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    POSTOPEK ZA PRIPRAVO AMIDO-KINOKSALIN-DI-N-OKSIDOV-(1,4) 2-METIL-3-KARBOKSILNE KISLINE
    43.
    发明专利
    POSTOPEK ZA PRIPRAVO AMIDO-KINOKSALIN-DI-N-OKSIDOV-(1,4) 2-METIL-3-KARBOKSILNE KISLINE 未知

    公开(公告)号：YU32937B

    公开(公告)日：1975-12-31

    申请号：YU229668

    申请日：1968-10-02

    Applicant: BAYER AG

    Inventor： LEY K ,  METZGER K ,  FRITSCHE D ,  EHOLZER U ,  NAST R

    IPC: C07D241/52 ,  C07D51/78

    Abstract: 1,235,869. Quinoxaline-1,4-dioxides. FARBENFABRIKEN BAYER A.G. 3 Oct., 1968 [4 Oct., 1967], No. 47013/68. Heading C2C. Novel quinoxaline-1,4-dioxides of the Formula I in which R 1 is H, C 1-4 alkyl, C 1-4 alkoxy, or Cl, R 2 is straight or branched chain alkyl radical which may be substituted by OH, C 1-5 alkoxy, carbalkoxy, or dialkylamino (which term includes saturated N-containing heterocyclic radicals, R 3 is H, straight or branched chain alkyl radical which may be substituted by OH 2 C 1-5 alkoxy, carbalkoxy, mono- or di-alkylamino or when R 3 is H, R 2 may be cyclohexyl or R 2 and R 3 together with the amide nitrogen atom may form part of a 5- or 6-membered ring are prepared by reacting the appropriate benzofuroxane with an acetoacetic acid amide of the formula in the presence of ammonia or a primary amine in an organic solvent at a temperature of 20‹ to 100‹ C. or by oxidizing with hydrogen peroxide a quinoxaline derivative of the Formula XXIII above in which X is a radical readily convertible into a COOH or CON(R 2 )R 3 , group in the presence of glacial acetic acid or acetic anhydride, or an organic per-acid or mixture thereof and converting the thus obtained 1,4-dioxide to a compound of Formula I above. Pharmaceutical compositions having antibacterial activity and suitable for oral or parenteral administration, contain the above novel compounds in admixture with a solid or liquid diluents or carriers.

    49.
    发明专利
    未知

    公开(公告)号：BR6802855D0

    公开(公告)日：1973-02-22

    申请号：BR20285568

    申请日：1968-10-04

    Applicant: BAYER AG

    Inventor： LEY K ,  METZGER K ,  FRITSCHE D ,  EHOLZER U ,  NAST R

    IPC: C07D241/52

    Abstract: 1,235,869. Quinoxaline-1,4-dioxides. FARBENFABRIKEN BAYER A.G. 3 Oct., 1968 [4 Oct., 1967], No. 47013/68. Heading C2C. Novel quinoxaline-1,4-dioxides of the Formula I in which R 1 is H, C 1-4 alkyl, C 1-4 alkoxy, or Cl, R 2 is straight or branched chain alkyl radical which may be substituted by OH, C 1-5 alkoxy, carbalkoxy, or dialkylamino (which term includes saturated N-containing heterocyclic radicals, R 3 is H, straight or branched chain alkyl radical which may be substituted by OH 2 C 1-5 alkoxy, carbalkoxy, mono- or di-alkylamino or when R 3 is H, R 2 may be cyclohexyl or R 2 and R 3 together with the amide nitrogen atom may form part of a 5- or 6-membered ring are prepared by reacting the appropriate benzofuroxane with an acetoacetic acid amide of the formula in the presence of ammonia or a primary amine in an organic solvent at a temperature of 20‹ to 100‹ C. or by oxidizing with hydrogen peroxide a quinoxaline derivative of the Formula XXIII above in which X is a radical readily convertible into a COOH or CON(R 2 )R 3 , group in the presence of glacial acetic acid or acetic anhydride, or an organic per-acid or mixture thereof and converting the thus obtained 1,4-dioxide to a compound of Formula I above. Pharmaceutical compositions having antibacterial activity and suitable for oral or parenteral administration, contain the above novel compounds in admixture with a solid or liquid diluents or carriers.

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