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    AMINO- AND MERCURIO-SUBSTITUTED 4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USES THEREOF
    2.
    发明申请
    AMINO- AND MERCURIO-SUBSTITUTED 4',5'-DIHYDROPSORALENS AND THERAPEUTICAL USES THEREOF 审中-公开
    AMINO-和MERCURIO-取代的4'，5'-二氢松香油及其治疗用途

    公开(公告)号：WO0031081A3

    公开(公告)日：2000-11-23

    申请号：PCT/US9927739

    申请日：1999-11-24

    Applicant: BUCKMAN LABOR INC ,  HEINDEL NED D ,  LASKIN JEFFREY D ,  HECK DIANE E ,  RAPP ROBERT D ,  MCNEEL THOMAS E ,  JABIN IVAN ,  WHITTEMORE MARILYN S

    Inventor： HEINDEL NED D ,  LASKIN JEFFREY D ,  HECK DIANE E ,  RAPP ROBERT D ,  MCNEEL THOMAS E ,  JABIN IVAN ,  WHITTEMORE MARILYN S

    IPC: A61P17/06 ,  A61P35/00 ,  C07D311/44 ,  C07D311/56 ,  C07D493/04 ,  C07F3/14 ,  A61K31/34

    CPC classification number: C07D493/04 ,  C07D311/44 ,  C07D311/56 ,  C07F3/14

    Abstract: 5'- substituted, 4', 5'- dihydropsoralen compounds (5) bearing tertiary amines (and salts thereof), quaternary ammonium moieties or organomercurial moieties are described. Also described are 2- substituted mercurimethyl -2-3- dihydro -benzofurans of formula (7). Also reported are versatile direct syntheses through a hitherto unknown compounds such as 3-R-4, 8-dimethyl -4',5'-dihydro -5'-bromomethylpsoralen or a 3-R-4, 8-dimethyl-4, 5'-dihydro- 5'-iodomethylpsoralen to prepare a structurally diverse array of partially reduced psoralens and benzofurans. The presence of a permanent ammonium charge in these psoralens precludes membrane passage and the mono-unsaturation precludes the cross linking of nuclear DNA, thereby minimizing the mutagenic/carcinogenic side effects long associated with psoralen-derived therapies. The presence of a mercury functionality provides a reactive cell-binding group on these psoralens with unique cytotoxicity without light activation and an enhancement of cytotoxicity activity upon light activation. The invention also relates to these partially reduced and quaternized psoralens, amino-substituted psoralens, and mercurio psoralens display impressive pharmacology against PAM 212 keratinocytes, a model cell line employed as a test system to indicate epidermal cytotoxicity and cancer. The compounds of the invention also have antimicrobicidal activity useful in pharmacologic agents for mammals (e.g. the treatment of tuberculosis) as well as in controlling the growth of microorganisms on substrates and in aqueous systems.

    Abstract translation: 描述了带有叔胺（及其盐），季铵部分或有机金属部分的5'-取代的，4'，5'-二氢补骨脂化合物（5）。 还描述了式（7）的2-取代的汞甲基-2-3-二氢 - 苯并呋喃。 还报道了通过迄今未知的化合物如3-R-4,8-​​二甲基-4'，5'-二氢-5'-溴甲基补骨脂素或3-R-4,8-​​二甲基-4,5 ' - 二氢-5'-碘甲基补骨脂素以制备结构多样化的部分减少的补骨脂素和苯并呋喃。 这些补骨脂素中永久性铵电荷的存在排除了膜通道，单不饱和度排除了核DNA的交联，从而使与补骨脂素衍生疗法长期相关的致突变/致癌性副作用最小化。 汞功能的存在提供了这些补骨脂素上的反应性细胞结合基团，其具有独特的细胞毒性而没有光激活并且在光活化时增强细胞毒性活性。 本发明还涉及这些部分还原的和季铵化的补骨脂素，氨基取代的补骨脂素和补骨脂素显示出对PAM212角质形成细胞的令人印象深刻的药理学，PAM212角质形成细胞是用作表明表皮细胞毒性和癌症的测试系统的模型细胞系。 本发明化合物还具有抗哺乳动物药理活性剂（例如治疗结核病）以及控制微生物在底物和水系统中生长的抗微生物活性。

    METHOD AND APPARATUS FOR MONITORING AND CONTROLLING EXOTHERMIC AND ENDOTHERMIC CHEMICAL REACTIONS
    4.
    发明申请
    METHOD AND APPARATUS FOR MONITORING AND CONTROLLING EXOTHERMIC AND ENDOTHERMIC CHEMICAL REACTIONS 审中-公开
    用于监测和控制过热和内毒素化学反应的方法和装置

    公开(公告)号：WO2014058607A2

    公开(公告)日：2014-04-17

    申请号：PCT/US2013061268

    申请日：2013-09-24

    Applicant: BUCKMAN LABOR INC

    Inventor： MCNEEL THOMAS E ,  CLARK RICHARD A ,  LUSK JR RICHARD D

    IPC: C01B21/09 ,  B01J14/00

    CPC classification number: C01B21/091 ,  B01J14/00 ,  B01J19/0013 ,  B01J2219/00063 ,  B01J2219/00164 ,  B01J2219/00198 ,  B01J2219/00202 ,  B01J2219/00213 ,  B01J2219/0022 ,  B01J2219/00225 ,  B01J2219/00231

    Abstract: A method of controlling an exothermic or endothermic chemical reaction is provided. The method involves measuring a temperature of a first reactant flowing at a first flow rate, contacting the first reactant with a second reactant flowing at a second flow rate to form a reaction product, measuring the temperature of the reaction product, and determining the temperature difference between the temperature of the first reactant and the temperature of the reaction product. The method can further involve adjusting the flow rate of at least one of the first reactant and the second reactant, or shutting down flow, based on the temperature difference. An apparatus to carry out the method is also provided. The method and apparatus can be useful in controlling many different reactions, including the reaction of sodium hypochlorite and ammonia to form monochloramine.

    Abstract translation: 提供了控制放热或吸热化学反应的方法。 该方法包括测量以第一流速流动的第一反应物的温度，使第一反应物与以第二流速流动的第二反应物接触以形成反应产物，测量反应产物的温度，并测定温度差 在第一反应物的温度和反应产物的温度之间。 该方法还可以包括基于温度差来调节第一反应物和第二反应物中的至少一种的流速或关闭流动。 还提供了一种执行该方法的装置。 该方法和装置可用于控制许多不同的反应，包括次氯酸钠和氨的反应形成一氯胺。

    METHOD AND APPARATUS FOR MEASURING AND CONTROLLNG ELECTROLYTICALLY-ACTIVE SPECIES CONCENTRATION IN AQUEOUS SOLUTIONS
    5.
    发明申请
    METHOD AND APPARATUS FOR MEASURING AND CONTROLLNG ELECTROLYTICALLY-ACTIVE SPECIES CONCENTRATION IN AQUEOUS SOLUTIONS 审中-公开
    用于测量和控制水溶性电解质活性物质浓度的方法和装置

    公开(公告)号：WO2013165823A8

    公开(公告)日：2014-01-09

    申请号：PCT/US2013038320

    申请日：2013-04-26

    Applicant: BUCKMAN LABOR INC

    Inventor： MCNEEL THOMAS E ,  CLARK RICHARD A ,  LUSK JR RICHARD D ,  LIYANAPATIRANA CHAMINDU

    IPC: G01N27/42

    CPC classification number: G01N27/423

    Abstract: A method is provided for measuring an electrolytically-active species concentration in an aqueous or non-aqueous solution for use in providing control of the concentration of the species in a source solution thereof based on the measurements. In the method, a sample containing an electrolytically-active species is added into a measurement cell that has a working electrode and an auxiliary electrode, and a constant current is applied to the measurement cell while the working and auxiliary electrodes are in contact with the sample with monitoring of voltage difference across the electrodes until a change in the voltage difference is detected. A feedback signal is generated based on a parameter of the change in the voltage difference that is directly proportional to the amount of the electrolytically-active species in the sample, which can be used for process control. An apparatus is also described.

    Abstract translation: 提供了一种用于测量水性或非水溶液中的电解活性物质浓度的方法，用于基于测量提供对其来源溶液中物质浓度的控制。 在该方法中，将含有电解活性物质的样品加入到具有工作电极和辅助电极的测量单元中，并且在工作和辅助电极与样品接触的同时向测量单元施加恒定电流 监测电极两端的电压差，直到检测到电压差的变化。 基于与可以用于过程控制的样品中的电解活性物质的量成正比的电压差变化的参数产生反馈信号。 还描述了一种装置。

    Method and apparatus for monitoring and controlling exothermic and endothermic chemical reactions
    10.
    发明专利
    Method and apparatus for monitoring and controlling exothermic and endothermic chemical reactions 未知

    公开(公告)号：AU2013330291B2

    公开(公告)日：2016-03-31

    申请号：AU2013330291

    申请日：2013-09-24

    Applicant: BUCKMAN LABOR INC

    Inventor： MCNEEL THOMAS E ,  CLARK RICHARD A ,  LUSK JR RICHARD D

    IPC: B01J19/00 ,  B01J14/00 ,  C01B21/09

    Abstract: A method of controlling an exothermic or endothermic chemical reaction is provided. The method involves measuring a temperature of a first reactant flowing at a first flow rate, contacting the first reactant with a second reactant flowing at a second flow rate to form a reaction product, measuring the temperature of the reaction product, and determining the temperature difference between the temperature of the first reactant and the temperature of the reaction product. The method can further involve adjusting the flow rate of at least one of the first reactant and the second reactant, or shutting down flow, based on the temperature difference. An apparatus to carry out the method is also provided. The method and apparatus can be useful in controlling many different reactions, including the reaction of sodium hypochlorite and ammonia to form monochloramine.

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