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    DISPERSIONS PREPARED BY USE OF SELF-STABILIZING AGENTS
    41.
    发明申请
    DISPERSIONS PREPARED BY USE OF SELF-STABILIZING AGENTS 审中-公开
    使用自稳定剂制备的分散体

    公开(公告)号：WO2005077337A3

    公开(公告)日：2006-03-23

    申请号：PCT/US2005002471

    申请日：2005-01-26

    Applicant: BAXTER INT ,  KIPP JAMES E ,  DOTY MARK ,  REBBECK CHRISTINE L

    Inventor： KIPP JAMES E ,  DOTY MARK ,  REBBECK CHRISTINE L

    IPC: A61K9/113 ,  A61K9/107 ,  A61K9/127 ,  A61K31/557 ,  A61K38/17 ,  A61K48/00

    CPC classification number: A61K9/1075 ,  A61K9/113 ,  A61K31/557

    Abstract: The present invention relates to a dispersion of an active agent, which includes a multiphase system of an organic phase and an aqueous phase. The agent, preferably poorly water soluble, possesses surface active properties and itself serves as a dispersantor a stabilizer for the dispersion. The dispersion is suitable for pharmaceutical, veterinary, cosmetic, and agricultural applications, and is suitable for in vivo delivery, particularly by parenteral routes.

    Abstract translation: 本发明涉及活性剂的分散体，其包括有机相和水相的多相体系。 优选水溶性差的试剂具有表面活性，并且其本身用作分散剂或分散体的稳定剂。 该分散体适用于药物，兽医，化妆品和农业应用，并且适合于体内递送，特别是通过肠胃外途径。

    A REFERENCE ELECTRODE SOLUTION CONTAINING ORGANIC AMMONIUM AND PHOSPHONIUM SALTS FOR POTENTIOMETRIC MEASUREMENT OF pH
    42.
    发明申请
    A REFERENCE ELECTRODE SOLUTION CONTAINING ORGANIC AMMONIUM AND PHOSPHONIUM SALTS FOR POTENTIOMETRIC MEASUREMENT OF pH 审中-公开
    包含有机氨和磷酸盐的参考电极溶液用于电位测量pH

    公开(公告)号：WO0033064A9

    公开(公告)日：2001-03-29

    申请号：PCT/US9928567

    申请日：1999-12-02

    Applicant: BAXTER INT

    Inventor： KIPP JAMES E ,  WEHRMANN GLENN JR ,  HAMMOND RICHARD B ,  REBBECK CHRISTINE L

    IPC: G01N27/30 ,  G01N27/416

    CPC classification number: G01N27/301

    Abstract: The present invention provides a reference electrode solution containing ammonium salts and phosphonium salts for the potentiometric measurement of pH and method of using the same. The use of the ammonium salts and the phosphonium salts to replace potassium chloride or sodium chloride as reference electrolytes in a standard reference electrode minimizes the formation of precipitates in sample solutions containing cation-sensitive compounds. Disruption of ion flow through the reference electrode is eliminated, and accurate pH measurements may be obtained in solutions that contain compounds having a strong affinity for hard cations.

    Abstract translation: 本发明提供了含有铵盐和鏻盐的参比电极溶液，用于电位测量pH值和使用该方法。 在标准参考电极中使用铵盐和鏻盐代替氯化钾或氯化钠作为参考电解质，使含有阳离子敏感化合物的样品溶液中沉淀物的形成最小化。 消除通过参比电极的离子流的破坏，并且可以在含有对硬阳离子具有强亲和力的化合物的溶液中获得精确的pH测量。

    43.
    发明专利
    未知

    公开(公告)号：BRPI0414970A2

    公开(公告)日：2012-12-11

    申请号：BRPI0414970

    申请日：2004-06-15

    Applicant: BAXTER INT

    Inventor： RABINOW BARRETT E ,  GENDELMAN HOWARD E ,  KIPP JAMES E

    IPC: A61K9/00 ,  A61K9/51 ,  A61K47/48

    Abstract: The present invention is concerned with delivering a pharmaceutical composition to the brain of a mammalian subject for treating brain diseases or disorders. The process includes the steps of: (i) providing a dispersion of the pharmaceutical composition as particles having an average particle size of from about 150 nm to about 100 microns, and (ii) administering the dispersion to the mammalian subject for delivery to the brain of a portion of the pharmaceutical composition by cells capable of reaching the brain. The dispersion of the pharmaceutical composition as particles, for example, can be phagocytized or adsorbed by the cells prior or subsequent to administration into the mammalian subject. The dispersion of the pharmaceutical composition can be administered to the central nervous system or the vascular system. After administration, the loaded cells transport the pharmaceutical composition as particles into the brain.

    PROCEDIMIENTO PARA PREPARAR SUSPENSIONES DE PARTICULAS SUBMICRONICAS DE AGENTES FARMACEUTICOS.
    49.
    发明专利
    PROCEDIMIENTO PARA PREPARAR SUSPENSIONES DE PARTICULAS SUBMICRONICAS DE AGENTES FARMACEUTICOS. 未知

    公开(公告)号：ES2260337T3

    公开(公告)日：2006-11-01

    申请号：ES01998077

    申请日：2001-12-20

    Applicant: BAXTER INT

    Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  WERLING JANE

    IPC: C07D407/14 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P31/10 ,  A61K9/20 ,  A61K9/51 ,  A61K31/192 ,  A61K31/55 ,  A61K31/573

    Abstract: Método para preparar partículas de tamaño submicrométrico de un compuesto farmacéuticamente activo cuya solubilidad es mayor en un primer disolvente miscible en agua que en un segundo disolvente que es acuoso, comprendiendo el proceso las etapas de: (i) disolver el compuesto farmacéuticamente activo en el primer disolvente miscible en agua para formar una solución, seleccionándose el primer disolvente de entre el grupo formado por N-metil-2-pirrolidinona, 2- pirrolidona, sulfóxido de dimetilo, dimetilacetamida, ácido láctico, metanol, etanol, isopropanol, 3- pentanol, n-propanol, glicerina, butilenglicol, etilenglicol, propilenglicol, monoglicéridos mono- y di-acilados, isosorbido de dimetilo, acetona, dimetilformamida, 1, 4-dioxano, acetato de etilo, acetato de propilo, polietilenglicol, polietilenglicol ésteres, sorbitanos de polietilenglicol, monoalquil polietilenglicol éteres, polipropilenglicol, alginato de polipropileno, propilenglicol 10 butanodiol, propilenglicol 10 metilglucosa éter, propilenglicol 20 metilglucosa éter, propilenglicol 15 estearil éter, dicaprilato de propilenglicol, dicaprato de propilenglicol, laurato de propilenglicol; (ii) mezclar la solución con el segundo disolvente para definir una presuspensión; y (iii) añadir energía a la presuspensión para formar partículas que tengan un tamaño de partícula medio efectivo inferior a aproximadamente 2 ìm, y dicha etapa de adición de energía comprende homogeneización, homogeneización por flujo a contracorriente, microfluidización o sonicación.

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