公开(公告)号：EP0977597A1

公开(公告)日：2000-02-09

申请号：EP97940615.4

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C.

IPC: A61K49/00 ,  A61B8/14

CPC classification number: A61B5/411 ,  A61B5/201 ,  A61K49/223 ,  A61K49/227

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

Abstract translation: 已经开发了用于提供患者内部区域的图像的方法。 该方法通过在成像过程中提供组织和血液之间的增强对比来减少成像假象。 该方法包括向患者施用与肾血管扩张剂组合的造影剂并对该区域进行超声成像。 使用该方法可以诊断肾疾病，包括肾动脉狭窄。

公开(公告)号：EP0959908A1

公开(公告)日：1999-12-01

申请号：EP98946919.0

申请日：1998-09-09

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C. ,  FRITZ, Thomas, A. ,  GERTZ, Edward, W.

IPC: A61K49

CPC classification number: A61K49/223 ,  A61K49/227 ,  A61K49/228 ,  B82Y5/00

Abstract: Novel contrast agents which may be used for diagnostic and therapeutic use. The compositions may comprise a lipid, a protein, polymer and/or surfactant, and a gas, in combination with a targeting ligand. In preferred embodiments, the targeting ligand targets coagula, including emboli and/or thrombi, particularly in patients suffering from an arrhythmic disorder. The contrast media can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.

公开(公告)号：EP0852477A1

公开(公告)日：1998-07-15

申请号：EP96908679.0

申请日：1996-03-06

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C.

IPC: A61K49 ,  A61B5 ,  A61K8 ,  A61K9 ,  A61K41 ,  A61K47 ,  A61Q19 ,  G01R33 ,  A61M5

CPC classification number: G01R33/5601 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6911 ,  A61K47/6913 ,  A61K47/6925 ,  A61K49/103 ,  A61K49/16 ,  A61K49/1806 ,  A61K49/1839 ,  A61K49/1863 ,  A61K49/1866 ,  A61K49/1878 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  B82Y5/00 ,  G01R33/56308

Abstract: A novel method of magnetic resonance focused surgical ultrasound by administering to a patient a magnetic resonance imaging (MRI) contrast medium comprising gas filled vesicles, then scanning the patient with MRI techniques, and then applying ultrasound to effect surgery. These methods may also use an MRI contrast medium comprising gaseous precursor filled vesicles which undergo a phase transition from a liquid to gas in vivo after administration. Additionally, the MRI contrast medium may comprise a therapeutic compound.

Abstract translation: 一种磁共振聚焦手术超声的新方法，其通过向患者施用包含充气囊泡的磁共振成像（MRI）造影剂，然后用MRI技术扫描患者，然后施加超声以实现手术。 这些方法还可以使用包含气体前体填充的囊泡的MRI造影剂，其在施用后在体内经历从液体到气体的相变。 另外，MRI造影剂可以包含治疗性化合物。

公开(公告)号：EP0831927A1

公开(公告)日：1998-04-01

申请号：EP96916685.0

申请日：1996-05-28

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C.

IPC: A61K47 ,  A61K9 ,  A61K49

CPC classification number: A61K49/1806 ,  A61K49/223 ,  A61K49/227 ,  Y10S514/962 ,  Y10S514/963

Abstract: Stabilized compositions comprising, in combination with a gas, a fluorinated amphiphilic compound. The compositions are particularly suitable for use in diagnostic applications, including ultrasound. The compositions can take the form of vesicular compositions, such as micelles and liposomes.

公开(公告)号：EP0818989A1

公开(公告)日：1998-01-21

申请号：EP96910602.0

申请日：1996-03-27

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C.

IPC: A61K9 ,  A61K8 ,  A61K41 ,  A61K47 ,  A61K49 ,  A61Q19 ,  A61M5

CPC classification number: A61K9/127 ,  A61K9/1271 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6907 ,  A61K47/6911 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  Y10T428/2984

Abstract: Compositions comprising, in an aqueous carrier, a lipid and a material which is capable of stabilizing the composition. The stabilizing material is associated non-covalently with said lipid and is present in an amount sufficient to coat the lipid but insufficient to raise the viscosity of the composition. The compositions are particularly suitable for use in diagnostic applications, including ultrasound. The compositions can take the form of vesicular compositions, such as micelles and liposomes.