公开(公告)号：CY2402B1

公开(公告)日：2004-09-10

申请号：CY0400002

申请日：2004-01-02

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T ,  BRITTO IGNATIUS LOY

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/135 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/08 ,  B05D5/08 ,  B05D7/22 ,  B05D7/24 ,  B65D83/14

Abstract: Metered dose inhaler having all or part of its internal surfaces coated with one or more fluorocarbon polymers, opt. in combination with one or more non-fluorocarbon polymers, is used for dispensing an inhalation drug formulation comprising albuterol (also known as salbutamol) or one of its salts, and a fluorocarbon propellant, opt. in combination with one or more other pharmacologically active agents or one or more excipients. Also claimed is a metered dose inhaler system comprising a metered dose inhaler fitted into a suitable channelling device for oral or nasal inhalation of the drug formulation.

公开(公告)号：RO118564B

公开(公告)日：2003-07-30

申请号：RO9700561

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC RES TRIANGL

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  B01F17/20 ,  C07F9/09 ,  C07F9/10

CPC classification number: A61K9/008 ,  C07F9/10 ,  Y10S514/975

Abstract: The present invention relates to a pharmaceutical aerosol composition, for use in administering the medicaments by inhaling in the medical treatment. According to the invention, the pharmaceutical aerosol composition comprises 0.005 up to 10% by weight related to the total weight of the composition, of one or more medicaments in particle form, one or more propellent agents comprising fluorocarbons or chlorofluorocarbons, which contain hydrogen, and 0.05 up to 15% by weight, related to the medicament composition, of a surfactant having the general formula Ia or Ib: where R1 is: RF-(CH)a-(CH=CH)b-(CH2)c-(CH=CH)d-(CH2)e-A-; RF-(CH2)f-OCH2CH(CH2OH)-CH2-A-; RF-(CH2)g-OCH2CH(CH2OH)-A-.

公开(公告)号：BG62839B1

公开(公告)日：2000-09-29

申请号：BG10134797

申请日：1997-03-21

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH A

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: The pharmaceutical aerosol composition consists of a medicamentous composition in the form of particles, hydrogen fluoride propellent or hydrogen-containing chloro hydrogen fluoride propellent and a surfactant having the general formula where n is a factor having the value from 1 to 18; m is a factor having the value from 0 to 17, and R1, R2 and R3 separately mean hydrogen stom or C1-4 alkyl group. 18 claims

公开(公告)号：CZ326197A3

公开(公告)日：1999-06-16

申请号：CZ326197

申请日：1996-04-11

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: B65D83/38 ,  A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/00 ,  B05D5/08 ,  B65D83/14

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：NZ292995A

公开(公告)日：1998-10-28

申请号：NZ29299595

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI

IPC: A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  A61K9/12 ,  C07F9/10 ,  C09K23/20 ,  A61K47/24

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：BR9604978A

公开(公告)日：1998-06-09

申请号：BR9604978

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  RIEBE MICHAEL THOMAS ,  HERMAN CRAIG S ,  LI-BOVET LI ,  BRITTO IGNATIUS LOY

IPC: A61K9/12 ,  A61K31/56 ,  A61K31/569 ,  A61M15/00 ,  A61M15/08 ,  A61M16/00 ,  A61P11/00 ,  B05D5/00 ,  B05D5/08 ,  B65D83/14

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising fluticasone propionate, or a physiologically acceptable solvate thereof, and a fluorocarbon propellant optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：BR9604976A

公开(公告)日：1998-06-09

申请号：BR9604976

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  RIEBE MICHAEL T ,  HERMAN CRAIG S ,  LI-BOVET LI

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/135 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/08 ,  B05D5/08 ,  B05D7/22 ,  B05D7/24 ,  B65D83/14

Abstract: Metered dose inhaler having all or part of its internal surfaces coated with one or more fluorocarbon polymers, opt. in combination with one or more non-fluorocarbon polymers, is used for dispensing an inhalation drug formulation comprising albuterol (also known as salbutamol) or one of its salts, and a fluorocarbon propellant, opt. in combination with one or more other pharmacologically active agents or one or more excipients. Also claimed is a metered dose inhaler system comprising a metered dose inhaler fitted into a suitable channelling device for oral or nasal inhalation of the drug formulation.

公开(公告)号：MX9702149A

公开(公告)日：1998-04-30

申请号：MX9702149

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/72 ,  A61K9/12 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: La presente invencion se refiere a una formulacion en aerosol farmacéutica que comprende un medicamento particulado, un propulsor de fluorocarburo o de clorofluorocarburo que contiene hidrogeno y un agente tensioactivo de la formula general (I), en donde n es un numero entero de 1 a 18; m es un numero entero de 0 a 17; y R1, R2 y R3 son cada uno independientemente un átomo de hidrogeno o un grupo alquilo con C1-4.

公开(公告)号：BG101972A

公开(公告)日：1998-04-30

申请号：BG10197297

申请日：1997-10-15

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/12 ,  A61K31/56 ,  A61K31/569 ,  A61M15/00 ,  A61M15/08 ,  A61M16/00 ,  A61P11/00 ,  B05D5/00 ,  B05D5/08 ,  B65D83/14

Abstract: The dosage fixing inhaler has partial or fully coveredinternal surfaces coated by one or more fluorocarbon polymers,optionally in combination with one or more nonfluorocarbonpolymers. It is applied for the dispersion of medicamentous formsfor inhalations consisting of fluticazon propionate or itsphysiologically acceptable solution and optionallyin fluorcarbonpropellent combination with one or more pharmacologically activeagents and one or more additional substances.22 claims

公开(公告)号：SK138997A3

公开(公告)日：1998-04-08

申请号：SK138997

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61M15/00 ,  B05D5/08 ,  B65D83/00 ,  B65D83/14

Abstract: A metered dose inhaler characterised in that part or all of its internal surfaces are coated with a polymer blend of one or more fluorocarbon polymers in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salmeterol, or a physiologically acceptable salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients, wherein a) the fluorocarbon polymer is selected from the group consisting of PTFE, PFA, FEP and mixtures thereof, b) the non-fluorocarbon polymer is selected from the group consisting of polyamideimides, polyimides, polyethersulfones, polyphenylene sulfides and amine-formaldehyde thermosetting resins, (c) the inhaler comprises a can made of metal whose interior surfaces are coated with the polymer blend.