公开(公告)号：US3686187A

公开(公告)日：1972-08-22

申请号：US3686187D

申请日：1970-05-25

Applicant: ABBOTT LAB

Inventor： COLE JOHN WAYNE ,  HALLAS ROBERT

IPC: C07D211/58 ,  C07D211/72 ,  C07D29/28

CPC classification number: C07D211/58 ,  C07D211/72

Abstract: A NEW SERIES OF PIPERDINE DERIVATIVES HAS BEEN DISCOVERED; THEY ARE COMPOUNDS CARRYING, IN THE 4-POSITION OF THE PIPERIDINE RING, A SUBSTITUTED ANILINO GROUP AND IN THE 1-POSITION, A P-FLUOROPHENYL RING SEPARATED FROM THE PIPERIDINE RING BY A CARBON CHAIN OF 4. THESE NEW COMPOUNDS AND THEIR NON-TOXIC ACID ADDITION SALTS ARE HIGHLY EFFECTIVE ANALGEICES OF LOW TOXICITY.

公开(公告)号：US3691176A

公开(公告)日：1972-09-12

申请号：US3691176D

申请日：1970-05-25

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  COLE JOHN WAYNE

IPC: C07D211/58 ,  C07D211/72 ,  C07D29/28

CPC classification number: C07D211/58 ,  C07D211/72

Abstract: A new series of piperidine derivatives has been discovered; they are the N-(3-(p-fluorophenoxy)propyl)piperidines carrying in the 4-position of the piperidine ring a substituted anilino group. These new compounds and their non-toxic acid addition salts are highly effective analgesics of low toxicity.

公开(公告)号：US3884902A

公开(公告)日：1975-05-20

申请号：US35712473

申请日：1973-05-04

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  MARTIN JERRY ROY ,  SOLOMAN JOHN

IPC: C07H17/08 ,  C07C129/18

CPC classification number: C07H17/08

Abstract: Covers erythromycin sulfonyl derivatives which are useful as antibiotics when administered to warm blooded animals.

Abstract translation: 涵盖红霉素磺酰基衍生物，当向温血动物施用时可用作抗生素。

公开(公告)号：US3869445A

公开(公告)日：1975-03-04

申请号：US42365273

申请日：1973-12-10

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  TADANIER JOHN SOLOMAN ,  VONESCH ANNE MARY

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: Covers sulfonyl derivatives of erythromycin A, B and C falling within the following structural formula:

WHERE R is selected from the group consisting of amino, monoalkyl amino, dialkyl amino, alkoxy, morpholino, substituted morpholino, piperazino, substituted piperazino, piperidino, substituted piperidino, alkylthio, alkylsulfonyl, arylthio, substituted arylthio, arylsulfonyl, substituted arylsulfonyl, thiamorpholino, aziridino, substituted aziridino, benzylthio, substituted benzylthio, thiamorpholinosulfone, substituted thiamorpholinosulfone, benzylsulfinyl, substituted benzylsulfinyl, arylsulfinyl, substituted arylsulfinyl, benzylsulfonyl, substituted benzylsulfonyl, cyanoalkyl, halocyanoalkyl, haloalkanoate, dialkanoate, ketaolkyl, ketoalkanoate, benzylamino, substituted benzylamino, benzoxy, substituted benzoxy, phenoxy, substituted phenoxy, benzycyano, and substituted benzylcyano; R1 is hydrogen or mmethyl, R2 is hydrogen or loweralkanoyl, R3 is hydrogen or hydroxy, and R4 is selected from the group consisting of loweralkyl, cycloalkyl, subtituted cycloalkyl, aryl, substituted aryl, benzyl, and substituted benzyl. The present sulfonyl derivatives of erythromycin A, B and C are useful as antibiotics.

Abstract translation: 涵盖红霉素A，B和C的磺酰基衍生物，其结构式如下：

公开(公告)号：EP0608215A4

公开(公告)日：1993-11-11

申请号：EP91918185

申请日：1991-08-23

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  HALLAS ROBERT

IPC: C07D455/03 ,  C07D498/06 ,  C07D498/16 ,  C07D513/06 ,  A61K31/44 ,  A61K31/47 ,  A61K31/495 ,  A61K31/50 ,  A61K31/535 ,  A61K31/54 ,  C07D221/04 ,  C07D221/22 ,  C07D279/36 ,  C07D455/02 ,  C07D471/06 ,  C07D513/00

CPC classification number: C07D455/00 ,  C07D513/06 ,  Y02P20/55

公开(公告)号：NZ336174A

公开(公告)日：2001-02-23

申请号：NZ33617497

申请日：1997-04-07

Applicant: ABBOTT LAB

Inventor： SPINA KENNETH P ,  OR YAT SUN ,  PHAN LY TAM ,  CHU DANIEL T ,  HALLAS ROBERT ,  ELLIOTT RICHARD L ,  TUFANO MICHAEL

IPC: C07H17/00 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  A61K31/71

Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of the formula:wherein A, B, D and E, R1, R2, and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of bacterial infections with such compositions, and processes for the preparation of the compounds.

公开(公告)号：CA2235942A1

公开(公告)日：1997-05-15

申请号：CA2235942

申请日：1996-10-17

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  ELLIOTT RICHARD L ,  PHAN LY TAM ,  SPINA KENNETH P ,  HALLAS ROBERT ,  CHU DANIEL T

IPC: A61K31/70 ,  C07H17/08 ,  C07H23/00

Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R1, R2 and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.

公开(公告)号：CA2099609A1

公开(公告)日：1992-02-25

申请号：CA2099609

申请日：1991-08-23

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  HALLAS ROBERT

IPC: C07D455/03 ,  C07D498/06 ,  C07D498/16 ,  C07D513/06 ,  A61K31/47 ,  A61K31/535 ,  A61K31/54 ,  A61K38/04 ,  C07K5/04 ,  C07K7/06

Abstract: 2099609 9203136 PCTABS00010 Quinobenzoxazine, quinobenzothiazines, and pyrido-acridine derivatives of formula (I), as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R1 is hydrogen or a carboxy-protecting group, R2 and R3 are substituents, A is oxygen, sulfur, or carbon, Z is a halogen or a nitrogen-containing group, X is hydrogen, halogen or alkyl, and W is hydrogen, alkyl, amino or halogen. The compounds have potent antineoplastic activity.

公开(公告)号：NZ230727A

公开(公告)日：1991-08-27

申请号：NZ23072789

申请日：1989-09-21

Applicant: ABBOTT LAB

Inventor： DANIEL TIM-WO CHU ,  HALLAS ROBERT

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/47 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07D401/04 ,  C07D471/04 ,  C07K1/113 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07K5/04 ,  A61K31/445 ,  A61K37/02

Abstract: 7-(3-A-amino-1-pyrrolidinyl) substituted naphthyridine and quinoline compounds wherein A is a solubilizing group selected from an amino acid residue or polypeptide chain.

公开(公告)号：GB2118180A

公开(公告)日：1983-10-26

申请号：GB8308762

申请日：1983-03-30

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN SOLOMAN ,  HALLAS ROBERT ,  FREIBERG LESLIE ALAN ,  BACINO DAVID JAMES

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/224 ,  C07H15/22 ,  A61K31/71

Abstract: Disclosed herein are fortimicin derivatives represented by the formula: wherein R is hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, loweracyl, aminoloweracyl, diaminoloweracyl, hydroxyloweracyl, N-loweralkylaminoloweracyl, N,N-diloweralkylaminoloweracyl, or aminohydroxyloweracyl, and the pharmaceutically acceptable salts thereof. Also disclosed are intermediates useful in the preparation of these compounds and compositions of these compounds together with a pharmaceutically acceptable carrier and/or diluent.