公开(公告)号：CA2648503C

公开(公告)日：2013-12-17

申请号：CA2648503

申请日：2007-04-06

Applicant: DAIICHI SANKYO CO LTD ,  UBE INDUSTRIES

Inventor： INOUE TERUHIKO ,  NAKAMURA KAZUYOSHI ,  HAGIHARA MASAHIKO ,  MIYATA HIROYUKI ,  WADA YUKINORI ,  YOKOTA NAOYUKI

IPC: C07D495/04 ,  A61K31/4365 ,  A61P7/02

Abstract: Prasugrel hydrochloride reduced in OXTP content. A process for producing prasugrel hydrochloride reduced in OXTP content is provided which comprises dissolving OXTP-containing prasugrel in a free form in an inert solvent and dropwise or otherwise adding hydrochloric acid thereto to react them.

公开(公告)号：CA2679925C

公开(公告)日：2012-10-02

申请号：CA2679925

申请日：2008-02-29

Applicant: DAIICHI SANKYO CO LTD ,  UBE INDUSTRIES

Inventor： MIYATA HIROYUKI ,  WADA YUKINORI ,  YOKOTA NAOYUKI

IPC: C07D495/04 ,  A61K31/4365 ,  A61P7/02

Abstract: An object of the present invention is to provide prasugrel hydrochloride with a reduced content of CATP, and the like. (see multi-step process above) In the formulae, R represents a protecting group for a hydroxyl group. A method for producing prasugrel hydrochloride represented by the above formula is provided, characterized by comprising, in step (i), controlling, at low values, the temperature during the addition, optionally dropwise, of a chlorinating agent and the reaction temperature after the addition, optionally dropwise, of the chlorinating agent.

公开(公告)号：BRPI0709739A2

公开(公告)日：2011-07-26

申请号：BRPI0709739

申请日：2007-04-06

Applicant: DAIICHI SANKYO CO LTD ,  UBE INDUSTRIES

Inventor： INOUE TERUHIKO ,  NAKAMURA KAZUYOSHI ,  HAGIHARA MASAHIKO ,  MIYATA HIROYUKI ,  WADA YUKINORI ,  YOKOTA NAOYUKI

IPC: C07D495/04 ,  A61K31/4365 ,  A61P7/02

Abstract: The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.

公开(公告)号：AU2003266617B2

公开(公告)日：2009-01-29

申请号：AU2003266617

申请日：2003-09-25

Applicant: UBE INDUSTRIES

Inventor： NISHIHARA MASAMICHI ,  SHIMIZU MOTOHISA ,  WADA YUKINORI ,  TOKUNAGA YASUNORI ,  SHIBAKAWA NOBUHIKO ,  HASEGAWA TOHRU ,  SHIRAI TOSHIYUKI ,  HAGIHARA MASAHIKO ,  SUZUKI NAOTO

IPC: C07D487/04 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P1/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention relates to pyrazole compounds represented by the formula (I): wherein R represents phenyl which may be substituted, R represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R represents H, alkyl or amino, R represents the formula (II) to (V): wherein R represents H or alkyl, R represents H, alkyl or substituted amino, R represents H or alkyl, R represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.

公开(公告)号：AU2008222000A1

公开(公告)日：2008-09-12

申请号：AU2008222000

申请日：2008-02-29

Applicant: DAIICHI SANKYO CO LTD ,  UBE INDUSTRIES

Inventor： YOKOTA NAOYUKI ,  WADA YUKINORI ,  MIYATA HIROYUKI

IPC: C07D495/04 ,  A61K31/4365 ,  A61P7/02

Abstract: An object of the present invention is to provide prasugrel hydrochloride with a reduced content of CATP, and the like. In the formulae, R represents a protecting group for a hydroxyl group. A method for producing prasugrel hydrochloride represented by the above formula is provided, characterized by comprising, in step (i), controlling, at low values, the temperature during the addition, optionally dropwise, of a chlorinating agent and the reaction temperature after the addition, optionally dropwise, of the chlorinating agent.

公开(公告)号：AU2003266617A1

公开(公告)日：2004-04-19

申请号：AU2003266617

申请日：2003-09-25

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  SHIBAKAWA NOBUHIKO ,  NISHIHARA MASAMICHI ,  SHIRAI TOSHIYUKI ,  SHIMIZU MOTOHISA ,  HASEGAWA TOHRU ,  TOKUNAGA YASUNORI ,  SUZUKI NAOTO ,  WADA YUKINORI

IPC: A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P1/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/14 ,  C07D403/14 ,  C07D487/04

Abstract: The present invention relates to pyrazole compounds represented by the formula (I): wherein R represents phenyl which may be substituted, R represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R represents H, alkyl or amino, R represents the formula (II) to (V): wherein R represents H or alkyl, R represents H, alkyl or substituted amino, R represents H or alkyl, R represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.

公开(公告)号：CA2500225A1

公开(公告)日：2004-04-08

申请号：CA2500225

申请日：2003-09-25

Applicant: UBE INDUSTRIES

Inventor： WADA YUKINORI ,  SHIBAKAWA NOBUHIKO ,  NISHIHARA MASAMICHI ,  SUZUKI NAOTO ,  HAGIHARA MASAHIKO ,  SHIRAI TOSHIYUKI ,  HASEGAWA TOHRU ,  TOKUNAGA YASUNORI ,  SHIMIZU MOTOHISA

IPC: A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P1/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/14 ,  C07D403/14 ,  C07D487/04

Abstract: Pyrazole compounds represented by the general formula (I) or pharmacological ly acceptable salts thereof, and pharmaceutical compositions containing the sam e as the active ingredient: (I) wherein R1 is optionally substituted phenyl; R 2 is H, halogeno, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, or substituted amino; Q is CH or N; R3 is H, alkyl, or amino; and R4 is a group represented by the general formula (II), (III), (IV), or (V): (II) (III) (II I) (V) (wherein R7 is H or alkyl; R8 is H, alkyl, or substituted amino; R9 is H or alkyl; and R12 is H, alkyl, halogenoalkyl, or substituted amino).

公开(公告)号：CA3031914C

公开(公告)日：2021-03-30

申请号：CA3031914

申请日：2017-07-25

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  FUSE SHINSAKU ,  SHIMIZU MOTOHISA ,  WADA YUKINORI

IPC: C12N5/02 ,  C12M3/00 ,  C12N5/071

Abstract: The present invention provides a cell cultivation method that includes: (1) a step in which a first culture medium including suspended cells is applied to a cell cultivation module; (2) a step in which a temperature at which cell cultivation is possible is maintained, and the cells are made to adsorb to the cell cultivation module; and (3) a step in which the cell cultivation module to which the cells are adsorbed is cultivated within a culture vessel with a second culture medium, wherein a polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, and the holes in the surface layers A and B are in communication with the macrovoids.

公开(公告)号：CA2974071C

公开(公告)日：2020-01-14

申请号：CA2974071

申请日：2016-01-26

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  SHIMIZU MOTOHISA ,  WADA YUKINORI

IPC: C12P1/00 ,  C12M1/14 ,  C12M3/04 ,  C12N7/00 ,  C12P21/00

Abstract: The present invention relates to a method of using cells to produce a substance, and involves applying the cells to a polyimide porous film, culturing the cells and producing the substance by means of the cells.

公开(公告)号：SG11201900674XA

公开(公告)日：2019-02-27

申请号：SG11201900674X

申请日：2017-07-25

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  FUSE SHINSAKU ,  SHIMIZU MOTOHISA ,  WADA YUKINORI

IPC: C12M3/00

Abstract: CELL CULTURE MODULE The present invention provides a cell cultivation module comprising a polymer porous 5 film and a casing that has two or more culture medium inflow/outflow ports and accommodates the polymer porous film, wherein the polymer porous film is a polymer porous film with a three- layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole 10 diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in communication with the macrovoids, and the polymer porous film is accommodated within the casing. 15 [No Suitable Figure]