公开(公告)号：EP1700852A4

公开(公告)日：2009-07-22

申请号：EP04807296

申请日：2004-12-17

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  IWAMOTO KEIJI ,  HARADA TAKASHI

IPC: C07D309/06 ,  C07B61/00

CPC classification number: C07D309/06

Abstract: A process for producing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropionate compound represented by the formula (1): (1) (wherein R1 and R2 may be the same or different and each represents a group not participating in the reaction, provided that R1 and R2 may be bonded to each other to form a ring optionally containing a heteroatom therein; and R3 represents a hydrocarbon group), characterized by reacting a 4-acyltetrahydropyran represented by the formula (2): (2) (wherein R1 and R2 have the same meanings as defined above) with a carbonic diester represented by the formula (3): (3) (wherein R3 has the same meaning as defined above, provided that the two R3's may be bonded to each other to form a ring) in the presence of a base. Also provided is a process for producing the 4-acyltetrahydropyran.

Abstract translation: 一种制备式（1）代表的3-（4-四氢吡喃基）-3-氧代丙酸烷基酯化合物的方法：（1）（其中R1和R2可以相同或不同，各自代表不参与反应的基团 （2）表示的4-酰基四氢吡喃的特征在于：（2）（式中，R 1和R 2可以相互结合而形成任选含有杂原子的环，R 3表示烃基） （3）表示的碳酸二酯：（3）（式中，R 3与上述定义相同，条件是两个R 3可以相互键合形成），其中R 1和R 2具有与上述定义相同的含义。 一个环）在一个基地的存在。 还提供了生产4-酰基四氢吡喃的方法。

公开(公告)号：EP1671937A4

公开(公告)日：2007-08-08

申请号：EP04773267

申请日：2004-09-17

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  IWAMOTO KEIJI ,  HARADA TAKASHI

IPC: C07C51/38 ,  B01J23/06 ,  B01J23/745 ,  B01J25/02 ,  B01J27/128 ,  B01J27/138 ,  B01J31/22 ,  C07B61/00 ,  C07C51/00 ,  C07C53/08 ,  C07C253/30 ,  C07C255/03 ,  C07D309/08

CPC classification number: C07C253/30 ,  C07C51/00

Abstract: A method for producing a nitrile compound, a carboxylic acid compound or a carboxylate compound represented by the general formula (2): (2) (wherein R, R and R are as defined below) is characterized in that an acetic acid compound represented by the general formula (1) (wherein R represents a cyano group, a carboxyl group or an ester group; R and R respectively represent a group which may have a substituent and does not take part in the reaction; and R and R may combine together to form a ring) is decarboxylated in the presence of a metal catalyst.

公开(公告)号：EP1533307A4

公开(公告)日：2006-06-21

申请号：EP03736125

申请日：2003-06-10

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  SUZUKI SHINOBU

IPC: C07D309/12

CPC classification number: C07D309/12

Abstract: A process for producing tetrahydropyran-4-ol, characterized by comprising: a cyclization step in which 3-buten-1-ol, a formaldehyde compound, and formic acid are reacted to form tetrahydropyranyl 4-formate, which is represented by the formula (1); (1) and a solvolysis step in which the tetrahydropyranyl 4-formate is solvoyzed to form tetrahydropyran-4-ol, which is represented by the formula (2).

公开(公告)号：EP1481971A4

公开(公告)日：2006-03-08

申请号：EP03703218

申请日：2003-02-06

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  HARADA TAKASHI ,  ODA HIROYUKI

IPC: C07D239/86 ,  C07D239/88 ,  C07D239/94

CPC classification number: C07D239/88 ,  C07D239/94

Abstract: Quinazolin-4-one or a derivative thereof is reacted with a chlorinating agent in a first organic solvent in the presence of an organic base. Subsequently, the reaction product is reacted with an amine compound represented by the formula R5-NH-R6 (R5 and R6 each represents hydrogen or an optionally substituted hydrocarbon group) in the presence of a second organic solvent. Thus, a 4-aminoquinazoline derivative can be obtained.

Abstract translation: 喹唑啉-4-酮或其衍生物与氯化剂在第一有机溶剂中在有机碱存在下反应。 随后，在第二有机溶剂存在下，使反应产物与式R5-NH-R6表示的胺化合物（R5和R6各自表示氢或任选取代的烃基）反应。 因此，可以获得4-氨基喹唑啉衍生物。

公开(公告)号：EP1477481A4

公开(公告)日：2005-06-15

申请号：EP03703066

申请日：2003-01-28

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  HARADA TAKASHI ,  ODA HIROYUKI ,  TAKAHASHI TAKESHI ,  SUZUKI SHINOBU

IPC: C07C201/08 ,  C07C205/59 ,  C07C205/60 ,  C07C227/04 ,  C07C229/56 ,  C07C229/64 ,  C07D239/88 ,  C07D239/90

CPC classification number: C07D239/88 ,  C07C67/31 ,  C07C69/92 ,  C07C201/08 ,  C07C205/59 ,  C07C205/60 ,  C07C227/04 ,  C07C229/56 ,  C07C229/64 ,  C07D239/90

Abstract: A process for producing a quinazolin-4-one derivative represented by the following formula (2): (2) (wherein R1, R2, R3, and R4 each represents a group not participating in the reaction and R1, R2, R3, and R4 may be bonded to each other to form a ring) which comprises reacting an anthranilic acid derivative represented by the following formula (1): (1) (wherein R5 represents hydrogen or a hydrocarbon group) with a formic acid derivative in the presence of an ammonium carboxylate.