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    SYSTEM FOR GENETICALLY TREATING CARDIAC CONDUCTION DISTURBANCES
    41.
    发明专利
    SYSTEM FOR GENETICALLY TREATING CARDIAC CONDUCTION DISTURBANCES 未知

    公开(公告)号：CA2260756C

    公开(公告)日：2007-07-10

    申请号：CA2260756

    申请日：1997-04-04

    Applicant: MEDTRONIC INC

    Inventor： MORISSETTE JOSEE ,  STOKES KENNETH B

    IPC: A61M5/00 ,  A61K31/70 ,  A61K38/17 ,  A61K48/00 ,  A61M5/32 ,  A61M25/00 ,  C07K14/705

    Abstract: The present invention provides delivery systems for delivering conduction protein genetic material to cardiac cells in localized areas of the heart to improve the conductance therein. More specifically, there is provided a system for delivering connexin proteins or nucleic acid molecules encoding connexin proteins to a site in the heart which has been determined by mapping procedures to have a conduction disturbance. For cases where conduction is impaired, selected genetic materi al is delivered by Applicants' delivery system to cells around the disturbance area, in order to enhance overall conductivity patterns; in other cases, genetic material is selected to slow conduction in affected areas, so as to prevent, e.g., brady-tachy syndrome.

    43.
    发明专利
    未知

    公开(公告)号：DE69514126T2

    公开(公告)日：2000-09-28

    申请号：DE69514126

    申请日：1995-02-01

    Applicant: MEDTRONIC INC

    Inventor： MCVENES RICK D ,  POHNDORF PETER J ,  STOKES KENNETH B ,  PROCTOR KEITH J

    IPC: A61N1/05

    Abstract: A chronic myocardial pacing lead for the delivery of stimulation energy to and the sensing of electrical signals from the myocardium of a human heart. In one embodiment the lead is bipolar, having a sleeve electrode (20) implanted into the myocardium and a pad electrode (15) positioned on the epicardium. The lead includes a drug for delivery through the sleeve electrode to the myocardium. The disclosed lead is highly flexible to minimize tissue reaction, this permits the lead to offer relatively low pacing thresholds, high impedance, and excellent sensing in a configuration which is relatively easy to implant.

    FLOATING MYOCARDIAL ELECTRODE FOR IMPLANTABLE PULSE GENERATOR
    48.
    发明专利
    FLOATING MYOCARDIAL ELECTRODE FOR IMPLANTABLE PULSE GENERATOR 未知

    公开(公告)号：CA2182609A1

    公开(公告)日：1995-08-10

    申请号：CA2182609

    申请日：1994-12-19

    Applicant: MEDTRONIC INC

    Inventor： STOKES KENNETH B ,  PROCTOR KEITH J ,  MCVENES RICK D

    IPC: A61N1/05

    Abstract: An implantable lead (10) for establishing electrical contact between a medical device and body tissue, in which an active fixation mechanism (18) secures the lead (10) in place while allowing a distal electrode (14) on the lead to mechanically "float" with respect to the body tissue. In one embodiment, the active fixation mechanism (18) comprises a curved hook disposed on the lead (10) at a point spaced proximally back from the distal end (14) of the lead (10). The curved hook (18) defines a helix around at least a portion of the lead's circumference. A hollow introducer needle is slidably disposed on the lead (10). The hollow needle is provided with a longitudinal slit in a distal section of its length, such that the distal section of the needle can be advanced over the distal end (14) the lead (10), past the fixation hook, which is received in the longitudinal slit. With the needle slid over the distal end (14) of the lead (10), the needle is stabbed angentially into an implant site, bringing the fixation hook (18) proximal to the surface of the body tissue. Then, the needle is twisted (bringing about a twisting of the lead (10)), causing the curved fixation hook (18) to pierce and engage the body tissue, securing the lead (10) in place. Then the needle is withdrawn from the body tissue and removed from the lead (10). In an alternative embodiment, the lead (10) can be placed by an endocardial approach using a flexible cannula with a longitudinally slotted tip.

    TOOL-LESS THREADED CONNECTOR ASSEMBLY
    50.
    发明专利
    TOOL-LESS THREADED CONNECTOR ASSEMBLY 未知

    公开(公告)号：CA2093940A1

    公开(公告)日：1993-11-07

    申请号：CA2093940

    申请日：1993-04-13

    Applicant: MEDTRONIC INC

    Inventor： STOKES KENNETH B ,  COMBEN RICHARD H

    IPC: A61N1/375 ,  A61N1/04

    Abstract: TOOL-LESS TREADED CONNECTOR ASSEMBLY A lead connection suitable for use in connecting a flexible coiled lead to an implantable device. The implantable device is provided with a threaded projection having an outer diameter sized with respect to the inner diameter of the lead's conductor coil to provide a secure interconnection therewith when attached thereto. The threaded projection is disposed on top and around a feedthrough pin projecting out of the implanted device's hermetic canister. The threaded projection is screwed into the conductor coil establishing sound electrical contact between the projection and the conductor. A strain relief collar surrounds the post and lead, and a twist-and-pull type connecting ring surrounds the base of the strain relief collar. The connecting post is prevented from being unscrewed from the conductor coil, since an unscrewing motion tends to tighten the conductor coil around the threaded post. Since no connecting structure is required at the connecting end of the lead, the lead can be cut to any appropriate length at the time of implant, thereby eliminating problems with excess implanted lead. If disconnection is required, the lead may be simply cut off just beyond the threaded connecting post, or the post may be unscrewed by applying inward radial or circumferential pressure on the conductor coils. In an alternative embodiment, the threaded projection is replaced with a tapered triangular post with either smooth or toothed edges, which is inserted into the coiled conductor lead.

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