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公开(公告)号：KR1020080113845A
公开(公告)日：2008-12-31
申请号：KR1020070062789
申请日：2007-06-26
Applicant: 포항공과대학교 산학협력단
CPC classification number: A61K31/496 , G01N33/5058
Abstract: A mechanism of inhibiting activity of P2X7 receptor on doparminergic neuronal cells is provided to prevent or cure the neurodegenerative disorder related to the activity of the P2X7 receptor by suppressing the volume increase and the necrosis of the nerve cell. A nerve cell protecting agent includes an inhibitor or an antagonist of the P2X7 receptor existing in the dopaminergic neuron as an active ingredient. The nerve cell protecting agent protects the nerve cell from the cell volume and the necrosis increased by the over-activity of the P2X7 receptor, by ATP.
Abstract translation: 提供抑制P2X7受体对多巴胺能神经元细胞活性的抑制机制，通过抑制体内增加和神经细胞坏死来预防或治愈与P2X7受体活性相关的神经变性疾病。 神经细胞保护剂包含作为活性成分存在于多巴胺能神经元中的P2X7受体的抑制剂或拮抗剂。 神经细胞保护剂通过ATP保护神经细胞免受细胞体积的破坏和P2X7受体的过度活性增加。
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公开(公告)号：KR102201371B1
公开(公告)日：2021-01-11
申请号：KR1020190076960
申请日：2019-06-27
Applicant: 포항공과대학교 산학협력단
Abstract: 본발명은신호분리기반의잡음환경내 실시간생체신호탐지장치및 그방법을제공한다. 본발명에따르면, 생체신호탐지장치를이용한생체신호탐지방법에있어서, 표적으로송출후 반사된레이다반사신호를프레임단위로수신하는단계와, 매프레임마다, 상기레이다반사신호에서추출된위상신호로부터저주파대역에대응된제1 위상성분및 고주파대역에대응된제2 위상성분을각각분리하는단계와, 상기제1 및제2 위상성분을미분하여잡음을제거하는단계와, 잡음이제거된제1 및제2 위상성분을각각 FFT 처리하여제1 및제2 주파수스펙트럼을획득하는단계와, 상기제1 및제2 주파수스펙트럼각각의개별관심대역내에서최대에너지를가진주파수를현재프레임에대한호흡수와심박수로각각탐지하는단계, 및상기호흡수와심박수의탐지값을프레임별 실시간출력하되, 호흡수와심박수각각의탐지값에대한속도변화를추정하여, 추정한속도변화가임계값이상인경우에는과거 N개프레임의탐지값을기초로현재프레임의탐지값을변경하여출력하는단계를포함한다. 본발명에따르면, 생체신호탐지시 표적의불필요한움직임으로인한잡음발생환경에서도생체신호를효과적으로탐지하고오탐지확률을최소화할수 있다.
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公开(公告)号：KR1020210001217A
公开(公告)日：2021-01-07
申请号：KR1020190076960
申请日：2019-06-27
Applicant: 포항공과대학교 산학협력단
Abstract: 본발명은신호분리기반의잡음환경내 실시간생체신호탐지장치및 그방법을제공한다. 본발명에따르면, 생체신호탐지장치를이용한생체신호탐지방법에있어서, 표적으로송출후 반사된레이다반사신호를프레임단위로수신하는단계와, 매프레임마다, 상기레이다반사신호에서추출된위상신호로부터저주파대역에대응된제1 위상성분및 고주파대역에대응된제2 위상성분을각각분리하는단계와, 상기제1 및제2 위상성분을미분하여잡음을제거하는단계와, 잡음이제거된제1 및제2 위상성분을각각 FFT 처리하여제1 및제2 주파수스펙트럼을획득하는단계와, 상기제1 및제2 주파수스펙트럼각각의개별관심대역내에서최대에너지를가진주파수를현재프레임에대한호흡수와심박수로각각탐지하는단계, 및상기호흡수와심박수의탐지값을프레임별 실시간출력하되, 호흡수와심박수각각의탐지값에대한속도변화를추정하여, 추정한속도변화가임계값이상인경우에는과거 N개프레임의탐지값을기초로현재프레임의탐지값을변경하여출력하는단계를포함한다. 본발명에따르면, 생체신호탐지시 표적의불필요한움직임으로인한잡음발생환경에서도생체신호를효과적으로탐지하고오탐지확률을최소화할수 있다.
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45.发明公开
公开(公告)号：KR20180018458A
公开(公告)日：2018-02-21
申请号：KR20170103181
申请日：2017-08-14
Applicant: 주식회사 노브메타파마 , 포항공과대학교 산학협력단
IPC: A61K31/4706 , A61K31/155 , A61K31/427 , A61K45/06
CPC classification number: A61K31/155 , A61K31/427 , A61K31/4706 , A61K45/06
Abstract: 본발명은 (a) 아모디아퀸(amodiaquine) 화합물또는이의약제학적으로허용가능한염; 및 (b) 항당뇨약물을유효성분으로함유하는 PPAR-γ(Peroxisome proliferator-activated receptor-gamma) 활성화에따른부작용을억제하면서, 당뇨병을예방또는치료하기위한약학적조성물에관한것으로, 구체적으로, 상기조성물은 PPAR-γ(Peroxisome proliferator-activated receptor-gamma) 활성화에반응하는제2형당뇨병및 PPAR-α(Peroxisome proliferator-activated receptor-alpha) 활성화에반응하는비만, 이상지질혈증, 심혈관계질환및 지방간으로이루어진군으로부터선택된하나이상을동시에예방또는치료하기위한것이다.
Abstract translation: 本发明涉及一种药物组合物，其包含（a）一种amodiquine化合物或其药学上可接受的盐; 和（b）作为有效成分的抗糖尿病药物，用于预防或治疗糖尿病，同时抑制由过氧化物酶体增殖物激活受体-γ（PPAR-γ）激活引起的副作用。 更具体地说，该组合物旨在同时预防或治疗2型糖尿病对过氧化物酶体增殖物激活受体-γ（PPAR-γ）活化的响应和至少一种选自肥胖症，血脂异常，心血管疾病和脂肪 肝脏，这些都是过氧化物酶体增殖物激活受体-γ（PPAR-γ）激活的响应。
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Patent Agency Ranking
公开(公告)号：KR101760614B1
公开(公告)日：2017-07-24
申请号：KR1020160084126
申请日：2016-07-04
Applicant: 포항공과대학교 산학협력단
IPC: G01S13/90
CPC classification number: G01S13/9035 , G01S2013/9064
Abstract: 본발명은수직거리해상도를이용한역합성개구면레이더영상재구성장치및 그방법에관한것이다. 본발명에따르면, 역합성개구면레이더영상재구성장치를이용한영상재구성방법에있어서, 표적에대한역합성개구면레이더신호를입력받는단계, 상기역합성개구면레이더신호로부터생성된역합성개구면레이더영상의수직거리해상도를추정하는단계, 상기추정된수직거리해상도와기 저장된훈련역합성개구면레이더영상의수직거리해상도를비교하는단계, 비교결과상기추정된수직거리해상도와상기훈련역합성개구면레이더영상의수직거리해상도가상이하면, 상기역합성개구면레이더신호의버스트(burst) 수를감소또는증가시키는단계, 그리고버스트수가감소또는증가된역합성개구면레이더신호를이용하여역합성개구면레이더영상을재구성하는단계를포함한다. 이와같이본 발명에따르면, 역합성개구면레이더영상의수직거리해상도를이용하여역합성개구면레이더영상의수직거리해상도를변경함으로써재구성한영상을표적식별에이용하는경우종래의표적식별방법에비해월등히향상된성능을제공할수 있다.
Abstract translation: 本发明涉及一种利用垂直距离分辨率重建逆合成开口表面雷达图像的设备和方法。 根据本发明，使用图像重建装置，其包括在所述图像重建方法频带合成开口表面雷达：接收频带合成开口表面雷达信号到目标，从所产生的频带合成开口表面雷达信号频带合成开口表面雷达 将估计的垂直距离分辨率与预先存储的训练反向合成开口表面雷达图像的垂直距离分辨率进行比较;将估计的垂直距离分辨率与训练反向合成开口表面进行比较 通过增加或减少逆合成开口表面雷达信号的脉冲串数量并通过使用逆合成开口表面雷达信号可以减小雷达图像的垂直距离分辨率， 并重建雷达图像。 以这种方式，根据本发明，使用该频带合成开口表面雷达图像的垂直距离分辨率时，通过改变频带合成开口表面雷达图像的垂直距离分辨率改进相比于常规目标识别方法显著使用所识别的目标到重建的图像 它可以提供一个性能。
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公开(公告)号：KR1020160061813A
公开(公告)日：2016-06-01
申请号：KR1020140164707
申请日：2014-11-24
Applicant: 포항공과대학교 산학협력단
IPC: A61K36/8962 , A61K36/81 , A61K36/18 , A61P3/02
CPC classification number: A61K36/8962 , A61K36/61 , A61K36/81 , A61K36/82 , A61K2236/00 , A61K2300/00 , A61K36/18 , Y10S514/824
Abstract: 본발명은마늘, 파프리카, 홍차, 및구아바의복합추출물을유효성분으로포함하는약제학적조성물및 기능성식품조성물에관한것으로, 본발명에따른약제학적조성물및 기능성식품조성물은운동수행능력을증강시키고체력을증진시키는데뛰어난효과를나타낸다. 따라서본 발명의조성물은의약분야또는기능성식품분야에서매우유용하게활용될수 있다.
Abstract translation: 本发明涉及包含大蒜，辣椒粉，红茶和番石榴的复合提取物作为活性成分的药物组合物和功能性食品组合物。 根据本发明，药物组合物和功能性食品组合物具有提高运动性能和体力的优异效果。 因此，本发明的组合物可用于医药和功能性食品领域。
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公开(公告)号：KR1020140048402A
公开(公告)日：2014-04-24
申请号：KR1020120113176
申请日：2012-10-11
Applicant: 포항공과대학교 산학협력단 , 재단법인 포항테크노파크
IPC: A61K31/7048 , A61P25/00
CPC classification number: A61K31/352 , A23L33/105 , A23V2002/00 , A61K9/0053
Abstract: According to the present invention, a composition comprising myricetin or a pharmaceutically acceptable salt thereof as an active ingredient enhances exercise performance and physical strength. In addition, the composition has an anti-aging function and a fatigue recovery function. Since the composition of the present invention improves mitochondrial function, thereby enhancing energy efficiency and increasing energy consumption, the present invention also has anti-obesity effects. Thus, the present invention can be effectively applied in the fields of functional food or medicine. [Reference numerals] (AA) Exercise duration time (m); (BB) Phosphate buffered saline water; (CC) Myricetin
Abstract translation: 根据本发明，包含杨梅素或其药学上可接受的盐作为活性成分的组合物增强运动性能和体力。 此外，该组合物具有抗衰老功能和疲劳恢复功能。 由于本发明的组合物改善线粒体功能，从而提高能量效率并增加能量消耗，本发明还具有抗肥胖效果。 因此，本发明可以有效地应用于功能性食品或医药领域。 （附图标记）（AA）运动持续时间（m）; （BB）磷酸缓冲盐水; （CC）杨梅素
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公开(公告)号：KR1020130022034A
公开(公告)日：2013-03-06
申请号：KR1020110084690
申请日：2011-08-24
Applicant: 포항공과대학교 산학협력단
IPC: G01N33/68 , G01N33/53 , A61K31/7088 , A61P25/00
CPC classification number: C12N15/1137 , A61K31/713 , C12N2310/14 , C12N2320/30 , C12Q1/485 , C12Q1/6809 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/573 , G01N2500/02 , G01N2500/04
Abstract: PURPOSE: A method for screening a chaperonin modulator is provided to effectively prevent or treat neurodegenerative diseases without cell apoptosis. CONSTITUTION: A method for screening a chaperonin modulator comprises: a step of preparing a candidate substance and VRK2; a step of measuring VRK2 expression level or kinase activation; and a step of measuring a change of VRK2 expression level or kinase activation when treating the candidate substance and VRK2 together. The chaperonin modulator increases the amount or extends the lifetime of chaperonin.
Abstract translation: 目的：提供筛选伴侣伴侣调节剂的方法，以有效预防或治疗无细胞凋亡的神经变性疾病。 构成：筛选伴侣调节剂的方法包括：制备候选物质和VRK2的步骤; 测量VRK2表达水平或激酶激活的步骤; 以及在一起处理候选物质和VRK2时测量VRK2表达水平或激酶活化变化的步骤。 伴侣调节剂增加伴侣蛋白的量或延长其伴侣的寿命。
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公开(公告)号：KR101135586B1
公开(公告)日：2012-04-17
申请号：KR1020090087528
申请日：2009-09-16
Applicant: 포항공과대학교 산학협력단
Abstract: PURPOSE: A memory device containing conjugated polymers as active layer is provided to ensure excellent performance using conjugated polymers as active layer which causes switching phenomenon at low operation voltage and on/off voltage states. CONSTITUTION: A conjugated polymer is represented by chemical formula I. In chemical formula I, R is C1-20 alkyl group, and Z is an aromatic or aliphatic derivate selected from the chemical formula A, wherein R' and R'' are C1-20 alkyl group and n is a repeating unit as an integer. A polymer memory device includes a lower electrode, an organic active layer, and an upper electrode.
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