公开(公告)号：KR850000064B1

公开(公告)日：1985-02-15

申请号：KR840005882

申请日：1984-09-25

Applicant: CIBA GEIGY AG

Inventor： HARTMANN ALBERT ,  BASCHANG GERHARD ,  WACKER OSKAR

IPC: C07H1/00 ,  A23K1/16 ,  A61K31/70 ,  A61P37/04 ,  C07H15/00 ,  C07K1/113 ,  C07K5/00 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535

公开(公告)号：KR850000063B1

公开(公告)日：1985-02-15

申请号：KR840005880

申请日：1984-09-25

Applicant: CIBA GEIGY AG

Inventor： HARTMANN ALBERT ,  BASCHANG GERHARD ,  WACKER OSKAR

IPC: C07H1/00 ,  A23K1/16 ,  A61K31/70 ,  A61P37/04 ,  C07H15/00 ,  C07K1/113 ,  C07K5/00 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535

公开(公告)号：NZ260459A

公开(公告)日：1995-12-21

申请号：NZ26045994

申请日：1994-05-05

Applicant: CIBA GEIGY AG

Inventor： WACKER OSKAR

IPC: A61K31/40 ,  A61K31/55 ,  A61P9/10 ,  A61P17/00 ,  A61P35/00 ,  A61P43/00 ,  C07D207/04 ,  C07D273/06 ,  C07D309/12 ,  C07D311/22 ,  C07D498/22

Abstract: There are described N-(tetrahydropyran-4-yloxyalkanoyl)staurosporin derivatives of the formula I in which R1 is hydrogen, hydroxyl, lower alkoxy or oxo, R2 is hydrogen or C1-4-alkyl and R3 is hydrogen or C1-4-alkyl, a process and novel intermediates for their preparation and a process for the preparation of the intermediates. The compounds of the formula I inhibit the enzyme protein kinase C with a high degree of selectivity and can be used, in particular, as antitumour active compounds.

公开(公告)号：AU2565995A

公开(公告)日：1995-12-21

申请号：AU2565995

申请日：1995-05-19

Applicant: CIBA GEIGY AG

Inventor： REGENASS URS ,  CARAVATTI GIORGIO ,  WACKER OSKAR

IPC: A61K31/55 ,  A61P35/00 ,  C07D498/22 ,  C07H9/06 ,  C07H19/044 ,  A61K31/70

公开(公告)号：MX9206408A

公开(公告)日：1993-10-01

申请号：MX9206408

申请日：1992-11-06

Applicant: CIBA GEIGY AG

Inventor： WACKER OSKAR ,  TRAXLER PETER

IPC: A61K31/70 ,  A61P35/00 ,  A61P43/00 ,  C07H9/06 ,  C07H15/26 ,  C07H19/02 ,  C12N9/99 ,  C07D498/22

Abstract: Staurosporin derivatives of the formula I are described, (I) in which R1 is hydrogen, hydroxyl, lower alkoxy or oxo and R2 is a radical of the formula II (II) in which the configuration of the sugar moiety is derived from D-glucose, D-galactose or D-mannose, and R3-R7 are as defined below. These compounds have a pronounced and selective inhibitory action on the enzyme proteinkinase C and have, inter alia, an antitumor action.

公开(公告)号：NO924284A

公开(公告)日：1993-05-10

申请号：NO924284

申请日：1992-11-06

Applicant: CIBA GEIGY AG

Inventor： WACKER OSKAR ,  TRAXLER PETER

IPC: A61K31/70 ,  A61P35/00 ,  A61P43/00 ,  C07H9/06 ,  C07H15/26 ,  C07H19/02 ,  C12N9/99

CPC classification number: C07H19/02 ,  C07H15/26

公开(公告)号：NO924284D0

公开(公告)日：1992-11-06

申请号：NO924284

申请日：1992-11-06

Applicant: CIBA GEIGY AG

Inventor： WACKER OSKAR ,  TRAXLER PETER

IPC: A61K31/70 ,  A61P35/00 ,  A61P43/00 ,  C07H9/06 ,  C07H15/26 ,  C07H19/02 ,  C12N9/99

Abstract: Staurosporin derivatives of the formula I are described, (I) in which R1 is hydrogen, hydroxyl, lower alkoxy or oxo and R2 is a radical of the formula II (II) in which the configuration of the sugar moiety is derived from D-glucose, D-galactose or D-mannose, and R3-R7 are as defined below. These compounds have a pronounced and selective inhibitory action on the enzyme proteinkinase C and have, inter alia, an antitumor action.

公开(公告)号：FI83524C

公开(公告)日：1991-07-25

申请号：FI840259

申请日：1984-01-23

Applicant: CIBA GEIGY AG

Inventor： BASCHANG GERHARD ,  HARTMANN ALBERT ,  WACKER OSKAR

IPC: A61K38/00 ,  A61P31/04 ,  A61P31/12 ,  A61P37/04 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/02 ,  C07K7/06 ,  C07K9/00

公开(公告)号：CS245797B2

公开(公告)日：1986-10-16

申请号：CS840684

申请日：1983-07-21

Applicant: CIBA GEIGY AG

Inventor： HARTMANN ALBERT ,  WACKER OSKAR ,  BASCHANG GERHARD ,  TARCSAY LAJOS

IPC: C07K9/00 ,  A61K38/00 ,  A61K38/14 ,  C07K15/14 ,  A61K37/02

公开(公告)号：NO860625A

公开(公告)日：1986-08-21

申请号：NO860625

申请日：1986-02-19

Applicant: CIBA GEIGY AG

Inventor： WACKER OSKAR ,  STANEK JAROSLAV ,  BASCHANG GERHARD ,  HARTMANN ALBERT

IPC: C07K9/00 ,  C07K

CPC classification number: C07K9/005