中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

92 records (took 0.041 seconds)

    2-SUBSTITUTED 1,2-BENZISOTHIAZOLE DERIVATIVES AND THEIR USE AS SEROTONIN ANTAGONISTS (5-HT1A, 5-HT1B AND 5-HT1D)
    47.
    发明专利
    2-SUBSTITUTED 1,2-BENZISOTHIAZOLE DERIVATIVES AND THEIR USE AS SEROTONIN ANTAGONISTS (5-HT1A, 5-HT1B AND 5-HT1D) 未知

    公开(公告)号：CA2307199A1

    公开(公告)日：1999-04-29

    申请号：CA2307199

    申请日：1998-10-05

    Applicant: BASF AG

    Inventor： LUBISCH WILFRIED ,  TESCHENDORF HANS-JURGEN ,  GARCIA-LADONA XAVIER ,  WICKE KARSTEN ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  EMLING FRANZ ,  BACH ALFRED

    IPC: A61K31/428 ,  A61P25/24 ,  A61P43/00 ,  C07D275/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/425

    Abstract: The invention relates to 2-substituted 1,2-benzisothiazole derivatives of formula (I), wherein R1 and R2 represent (C1-6) alkyl, independently of each other; A represents branched or unbranched (C1-10)-alkylene or straightchained or branched (C2-10)-alkylene comprising at least one group Z which is selected from O, S, NR7, cyclopropyl, CHOH, a double or triple bond; B represents 4-piperidine, 4-tetrahydro-1, 2, 3, 6 pyridine, 4-piperazine and the corresponding ring compounds enlarged with a methylene group, an N-atom of B providing the link with A; Ar represents phenyl which is optionally substituted by (C1-6) alkyl -branched or unbranched-, O-( C1-6)-alkyl branched or unbranched-, OH, F, Cl, Br, I, trifluoromethyl, NR5R6, CO2R7, cyano or phenyl; tetralin, indan, highly condensed aromatics such as naphthalin optionally substituted by (C1-4) alkyl or O(C1-4) alkyl; anthracene or 5- or 6-membered aromatic heterocyclene with 1 to 2 heteroatoms which are selected independently of each other from O and N and which can still be anellated with further aromatic radicals such as quinoline, isoquinoline, phthalazine, indole and quinazoline which can itself be substituted again with phenyl; and R3 and R4 have the meanings given in the description. The invention also relates to the production of the inventive derivatives and to their use as serotonin antagonists.

    3-substituted pyrido {3',4':4,5} thieno {2,3-d} pyrimidine derivatives, and production and use of the same
    48.
    发明专利
    3-substituted pyrido {3',4':4,5} thieno {2,3-d} pyrimidine derivatives, and production and use of the same 未知

    公开(公告)号：AU8535798A

    公开(公告)日：1998-12-30

    申请号：AU8535798

    申请日：1998-05-29

    Applicant: BASF AG

    Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JURGEN ,  GARCIA-LADONA FRANCISCO-JAVIER ,  EMLING FRANZ

    IPC: A61K31/505 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/14

    Abstract: PCT No. PCT/EP98/03231 Sec. 371 Date Dec. 8, 1999 Sec. 102(e) Date Dec. 8, 1999 PCT Filed May 29, 1998 PCT Pub. No. WO98/56793 PCT Pub. Date Dec. 17, 19983-Substituted 3,4,5,6,7,8-hexahydropyrido [3',4':4,5]-thieno[2,3-d]pyrimidine derivatives of the formula I where R1 is a hydrogen atom, a C1-C4-alkyl group, an acetyl group, a phenylalkyl C1-C4 radical, the aromatic system being unsubstituted or substituted by halogen, C1-C4-alkyl, trifluoromethyl, hydroxyl, C1-C4-alkoxy, amino, cyano or nitro groups, or is a phenylalkanone radical, it being possible for the phenyl group to be substituted by halogen, R2 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which may be fused to a benzene nucleus which can be unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups and may contain 1 nitrogen atom, or to a 5- or 6-membered ring which may contain 1-2 oxygen atoms, A is NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, carbon atom or CH, it also being possible for the linkage between Y and Z to be a double bond, and n is 2, 3 or 4, and the physiologically tolerated salts thereof.

    3-SUBSTITUTED PYRIDO [3',4': 4,5] THIENO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND USE
    49.
    发明专利
    3-SUBSTITUTED PYRIDO [3',4': 4,5] THIENO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND USE 未知

    公开(公告)号：MY132993A

    公开(公告)日：2007-10-31

    申请号：MYPI9802644

    申请日：1998-06-13

    Applicant: BASF AG

    Inventor： BACH ALFRED ,  STARCK DOROTHEA DR ,  GARCIA-LADONA FRANCISCO-JAVIER ,  EMLING FRANZ ,  STEINER GERD DR ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN ,  DULLWEBER UTA

    IPC: A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/14

    Abstract: 3-SUBSTITUTED 3,4,S,6,7,8-HEXAHYDROPYRIDO [3',4':4,5]-THIENO[2,3-D]PYRIRNIDINE DERIVATIVES OF THE FORMULA I WHERE RL IS A HYDROGEN ATOM, A CL-C4-ALKYL GROUP, AN ACETYL GROUP, A PHENYLALKYL CL-C4 RADICAL, THE AROMATIC SYSTEM BEING UNSUBSTITUTED OR SUBSTITUTED BY HALOGEN, CL-C4-ALKYL, TRIFLUOROMETHYL, HYDROXYL, CL-C4-ALKOXY, AMINO, CYANO OR NITRO GROUPS, OR IS A PHENYLALKANONE RADICAL, IT BEING POSSIBLE FOR THE PHENYL GROUP TO BE SUBSTITUTED BY HALOGEN, R2 IS A PHENYL, PYRIDYL, PYRIMIDINYL OR PYRAZINYL GROUP WHICH IS UNSUBSTITUTED OR'MONO- OR DISUBSTITUTED BY HALOGEN ATOMS, CL-C4-ALKYL, TRIFLUOROMETHYL, TRIFLUOROMETHOXY, HYDROXYL, CL-C4- ALKOXY, AMINO, MONOMETHYLAMINO, DIMETHYLAMINO, CYANO OR NITRO GROUPS AND WHICH MAY BE FUSED TO A BENZENE NUCLEUS WHICH CAN BE UNSUBSTITUTED OR MONO- OR DISUBSTITUTED BY HALOGEN ATOMS, CL-C4 ALKYL, HYDROXYL, TRIFLUOROMETHYL, CL-C4-ALKOXY, AMINO, CYANO OR NITRO GROUPS AND MAY CONTAIN 1 NITROGEN ATOM, OR TO A 5- OR 6-MEMBERED RING WHICH MAY CONTAIN 1-2 OXYGEN ATOMS, A IS NH OR AN OXYGEN ATOM, Y IS CH2, CH2-CH2, CH2-CH2-CH2 OR CH2-CH, Z IS A NITROGEN ATOM, CARBON ATOM OR CH, IT ALSO BEING POSSIBLE FOR THE LINKAGE BETWEEN Y AND Z TO BE A DOUBLE BOND, AND N IS 2, 3 OR 4, AND THE PHYSIOLOGICALLY TOLERATED SALTS THEREOF.

    3-Substituted 3,4-dihydrothieno[2,3-d]pyrimidine derivatives, process of their preparation and use
    50.
    发明专利
    3-Substituted 3,4-dihydrothieno[2,3-d]pyrimidine derivatives, process of their preparation and use 未知

    公开(公告)号：CZ290464B6

    公开(公告)日：2002-07-17

    申请号：CZ443199

    申请日：1998-05-29

    Applicant: BASF AG

    Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JURGEN ,  GARCIA-LADONA FRANCISCO-JAVIER ,  EMLING FRANZ

    IPC: A61K31/495 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/04

    Abstract: In the present invention there are disclosed 3-substituted 3,4-dihydrothieno[2,3-d]pyrimidine derivatives of the general formula I, in which Re1 and Re2 represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, Re3 represents a phenyl, pyridyl, pyrimidinyl or pyrazinyl group, which can be optionally mono- or disubstituted with a halogen atom or with the following groups; alkyl containing 1 to 4 carbon atoms, trifluoromethyl, trifluoromethoxy, hydroxy, alkoxy containing 1 to 4 carbon atoms, amino, monomethylamino, dimethylamino, cyano or nitro and which can be condensed with a benzene nucleus that can be optionally mono- or disubstituted with a halogen atom or with the following groups; alkyl containing 1 to 4 carbon atoms, hydroxy, trifluoromethyl, alkoxy containing 1 to 4 carbon atoms, amino, cyano or nitro and which can optionally contain 1 nitrogen atom, or with 5- or 6-membered ring that can contain 1 to 2 oxygen atoms, A represents NH or an oxygen atom, Y represents CHi2, CHi2-CHi2, CHi2-CHi2-CHi2 or CHi2-CH, Z represents a nitrogen atom, a carbon atom or CH, whereby the bond between Y and Z can be also a double bond and n is 2, 3 or 4, and their physiologically acceptable salts. The invented derivatives are intended for treating depressions and related disorders with activity as selective antagonist 5-HTi1B and 5-HTi1A.

Patent Agency Ranking