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    44.
    发明专利
    未知

    公开(公告)号：PT1144417E

    公开(公告)日：2002-12-31

    申请号：PT99962909

    申请日：1999-11-30

    Applicant: BUCKMAN LABOR INC

    Inventor： MCNEEL THOMAS E ,  WHITTEMORE MARILYN S ,  HEINDEL NED D ,  LASKIN JEFFREY D ,  RAPP ROBERT D ,  GUILLON CHRISTOPHE ,  HECK DIANE E

    IPC: C07D493/04 ,  A61K31/35

    Abstract: The invention relates to 4'-substituted-4',5'-dihydropsoralen compounds of formula(V):In the formula R is hydrogen, a halogen, CN or an acyl group; T is a halogen, CN, a carboalkoxy group NR1R2, or (N+R1R2R3)X-, R1 and R2 are independently a C1-C6 alkyl, or R1 and R2 together with the nitrogen form a 5-8 member heterocyclic ring, or when T is (N+R1R2R3)X-, R1 and R2 together with the nitrogen form a 5-8 member heterocyclic ring or heterocyclic aromatic ring; R3 is hydrogen, a C1-C12 alkyl, or, when R1 and R2 together with the nitrogen form a heterocyclic aromatic ring, R3 is a double bond within the heterocyclic aromatic ring; X- is a halide. In another embodiment, the invention relates to processes for preparing 4'-substituted-4',5'-dihydropsoralen compounds described above. The compounds of the invention have beneficial pharmaceutical properties and can be used alone or in pharmaceutical compositions used to treat a proliferative skin disorder and to treat microbial infections in a mammal by administering to the mammal an effective amount of a compound of the invention and then irradiating the mammal with ultraviolet light.

    4'-SUBSTITUTED-4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USESTHEREOF
    48.
    发明专利
    4'-SUBSTITUTED-4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USESTHEREOF 未知

    公开(公告)号：CA2352258A1

    公开(公告)日：2000-06-08

    申请号：CA2352258

    申请日：1999-11-30

    Applicant: BUCKMAN LABOR INC

    Inventor： HEINDEL NED D ,  LASKIN JEFFREY D ,  MCNEEL THOMAS E ,  HECK DIANE E ,  WHITTEMORE MARILYN S ,  RAPP ROBERT D ,  GUILLON CHRISTOPHE

    IPC: C07D493/04 ,  A61K31/35

    Abstract: The invention relates to 4'-substituted-4',5'-dihydropsoralen compounds of formula (V). In the formula R is hydrogen, a halogen, CN or an acyl group; T is a halogen, CN, a carboalkoxy group NR1R2, or (N+R1R2R3)X-, R1 and R2 are independently a C1-C6 alkyl, or R1 and R2 together with the nitrogen form a 5- 8 member heterocyclic ring, or when T is (N+R1R2R3)X-, R1 and R2 together wi th the nitrogen form a 5-8 member heterocyclic ring or heterocyclic aromatic ring; R3 is hydroge, a C1-C12 alkyl, or, when R1 and R2 together with the nitrogen form a heterocyclic aromatic ring, R3 is a double bond within the heterocyclic aromatic ring; X is a halide. In another embodiment, the invention relates to processes for preparing 4'-substituted-4',5'- dihydropsoralen compounds described above. The compounds of the invention ha ve beneficial pharmaceutical properties and can be used alone or in pharmaceutical compositions used to treat a proliferative skin disorder and to treat microbial infections in a mammal by administering to the mammal an effective amount of a compound of the invention and then irradiating the mammal with ultraviolet light.

    Process for the treatment of metal-containing water and recovery of metals thereofrom
    49.
    发明专利
    Process for the treatment of metal-containing water and recovery of metals thereofrom 未知

    公开(公告)号：AU1210199A

    公开(公告)日：1999-03-25

    申请号：AU1210199

    申请日：1999-01-15

    Applicant: BOARD OF REGENTS OF THE UNIVERSITY AND COMMUNITY COLLEGE SYSTEM OF NEVADA THE ,  BUCKMAN LABOR INC

    Inventor： MISRA MANORANJAN ,  MCNEEL THOMAS E ,  YANG KANG ,  KRAVETZ MARK E

    IPC: C02F1/58 ,  C01G49/00 ,  C02F1/62 ,  C02F1/64 ,  C02F1/66 ,  C02F1/70 ,  C02F1/72 ,  C02F9/00

    Abstract: Metals contained in various wastewaters are selectively recovered as metal precipitates and/or as spinel ferrite and water suitable for discharge into the environment is obtained. High grade magnetic spinel ferrite is recovered from wastewaters having aluminum and arsenic if present in the wastewater, removed from the wastewater. There are three process stages for the treatment of wastewater. In the first process stage which is optional, at least a portion of at least one non-ferrous or non-ferric metal is precipitated from the wastewater by subjecting the wastewater to an oxidizing agent to increase the oxidation-reduction potential of the water, by adjusting the pH of the wastewater to a pH at which the metal precipitates from the water and by adding an organic or inorganic sulfur compound, capable of causing the metal to form a precipitate, to the water in a quantity sufficient to precipitate the metal. When aluminum is present in the wastewater, aluminum is recovered from the water by adding a reducing agent to lower the oxidation-reduction potential of the water and by adjusting the pH of the water to about 5. The aluminum which precipitates in the aqueous solution, is removed from the water. In the third precipitation stage, iron is recovered as spinel ferrite in an ambient temperature process by adding a reducing agent to the water, adding a soluble ferrous salt to the water, adjusting the pH to about 9-12 and oxidizing the water with an oxidizer, e.g., air, to form spinel ferrite. If aluminum and/or arsenic are present in the wastewater and are removed from the wastewater by the process, high grade magnetic spinel ferrite is recovered.

    Methods and compositions for controlling biofouling using sulfamic acids
    50.
    发明专利
    Methods and compositions for controlling biofouling using sulfamic acids 未知

    公开(公告)号：AU8662698A

    公开(公告)日：1999-02-22

    申请号：AU8662698

    申请日：1998-07-27

    Applicant: BUCKMAN LABOR INC

    Inventor： MCNEEL THOMAS E ,  WHITTEMORE MARILYN S ,  BRYANT STEPHEN D ,  VUNK GRACIELA H

    IPC: A61K8/40 ,  A01N41/02 ,  A61K8/46 ,  A61Q11/00 ,  C02F1/50 ,  A61K7/22

    Abstract: The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfamic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfamic acid used in the method of the invention has the formula R1R2NS(O)2(OH). In this formula, R1 and R2 are independently a hydrogen, a C4-C20 alkyl group or a cyclohexyl group. However, R1 and R 2 are not both hydrogen. Alternatively, R1 and R2, together with the N, may also form a 5-8 membered heterocyclic ring having the formula:In the heterocyclic ring, X is O, NH, or CH2. The salt of sulfamic acid can be an acid salt or quaternized sulfamic acid salt. The present invention also relates to a composition containing sulfamic acids or salts thereof useable in the above methods. The compositions comprise at least one sulfamic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.

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