公开(公告)号：AU7930987A

公开(公告)日：1988-05-19

申请号：AU7930987

申请日：1987-10-02

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  CLERC ROGER ,  CERLETTI NICO ,  BRUGGEN JOSEF ,  TARCSAY LAJOS ,  SORG CLEMENS ,  WIESENDANGER WALTER

IPC: G01N33/50 ,  A61K38/00 ,  A61P29/00 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/52 ,  C07K14/54 ,  C07K14/545 ,  C07K16/00 ,  C07K16/24 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/19 ,  C12N15/85 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/865 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  C07K13/00 ,  C07K7/10 ,  C12N15/00 ,  C07G17/00 ,  C12N1/20 ,  C12N1/18 ,  C12N5/00 ,  C07K15/12 ,  C07K3/20 ,  C07K3/22 ,  G01N33/545 ,  G01N33/68 ,  C12P19/34 ,  A61K37/43

Abstract: The invention concerns polypeptides related to human macrophage migration inhibition factor, in particular the polypeptides called MRP-8 and MRP-14, processes for their preparation, mRNAs, DNAs and hybrid vectors coding for said polypeptides, hosts transformed with such a hybrid vector, monoclonal and polyclonal antibodies to said polypeptides , and diagnostic methods for inflammatory conditions and cystic fibrosis.

公开(公告)号：NO874159A

公开(公告)日：1988-04-05

申请号：NO874159

申请日：1987-10-02

Applicant: CIBA GEIGY AG

Inventor： ODNIK KAREL GERRIT ,  CLEREC ROGER ,  CERLETTI NICO ,  BRUEGGEN JOSEF ,  TARCSAY LAJOS ,  SORG CLEMENS ,  WIESENDANGER WALTER

IPC: G01N33/50 ,  A61K38/00 ,  A61P29/00 ,  C07H21/04 ,  C07K1/20 ,  C07K1/22 ,  C07K14/52 ,  C07K14/54 ,  C07K14/545 ,  C07K16/00 ,  C07K16/24 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/19 ,  C12N15/85 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/865 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  C07K ,  C12N

CPC classification number: C07K16/24 ,  A61K38/00 ,  C07K14/52 ,  C12N15/85 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/55 ,  C12N2830/702

公开(公告)号：FI75578B

公开(公告)日：1988-03-31

申请号：FI802294

申请日：1980-07-21

Applicant: CIBA GEIGY AG

Inventor： TARCSAY LAJOS ,  HARTMANN ALBERT ,  BASCHANG GERHARD ,  STANEK JAROSLAV

IPC: C07H13/00 ,  A61K38/00 ,  A61K38/14 ,  A61K39/39 ,  A61P37/04 ,  C07K1/06 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07K5/02 ,  C07H15/04 ,  C07F9/09

Abstract: The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for increasing the antibiotic effectiveness of antibiotics. (I) In the formula I, X represents carbonyl or carbonyloxy, R1 represents optionally substituted alkyl or aryl, R2, R3, R4 and R6 represent hydrogen or lower alkyl, R5 represents hydrogen, optionally substituted lower alkyl, cycloalkyl, aryl or nitrogen-containing heterocyclyl, or R4 and R5 together represent also C3-C4 alkylene, R7 represents hydrogen or free, esterified or amidated carboxyl, one of the radicals A1 and A2 represents a radical of the formula II and the other of the radicals A1 and A2 represents optionally substituted or functionally modified hydroxy or amino. (II) In the formula II, T represents NH or O, Y represents an optionally substituted alkylene group that can also be interrupted by oxycarbonyl or iminocarbonyl, W represents hydrogen and Z represents an optionally esterified or etherified 1,2-dihydroxyethyl or 2-hydroxyethyl group, or W and Z represent an optionally esterified or etherified hydroxymethyl group.

公开(公告)号：HU191371B

公开(公告)日：1987-02-27

申请号：HU259883

申请日：1983-07-22

Applicant: CIBA GEIGY AG

Inventor： HARTMANN ALBERT ,  BASCHANG GERHARD ,  TARCSAY LAJOS ,  WACKER OSKAR

IPC: A61K31/70 ,  A61K38/00 ,  A61K38/14 ,  A61K38/17 ,  A61P31/12 ,  A61P35/00 ,  C07H15/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07K5/02 ,  A61K37/02

Abstract: The compounds of the formula I (I) in which each of R1, R4 and R6, independently of the others, represents hydrogen or lower alkanoyl, R2 represents C1-4-alkyl, hydroxymethyl or phenyl, R3 represents hydrogen or methyl, R5 represents hydrogen or C1-3-alkyl, R7 represents C1-3-alkyl that is unsubstituted or substituted by hydroxy, mercapto or methylthio, R8 represents hydrogen or lower alkyl, X represents oxygen or the group NH, Y represents C1-4-alkylidene, and each of R9 and R10, independently of the other, represents C11-17-alkyl or C11-17-alkenyl, and their salts, have an immunostimulating activeity.

公开(公告)号：DD239117A5

公开(公告)日：1986-09-17

申请号：DD28175285

申请日：1985-10-15

Applicant: CIBA GEIGY AG

Inventor： TARCSAY LAJOS ,  EIBL HANSJOERG ,  FANKHAUSER PETER ,  PEIL ANITA

IPC: A61K9/00 ,  A61K9/127 ,  A61K9/50 ,  A61K47/24 ,  C07F9/10 ,  A61K45/02 ,  A61K45/05 ,  A61K31/54 ,  A61K31/56 ,  A61K37/00

Abstract: The invention relates to pharmaceutical compositions containing synthetic, substantially pure phosphatidyl serine and phosphatidyl choline and a substance or a mixture of substances having biological activity. The invention also relates to mixtures comprising synthetic, substantially pure phosphatidyl serine and phosphatidyl choline, and also to processes for the manufacture of the pharmaecutical compositions, and the use thereof.

公开(公告)号：FI853982L

公开(公告)日：1986-04-17

申请号：FI853982

申请日：1985-10-14

Applicant: CIBA GEIGY AG

Inventor： TARCSAY LAJOS ,  EIBL HANSJOERG ,  FANKHAUSER PETER ,  PEIL ANITA

IPC: A61K9/127 ,  A61K9/00 ,  A61K9/50 ,  A61K47/24 ,  C07F9/10 ,  A61K

Abstract: The invention relates to pharmaceutical compositions containing synthetic, substantially pure phosphatidyl serine and phosphatidyl choline and a substance or a mixture of substances having biological activity. The invention also relates to mixtures comprising synthetic, substantially pure phosphatidyl serine and phosphatidyl choline, and also to processes for the manufacture of the pharmaecutical compositions, and the use thereof.

公开(公告)号：ZA8503915B

公开(公告)日：1986-01-29

申请号：ZA8503915

申请日：1985-05-23

Applicant: CIBA GEIGY AG

Inventor： SORG CLEMENS ,  BURMEISTER GERD ,  TARCSAY LAJOS ,  WIESENDANGER WALTER

IPC: A61K20060101 ,  C07K20060101 ,  C12N20060101 ,  C12P20060101 ,  G01N20060101 ,  A61K ,  C07K ,  C12N ,  C12P ,  G01N

公开(公告)号：DK229985A

公开(公告)日：1985-11-25

申请号：DK229985

申请日：1985-05-23

Applicant: CIBA GEIGY AG

Inventor： SORG CLEMENS PROF ,  BURMEISTER GERD ,  TARCSAY LAJOS ,  WIESENDANGER WALTER

IPC: A61K38/00 ,  A61K38/16 ,  A61K39/00 ,  A61K39/395 ,  A61P29/00 ,  A61P37/00 ,  C07K1/20 ,  C07K1/22 ,  C07K14/00 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K19/00 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  C07K ,  C12N ,  G01N

公开(公告)号：CA1190221A

公开(公告)日：1985-07-09

申请号：CA394632

申请日：1982-01-21

Applicant: CIBA GEIGY AG

Inventor： BASCHANG GERHARD ,  HARTMANN ALBERT ,  WACKER OSKAR ,  TARCSAY LAJOS

IPC: A61K39/39 ,  A61P31/04 ,  A61P37/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07C103/52

Abstract: Derivatives of D-glucose, D-galactose or D-mannose of the formula I (I) are immunostimulants and can be used e.g. as adjuvants or for the prophylaxis of infectious diseases. The characteristic feature is that at least one of the substituents R1, R2, R6, R12, R13 and, in certain cases R9 and R11, contains a phosphoryl substituent of formula Ib or Ic (Ib), (Ic) in which represents an aliphatic or cycloaliphatic radical having at least 7 carbon atoms, R16 represents hydrogen and R17 represents 2-hydroxyethyl or 1,2-dihydroxyethyl, wherein at least one hydroxy group is esterified or etherified by a radical having at least 7 carbon atoms, or wherein each of R16 and R17 independently of the other, represents esterified or etherified hydroxymethyl, the esterifying or etherifying radicals having at least 7 carbon atoms.

公开(公告)号：DK229985D0

公开(公告)日：1985-05-23

申请号：DK229985

申请日：1985-05-23

Applicant: CIBA GEIGY AG

Inventor： SORG CLEMENS PROF ,  BURMEISTER GERD ,  TARCSAY LAJOS ,  WIESENDANGER WALTER

IPC: A61K38/00 ,  A61K38/16 ,  A61K39/00 ,  A61K39/395 ,  A61P29/00 ,  A61P37/00 ,  C07K1/20 ,  C07K1/22 ,  C07K14/00 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K19/00 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  C07K ,  G01N