公开(公告)号：JP2010190910A

公开(公告)日：2010-09-02

申请号：JP2010106599

申请日：2010-05-06

Applicant: Luminex Corp ,  ルミネックス・コーポレーション

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: PROBLEM TO BE SOLVED: To provide a method for controlling one or more parameters of a flow cytometer type measurement system. SOLUTION: This method includes the step of monitoring the parameters of the measurement system during the measurement of a sample microsphere and the step of altering the parameters on the basis of monitoring in real time. A method separate from this method includes the step of monitoring the temperature in the vicinity of the measurement system, the step of altering the bias voltage of an avalanche photodiode in response to temperature using experientially led-out data, and the step of altering the output signal of a photomultiplier in response to the temperature using a characteristic curve. Some methods include the step of monitoring the temperature of a fluid wherein the sample microsphere is arranged. The fluid passes through the flow cytometer type measurement system to flow. This method also includes the step of determining the speed of the sample microsphere in the measurement system from the viscosity of the fluid at that temperature. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于控制流式细胞仪型测量系统的一个或多个参数的方法。 解决方案：该方法包括在样品微球的测量期间监测测量系统的参数的步骤以及在实时监测的基础上改变参数的步骤。 与该方法分开的方法包括监测测量系统附近的温度，使用经验性导出的数据来响应于温度改变雪崩光电二极管的偏置电压的步骤，以及改变输出的步骤 使用特性曲线响应于温度的光电倍增管的信号。 一些方法包括监测其中布置样品微球的流体的温度的步骤。 流体通过流式细胞仪型测量系统流动。 该方法还包括从该温度下的流体粘度确定测量系统中样品微球的速度的步骤。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：KR20180031642A

公开(公告)日：2018-03-28

申请号：KR20180027130

申请日：2018-03-07

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  CALVIN EDWARD A ,  COLLINS CHARLES J ,  DEICHER WILLIAM R ,  KRAGER JARDEN E ,  SCHILFFARTH ADAM R ,  JOHNSON ROSS G ,  BOZARTH COLIN D ,  SELVARAJ VICTOR ,  SMITH ERIC D ,  ARAB NICOLAS F ,  BERNARD BRUCE J C ,  CONNER DONALD A ,  ROACH ROBERT S ,  SMITH DAVID L

IPC: G01N33/543 ,  G01N15/14 ,  G01N21/05 ,  G01N21/27 ,  G01N21/64 ,  G01N35/00

CPC classification number: G01N21/05 ,  G01N15/1463 ,  G01N21/274 ,  G01N21/645 ,  G01N33/54333 ,  G01N35/00693 ,  G01N35/00732 ,  G01N35/0098 ,  G01N2015/1452 ,  G01N2021/0367 ,  G01N2021/058 ,  G01N2035/00544 ,  G01N2035/00564 ,  G01N2201/1211 ,  Y10T436/12

Abstract: 하나이상의재료의측정을수행하기위한시스템들및 방법들이제공된다. 이중하나의시스템은하나이상의저장배젤들에서측정장치의이미징볼륨으로하나이상의재료들을전송하도록구성된다. 다른시스템은측정장치의이미징볼륨내의하나이상의재료를이미징하도록구성된다. 또한추가적인시스템은측정장치의이미징볼륨내의하나이상의재료들을주로(substantially) 고정하도록구성된다. 또다른시스템은하나이상의저장배젤들에서측정장치의이미징볼륨으로하나이상의재료를상기이미징볼륨내의상기하나이상의재료들을이미징하기위하여, 상기이미징볼륨내의상기하나이상의재료들을주로고정하기위하여또는그 들의조합을위하여전송하도록구성된다.

Abstract translation: 提供了用于执行一种或多种材料的测量的系统和方法。 一个系统被配置成将一种或多种材料从一个或多个存储容器转移到测量装置的成像体积中。 另一个系统被配置成对测量装置的成像体积中的一种或多种材料成像。 另外的系统被配置成将一种或多种材料基本上固定在测量装置的成像体积中。 另一系统被构造成将一种或多种材料从一个或多个存储容器转移到测量装置的成像体积中，以对成像体积中的一种或多种材料进行成像，以基本上将一种或多种材料固定在成像体积中 或其某种组合。

公开(公告)号：WO2005017499A8

公开(公告)日：2006-07-06

申请号：PCT/US2004026225

申请日：2004-08-13

Applicant: LUMINEX CORP ,  ROTH WAYNE D ,  MOORE DOUGLAS E

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

Abstract translation: 提供了用于控制流式细胞仪型测量系统的一个或多个参数的各种方法。 一个实施例包括在样品微球的测量期间监测测量系统的参数。 该方法还包括基于监视实时更改参数。 另一种方法包括监测靠近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度来改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体样品微球的设置温度。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。

公开(公告)号：WO2008061058B1

公开(公告)日：2008-09-12

申请号：PCT/US2007084417

申请日：2007-11-12

Applicant: LUMINEX CORP ,  KRAGER JARDEN E ,  DEICHER WILLIAM R ,  SCHILFFARTH ADAM RICHARD ,  PEMPSELL PAUL ,  ROTH WAYNE D

Inventor： KRAGER JARDEN E ,  DEICHER WILLIAM R ,  SCHILFFARTH ADAM RICHARD ,  PEMPSELL PAUL ,  ROTH WAYNE D

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N21/6428 ,  G01N21/76 ,  G01N2015/1409 ,  Y10T137/0352 ,  Y10T137/85986 ,  Y10T436/2575

Abstract: A flow cytometer is provided which includes an interrogation flow cell and a plurality of assay fluidic lines extending into the interrogation flow cell. A method of operating such a flow cytometer includes priming the interrogation flow cell with a sheath fluid and injecting different assay fluids into a flow of the sheath fluid through the plurality of fluidic lines. A fluidic line assembly is provided which includes a plurality of capillary tubes coupled to a base section configured for coupling to an interrogation flow cell assembly of a flow cytometer. The capillary tubes are dimensionally configured such that when the fluidic line assembly is arranged within the flow cytometer and fluid is dispensed from one or more of the capillary tubes at a given pressure differential with respect to an encompassing sheath fluid within the interrogation flow cell the fluid is substantially centrally aligned within the interrogation flow cell.

Abstract translation: 提供流式细胞仪，其包括询问流动池和延伸到询问流动池中的多个测定流体线。 操作这种流式细胞仪的方法包括用鞘液灌注询问流动池并将不同的化验流体注入通过多条流体管线的鞘液流中。 提供流体管线组件，其包括耦合到基部的多个毛细管，所述基部被配置为耦合到流式细胞仪的询问流动池组件。 毛细管在尺寸上构造成使得当流体管线组件布置在流式细胞仪内并且流体从相对于询问流动池内的包围鞘液的给定压差从一个或多个毛细管分配时，流体 基本上在询问流动单元内居中对齐。

公开(公告)号：JP2013190434A

公开(公告)日：2013-09-26

申请号：JP2013085111

申请日：2013-04-15

Applicant: Luminex Corp ,  ルミネックス コーポレーション

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14 ,  G01N21/64

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: PROBLEM TO BE SOLVED: To provide a method for controlling parameters of a flow cytometer type measurement system.SOLUTION: In order to control parameters during measurement of a sample microsphere, a temperature proximate to a measurement system is monitored. In order to fix the length of time when the microsphere is present in a detection window, a movement velocity of the microsphere is determined by controlling a pressure applied to a sample in accordance with viscosity. A bias voltage of an avalanche photo diode used in a detector is altered in response to the temperature.

Abstract translation: 要解决的问题：提供一种用于控制流式细胞仪型测量系统的参数的方法。解决方案：为了在样品微球测量期间控制参数，监测靠近测量系统的温度。 为了确定微孔存在于检测窗口中的时间长度，通过根据粘度控制施加到样品上的压力来确定微球的移动速度。 检测器中使用的雪崩光电二极管的偏置电压随温度而变化。

公开(公告)号：JP2010210637A

公开(公告)日：2010-09-24

申请号：JP2010106598

申请日：2010-05-06

Applicant: Luminex Corp ,  ルミネックス・コーポレーション

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: PROBLEM TO BE SOLVED: To provide a method for controlling one or more parameters of a flow cytometer type measurement system. SOLUTION: This method includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于控制流式细胞仪型测量系统的一个或多个参数的方法。

解决方案：该方法包括在测量样品微球时监测测量系统的参数。 该方法还包括基于监视实时更改参数。 另一种方法包括监测靠近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度来改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体样品微球的设置温度。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2010197403A

公开(公告)日：2010-09-09

申请号：JP2010106584

申请日：2010-05-06

Applicant: Luminex Corp ,  ルミネックス・コーポレーション

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: PROBLEM TO BE SOLVED: To provide a method for controlling a component contributing to at least main error of a flow cytometer type measuring system.
SOLUTION: This method includes monitoring a parameter of the measurement system during measurement of sample microspheres and altering the parameter in real time based on the monitoring. Another method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed. The fluid flows through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于控制有助于流式细胞仪型测量系统的至少主要误差的分量的方法。

解决方案：该方法包括在测量样品微球时监测测量系统的参数，并根据监测实时更改参数。 另一种方法包括使用经验导出的数据来响应于温度改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测其中设置样品微球的流体的温度。 流体流过流式细胞仪型式测量系统。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2012127969A

公开(公告)日：2012-07-05

申请号：JP2012000147

申请日：2012-01-04

Applicant: Luminex Corp ,  ルミネックス コーポレーション

Inventor： ROTH WAYNE D

IPC: G01N21/64 ,  G06T1/00

CPC classification number: G06K9/0014 ,  G01N15/1463 ,  G06T7/0012 ,  G06T7/194 ,  G06T2207/10064 ,  G06T2207/20021 ,  G06T2207/30024 ,  G06T2207/30072

Abstract: PROBLEM TO BE SOLVED: To provide a method for image data processing, a storage medium and a system.SOLUTION: The method, the storage medium and the system comprise a configuration of executing one or a plurality of steps of: background signal measurement; particle identification using classification dye emission and cluster rejection; alignment between images; particle correlation between the images; fluorescence integration of reporter emission; and image plane normalization.

Abstract translation: 要解决的问题：提供一种用于图像数据处理的方法，存储介质和系统。 解决方案：该方法，存储介质和系统包括执行一个或多个步骤的配置：背景信号测量; 使用分类染料排放和聚类排斥的粒子鉴定; 图像之间的对齐; 图像之间的粒子相关性; 记录发光荧光一体化; 和图像平面归一化。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2012108927A

公开(公告)日：2012-06-07

申请号：JP2012000148

申请日：2012-01-04

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D

IPC: G06T1/00 ,  G01N21/64 ,  G06T3/00 ,  H04N1/04

Abstract: PROBLEM TO BE SOLVED: To provide methods, storage media, and systems for image data processing.SOLUTION: Embodiments for the methods, storage media, and systems include configurations for performing one or more of the following steps: background signal measurement; particle identification using classification dye emission and cluster rejection; inter-image alignment; inter-image particle correlation; fluorescence integration of reporter emission; and image plane normalization.

公开(公告)号：JP2010190909A

公开(公告)日：2010-09-02

申请号：JP2010106580

申请日：2010-05-06

Applicant: Luminex Corp ,  ルミネックス・コーポレーション

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: PROBLEM TO BE SOLVED: To provide a method for controlling one or more parameters of a flow cytometer type measurement system. SOLUTION: This method includes the step of monitoring the parameters of the measurement system during the measurement of a sample microsphere and the step of altering the parameters on the basis of monitoring in a real time. A method separate from this method includes the step of monitoring the temperature in the vicinity of the measurement system, the step of altering the bias voltage of an avalanche photodiode in response to temperature using experientially led-out data, and the step of altering the output signal of a photomultiplier in response to the temperature using a characteristic curve. Some methods include the step of monitoring the temperature of a fluid wherein the sample microsphere is arranged. The fluid passes through the flow cytometer type measurement system to flow. This method also includes the step of determining the speed of the sample microsphere in the measurement system from the viscosity of the fluid at that temperature. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于控制流式细胞仪型测量系统的一个或多个参数的方法。 解决方案：该方法包括在样品微球的测量期间监测测量系统的参数的步骤以及在实时监测的基础上改变参数的步骤。 与该方法分开的方法包括监测测量系统附近的温度，使用经验性导出的数据来响应于温度改变雪崩光电二极管的偏置电压的步骤，以及改变输出的步骤 使用特性曲线响应于温度的光电倍增管的信号。 一些方法包括监测其中布置样品微球的流体的温度的步骤。 流体通过流式细胞仪型测量系统流动。 该方法还包括从该温度下的流体粘度确定测量系统中样品微球的速度的步骤。 版权所有（C）2010，JPO＆INPIT