公开(公告)号：JPH08245556A

公开(公告)日：1996-09-24

申请号：JP5263396

申请日：1996-02-16

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  GERLACH UWE ,  MANIA DIETER ,  GOEGELEIN HEINZ ,  KAISER JOACHIM

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/36 ,  C07C303/40 ,  C07C311/57 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/00 ,  C07C335/42

公开(公告)号：JPH07304728A

公开(公告)日：1995-11-21

申请号：JP2411994

申请日：1994-02-22

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  HARTUNG JENS ,  GOEGELEIN HEINZ ,  KAISER JOACHIM ,  LINZ WOLFGANG ,  WETTLAUFER DAVID

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C07C303/40 ,  C07C311/46 ,  C07C311/58 ,  C07C323/67 ,  C07C335/42

公开(公告)号：CA2168517C

公开(公告)日：2007-02-27

申请号：CA2168517

申请日：1996-01-31

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  HARTUNG JENS ,  CRAUSE PETER ,  MANIA DIETER ,  GOGELEIN HEINZ ,  KAISER JOACHIM

IPC: C07D333/34 ,  A61K31/38 ,  A61K31/381 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07C335/00

Abstract: Substituted thiophenesulfonylureas and -thioureas, preparation processes and use of pharmaceutical preparations based on these compounds Substituted thiophenesulfonylureas and -thioureas I (see formula) in which R(1), R(2), X, Y and Z have the meanings indi- cated in the patent claims, exhibit effects on the cardiovascular system.

公开(公告)号：SK284325B6

公开(公告)日：2005-01-03

申请号：SK13496

申请日：1996-01-30

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  HARTUNG JENS ,  CRAUSE PETER ,  MANIA DIETER ,  GOGELEIN HEINZ ,  KAISER JOACHIM

IPC: A61K31/38 ,  A61K31/381 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07C335/00 ,  C07D333/34

Abstract: Substituted thiophene sulphonyl ureas and -thioureas of general formula (I), wherein R(1), R(2), X, Y and Z have the meaning stated in the claims, exhibit effects on the cardiovascular system.

公开(公告)号：NO315160B1

公开(公告)日：2003-07-21

申请号：NO960411

申请日：1996-01-31

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  HARTUNG JENS ,  CRAUSE PETER ,  MANIA DIETER ,  GOEGELEIN HEINZ ,  KAISER JOACHIM

IPC: A61K31/38 ,  A61K31/381 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07C335/00 ,  C07D333/34

Abstract: N-((2-Benzamidoethyl)- thiophene-sulphonyl)-urea or-thiourea derivs. of formula (I) are new. R1 = H, halogen, Me, Et, OMe, OEt, SMe, SEt, 1-2C fluoroalkyl or 1-2C fluoroalkoxy; X = O or S; R2 = H, Me or CF3; Y, Z = H, F, Cl, Br, I, Me, Et, OMe or OEt.

公开(公告)号：SI9600053B

公开(公告)日：2001-12-31

申请号：SI9600053

申请日：1996-02-20

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  GERLACH UWE ,  MANIA DIETER ,  GOEGELEIN HEINZ ,  KAISER JOACHIM

IPC: C07D331/02 ,  A61K31/18 ,  A61K31/38 ,  A61K31/64 ,  A61P9/00 ,  A61P9/02 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/46 ,  C07C335/42 ,  C07D203/08 ,  C07D295/00 ,  C07D303/48 ,  C07C303/36 ,  C07D295/04 ,  C07C233/57

Abstract: N-(3-substd. benzensulphonyl)-urea or -thiourea derivs. of formula (I) and their salts are new. R1 = H, 1-7C alkyl or 3-7C cycloalkyl; R2 = H, F, Cl, 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl or CbH2b+1, in which one or more C can be replaced by Het; Het = heteroatoms, e.g. O, NH or S; b = 1-8; 1-8C alkyl in which 1-4C may be replaced by O, N or S; R3 = H, 1-12C alkyl, 3-10C cycloalkyl, 1-6C fluoroalkyl, 3-6C fluorocycloalkyl or CaH2a+1 in which 1-4C are replaced by Het; a = 1-10; R4 = aryl or as R3; or R3+R4 = CbH2b, in which one or more CH2 can be replaced by Het; R5 = as R4; R6 = as R4 but not 3-10C cycloalkyl; Q, X = O or S; Y = -(C(R7)2)c, O, S or NH; c = 1-4; R7 = H, 1-4C alkyl, F, Cl or Br.

公开(公告)号：SI9600050B

公开(公告)日：2001-12-31

申请号：SI9600050

申请日：1996-02-16

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  GERLACH UWE ,  MANIA DIETER ,  GOEGELEIN HEINZ ,  KAISER JOACHIM

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/36 ,  C07C303/40 ,  C07C311/57 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/00 ,  C07C335/42 ,  C07C233/06

Abstract: Substd. benzene sulphonyl urea and thiourea cpds. of formula (I) and their salts are new. R1 = H, 1-7C alkyl or 3-7C cycloalkyl; R2 = H, 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl, or 1-8C chain (in which 1-4C atoms are replaced by Het), F or Cl; R3, R4 = H, 1-12C alkyl, 3-10C cycloalkyl, 1-6C fluoroalkyl, 3-6C fluorocycloalkyl, or 1-10C chain in which 1-4C atoms are replaced by Het; or R3+R4 = (CH2)p, opt. with 1 or more CH2 replaced by heteroatoms; p = 2-8; Q, X = O or S; Y = (CR5R6)m; R5; R6 = H, Me or Et (opt. different in different CR5R6 gps.); Het = heteroatom such as O, N or S, m = 1-4.

公开(公告)号：PL181656B1

公开(公告)日：2001-08-31

申请号：PL31253196

申请日：1996-01-29

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  GERLACH UWE ,  CRAUSE PETER ,  MANIA DIETER ,  GOEGELEIN HEINZ ,  KAISER JOACHIM

IPC: C07D333/20 ,  A61K31/18 ,  A61K31/34 ,  A61K31/35 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/40 ,  A61K31/425 ,  A61K31/426 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/40 ,  C07C335/42 ,  C07D207/32 ,  C07D207/335 ,  C07D213/40 ,  C07D277/28 ,  C07D307/52

Abstract: Substd. benzenesulphonylurea or -thiourea cpds. of formula (I) are new: R1 = H, 1-6C alkyl, or 3-6C cycloalkyl; R2 = 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl, or a 1-8C chain in which 1-3C may be replaced by O, NH or S; R3, R4 = H or 1-6C alkyl; or R3 + R4 = (CH2)p; p = 2-5; E, X = O or S; Y = ÄC(R5)2Üm; R5 = H, Me or Et; m = 1 or 2; Ar = phenyl, thienyl, furyl, pyrrolyl, thiazolyl, naphthyl or pyridyl (all opt. substd. by 1-3 Me, Et, MeO, EtO, Cl, Br or F).

公开(公告)号：HRP960077B1

公开(公告)日：2001-06-30

申请号：HRP960077

申请日：1996-02-15

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  GERLACH UWE ,  MANIA DIETER ,  GOEGELEIN HEINZ ,  KAISER JOACHIM

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42

Abstract: Substd. benzene sulphonyl urea and thiourea derivs. of formula (I) and their salts are new. R1 = H, Me or CF3; R2 = 4-10C alkoxy with 1-6C replaced by O, S or NH; Q = O or S; Y = ÄC(R3)2Üm; R3 = H, Me or Et; R' = H, halo or 1-6C alkyl; R" = halo, 1-4C alkoxy or 1-4C alkyl; and m = 1-4.

公开(公告)号：PT661264E

公开(公告)日：2000-12-29

申请号：PT94120773

申请日：1994-12-27

Applicant: HOECHST AG

Inventor： KAISER JOACHIM ,  ENGLERT HEINRICH ,  GERLACH UWE ,  MANIA DIETER ,  HARTUNG JENS ,  GOGELEIN HEINZ

IPC: C07D217/24 ,  A61K31/40 ,  A61K31/64 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07C303/36 ,  C07C311/58 ,  C07C335/42 ,  C07D207/38 ,  C07D521/00

Abstract: There are described substituted benzenesulphonylureas and -thioureas of the formula I where R(1) is H, (cyclo)(CH2)a(fluoro)alk(en)yl, R(2) is H, Hal, (fluoro)(mercapto)(CH2)e(cyclo)alk(oxy)(yl), NR(4)R(5) where R(4) and R(5) together are a (CH2)2-7 chain, or R(4), R(5), R(6) are H, (alkyl)(cyclo)(fluoro)alk(en)yl, E is O, S; Y is -[CR(7)2]n-R(3) B is (C3-C6)-alkenyl, or R(3) is X is H, Hal, alkyl; Z is Hal, (cyclo)alk(yl)(oxy). Compounds I are used for the treatment of cardiac arrhythmias and for the prevention of sudden heart death caused by arrhythmia and can therefore be used as antiarrhythmics. They are particularly suitable in those cases in which arrhythmias are the result of constriction of a coronary vessel, such as in angina pectoris or in acute cardiac infarct.