公开(公告)号：JP2010190910A

公开(公告)日：2010-09-02

申请号：JP2010106599

申请日：2010-05-06

Applicant: Luminex Corp ,  ルミネックス・コーポレーション

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: PROBLEM TO BE SOLVED: To provide a method for controlling one or more parameters of a flow cytometer type measurement system. SOLUTION: This method includes the step of monitoring the parameters of the measurement system during the measurement of a sample microsphere and the step of altering the parameters on the basis of monitoring in real time. A method separate from this method includes the step of monitoring the temperature in the vicinity of the measurement system, the step of altering the bias voltage of an avalanche photodiode in response to temperature using experientially led-out data, and the step of altering the output signal of a photomultiplier in response to the temperature using a characteristic curve. Some methods include the step of monitoring the temperature of a fluid wherein the sample microsphere is arranged. The fluid passes through the flow cytometer type measurement system to flow. This method also includes the step of determining the speed of the sample microsphere in the measurement system from the viscosity of the fluid at that temperature. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于控制流式细胞仪型测量系统的一个或多个参数的方法。 解决方案：该方法包括在样品微球的测量期间监测测量系统的参数的步骤以及在实时监测的基础上改变参数的步骤。 与该方法分开的方法包括监测测量系统附近的温度，使用经验性导出的数据来响应于温度改变雪崩光电二极管的偏置电压的步骤，以及改变输出的步骤 使用特性曲线响应于温度的光电倍增管的信号。 一些方法包括监测其中布置样品微球的流体的温度的步骤。 流体通过流式细胞仪型测量系统流动。 该方法还包括从该温度下的流体粘度确定测量系统中样品微球的速度的步骤。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2010190909A

公开(公告)日：2010-09-02

申请号：JP2010106580

申请日：2010-05-06

Applicant: Luminex Corp ,  ルミネックス・コーポレーション

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: PROBLEM TO BE SOLVED: To provide a method for controlling one or more parameters of a flow cytometer type measurement system. SOLUTION: This method includes the step of monitoring the parameters of the measurement system during the measurement of a sample microsphere and the step of altering the parameters on the basis of monitoring in a real time. A method separate from this method includes the step of monitoring the temperature in the vicinity of the measurement system, the step of altering the bias voltage of an avalanche photodiode in response to temperature using experientially led-out data, and the step of altering the output signal of a photomultiplier in response to the temperature using a characteristic curve. Some methods include the step of monitoring the temperature of a fluid wherein the sample microsphere is arranged. The fluid passes through the flow cytometer type measurement system to flow. This method also includes the step of determining the speed of the sample microsphere in the measurement system from the viscosity of the fluid at that temperature. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于控制流式细胞仪型测量系统的一个或多个参数的方法。 解决方案：该方法包括在样品微球的测量期间监测测量系统的参数的步骤以及在实时监测的基础上改变参数的步骤。 与该方法分开的方法包括监测测量系统附近的温度，使用经验性导出的数据来响应于温度改变雪崩光电二极管的偏置电压的步骤，以及改变输出的步骤 使用特性曲线响应于温度的光电倍增管的信号。 一些方法包括监测其中布置样品微球的流体的温度的步骤。 流体通过流式细胞仪型测量系统流动。 该方法还包括从该温度下的流体粘度确定测量系统中样品微球的速度的步骤。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：WO2005017499A3

公开(公告)日：2005-08-18

申请号：PCT/US2004026225

申请日：2004-08-13

Applicant: LUMINEX CORP ,  ROTH WAYNE D ,  MOORE DOUGLAS E

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

Abstract translation: 提供了用于控制流式细胞仪型测量系统的一个或多个参数的各种方法。 一个实施例包括在样品微球的测量期间监测测量系统的参数。 该方法还包括基于监视实时更改参数。 另一种方法包括监测靠近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度来改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体样品微球的设置温度。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。

公开(公告)号：WO2006055722A9

公开(公告)日：2006-11-09

申请号：PCT/US2005041701

申请日：2005-11-16

Applicant: LUMINEX CORP ,  MOORE DOUGLAS E

Inventor： MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/14 ,  G01N2015/1477

Abstract: A system and method for processing sample data from a flow analyser (420) employing hardware, such as a Field Programmable Gate Array (FPGA), to process the sample data in small pipelined steps. The processing includes a circular buffer where the read and write of data is synchronous, preventing buffer overrun or data loss. This pipeline processing approach allows increasing data acquisition channels or additional processing steps without limiting processing speed.

Abstract translation: 一种用于从采用诸如现场可编程门阵列（FPGA）之类的硬件的流量分析器（420）处理样本数据的系统和方法，用于以小流水线步骤处理样本数据。 该处理包括循环缓冲器，其中数据的读取和写入是同步的，防止缓冲区溢出或数据丢失。 该流水线处理方法允许增加数据采集通道或附加处理步骤而不限制处理速度。

公开(公告)号：WO2005017499A8

公开(公告)日：2006-07-06

申请号：PCT/US2004026225

申请日：2004-08-13

Applicant: LUMINEX CORP ,  ROTH WAYNE D ,  MOORE DOUGLAS E

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

Abstract translation: 提供了用于控制流式细胞仪型测量系统的一个或多个参数的各种方法。 一个实施例包括在样品微球的测量期间监测测量系统的参数。 该方法还包括基于监视实时更改参数。 另一种方法包括监测靠近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度来改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体样品微球的设置温度。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。

公开(公告)号：JP2013190434A

公开(公告)日：2013-09-26

申请号：JP2013085111

申请日：2013-04-15

Applicant: Luminex Corp ,  ルミネックス コーポレーション

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14 ,  G01N21/64

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: PROBLEM TO BE SOLVED: To provide a method for controlling parameters of a flow cytometer type measurement system.SOLUTION: In order to control parameters during measurement of a sample microsphere, a temperature proximate to a measurement system is monitored. In order to fix the length of time when the microsphere is present in a detection window, a movement velocity of the microsphere is determined by controlling a pressure applied to a sample in accordance with viscosity. A bias voltage of an avalanche photo diode used in a detector is altered in response to the temperature.

Abstract translation: 要解决的问题：提供一种用于控制流式细胞仪型测量系统的参数的方法。解决方案：为了在样品微球测量期间控制参数，监测靠近测量系统的温度。 为了确定微孔存在于检测窗口中的时间长度，通过根据粘度控制施加到样品上的压力来确定微球的移动速度。 检测器中使用的雪崩光电二极管的偏置电压随温度而变化。

公开(公告)号：JP2010210637A

公开(公告)日：2010-09-24

申请号：JP2010106598

申请日：2010-05-06

Applicant: Luminex Corp ,  ルミネックス・コーポレーション

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: PROBLEM TO BE SOLVED: To provide a method for controlling one or more parameters of a flow cytometer type measurement system. SOLUTION: This method includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于控制流式细胞仪型测量系统的一个或多个参数的方法。

解决方案：该方法包括在测量样品微球时监测测量系统的参数。 该方法还包括基于监视实时更改参数。 另一种方法包括监测靠近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度来改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体样品微球的设置温度。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2010197403A

公开(公告)日：2010-09-09

申请号：JP2010106584

申请日：2010-05-06

Applicant: Luminex Corp ,  ルミネックス・コーポレーション

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: PROBLEM TO BE SOLVED: To provide a method for controlling a component contributing to at least main error of a flow cytometer type measuring system.
SOLUTION: This method includes monitoring a parameter of the measurement system during measurement of sample microspheres and altering the parameter in real time based on the monitoring. Another method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed. The fluid flows through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于控制有助于流式细胞仪型测量系统的至少主要误差的分量的方法。

解决方案：该方法包括在测量样品微球时监测测量系统的参数，并根据监测实时更改参数。 另一种方法包括使用经验导出的数据来响应于温度改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测其中设置样品微球的流体的温度。 流体流过流式细胞仪型式测量系统。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：WO2006055722B1

公开(公告)日：2006-07-27

申请号：PCT/US2005041701

申请日：2005-11-16

Applicant: LUMINEX CORP ,  MOORE DOUGLAS E

Inventor： MOORE DOUGLAS E

IPC: G01N15/14

CPC classification number: G01N15/14 ,  G01N2015/1477

Abstract: A system and method for processing sample data from a flow analyser (420) employing hardware, such as a Field Programmable Gate Array (FPGA), to process the sample data in small pipelined steps. The processing includes a circular buffer where the read and write of data is synchronous, preventing buffer overrun or data loss. This pipeline processing approach allows increasing data acquisition channels or additional processing steps without limiting processing speed.

Abstract translation: 一种用于处理来自采用诸如现场可编程门阵列（FPGA）之类的硬件的流量分析器（420）的采样数据以在小流水线步骤中处理采样数据的系统和方法。 处理包括一个循环缓冲区，数据的读写是同步的，防止缓冲区溢出或数据丢失。 这种流水线处理方法允许增加数据采集通道或额外的处理步骤而不限制处理速度。

公开(公告)号：AU2010202159B2

公开(公告)日：2012-06-21

申请号：AU2010202159

申请日：2010-05-27

Applicant: LUMINEX CORP

Inventor： ROTH WAYNE D ,  MOORE DOUGLAS E

IPC: G01N15/14

Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during 5 measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a 10 temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.