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    Alkoxy substituted sterically hindered phenols
    1.
    发明授权
    Alkoxy substituted sterically hindered phenols 失效
    ALKOXY取代的立方异丙酚

    公开(公告)号：US3799990A

    公开(公告)日：1974-03-26

    申请号：US13050671

    申请日：1971-04-01

    Applicant: BAYER AG

    Inventor： NAST R ,  OERTEL H ,  LEY K

    IPC: C08G18/32 ,  C08K5/13 ,  C07C43/22

    CPC classification number: C08G18/3271 ,  C08G18/325 ,  C08K5/13 ,  C08L75/04

    Abstract: Polyurethans stabilized against degradation and discoloration caused by the action of light or UV radiation, oxygen, substances present in the atmosphere, such as nitrogen oxides, and heat by the addition of alkoxy substituted sterically hindered phenols which has a 2-(2''-hydroxy-3-''-tertiary alkylbenzyl) anisole unit:

    Abstract translation: 聚氨酯稳定，防止由于光或紫外线辐射，氧气，大气中存在的物质如氮氧化物引起的降解和变色，以及通过加入烷氧基取代的位阻酚，其具有2-（2'-羟基 -3'-叔烷基苄基）苯甲醚单元：作为稳定剂。

    2-halomethyl-3-carboxylic acid-amido-quinoxaline-1,4-di-n-oxides as antibacterial agents and pharmaceutical compositions comprising said oxides
    3.
    发明授权
    2-halomethyl-3-carboxylic acid-amido-quinoxaline-1,4-di-n-oxides as antibacterial agents and pharmaceutical compositions comprising said oxides 失效
    作为抗菌剂和包含上述氧化物的药物组合物的2-甲基乙酰氧基-3-羧酸 - 氨基 - 喹喔啉-1,4-二异丙氧基

    公开(公告)号：US3754087A

    公开(公告)日：1973-08-21

    申请号：US3754087D

    申请日：1969-11-12

    Applicant: BAYER AG

    Inventor： LEY K ,  KHOLZER U ,  FRITSCHE D ,  NAST R ,  METZGER K

    IPC: C07D241/52 ,  A61K27/00

    CPC classification number: C07D241/52

    Abstract: 2-HALOMETHYL-3-CARBOXYLIC ACID-AMIDO-QUINOXALINE-1.4 DI-N-OXIDES OF THE FORMULA:

    1,4-DI(O=),2-(HAL-CH2-),3-(R2-N(-R3)-CO-),R1-QUINOXALINE

    WHEREIN: R1 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY OR CHLORINE R2 IS HYDREGEN, STRAIGHT OR BRANCHED CHAIN ALKYL OR STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY, LOWER ALKOXY, ACYLOXY, MONOALKYLAMINO OR DIALKYLAMINO, R3 IS HYDROGEN, STRAIGHT OR BRANCHED CHAIN ALKYL, STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY, LOWER ALKOXY, ACYLOXY, MONOALKYLAMINO OR DIALKYLAMINO, OR WHEN R2 IS HYDDROGEN, CYCLOHEXYL, OR R2 AND R3 TOGETHER WITH THE AMIDE NITROGEN ATOM FROM PART OF A 5- OR 6MEMBRED HETEROCYCLIC RING, AND HAL IS CHLORINE OR BROMINE, IN COMBINATION WITH A PHARMACEUTICALLY ACCETABLE INERT CARRIER ARE USEFUL FOR THEIR ANTIBACTERIAL EFFECT. THESE COMPOSITIONS OR THE ACTIVE COMPOUND CAN BE ADMINISTERED SUBCUTANEOUSLY OR ORALLY TO HUMANS OR ANIMALS.

    POSTOPEK ZA PRIPRAVO AMIDO-KINOKSALIN-DI-N-OKSIDOV-(1,4) 2-HALOGENMETIL-3- KARBOKSALNE KISLINE
    7.
    发明专利
    POSTOPEK ZA PRIPRAVO AMIDO-KINOKSALIN-DI-N-OKSIDOV-(1,4) 2-HALOGENMETIL-3- KARBOKSALNE KISLINE 未知

    公开(公告)号：YU32936B

    公开(公告)日：1975-12-31

    申请号：YU229568

    申请日：1968-10-02

    Applicant: BAYER AG

    Inventor： EHOLZER U ,  FRITSCHE D ,  NAST R ,  METZGER K

    IPC: C07D241/52 ,  C07D51/78

    Abstract: 1,188,249. 2 - Halomethyl - quinoxaline -1,4- di - N - oxide - 3 - carboxylic acid amide derivatives. FARBENFABRIKEN BAYER A.G. 3 Oct., 1968 [4 Oct., 1967], No. 47012/68. Heading C2C. Novel 2 - halomethyl quinoxaline - 1,4 - di- N - oxide - 3 - carboxylic acid amide derivatives of the general formula wherein R 1 is a hydrogen or chlorine atom or a C 1-4 alkyl or C 1-4 alkoxy group; R 2 is a hydrogen atom or an alkyl group optionally substituted by a hydroxy, C 1-4 alkoxy, C 1-5 carbalkoxy, acyloxy or mono- or di-C 1-4 alkylamino radical; R 3 is a hydrogen atom or an alkyl group optionally substituted by a hydroxy, C 1-4 alkoxy, C 1-5 carbalkoxy, acyloxy or mono- or di-C 1-4 alkylamino radical or, when R 2 is a hydrogen atom, a cyclohexyl group; or R 2 and R 3 , together with the nitrogen atom to which they are attached, form a 5- or 6-membered saturated heterocyclic ring which may contain a further nitrogen atom or an oxygen atom and the further nitrogen atom may be attached to a C 1-4 alkyl radical which may be substituted by a hydroxy, methoxy or acetoxy radical; and Hal is a chlorine or bromine atom, are prepared (a) by reaction of a 2-methyl-quinoxaline-1,4- di-N-oxide derivative of the general formula with a halogenating agent in an organic solvent at a temperature of 20-120‹ C. or (b) by oxidation of a 2-halomethyl-quinoxaline derivative of the general formula with hydrogen peroxide or an organic per-acid. N - 2 - di - Methyl - quinoxaline - 1,4 - di - N - oxide - 3 - carboxylic acid amide is prepared by reaction of methylamine with diketene, followed by addition to the resulting reaction mixture of benzofuroxan and ammonia. Pharmaceutical compositions having antibacterial activity comprise, as active ingredient, a 2-halomethyl - quinoxaline - 1,4 - di - N - oxide- 3-carboxylic acid amide derivative of the first general formula above, in admixture with a solid or liquid diluent or carrier, and may be administered orally, rectally or parenterally.

    9.
    发明专利
    未知

    公开(公告)号：DK121658B

    公开(公告)日：1971-11-15

    申请号：DK466269

    申请日：1969-08-29

    Applicant: BAYER AG

    Inventor： NAST R ,  METZGER K ,  FRITSCHE D ,  LEY K ,  EHOLZER U

    IPC: C07D241/52 ,  C07D51/78

    Abstract: 1,229,519. Quinoxaline derivatives. FARBENFABRIKEN BAYER A.G. 15 Aug., 1969 [30 Aug., 1968], No. 40859/69. Heading C2C. Novel quinoxaline derivatives of the formula in which R 1 is H, Cl, C 1-4 alkyl or C 1-4 alkoxy, R 2 and R 3 , which may be the same or different, are H or an aliphatic radical, which may be substituted by OH, C 1-4 alkoxy, carbalkoxy, or mono- or di-alkylamino, or are both alkylene and together with the N atom to which they are attached form a 5, 6 or 7 heterocyclic ring optionally containing a further N or O atom, and R 4 is H, C 1-4 alkyl or optionally substituted phenyl, are prepared by reacting the appropriate 2-chloro (or bromo) methyl-3-carbonamido-quinoxaline-di-N-oxide with the corresponding α-hydroxycarboxylic acid salts of the formula in which M# is Na#, K#, NH 4 # or trialkylammonium cation, in organic solvents or diluents at temperatures of between 10‹ and 160‹ C. Pharmaceutical compositions, suitable for oral or parenteral administration and having antibacterial activity, contain the above novel compounds as active ingredients in admixture with suitable pharmaceutically acceptable diluents or carriers. The active compounds may also be mixed with animal feed stuffs.

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