公开(公告)号：JPS6368596A

公开(公告)日：1988-03-28

申请号：JP21036187

申请日：1987-08-26

Applicant: HOECHST AG

Inventor： FRANCO CHRISTOPHER MILTON MATH ,  CHATTERJEE SUGATA ,  FEHLHABER HANS-WOLFRAM ,  RUPP RICHARD HELMUT ,  REDDY GOUKANAPALLI CHANDRA SHE ,  GANDHI JULIA ,  GANGULI BIMAL MARESH ,  KOGLER HERBERT

IPC: A61K31/70 ,  C07H15/26 ,  C07H17/08 ,  C12P19/58 ,  C12P19/62 ,  C12R1/465

Abstract: The macrolide antibiotic is swalpamycin and is prepared using a Streptomyces species and is used as medicament for the treatment of infections caused by bacteria, mycoplasmas and actinomycetes.

公开(公告)号：PT91468B

公开(公告)日：1995-05-04

申请号：PT9146889

申请日：1989-08-17

Applicant: HOECHST AG

Inventor： SEIBERT GERHARD ,  CHATTERJEE SUGATA ,  TEETZ VOLKER ,  KOGLER HERBERT ,  FEHLHABER HANS-WOLFRAM ,  GANGULI BIMAL NARESH ,  RUPP RICHARD HELMUT ,  CHATTERJEE DEEPAK KUMAR ,  CHATTERJEE SUKUMAR ,  JANI RANJENDRA KUMAR HARIPRASA

IPC: C12N1/20 ,  A61K38/00 ,  A61P31/04 ,  C07K7/08 ,  C07K7/56 ,  C07K14/195 ,  C07K14/41 ,  C12P21/02 ,  C12P21/04 ,  C12R1/01 ,  C12R1/07 ,  A61K37/02

Abstract: Mersacidin, a cyclic peptide of the formula I (I) has antibiotic activity.

公开(公告)号：DK168012B1

公开(公告)日：1994-01-17

申请号：DK522789

申请日：1989-10-20

Applicant: HOECHST AG

Inventor： BAL-TEMBE SWATI ,  BLUMBACH JUERGEN ,  DOHADWALLA ALIHUSSEIN NOMANBHA ,  LAL BANSI ,  PUNEKAR NARAYAN SUDHINDRA ,  RAJGOPALAN RAMANUJAM ,  RUPP RICHARD HELMUT ,  BICKEL MARTIN

IPC: C07D295/08 ,  A61K31/445 ,  C07D211/36 ,  C07D295/088 ,  C07D295/092

Abstract: Compounds of the formula III in which R4 - R6 have the given meaning, have a spasmolytic activity.

公开(公告)号：NZ237442A

公开(公告)日：1993-05-26

申请号：NZ23744291

申请日：1991-03-15

Applicant: HOECHST AG

Inventor： YATENDRA KHANDELWAL ,  RAJESHWARI KANNAN ,  BANSI LAL ,  RAMANUJAM RAJAGOPALAN ,  VIJAY ATMARAM AROSKAR ,  ALI HUSSEIN NOMANBHAI DOHADWAL ,  RUPP RICHARD HELMUT

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/695 ,  A61P9/04 ,  A61P27/02 ,  C07D311/92 ,  C07F7/18 ,  C07D405/12 ,  C07D413/12 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535

Abstract: Labdanes of the formula a process for their manufacture, pharmaceutical preparations containing an effective amount of these compounds and their use for the manufacture of a pharmaceutical preparation for treatment of cardiovascular diseases and high intraocular pressure.

公开(公告)号：PT88923B

公开(公告)日：1993-01-29

申请号：PT8892388

申请日：1988-11-03

Applicant: HOECHST AG

Inventor： KANNAN RAJESHWARI ,  LAL BANSI ,  RAJAGOPALAN RAMANUJAM ,  NOMANBHAIDOHADWALLA ALIHUSSEIN ,  RUPP RICHARD HELMUT ,  KHANDELWAL YATENDRA

IPC: A61K31/35 ,  A61K31/352 ,  A61P9/04 ,  A61P9/12 ,  A61P27/02 ,  C07D311/92 ,  C07F7/18 ,  A61K31/695

Abstract: Acyl-labdane derivatives of the formula a process for their preparation and the use of the substances as pharmaceutical agents, in particular as medicaments having activity against increased internal ocular pressure and increased blood pressure.

公开(公告)号：PT87427B

公开(公告)日：1992-09-30

申请号：PT8742788

申请日：1988-05-06

Applicant: HOECHST AG

Inventor： LAL BANSI ,  VENUGOPALAN BINDUMADHAVAN ,  CHATTERJEE DIPAK KUMAR ,  SOUZA NOEL JOHN DE ,  RUPP RICHARD HELMUT

IPC: A61K31/335 ,  A61K31/47 ,  A61K31/49 ,  A61K31/635 ,  A61P33/02 ,  C07D493/18 ,  A61K31/55

Abstract: The present invention relates to combinations of the antimalarials artemisinin, dihydroartemisinin, arteether, artemether, artesunate or other artemisinin derivatives with one or more of the antimalarials chloroquine, 10-O-methylfloxacrine, quinine, mefloquine, amodiaquine, pyrimethamine, sulfadoxine and primaquine. Synergistic effects are achieved on treatment of mammals, including humans, with subcurative doses of the individual substances.

公开(公告)号：AU628794B2

公开(公告)日：1992-09-24

申请号：AU2636888

申请日：1988-11-30

Applicant: HOECHST AG

Inventor： KHANDELWAL YATENDRA ,  RUPP RICHARD HELMUT ,  MORAES GRETA ,  LAL BANSI ,  AROSKAR VIJAY ATMARAM ,  DOHADWALLA ALIHUSSEIN NOMANBHA

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/40 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12 ,  C07D311/92 ,  C07D405/12 ,  C07D407/12 ,  C07D413/12 ,  C07F7/18 ,  A61K31/335

Abstract: Labdane derivatives of the formula a process for their preparation and the use of the substances as pharmaceutical agents, in particular as medicaments having positively inotropic action, having action against increased internal ocular pressure and increased blood pressure.

公开(公告)号：AU628026B2

公开(公告)日：1992-09-10

申请号：AU2464988

申请日：1988-11-03

Applicant: HOECHST AG

Inventor： KHANDELWAL YATENDRA ,  KANNAN RAJESHWARI ,  LAL BANSI ,  DOHADWALLA ALIHUSSEIN NOMANBHA ,  RAJGOPALAN RAMANUJAM ,  RUPP RICHARD HELMUT

IPC: A61K31/35 ,  A61K31/352 ,  A61P9/04 ,  A61P9/12 ,  A61P27/02 ,  C07D311/92 ,  C07F7/18 ,  A61K31/445 ,  A61K31/535

Abstract: Acyl-labdane derivatives of the formula a process for their preparation and the use of the substances as pharmaceutical agents, in particular as medicaments having activity against increased internal ocular pressure and increased blood pressure.

公开(公告)号：HU203091B

公开(公告)日：1991-05-28

申请号：HU613388

申请日：1988-12-01

Applicant: HOECHST AG

Inventor： KHANDELWAL YATENDRA ,  MORAES GRETA ,  LAL BANSI ,  AROSKAR VIJAY ATMARAM ,  DOHADWALLA ALIHUSSEIN NOMANBHA ,  RUPP RICHARD HELMUT

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/55 ,  A61P9/12 ,  A61P27/02 ,  C07D311/92 ,  C07D405/12 ,  C07D413/12

Abstract: Polyoxygenated labdane derivatives of the formula … … a process for their preparation and the use of the substances as pharmaceutical agents, in particular as medicaments having activity against increased internal ocular pressure and increased blood pressure.

公开(公告)号：PT92145A

公开(公告)日：1990-04-30

申请号：PT9214589

申请日：1989-10-27

Applicant: HOECHST AG

Inventor： SEDLACEK HANS HARALD ,  LAL BANSI ,  CZECH JORG ,  NAIK RAMCHANDRA GANAPATI ,  RUPP RICHARD HELMUT ,  DICKNEITE GERHARD

IPC: A61K31/35 ,  A61K31/40 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/55 ,  A61P35/00 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C12N9/99 ,  C07D401/00 ,  C07D405/00 ,  A61K31/435 ,  A61K31/335

Abstract: Compounds of the formula I in which the substituents R1-R5 and n and m have the said meanings, are suitable for controlling tumours. The present invention relates to the use of 4H-1-benzopyran-4-one derivatives, to 4H-1-benzopyran-4-one derivatives and to medicines containing same. Benzopyran derivatives have already been disclosed in European Patent No. 0137193 and German Offenlegungsschrift 36 12 337. In the latter, compounds of the formula a) are disclosed.