for maturing dendritic cells using heparin binding hemagglutin(HBHA) is provided to effectively activate immune response. CONSTITUTION: A method for maturing dendritic cells comprises a step of treating 0.5-1.0 ug/ml of HBHA(heparin-binding hemagglutin) to immature dendritic cells and a step of culturing for 24 hours. The HBHA is a recombinant HBHA(rMS-HBHA) expressed in M. smegmatis.
Abstract translation: 目的：提供使用肝素结合血凝素（HBHA）成熟树突状细胞的方法，以有效激活免疫应答。 构成：成熟树突细胞的方法包括将0.5-1.0ug / ml的HBHA（肝素结合血凝素）处理成未成熟树突状细胞的步骤和培养24小时的步骤。 HBHA是在耻垢分枝杆菌中表达的重组HBHA（rMS-HBHA）。
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公开(公告)号：KR1020110020881A
公开(公告)日：2011-03-03
申请号：KR1020110003716
申请日：2011-01-13
Applicant: 충남대학교산학협력단 , 연세대학교 산학협력단
CPC classification number: G01N33/6893 , C12Q1/6883 , C12R1/325 , G01N33/5302
Abstract: PURPOSE: A specific protein for serological diagnosis for Crohn's disease is provided to specifically response to a serum from a patient with Crohn's disease. CONSTITUTION: A marker for diagnosing Crohn's disease contains TrpC(Indole-3-glycerolphosphate synthase) which is an antigen specifically responding to serum of Crohn's disease and is derived from human Mycobacterium avium subsp. Paratuberculosis. The marker also contains FbpC1(Fibronectin binding protein C1), FadB1(Fatty oxidation protein B1), LprG(Probable conserve lipoprotein LprG), Gap(Glyceraldehyde 3-phosphate dehydrogenase), Tpi(Triosephosphate isomerase), Tal(Transaldorase), aconitate hydratase, ArgJ(Arginine biosynthesis bifunctional protein), FbpB(Fibronectin binding protein B), HisG(Histidine synthesis protein G), Wag31(Conserved hypothetical protein), Mdh(Malate dehydrogenase), LppZ(Putative lipoprotein), or superoxide dismutase antigen. A composition or kit for diagnosing Crohn's disease contains the marker.
Abstract translation: 目的：提供克罗恩病血清学诊断的特异性蛋白质，以特异性应答克罗恩病患者的血清。 构成：用于诊断克罗恩病的标记物含有TrpC（吲哚-3-磷酸甘油合成酶），其是特异性响应于克罗恩病血清的抗原，来自人类鸟分枝杆菌亚种。 副结核病。 该标记还含有FbpC1（纤连蛋白结合蛋白C1），FadB1（脂肪氧化蛋白B1），LprG（可能保存的脂蛋白LprG），Gap（Glyceraldehyde 3-phosphate dehydrogenase），Tpi（Triosephosphate isomerase），Tal（Transaldorase），itate酸水合酶 ，ArgJ（精氨酸生物合成双功能蛋白），FbpB（纤连蛋白结合蛋白B），HisG（组氨酸合成蛋白G），Wag31（保守假想蛋白），Mdh（苹果酸脱氢酶），LppZ（推定脂蛋白）或超氧化物歧化酶抗原。 用于诊断克罗恩病的组合物或试剂盒含有标记物。
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