公开(公告)号：FI821583A0

公开(公告)日：1982-05-05

申请号：FI821583

申请日：1982-05-05

Applicant: HOECHST AG

Inventor： BECK GERHARD ,  BARTMANN WILHELM ,  KNOLLE JOCHEN ,  RUPP RICHARD HELMUT

IPC: A61K31/40 ,  A61K31/4025 ,  A61P43/00 ,  C07D207/24 ,  C07D409/12 ,  C07D

Abstract: The present invention relates to DELTA 1-pyrroline thiolactim ethers of the general formula I I which have a more specific action and/or a longer-lasting action than PGI2, and to a process for their preparation. The compounds are distinguished by a platelet aggregation-inhibiting action and a blood vessel-relaxing and hypotensive action, and can therefore be used as medicaments.

公开(公告)号：AU4002478A

公开(公告)日：1980-03-27

申请号：AU4002478

申请日：1978-09-20

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM ,  BECK GERHARD ,  LERCH ULRICH ,  SCHOLKENS BERNWARD

IPC: A61K31/20 ,  A61K31/215 ,  A61K31/557 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07C177/00 ,  A61K31/19 ,  C07D317/72 ,  C07D409/08 ,  C07D409/14

公开(公告)号：CA1073903A

公开(公告)日：1980-03-18

申请号：CA231817

申请日：1975-07-18

Applicant: HOECHST AG

Inventor： BECK GERHARD ,  BARTMANN WILHELM ,  LERCH ULRICH ,  SCHOLKENS BERNWARD

IPC: A61K31/21 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C271/28 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07C177/00

Abstract: ANALOGUES OF PROSTANOIC ACIDS AND PROCESS FOR THEIR MANUFACTURE of the disclosure: The present invention relates to new analogues which do not occur naturally of prostanoic acids of the formula I I The compounds of the invention have spasmogenic, bronchodilatant and hypotensive properties. Therefore, they can be used as medicaments. This invention also relates to a process for preparing the compounds of the invention.

公开(公告)号：AU4953479A

公开(公告)日：1980-02-07

申请号：AU4953479

申请日：1979-08-03

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM ,  BECK GERHARD ,  KONZ ELMAR ,  LERCH ULRICH

IPC: A61K31/21 ,  A61K31/19 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D317/54 ,  C07D317/72 ,  C07D319/06 ,  C07D319/08 ,  C07C177/00 ,  A61K31/215 ,  C07C49/44 ,  C07C49/58 ,  C07D407/08

公开(公告)号：AU4776179A

公开(公告)日：1979-12-13

申请号：AU4776179

申请日：1979-06-05

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  BARTMANN WILHELM ,  GERHARDS HERMANN

IPC: A61K31/495 ,  C07D209/08 ,  C07D209/34 ,  C07D215/38 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14

Abstract: Phenylpiperazine derivatives of the formula I I in which R1 denotes hydrogen or C1-C6alkyl, R2 denotes hydrogen or one or several, identical or different substituents selected from the group of C1-C6-alkyl, C1-C6alkoxy, halogen, trifluoromethyl, hydroxy, nitro, amino and methylene-dioxy, R3 denotes hydrogen, hydroxy, C1-C6alkanoyloxy, and n is 1 or 2, and the physiologically acceptable salts thereof, processes for their manufacture and medicaments containing or consisting of said compounds.

公开(公告)号：AU1530676A

公开(公告)日：1978-01-05

申请号：AU1530676

申请日：1976-06-25

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM ,  KUNSTMANN RUDOLF ,  LERCH ULRICH ,  SCHOLKENS BERNWARD

IPC: A61K31/40 ,  C07D207/26 ,  C07D405/06 ,  C07D405/08 ,  C07D405/12 ,  C07D409/06 ,  C07D409/08 ,  C07D409/12 ,  C07D498/04

公开(公告)号：FI763622A

公开(公告)日：1977-06-20

申请号：FI763622

申请日：1976-12-16

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF ,  BARTMANN WILHELM ,  KAISER JOACHIM

IPC: C07D209/40 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/06 ,  A61P9/12 ,  C07D209/42 ,  C07D401/12 ,  C07D405/12 ,  C07D

公开(公告)号：AU8629675A

公开(公告)日：1977-05-12

申请号：AU8629675

申请日：1975-11-04

Applicant: HOECHST AG

Inventor： KUHLEIN KLAUS ,  REUSCHLING DIETER-BERND ,  BEBEJ MILOS ,  BARTMANN WILHELM ,  BECK GERHARD

IPC: C07D207/26 ,  C07D207/277 ,  C07D405/12 ,  C07D405/06 ,  A61K31/40

Abstract: The present invention relates to pyrrolidone derivatives which are analogous to natural prostaglandins and to a process for preparing the same. The compounds according to the present invention have prostaglandin-like properties and may be used as pharmaceuticals.

公开(公告)号：AU8224575A

公开(公告)日：1976-12-23

申请号：AU8224575

申请日：1975-06-19

Applicant: HOECHST AG

Inventor： TEUFEL HERMANN ,  BARTMANN WILHELM ,  BECK GERHARD ,  GRANZER ERNOLD

IPC: A61K31/15 ,  A61K20060101 ,  C07C20060101 ,  C07C67/00 ,  C07C239/00 ,  C07C251/66 ,  C07C131/00

Abstract: Procedure for the preparation of substituted 0-acyl acrylaldoximes of the formula I **(See formula)** where X represents a chlorine or bromine atom, R represents an alcoholic, alkoxy or alkylamino group, an alkenyl, alkenoxy or alkenylamino group each having 1 to 12 carbon atoms, or an aryl, aryloxy, arylalkyl group, arylalkoxy, arylamino or arylalkoxylaminos possibly substituted with one or two alcohol groups, each with 1 to 6 carbon atoms-, and R1, R2, R3 and R4 are the same or different and mean in each case a hydrogen atom, a halogen atom or an alcoholic or alkoxy group in each case with 1 to 6 carbon atoms, characterized in that the 2,3-diaryl-3-halogen-acryloxy compounds of formula II are acylated **(See formula)** wherein X, R1, R2, R3 and R4 have the meanings given in the description of formula I, in the presence of aprotic solvents with the aid of acylating agents, to form 0-acyl-2,3-diaryl-3- halogen-acryl-oximes of formula I. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：AU7333374A

公开(公告)日：1976-03-18

申请号：AU7333374

申请日：1974-09-16

Applicant: HOECHST AG

Inventor： BABEJ MILOS ,  BARTMANN WILHELM ,  LERCH ULRICH

IPC: C07D307/16 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/54 ,  C07D309/12 ,  C07C61/32 ,  C07C65/14 ,  C07D5/16 ,  A61K27/00 ,  C07C61/36 ,  C07C65/02 ,  C07C65/20

Abstract: New derivatives of prostanoic acids are described as well as a process for their manufacture. The new compounds show valuable pharmacological activities and can be used for treating e.g. asthma bronchiale, high blood pressure and edema.