公开(公告)号：US4518533A

公开(公告)日：1985-05-21

申请号：US423350

申请日：1982-09-24

Applicant: Jacques Gosteli ,  Ivan Ernest ,  Robert B. Woodward

Inventor： Jacques Gosteli ,  Ivan Ernest ,  Robert B. Woodward

IPC: C07D499/897 ,  C07D205/08 ,  C07D205/09 ,  C07D499/04 ,  C07D499/06 ,  C07D499/86 ,  C07D499/87 ,  C07D499/88 ,  C07F9/568 ,  C07D403/12 ,  C07D487/04

CPC classification number: C07F9/5683 ,  C07D205/09 ,  C07D499/88

Abstract: 2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group andR.sub.2 represents hydroxy or a radical R.sub.2.sup.A forming together with the carbonyl grouping --C(.dbd.O)--a protected carboxyl group,1-oxides thereof, as well as salts of such compounds having salt-forming groups, in racemic and optically active form, processes for their preparation, pharmaceutical compositions containing such compounds, and their use as antibiotics, and intermediates and their processes which are useful in the production of the compounds of the formula I.

Abstract translation: 其中R 1表示氢，通过碳原子键合到环碳原子上的有机基团或醚化的巯基，R 2表示羟基或基团R 2 A的2-蒎烯-3-羧酸化合物 与羰基-C（= O） - 保护的羧基，其1-氧化物以及具有成盐基团的化合物的盐以外消旋和旋光形式一起形成，其制备方法，药物组合物 含有这些化合物及其作为抗生素的用途，以及可用于制备式I化合物的中间体及其方法。

公开(公告)号：US4213920A

公开(公告)日：1980-07-22

申请号：US920102

申请日：1978-06-28

Applicant: Jacques Gosteli

Inventor： Jacques Gosteli

IPC: C07B39/00 ,  C07C45/40 ,  C07C47/54 ,  C07C205/06 ,  C07C205/11 ,  C07C45/00

CPC classification number: C07B39/00 ,  C07C201/12 ,  C07C45/40

Abstract: A process for the production of benzaldehydes which are substituted in the ortho-position by an electrophilic group R, which comprises brominating an ortho-substituted compound of the formula I ##STR1## in which R represents the nitro group, the cyano group, an alkoxy group of 1 to 8 carbon atoms or a halogen atom, under irradiation with visible light in an inert solvent, to give the bromide of the formula II ##STR2## converting the resulting bromide by treatment with an alkali bromide in an inert solvent into a styrene compound of the formula III ##STR3## and ozonising this latter compound in an inert solvent to give the compound of the formula IV ##STR4##

Abstract translation: 一种生产通过亲电子基团R在邻位被取代的苯甲醛的方法，该方法包括溴化式I的邻位取代的化合物，其中R表示硝基，氰基 ，1〜8个碳原子的烷氧基或卤素原子，在惰性溶剂中用可见光照射，得到式II的溴化物（II），用碱金属溴化物处理得到的溴化物 惰性溶剂转化成式III（III）的苯乙烯化合物，并在惰性溶剂中将后一种化合物臭氧化，得到式IV化合物（IV）

公开(公告)号：US4206152A

公开(公告)日：1980-06-03

申请号：US971772

申请日：1978-12-21

Applicant: Jacques Gosteli

Inventor： Jacques Gosteli

IPC: C07C47/52 ,  C07C45/00 ,  C07C45/43 ,  C07C47/544 ,  C07C47/565 ,  C07C51/00 ,  C07C51/373 ,  C07C65/30 ,  C07C67/00 ,  C07C201/00 ,  C07C205/44 ,  C07C253/00 ,  C07C255/56

CPC classification number: C07C201/12 ,  C07C45/43 ,  C07C47/544 ,  C07C47/565 ,  C07C51/373

Abstract: The present invention provides a process for the production of unsubstituted or substituted o-phthalaldehydes by hydrolysis of .alpha.,.alpha., .alpha.',.alpha.'-tetrahalogeno-o-xylenes with a carboxylate in an aqueous medium in the presence of a phase transfer catalyst and an organic base.

Abstract translation: 本发明提供了一种通过在相转移催化剂存在下在水介质中用α，α，α'，α'-四卤代邻位二甲苯与羧酸酯水解制备未取代或取代的邻邻邻苯二甲醛的方法， 有机基地。