公开(公告)号：ZA9703362B

公开(公告)日：1997-11-18

申请号：ZA9703362

申请日：1997-04-18

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CHU DANIEL T ,  HALLAS ROBERT ,  TUFANO MICHAEL ,  PHAN LY T ,  SPINA KENNETH P ,  ELLIOTT RICHARD L

IPC: A61K20060101 ,  C07D20060101 ,  C07D ,  A61K

CPC classification number: Y02P20/55

公开(公告)号：IE76284B1

公开(公告)日：1997-10-08

申请号：IE296489

申请日：1989-09-15

Applicant: ABBOTT LAB

Inventor： CHU DANIEL TIM-WO ,  HALLAS ROBERT

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/47 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07D401/04 ,  C07D471/04 ,  C07K1/113 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07D221/04

Abstract: 7-(3-A-amino-1-pyrrolidinyl) substituted naphthyridine and quinoline compounds wherein A is a solubilizing group selected from an amino acid residue or polypeptide chain.

公开(公告)号：AU616053B2

公开(公告)日：1991-10-17

申请号：AU4172489

申请日：1989-09-21

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  CHU DANIEL TIM-WO

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/47 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07D401/04 ,  C07D471/04 ,  C07K1/113 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07D401/10 ,  A61K31/40

Abstract: 7-(3-A-amino-1-pyrrolidinyl) substituted naphthyridine and quinoline compounds wherein A is a solubilizing group selected from an amino acid residue or polypeptide chain.

公开(公告)号：FR2524885A1

公开(公告)日：1983-10-14

申请号：FR8305782

申请日：1983-04-08

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN SOLOMAN ,  HALLAS ROBERT ,  FREIBERG LESLIE ALAN ,  BACINO DAVID JAMES

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/224 ,  C07D309/10 ,  A61K31/35

Abstract: Disclosed herein are fortimicin derivatives represented by the formula: wherein R is hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, loweracyl, aminoloweracyl, diaminoloweracyl, hydroxyloweracyl, N-loweralkylaminoloweracyl, N,N-diloweralkylaminoloweracyl, or aminohydroxyloweracyl, and the pharmaceutically acceptable salts thereof. Also disclosed are intermediates useful in the preparation of these compounds and compositions of these compounds together with a pharmaceutically acceptable carrier and/or diluent.

公开(公告)号：DE3312718A1

公开(公告)日：1983-10-13

申请号：DE3312718

申请日：1983-04-08

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN SOLOMAN ,  HALLAS ROBERT ,  FREIBERG LESLIE ALAN ,  BACINO DAVID JAMES

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/224 ,  C07D309/14 ,  A61K31/35 ,  A61K31/42 ,  C07D498/02

Abstract: Disclosed herein are fortimicin derivatives represented by the formula: wherein R is hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, loweracyl, aminoloweracyl, diaminoloweracyl, hydroxyloweracyl, N-loweralkylaminoloweracyl, N,N-diloweralkylaminoloweracyl, or aminohydroxyloweracyl, and the pharmaceutically acceptable salts thereof. Also disclosed are intermediates useful in the preparation of these compounds and compositions of these compounds together with a pharmaceutically acceptable carrier and/or diluent.

公开(公告)号：IT8320509D0

公开(公告)日：1983-04-08

申请号：IT2050983

申请日：1983-04-08

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN SOLOMAN ,  HALLAS ROBERT ,  FREIBERG LESLIE ALAN ,  BACINO DAVID JAMES

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/224 ,  A61K

Abstract: Disclosed herein are fortimicin derivatives represented by the formula: wherein R is hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, loweracyl, aminoloweracyl, diaminoloweracyl, hydroxyloweracyl, N-loweralkylaminoloweracyl, N,N-diloweralkylaminoloweracyl, or aminohydroxyloweracyl, and the pharmaceutically acceptable salts thereof. Also disclosed are intermediates useful in the preparation of these compounds and compositions of these compounds together with a pharmaceutically acceptable carrier and/or diluent.

公开(公告)号：DE3036173A1

公开(公告)日：1981-04-16

申请号：DE3036173

申请日：1980-09-25

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN SOLOMAN ,  HALLAS ROBERT ,  MARTIN JERRY ROY

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7042 ,  A61P31/04 ,  C07H15/224 ,  C07H17/00 ,  C07H15/22 ,  A61K31/71 ,  C07H15/26

公开(公告)号：CA1022169A

公开(公告)日：1977-12-06

申请号：CA198887

申请日：1974-05-03

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  TADANIER JOHN S ,  VON ESCH ANNE M

IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Covers 4''-O-sulfonyl erythromycin-9-O-oxime derivatives falling within the following structural formula:

公开(公告)号：AU6790674A

公开(公告)日：1975-10-16

申请号：AU6790674

申请日：1974-04-16

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  ESCH ANNE MARY VON ,  TADANIER JOHN SOLOMAN

IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07D9/00 ,  A61K21/00

Abstract: Covers 4''-O-sulfonyl erythromycin-9-O-oxime derivatives falling within the following structural formula:

公开(公告)号：DK173511B1

公开(公告)日：2001-01-15

申请号：DK466889

申请日：1989-09-21

Applicant: ABBOTT LAB

Inventor： CHU DANIEL TIM-WO ,  HALLAS ROBERT

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/47 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07D401/04 ,  C07D471/04 ,  C07K1/113 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10

Abstract: 7-(3-A-amino-1-pyrrolidinyl) substituted naphthyridine and quinoline compounds wherein A is a solubilizing group selected from an amino acid residue or polypeptide chain.