公开(公告)号：NO752202L

公开(公告)日：1975-12-23

申请号：NO752202

申请日：1975-06-20

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/20 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D239/54 ,  C07D239/553 ,  C07D239/56 ,  C07D253/075 ,  C07D501/04 ,  C07D501/06 ,  C07D501/36 ,  C07D501/57 ,  C07D

公开(公告)号：NO752202A

公开(公告)日：1975-12-23

申请号：NO752202

申请日：1975-06-20

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/20 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D239/54 ,  C07D239/553 ,  C07D239/56 ,  C07D253/075 ,  C07D501/04 ,  C07D501/06 ,  C07D501/36 ,  C07D501/57 ,  C07D

CPC classification number: C07D239/54 ,  C07D239/553 ,  C07D239/56 ,  C07D253/075 ,  C07D501/36 ,  Y02P20/55

公开(公告)号：SE7506908L

公开(公告)日：1975-12-22

申请号：SE7506908

申请日：1975-06-16

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/20 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D239/54 ,  C07D239/553 ,  C07D239/56 ,  C07D253/075 ,  C07D501/04 ,  C07D501/06 ,  C07D501/36 ,  C07D501/57 ,  F02C7/00

公开(公告)号：YU46444B

公开(公告)日：1993-10-20

申请号：YU40388

申请日：1988-03-01

Applicant: HOFFMANN LA ROCHE

Inventor： KLOETZER W ,  MONTAVON M ,  MUESSNER R ,  SINGEWALD N

IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/417 ,  A61P3/00 ,  A61P29/00 ,  C07D233/61 ,  C07D233/64 ,  C07D233/80 ,  C07D233/84 ,  C07D233/88 ,  C07D521/00

Abstract: POSTUPAK ZA IZRADU DERIVATA IMIDAZOLA, opšte formule u kojoj R(na prvi stepen) i R(na drugi stepen) označavaju alkil sa 1 do 4 C-atoma, R(na peti stepen) označava vodonik ili alkil sa 1 do 4 C-atoma, dok R(na šesti stepen) označava vodonik, alkil sa 1 do 4 C-atoma, alkiltio sa 1 do 4 C-atoma ili morfolinoi njihovih fermaceutski prihvatljivih kiselinskih adicionih soli, naznačen time, što se jedinjenje opšte formule u kojoj R(na prvi stepen), R(na drugi stepen), R(na peti stepen) i R(na šesti stepen) imaju gore navedeno značenje redukuje katalitičkom hidrogenizacijom u prisustvu katalizatora kao što je paladijm u inertnom organskom rastvaraču kao što je metanol na sobnoj temperaturi i pri normalnom pritisku uz celishodno dodavanje kiseline kao što je hlorovodonična kiselina ili pomoću kompleksnog hidrida kao što je natrijum cijanoborhidrid u pogodnom rastvaraču kao što je glacijalna sirćetna kiselina na sobnoj temperaturi i normalnom pritisku.

公开(公告)号：YU216188A

公开(公告)日：1990-04-30

申请号：YU216188

申请日：1988-11-24

Applicant: HOFFMANN LA ROCHE

Inventor： FURLENMEIER A ,  HUBSCHWERLEN C ,  MONTAVON M

IPC: C07D499/897 ,  A61K31/397 ,  A61K31/40 ,  A61K31/435 ,  A61K31/47 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D463/00 ,  C07D477/00 ,  C07D477/08 ,  C07D499/00 ,  C07D499/32 ,  C07D499/893 ,  C07D501/04 ,  C07D501/06 ,  C07D501/16 ,  C07D501/18 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D505/00 ,  C07D513/04 ,  A61K31/43

Abstract: Novel esters of pharmacologically active carboxylic acids, which can be cleaved under physiological conditions, in particular of antibiotically active carboxylic acids from the beta -lactam antibiotic field, are described, which are characterised in that the alcohol component of the ester is a group of the general formula in which R denotes hydrogen or lower alkyl, R denotes hydrogen, lower alkyl, lower haloalkyl, lower alkenyl, lower alkoxycarbonyl, aryl or heteroaryl or, together with R denotes lower alkylene, R denotes hydrogen, lower alkyl or lower alkoxycarbonyl, R denotes the group -COOR , -COR , -SO2-R , -CONR R or -PO(OR )2, R denotes a saturated or unsaturated hydrocarbon radical having up to 12 carbon atoms, in which up to two methylene groups can be replaced by oxygen atoms, or denotes aryl or aryl-lower alkyl, R denotes lower alkyl or aryl, R and R each denotes hydrogen or lower alkyl or together denotes lower alkylene in which a methylene group can be replaced by an oxygen or sulphur atom or by an imino or lower alkylimino group, and R denotes lower alkyl. If a basic substituent is present, these esters can also be present in the form of pharmaceutically acceptable acid addition salts.

公开(公告)号：ZA816068B

公开(公告)日：1983-02-23

申请号：ZA816068

申请日：1981-09-01

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D249/12 ,  C07D ,  A61K

公开(公告)号：SE8105628L

公开(公告)日：1983-01-18

申请号：SE8105628

申请日：1981-09-23

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: A61K31/546 ,  C07D249/12 ,  C07D501/36

公开(公告)号：BE890460A

公开(公告)日：1982-03-23

申请号：BE206037

申请日：1981-09-23

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D249/12 ,  C07D

公开(公告)号：ZA807099B

公开(公告)日：1981-11-25

申请号：ZA807099

申请日：1980-11-14

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D501/00 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C20060101 ,  C07D20060101 ,  C07D501/04 ,  C07D501/16 ,  C07D501/36 ,  C07D501/46 ,  C07D

Abstract: For the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A process for the manufacture of acyl derivatives of general formula I see diagramm : EP0030294,P12,F1 in which R represents hydrogen or a readily hydrolyzable ester group, as well as of salts of these compounds and hydrates of these compounds or of their salts by reating a halide of general formula II see diagramm : EP0030294,P12,F2 in which R has the significance given above and Y represents a halogen atom, or a salt of this compound with thiourea and, if desired, converting a compound of formula I obtained into a salt or hydrate or into a hydrate of this salt, characterized in that X signifies one of the groups see diagramm : EP0030294,P13,F3 in which R' represents hydrogen or a readily hydrolysable ether group.

公开(公告)号：AU6851181A

公开(公告)日：1981-10-01

申请号：AU6851181

申请日：1981-03-18

Applicant: HOFFMANN LA ROCHE

Inventor： MONTAVON M ,  REINER R

IPC: C07D249/12 ,  C07D253/075 ,  C07D501/36 ,  A61K31/545 ,  C07D201/18 ,  C07D253/06