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    Novel methods of ultrasound treatment using gas or gaseous precursor-filled compositions
    1.
    发明申请
    Novel methods of ultrasound treatment using gas or gaseous precursor-filled compositions 有权
    使用气体或气体前体填充组合物的超声治疗的新方法

    公开(公告)号：US20010031243A1

    公开(公告)日：2001-10-18

    申请号：US09813484

    申请日：2001-03-21

    Applicant: ImaRx Pharmaceutical Corp.

    Inventor： Evan C. Unger

    IPC: A61K049/22

    CPC classification number: A61K41/0028 ,  A61K49/227

    Abstract: The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above the boiling point of the instilled gaseous precursor prior to their in vivo administration to a patient. Further optimization of contrast enhancement is achieved by administering the gaseous precursor filled compositions to a patient as an infusion. Enhanced effectiveness is also achieved for ultrasound mediated targeting and drug delivery.

    Abstract translation: 除其他外，本发明描述了令人惊奇的发现，即当气体前体填充的组合物在其体内给药之前被热预活化至等于或高于滴注的气态前体的沸点的温度时，作为声学活性造影剂是非常有效的 给病人 通过将气体前体填充的组合物作为输注施用于患者来实现对比度增强的进一步优化。 超声介导的靶向和药物递送也可实现增强的有效性。

    PERFLUORINATED-ETHER COMPOSITIONS AS DIAGNOSTIC CONTRAST AGENTS
    5.
    发明申请
    PERFLUORINATED-ETHER COMPOSITIONS AS DIAGNOSTIC CONTRAST AGENTS 审中-公开
    全氟化合物作为诊断对比剂

    公开(公告)号：WO1998023298A1

    公开(公告)日：1998-06-04

    申请号：PCT/US1997019900

    申请日：1997-11-03

    Applicant: IMARx PHARMACEUTICAL CORP.

    Inventor： IMARx PHARMACEUTICAL CORP. ,  UNGER, evan, C.

    IPC: A61K49/04

    CPC classification number: A61K49/223

    Abstract: Compositions and methods for providing an image of an internal region of a patient. Embodiments of the invention involve vesicle compositions comprising, in an aqueous carrier, a perfluorinated ether compound and vesicles comprising one or more stabilizing compounds. The compositions may be administered to a patient, and the patient may be scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of an internal region.

    Abstract translation: 用于提供患者内部区域的图像的组合物和方法。 本发明的实施方案涉及囊泡组合物，其在水性载体中包含全氟化醚化合物和包含一种或多种稳定化合物的囊泡。 可以将组合物施用于患者，并且可以使用诸如超声波的诊断成像来扫描患者，以获得内部区域的可视图像。

    IMPROVED METHODS FOR DIAGNOSTIC IMAGING USING A CONTRAST AGENT AND A VASODILATOR
    6.
    发明申请
    IMPROVED METHODS FOR DIAGNOSTIC IMAGING USING A CONTRAST AGENT AND A VASODILATOR 审中-公开
    改进的使用对比剂和血管扩张剂进行诊断成像的方法

    公开(公告)号：WO1998010798A1

    公开(公告)日：1998-03-19

    申请号：PCT/US1997014957

    申请日：1997-08-26

    Applicant: IMARX PHARMACEUTICAL CORP.

    Inventor： IMARX PHARMACEUTICAL CORP. ,  UNGER, Evan, C.

    IPC: A61K49/00

    CPC classification number: A61B5/411 ,  A61B5/201 ,  A61K49/223 ,  A61K49/227

    Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

    Abstract translation: 已经开发了用于提供患者的内部区域的图像的方法。 该方法通过在成像期间通过提供组织和血液之间的增强的对比来减少成像伪像。 该方法包括向患者施用与肾血管扩张剂组合的造影剂并对该区域进行超声成像。 可以使用该方法诊断肾脏疾病，包括肾动脉狭窄。

    NOVEL SILICON AMPHIPHILIC COMPOUNDS AND THE USE THEREOF
    8.
    发明申请
    NOVEL SILICON AMPHIPHILIC COMPOUNDS AND THE USE THEREOF 审中-公开
    新型硅酮化合物及其用途

    公开(公告)号：WO1998009600A2

    公开(公告)日：1998-03-12

    申请号：PCT/US1997015033

    申请日：1997-08-26

    Applicant: IMARX PHARMACEUTICAL CORP.

    Inventor： IMARX PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  SHEN, DeKANG ,  WU, Guanli

    IPC: A61K00/00

    CPC classification number: A61K51/1227 ,  A61K49/1806 ,  A61K49/223 ,  C07F7/0838

    Abstract: Novel silicon amphiphilic compounds which comprise a silicon residue. The silicon amphiphilic compounds are particularly suitable for use in compositions for diagnostic imaging, such as ultrasound. Compositions of the silicon amphiphilic compounds comprise a gas or gaseous precursor, and may take the form of vesicle compositions, such as micelles or liposomes.

    Abstract translation: 包含硅残渣的新型硅两亲化合物。 硅两亲化合物特别适用于用于诊断成像的组合物，例如超声波。 硅两亲化合物的组合物包含气体或气体前体，并且可以采取囊泡组合物的形式，例如胶束或脂质体。

    METHODS AND APPARATUS FOR PERFORMING DIAGNOSTIC AND THERAPEUTIC ULTRASOUND SIMULTANEOUSLY
    10.
    发明申请
    METHODS AND APPARATUS FOR PERFORMING DIAGNOSTIC AND THERAPEUTIC ULTRASOUND SIMULTANEOUSLY 审中-公开
    用于同时执行诊断和治疗超声的方法和装置

    公开(公告)号：WO1996039079A1

    公开(公告)日：1996-12-12

    申请号：PCT/US1996007621

    申请日：1996-05-24

    Applicant: IMARx PHARMACEUTICAL CORP.

    Inventor： IMARx PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  YELLOWHAIR, David, W.

    IPC: A61B08/00

    CPC classification number: A61B8/12 ,  A61B8/0833 ,  A61B8/0883 ,  A61B8/445 ,  A61B8/4483 ,  A61B8/481 ,  A61K41/0028 ,  A61K49/223 ,  A61N7/00 ,  G01S15/8925 ,  G01S15/899

    Abstract: Methods and apparatus (12-102) for performing diagnostic ultrasound simultaneously with the application of therapeutic ultrasonic waves are disclosed. The methods and apparatus (12-102) are particularly advantageous in performing ultrasonic imaging of a region of a patient while simultaneously applying therapeutic ultrasonic waves to the region for the purpose of rupturing vesicles administered to that region for purposes such as enhanced cavitation or the targeted release of a bioactive agent into the region. An operator is able to monitor the rupture of vesicles in real time.

    Abstract translation: 公开了与应用治疗超声波同时执行诊断超声的方法和装置（12-102）。 方法和装置（12-102）在对患者的区域进行超声波成像同时对该区域施加治疗性超声波以便为了破坏施用于该区域的囊泡的目的而特别有利，例如增强的空化或靶向 将生物活性剂释放到该区域。 操作者能够实时监测囊泡破裂。

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