公开(公告)号：WO0009255A3

公开(公告)日：2000-11-23

申请号：PCT/US9918358

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC ,  TURNER HOWARD ,  DALES G CAMERON ,  ERDEN LYNN VAN ,  BEEK JOHANNES A M VAN ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G05B23/02 ,  G05D21/00 ,  G01K17/00 ,  G01L5/00 ,  G01L7/00 ,  G01N7/00 ,  G01N11/00 ,  G01N21/64 ,  G01N29/00

CPC classification number: G01N21/253 ,  B01F13/065 ,  B01F13/08 ,  B01F15/00207 ,  B01F15/00357 ,  B01F15/00396 ,  B01J19/0006 ,  B01J19/0013 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00029 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00333 ,  B01J2219/00335 ,  B01J2219/00351 ,  B01J2219/00367 ,  B01J2219/00373 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/54 ,  B01L2200/026 ,  B01L2300/049 ,  B01L2300/06 ,  B01L2300/0627 ,  B01L2300/14 ,  B01L2300/1805 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  Y10T436/11

Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also for conventional experimental reactors as well. The apparatus generally includes multiple vessels (102, 206, 236, 266, 338, 362, 396, 522, 710, 876, 912, 1286, 1542) for containing reaction mixtures, and systems (180, 230, 260, 270, 272, 500, 1544, 1546, 1548, 1604) for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system (146, 1002) for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers (160, 268, 678, 720, 928, 1500, 1508, 1604), and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

Abstract translation: 公开了用于控制和监测多个反应的进展和性质的装置和方法。 该方法和装置对于组合文库的合成，筛选和表征特别有用，而且对于常规实验反应器也是特别有用的。 该装置通常包括用于容纳反应混合物的多个容器（102,206,236,266,338,362,396,526,710,876,912,1286,1542）和系统（180,230,260,270,272 ，500,1544,1546,1548,1604），用于控制各个反应混合物或反应混合物组的搅拌速率和温度。 此外，该装置可以包括用于独立地控制每个容器中的压力的​​设备，以及用于以不同于环境压力的压力将液体注入到容器中的系统（146,1002）。 单独反应混合物的原位监测为过程控制器（160,268,678,720,928,1500,1508,1604）提供反馈，并且还提供用于确定反应速率，产物产率和反应产物的各种性质的数据， 包括粘度和分子量。 公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。

公开(公告)号：WO2006107900A2

公开(公告)日：2006-10-12

申请号：PCT/US2006012374

申请日：2006-03-31

Applicant: SYMYX TECHNOLOGIES INC ,  CYPES STEPHEN ,  UHRICH MARK ,  CARLSON ERIC D ,  KOLOSOV OLEG ,  PADOWITZ DAVID ,  BENNETT JAMES ,  MATSIEV LEONID

Inventor： CYPES STEPHEN ,  UHRICH MARK ,  CARLSON ERIC D ,  KOLOSOV OLEG ,  PADOWITZ DAVID ,  BENNETT JAMES ,  MATSIEV LEONID

IPC: G01N29/02 ,  G01N9/00 ,  G01N11/10 ,  G01N27/00 ,  G01N29/036 ,  G01N29/22

CPC classification number: B01D5/009 ,  B01D3/00 ,  B01D3/06 ,  B01D3/14 ,  B01D3/22 ,  B01D3/322 ,  B01J19/0006 ,  B01J2219/00191 ,  G01N9/002 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N2291/0226 ,  G01N2291/0253 ,  G01N2291/0254 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2291/101 ,  G01N2291/106

Abstract: Fluid sensor methods and systems adapted for monitoring and/or controlling distillation operations in fluidic systems, such as batch distillation operations or continuous distillation operations, are disclosed. Preferred embodiments are directed to process monitoring and/or process control for unit operations involving endpoint determination of a distillation, for example, as applied to a liquid-component-switching operation (e.g., a solvent switching operation), a liquid-liquid separation operation, a solute concentration operation, a dispersed-phase concentration operation, among others.

Abstract translation: 公开了用于监测和/或控制流体系统中的蒸馏操作的流体传感器方法和系统，例如间歇式蒸馏操作或连续蒸馏操作。 优选的实施方案涉及涉及终点确定蒸馏的单元操作的过程监控和/或过程控制，例如应用于液体成分切换操作（例如，溶剂切换操作），液 - 液分离操作 溶质浓缩操作，分散相浓缩操作等。

公开(公告)号：WO2004086020A3

公开(公告)日：2005-03-24

申请号：PCT/US2004008555

申请日：2004-03-19

Applicant: SYMYX TECHNOLOGIES INC ,  KOLOSOV OLEG V ,  GAMMER VLADIMIR ,  MATSIEV LEONID ,  SPITOVSY MIKHAIL B

Inventor： KOLOSOV OLEG V ,  GAMMER VLADIMIR ,  MATSIEV LEONID ,  SPITOVSY MIKHAIL B

IPC: G01N9/00 ,  G01N27/00 ,  G01N33/28

CPC classification number: G01N33/28 ,  G01N2291/0427

Abstract: A circuit for determining characteristics of a fluid under-test is provided. The circuit includes analog-to-digital processing circuitry for interfacing with a sensor and host electronics. The analog-to-digital processing circuitry includes a frequency generator for providing stimulus to the sensor and receiving a response signal from the sensor. Conditioning circuitry for reducing analog signal offsets in the response signal and signal detection circuitry for identifying amplitude data of the response signal are provided. Further provided is analog-to-digital conversion circuitry for converting the detected amplitude data into digital form. Memory for holding calibration data and approximated fluid characteristics of the fluid under-test is included in the circuitry. The digital form of the response signal is processed in conjunction with the calibration data and approximated fluid characteristics to generate fluid characteristics of the actual fluid under-test. In other disclosed embodiments, the fluid characteristics can be obtained directly from a processed signal, which is differentially processed through a compensation device that is actively controlled by circuitry. In this alternative embodiment, curve fitting processing is not needed, as the processed signal itself provides the information that identifies the fluid characteristics for the fluid under-test.

Abstract translation: 提供了一种用于确定待测流体特性的电路。 该电路包括用于与传感器和主机电子设备进行接口的模数转换处理电路。 模数处理电路包括用于向传感器提供刺激并从传感器接收响应信号的频率发生器。 提供了用于减少响应信号中的模拟信号偏移的调节电路和用于识别响应信号的幅度数据的信号检测电路。 还提供了用于将检测到的幅度数据转换成数字形式的模数转换电路。 用于保持校准数据的存储器和被测流体的近似流体特性包括在电路中。 响应信号的数字形式结合校准数据和近似流体特性进行处理，以产生实际待测液体的流体特性。 在其他公开的实施例中，流体特性可以直接从经由由电路主动控制的补偿装置进行差分处理的处理信号获得。 在该替代实施例中，不需要曲线拟合处理，因为处理的信号本身提供识别流体未被测试的流体特性的信息。

公开(公告)号：WO2004036207A3

公开(公告)日：2004-09-02

申请号：PCT/US0332983

申请日：2003-10-17

Applicant: SYMYX TECHNOLOGIES INC ,  MATSIEV LEONID ,  VARNI JOHN F ,  KOLOSOV OLEG ,  UHRICH MARK D ,  FELAND JOHN

Inventor： MATSIEV LEONID ,  VARNI JOHN F ,  KOLOSOV OLEG ,  UHRICH MARK D ,  FELAND JOHN

IPC: F25B49/00 ,  G01N3/56 ,  G01N9/00 ,  G01N11/00 ,  G01N11/10 ,  G01N11/16 ,  G01N19/02 ,  G01N27/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/22 ,  G01N29/30 ,  G01N29/34 ,  G01N29/44 ,  G01N33/487

CPC classification number: G01N29/343 ,  G01N9/002 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N29/223 ,  G01N29/228 ,  G01N29/30 ,  G01N2009/006 ,  G01N2291/014 ,  G01N2291/0226 ,  G01N2291/0253 ,  G01N2291/0254 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0422 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2291/101

Abstract: A sensor system and method for analyzing a fluid contained within an environmental control system (100), comprising the steps of providing a system (100) including a passage for containing a thermal change fluid; placing a sensor (108) including a mechanical resonator in the passage; operating the resonator to have at least a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. A preferred sensor includes a tuning fork resonator.

Abstract translation: 一种用于分析环境控制系统（100）中包含的流体的传感器系统和方法，包括以下步骤：提供包括用于容纳热变换流体的通道的系统（100） 将包括机械谐振器的传感器（108）放置在所述通道中; 操作所述谐振器以使其至少一部分翻转通过所述流体; 以及监测谐振器对通道中流体的响应。 优选的传感器包括音叉谐振器。

公开(公告)号：WO2007005528A2

公开(公告)日：2007-01-11

申请号：PCT/US2006025385

申请日：2006-06-29

Applicant: SYMYX TECHNOLOGIES INC ,  UNIVATION TECH LLC ,  BURDETT IAN ,  LYNN TIMOTHY ,  KOLOSOV OLEG ,  ZILKER DANIEL PAUL JR ,  MATSIEV LEONID

Inventor： BURDETT IAN ,  LYNN TIMOTHY ,  KOLOSOV OLEG ,  ZILKER DANIEL PAUL JR ,  MATSIEV LEONID

IPC: F27B15/18 ,  F27B15/20 ,  G01H3/06

CPC classification number: F27D19/00 ,  B01J8/1809 ,  B01J2208/00274 ,  B01J2219/002 ,  B01J2219/00247 ,  B01J2219/00254 ,  C08F10/00 ,  C08F2400/02 ,  F27B15/20 ,  F27D21/00 ,  G01N2291/0427 ,  C08F2/00 ,  C08F2/34

Abstract: Particle and multi-phase system monitoring methods, systems and apparatus are disclosed. Preferred embodiments comprise one or more mechanical resonator sensing elements. In preferred embodiments a sensor or a sensor subassembly is ported to a fluidized bed vessel such as a fluidized bed polymerization reactor.

Abstract translation: 公开了粒子和多相系统监测方法，系统和装置。 优选实施例包括一个或多个机械谐振器感测元件。 在优选实施例中，传感器或传感器子组件移入流化床容器，例如流化床聚合反应器。

公开(公告)号：WO2004086027A3

公开(公告)日：2005-06-09

申请号：PCT/US2004008526

申请日：2004-03-19

Applicant: SYMYX TECHNOLOGIES INC ,  PADOWITZ DAVID ,  MATSIEV LEONID ,  KOLOSOV OLEG

Inventor： PADOWITZ DAVID ,  MATSIEV LEONID ,  KOLOSOV OLEG

IPC: G01N9/00 ,  G01N24/00 ,  G01N27/00 ,  G01N29/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/22 ,  G01N33/28 ,  G01N35/00 ,  G01N35/08 ,  H03H3/02

CPC classification number: G01N29/036 ,  G01N29/022 ,  G01N29/222 ,  G01N35/085 ,  G01N2035/00237 ,  G01N2291/0224 ,  G01N2291/0226 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0422 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2291/101

Abstract: A sensor and methods for making and using the same in which a mechanical resonator is employed, comprising a resonator portion for resonating in a fluid without the substantial generation of acoustic waves; and an electrical connection between the resonator portion for oscillating and a source of an input signal; wherein the portion for resonating, the electrical connection or both includes a base material and a performance-tuning material that is different from the base material.

Abstract translation: 一种用于制造和使用机械谐振器的传感器及其使用方法，包括用于在流体中谐振而不产生大量声波的谐振器部分; 以及用于振荡的谐振器部分和输入信号源之间的电连接; 其中用于谐振的部分，电连接或两者包括基材和不同于基材的性能调节材料。

公开(公告)号：WO2004036191B1

公开(公告)日：2004-07-08

申请号：PCT/US0332982

申请日：2003-10-17

Applicant: SYMYX TECHNOLOGIES INC ,  MATSIEV LEONID ,  BENNETT JAMES ,  PINKAS DANIEL M ,  SPITKOVSKY MIKHAIL ,  KOLOSOV OLEG ,  GUAN SHENHENG

Inventor： MATSIEV LEONID ,  BENNETT JAMES ,  PINKAS DANIEL M ,  SPITKOVSKY MIKHAIL ,  KOLOSOV OLEG ,  GUAN SHENHENG

IPC: G01F23/296 ,  G01N9/00 ,  G01N11/16 ,  G01N29/036 ,  G01N29/34 ,  G01N29/02

CPC classification number: F02D41/021 ,  F02D2200/0611 ,  F02D2250/11 ,  G01F23/2966 ,  G01N9/002 ,  G01N11/16 ,  G01N29/022 ,  G01N29/036 ,  G01N29/30 ,  G01N29/348 ,  G01N2291/014 ,  G01N2291/0226 ,  G01N2291/02416 ,  G01N2291/02818 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

Abstract: A method for analyzing a fluid contained within a machine, comprising the steps of providing a machine system (100) including a passage (104) for containing a fluid; placing a sensor (106) including a mechanical resonator in the passage; operating the resonator to have a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. One specific sensor includes a tuning fork resonator.

Abstract translation: 一种用于分析包含在机器内的流体的方法，包括提供包括用于容纳流体的通道（104）的机器系统（100）的步骤; 将包括机械谐振器的传感器（106）放置在所述通道中; 操作谐振器以使其一部分翻转通过流体; 以及监测谐振器对通道中流体的响应。 一个具体的传感器包括音叉谐振器。

公开(公告)号：EP1021711A4

公开(公告)日：2000-07-26

申请号：EP97945564

申请日：1997-10-08

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MCFARLAND ERIC ,  MATSIEV LEONID

IPC: B01J19/00 ,  C07B61/00 ,  C07F15/00 ,  C07F15/04 ,  C08F10/00 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N3/00 ,  G01N9/00 ,  G01N21/21 ,  G01N21/25 ,  G01N21/64 ,  G01N21/66 ,  G01N29/02 ,  G01N29/036 ,  G01N29/24 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  G01N33/53 ,  G01N33/543 ,  H01J49/00 ,  H01J49/04 ,  H03H9/19 ,  G01N29/06

CPC classification number: G01N29/2425 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00583 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C40B20/08 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/12 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N9/002 ,  G01N11/16 ,  G01N21/211 ,  G01N21/253 ,  G01N21/6402 ,  G01N21/6452 ,  G01N21/66 ,  G01N25/4813 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2418 ,  G01N29/30 ,  G01N29/348 ,  G01N29/42 ,  G01N29/4418 ,  G01N29/4427 ,  G01N31/10 ,  G01N2009/006 ,  G01N2203/0094 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/02827 ,  G01N2291/02863 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0427 ,  G01N2291/106 ,  H01J49/0409 ,  H01J49/0468

Abstract: Methods and apparatus for screening diverse arrays of materialsa nd for imaging a library of materials are provided using ultrasonic imaging techniques. Systems include tranducer lens (109) or mechanical resonator for exiting an element of library deposited onto a substrate (103) such that acoustic waves are propagated through, and from, the library element (101). The acoustic waves propagated from the element are detected and processed to yield a visual image of the library element; such acoustic wave data is processed to obtain information about various properties of the library elements (e.g. elasticity, molecular weight, viscosity, specific weight, dielectric properties, conductivity, etc.) of individual liquid elements. Acoustic waves are generated in an imaging tank filled with coupling liquid (107), with the library of materials then placed in the tank while the surface of the coupling liquid is scanned with a laser beam. The physical structure of the liquid surface distubed by these acoustic waves is recorded.