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    New benzothiazolyl derivatives useful for the treatment of diabetes, cardiovascular disorders, psoriasis, dementia, osteoporosis, inflammation, obesity, anorexia, bulimia, hormono-dependent cancers and other disorders
    44.
    发明专利
    New benzothiazolyl derivatives useful for the treatment of diabetes, cardiovascular disorders, psoriasis, dementia, osteoporosis, inflammation, obesity, anorexia, bulimia, hormono-dependent cancers and other disorders 未知

    公开(公告)号：FR2830012A1

    公开(公告)日：2003-03-28

    申请号：FR0112205

    申请日：2001-09-21

    Applicant: SERVIER LAB

    Inventor： LESIEUR DANIEL ,  BLANC DELMAS ELODIE ,  BENNEJEAN CAROLINE ,  CHAVATTE PHILIPPE ,  GUILLAUMET GERALD ,  DACQUET CATHERINE ,  LEVENS NIGEL ,  BOUTIN JEAN ALBERT ,  RENARD PIERRE

    IPC: A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/10 ,  A61P35/00 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  A61K31/428

    Abstract: Benzothiazolyl derivatives (I), their enantiomers, diastereoisomers, and addition salts with acids and bases. Benzothiazolyl derivatives of formula (I), their enantiomers, diastereoisomers, and addition salts with acids and bases. X = O, S, CH2 or is CH linked to R ; Y = O or S; R and R = H, alkyl, aralkyl, aryloxy, arylalkyloxy, alkoxy, OH, amino, mono- and di-alkylamino; or R +R = oxo, thioxo, or imino; A = alkylene in which one methylene group may be replaced by O, S, or NH, N-alkyl, phenylene or naphthylene; B = alkylene, alkenylene, or alkynylene; D and D' = a benzene or pyridine ring, optionally substituted by 1-3 halo, CN, NO2, R, OR, -S(O)n-R, C(Z)R, -CH(OR)-R', C(Z)OR, NRR', C(Z)NRR', -CR=N-OR, -NR-C(Z)R', -NR-C(Z)OR', and OC(Me)2-COOR; R and R' = H, alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl, heteroarylalkyl, cycloalkyl, or cycloalkyl alkyl; Z = O or S; n = 0-2; R and R = H, halo, R, OR, or NRR'; or R +R = 5-6 membered ring that may contain O, N, or S; R = H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkylcarbonyl, arylcarbonyl, or heteroaryl carbonyl, all of which may be substituted by one or more R , -CH2CHR R , -CH=CR R , halo, OH, NO2, CN, NH2 or alkoxy; R = -(CH2)t-C(=Z)Z'; t = 0-6; Z' = OR or NRR'; R and R = -C(=Z)Z' Where alkyl, alkoxy, alkylene, alkenyl, alkynyl, alkenylene and alkynylene groups have 1-6 C atoms, cycloalkyl groups have 3-8 C atoms, aryl means phenyl, naphthyl, or biphenyl, optionally partially hydrogenated, heteroaryl groups have one or two rings containing 5-10 members, optionally partially hydrogenated and containing 1-3 O, N and/or S atoms, and the aryl and heteroaryl groups may be substituted by 1-3 groups selected from alkyl, alkoxy, carboxy, formyl, amino, mono- and dialkylamino, ester, amido, NO2, CN, and OC(Me)2COOR.

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