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    Amino-substituted benzo(g)pteridine-di-n-oxides
    4.
    发明授权
    Amino-substituted benzo(g)pteridine-di-n-oxides 失效
    氨基取代的苄基（G）哌啶二氧化氮

    公开(公告)号：US3793323A

    公开(公告)日：1974-02-19

    申请号：US3793323D

    申请日：1971-07-07

    Applicant: BAYER AG

    Inventor： METZGER K ,  SENG F ,  LEY K

    IPC: C07D241/52 ,  C07D475/06 ,  C07D57/28

    CPC classification number: C07D241/52 ,  C07D475/06

    Abstract: 4-AMINO - PYRIMIDO - (4,5,B) - QUINOXALINE - 5,10DIOXIDES OF THE FORMULA:

    4-(R-NH-),5,10-DI(O=)BENZO(G)PTERIDINE

    WHEREIN R IS HYDROGEN, A STRAIGHT OR BRANCHED CHAIN SATURATED OR PARTIALLY UNSATURATED SUBSTITUTED OR UNSUBSTITUTED ALIPHATIC MOIETY OR A SUBSTITUTED OR UNSUBSTITUTED CYCLOALIPHATIC MOIETY, ARE PRODUCED BY REACTING QUINOXALINE-DI-N-OXISE OF THE FORMULA:

    1,4-DI(O=),2-((CH3-)2-N-CH=N-),3-(NC-)QUINOXALINE

    WITH AN AMINE OF THE GENERAL FORMULA R-NH2, WHEREIN R IS AS DEFINED, ABOVE IN A DILUENT, AT A TEMPERATURE IN THE RANGE OF 20* TO 100* C. THESE COMPOUNDS ARE USEFUL FRO THEIR ANTIOMICROBIAL ACTIVITY. THEY EXHIBIT ACTIVITY AGAINST BOTH GRAM POSITIVE AND GRAM NEGATIVE BACTERIA.

    5-imino-1,2,4-triazines and their production
    5.
    发明授权
    5-imino-1,2,4-triazines and their production 失效
    5-IMINO-1,2,4-TRIAZINES及其生产

    公开(公告)号：US3752808A

    公开(公告)日：1973-08-14

    申请号：US3752808D

    申请日：1971-01-19

    Applicant: BAYER AG

    Inventor： JAUTELAT M ,  KABBE H ,  LEY K

    IPC: A01N43/707 ,  C07D253/075 ,  C07D55/18

    CPC classification number: C07D253/075 ,  A01N43/707

    Abstract: NOVEL 5-IMINO-1,2,4-TRIAZINE COMPOUNDS OF THE FORMULA

    3-R2,4-R1,5-(HN=),6-R-4,5-DIHYDRO-1,2,4-TRIAZINE
    IN WHICH R IS AN ALIPHATIC, ARYLALIPHATIC, AROMATIC OR HETEROCYCLIC RADICAL WHICH MAY BE SUBSTITUTED BY HYDROXY, HALOGEN, ALKYL AND/OR NITRO, R1 IS AN ALIPHATIC HYDROCARBON RADICAL, AMINO, ALKYLAMINO OR DIALYLAMINO, R2 IS HYDROGEN OR AN ALIPHATIC HYDROCARBON RADICAL, AND X IS OXYGEN, SULFUR OR NR3 WHERE R3 IS FOR HYDROGEN OR AN ALIPHATIC HYDROCARBON RADICAL, POSSESS OUTSTANDING HERBICIDAL, ESPECIALLY SELECTIVE HERBICIDAL ACTIVITY, AND FURTHERMORE ARE INTERMEDIATES FOR THE PREPARATION OF OTHER HERBICIDAL COMPOUNDS. THE INVENTION ALSO PROFIVES A NOVEL PROCESS FOR MAKING THE NOVEL 5-IMINO-1,2,4-TRIAZINE COMPOUNDS BY REACTING A CORRESPONDING A-IMINONITRILE WITH A HYDRAZINE DERIVATIVE.

    New imines, their preparation and their pharmaceutical use
    7.
    发明授权
    New imines, their preparation and their pharmaceutical use 失效
    新药，他们的制剂及其药物使用

    公开(公告)号：US3846414A

    公开(公告)日：1974-11-05

    申请号：US35930973

    申请日：1973-05-11

    Applicant: BAYER AG

    Inventor： SENG F ,  LEY K ,  METZGER K

    IPC: A23K1/16 ,  C07D241/52 ,  C07D277/18 ,  C07D401/12 ,  C07D491/04 ,  C07D51/78

    CPC classification number: C07D277/18 ,  A23K20/116 ,  A23K20/137 ,  C07D241/52 ,  C07D401/12 ,  C07D491/04

    Abstract: Imines of 2-formylquinoxaline-3-carboxylic acid-1,4-dioxides and their salts are obtained through treatment of the lactone or a salt of 2-dihydroxymethylquinoxaline-N,N-dioxide-3-carboxylic acid with a reactant bearing a free primary amino group. The resultant compounds and their non-toxic salts are antibacterial agents and can be incorporated in pharmaceutical compositions and feedstuffs for this use. A typical embodiment is 2(carbomethoxyhydrazonomethyl)-quinoxaline-3-carboxylic acid-1,4dioxide.

    Abstract translation: 2-甲酰基喹喔啉-3-羧酸-1,4-二氧化物及其盐的亚胺通过用含有自由基的反应物处理内酯或2-二羟基甲基喹喔啉-N，N-二甲基-3-羧酸的盐得到 伯氨基。 所得化合物及其无毒盐是抗菌剂，可以并入用于该用途的药物组合物和饲料中。 典型的实施方案是2-（甲酯基亚肼基甲基） - 喹喔啉-3-羧酸-1,4-二氧化物。

    2-halomethyl-3-carboxylic acid-amido-quinoxaline-1,4-di-n-oxides as antibacterial agents and pharmaceutical compositions comprising said oxides
    9.
    发明授权
    2-halomethyl-3-carboxylic acid-amido-quinoxaline-1,4-di-n-oxides as antibacterial agents and pharmaceutical compositions comprising said oxides 失效
    作为抗菌剂和包含上述氧化物的药物组合物的2-甲基乙酰氧基-3-羧酸 - 氨基 - 喹喔啉-1,4-二异丙氧基

    公开(公告)号：US3754087A

    公开(公告)日：1973-08-21

    申请号：US3754087D

    申请日：1969-11-12

    Applicant: BAYER AG

    Inventor： LEY K ,  KHOLZER U ,  FRITSCHE D ,  NAST R ,  METZGER K

    IPC: C07D241/52 ,  A61K27/00

    CPC classification number: C07D241/52

    Abstract: 2-HALOMETHYL-3-CARBOXYLIC ACID-AMIDO-QUINOXALINE-1.4 DI-N-OXIDES OF THE FORMULA:

    1,4-DI(O=),2-(HAL-CH2-),3-(R2-N(-R3)-CO-),R1-QUINOXALINE

    WHEREIN: R1 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY OR CHLORINE R2 IS HYDREGEN, STRAIGHT OR BRANCHED CHAIN ALKYL OR STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY, LOWER ALKOXY, ACYLOXY, MONOALKYLAMINO OR DIALKYLAMINO, R3 IS HYDROGEN, STRAIGHT OR BRANCHED CHAIN ALKYL, STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY, LOWER ALKOXY, ACYLOXY, MONOALKYLAMINO OR DIALKYLAMINO, OR WHEN R2 IS HYDDROGEN, CYCLOHEXYL, OR R2 AND R3 TOGETHER WITH THE AMIDE NITROGEN ATOM FROM PART OF A 5- OR 6MEMBRED HETEROCYCLIC RING, AND HAL IS CHLORINE OR BROMINE, IN COMBINATION WITH A PHARMACEUTICALLY ACCETABLE INERT CARRIER ARE USEFUL FOR THEIR ANTIBACTERIAL EFFECT. THESE COMPOSITIONS OR THE ACTIVE COMPOUND CAN BE ADMINISTERED SUBCUTANEOUSLY OR ORALLY TO HUMANS OR ANIMALS.

    Methods and compositions for treating bacterial infections employing imines
    10.
    发明授权
    Methods and compositions for treating bacterial infections employing imines 失效
    用于治疗使用IMINES的细菌感染的方法和组合物

    公开(公告)号：US3856957A

    公开(公告)日：1974-12-24

    申请号：US32395373

    申请日：1973-01-15

    Applicant: BAYER AG

    Inventor： SENG F ,  LEY K ,  METZGER K

    IPC: A23K1/16 ,  C07D241/52 ,  C07D277/18 ,  C07D401/12 ,  C07D491/04 ,  A61K27/00

    CPC classification number: C07D277/18 ,  A23K20/116 ,  A23K20/137 ,  C07D241/52 ,  C07D401/12 ,  C07D491/04

    Abstract: Imines of 2-formylquinoxaline-3-carboxylic acid-1,4-dioxides and their salts are obtained through treatment of the lactone or a salt of 2-dihydroxymethylquinoxaline-N,N-dioxide-3-carboxylic acid with a reactant bearing a free primary amino group. The resultant compounds and their non-toxic salts are antibacterial agents and can be incorporated in pharmaceutical compositions and feedstuffs for this use. A typical embodiment is 2(carbomethoxyhydrazonomethyl)-quinoxaline-3-carboxylic acid-1,4dioxide.

    Abstract translation: 2-甲酰基喹喔啉-3-羧酸-1,4-二氧化物及其盐的亚胺通过用含有自由基的反应物处理内酯或2-二羟基甲基喹喔啉-N，N-二甲基-3-羧酸的盐得到 伯氨基。 所得化合物及其无毒盐是抗菌剂，可以并入用于该用途的药物组合物和饲料中。 典型的实施方案是2-（甲酯基亚肼基甲基） - 喹喔啉-3-羧酸-1,4-二氧化物。

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