公开(公告)号：CA2535333C

公开(公告)日：2015-04-21

申请号：CA2535333

申请日：2004-08-13

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

公开(公告)号：AU2014250695B2

公开(公告)日：2014-12-11

申请号：AU2014250695

申请日：2014-10-17

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  CALVIN EDWARD A ,  COLLINS CHARLES J ,  DEICHER WILLIAM R ,  KRAGER JARDEN E ,  SCHILFFARTH ADAM R ,  JOHNSON ROSS G ,  BOZARTH COLIN D ,  SELVARAJ VICTOR ,  SMITH ERIC D ,  ARAB NICOLAS F ,  BERNARD BRUCE J C ,  CONNER DONALD A ,  ROACH ROBERT S ,  SMITH DAVID L

IPC: G01N15/00 ,  G01N21/64

Abstract: Systems and methods for performing measurements of one or more materials are provided. One system is configured to transfer one or more materials to an imaging volume 5 of a measurement device from one or more storage vessels. Another system is configured to image one or more materials in an imaging volume of a measurement device. An additional system is configured to substantially immobilize one or more materials in an imaging volume of a measurement device. A further system is configured to transfer one or more materials to an imaging volume of a measurement device from one or more storage vessels, to image 10 the one or more materials in the imaging volume, to substantially immobilize the one or more materials in the imaging volume, or some combination thereof. m N m j0 C-C) I!' a_ Lij ED)L m i - - - -- -- - - - -- - -- - - -- :

公开(公告)号：AU2010202161B2

公开(公告)日：2012-02-09

申请号：AU2010202161

申请日：2010-05-27

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

Abstract: C:\NRPortbr\DCC\AXL\298067_ .DOC-27A5/2010 Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during 5 measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a 10 temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature. ,-26 28-> 34 32->3 \ \/ ~2 0 16 Fig. 1 3072~ , *:27 - , ~ 3512 V . __ _ _ _ 1 2 3 41 6 G 7 9 0 10 11 12 13 14 16 16 17 18 10 Z) 21 Tonlpara~ire Index Fig2

公开(公告)号：AU2010202160A1

公开(公告)日：2010-06-17

申请号：AU2010202160

申请日：2010-05-27

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

Abstract: A method for controlling one or more parameters of a flow cytometer type measurement system, is disclosed. The comprises the following steps - measuring a time in which a microsphere (10) travels from a first detection window of the flow cytometer type measurement system to a second detection window of the measurement system; and - altering an applied pressure of the measurement system such that the time is substantially constant.

公开(公告)号：CA2767108C

公开(公告)日：2013-10-22

申请号：CA2767108

申请日：2004-08-13

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/10 ,  G01N15/14

Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

公开(公告)号：CA2767032C

公开(公告)日：2013-02-19

申请号：CA2767032

申请日：2004-08-13

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/10 ,  G01N15/14

Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

公开(公告)号：AU2010202162A1

公开(公告)日：2010-06-17

申请号：AU2010202162

申请日：2010-05-27

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

Abstract: A method for controlling one or more parameters of a flow cytometer type measurement system, is disclosed. The comprises the following steps - measuring a time in which a microsphere (10) travels from a first detection window of the flow cytometer type measurement system to a second detection window of the measurement system; and - altering an applied pressure of the measurement system such that the time is substantially constant.

公开(公告)号：CA2979457A1

公开(公告)日：2010-01-21

申请号：CA2979457

申请日：2009-07-17

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D

IPC: G01N15/00

Abstract: Methods and systems are provided which include configurations for the reassigning unit locations of a classification matrix at which two or more classification regions overlap as non-classification regions. In addition, methods and systems are provided which include configurations for mathematically creating classification regions which may be characterized by values which more accurately correspond to measured values of particles. Other embodiments of methods and systems include configurations for acquiring data corresponding to measurable parameters of a particle and identifying a location within a classification matrix to which at least some of the data corresponds. Such methods and systems further include configurations for translating either the data corresponding to the identified unit location or a target space located at known locations within the classification matrix a preset number of predetermined coordinate paths until a conclusion that the particle may be classified to particular particle category or a reject class is attained.

公开(公告)号：CA2730982A1

公开(公告)日：2010-01-21

申请号：CA2730982

申请日：2009-07-17

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D

IPC: G06F17/00 ,  G01N35/00

Abstract: Methods and systems are provided which include configurations for the reassigning unit locations of a classification matrix at which two or more classification regions overlap as non-classification regions. In addition, methods and systems are provided which include configurations for mathematically creating classification regions which may be characterized by values which more accurately correspond to measured values of particles. Other embodiments of methods and systems include configurations for acquiring data corresponding to measurable parameters of a particle and identifying a location within a classification matrix to which at least some of the data corresponds. Such methods and systems further include configurations for translating either the data corresponding to the identified unit location or a target space located at known locations within the classification matrix a preset number of predetermined coordinate paths until a conclusion that the particle may be classified to particular particle category or a reject class is attained.

公开(公告)号：CA2653761A1

公开(公告)日：2007-12-13

申请号：CA2653761

申请日：2007-06-04

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  DUONG DUNG ,  COLLINS CHARLES J

IPC: G01N33/543

Abstract: Systems and methods for performing measurements of one or more materials are provided. One system is configured to transfer one or more materials to an imaging volume of a measurement device from one or more storage vessels. Another system is configured to image one or more materials in an imaging vo lume of a measurement device. An additional system is configured to substant ially immobilize one or more materials in an imaging volume of a measurement device. A further system is configured to transfer one or more materials to an imaging volume of a measurement device from one or more storage vessels, to image the one or more materials in the imaging volume, to substantially immobilize the one or more materials in the imaging volume, or some combinat ion thereof.