公开(公告)号：SG11201900715QA

公开(公告)日：2019-02-27

申请号：SG11201900715Q

申请日：2017-07-25

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  FUSE SHINSAKU ,  SHIMIZU MOTOHISA ,  WADA YUKINORI

IPC: C12N5/02 ,  C12M3/00 ,  C12N5/071

Abstract: PWO1 METHOD FOR CULTURING CELL, AND METHOD FOR REMOVING AND KILLING CELL FROM CELL SUSPENSION 5 The present invention provides a cell cultivation method that includes: (1) a step in which a first culture medium including suspended cells is applied to a cell cultivation module; (2) a step in which a temperature at which cell cultivation is possible is maintained, and the cells are made to adsorb to the cell cultivation module; and (3) a step in which the cell cultivation module to which the cells are adsorbed is cultivated within a culture vessel with a second culture medium, 10 wherein a polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface 15 layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, and the holes in the surface layers A and B are in communication with the macrovoids. [No Suitable Figure] 20 58

公开(公告)号：CA3031915A1

公开(公告)日：2018-02-01

申请号：CA3031915

申请日：2017-07-25

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  FUSE SHINSAKU ,  SHIMIZU MOTOHISA ,  WADA YUKINORI

IPC: C12M3/00

Abstract: The present invention provides a cell cultivation module comprising a polymer porous film and a casing that has two or more culture medium inflow/outflow ports and accommodates the polymer porous film, wherein the polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in communication with the macrovoids, and the polymer porous film is accommodated within the casing.

公开(公告)号：SG11201706114RA

公开(公告)日：2017-09-28

申请号：SG11201706114R

申请日：2016-01-26

Applicant: UBE INDUSTRIES ,  UNIV TSUKUBA

Inventor： FUKAMIZU AKIYOSHI ,  KIM JUN-DAL ,  HAGIHARA MASAHIKO ,  WADA YUKINORI

IPC: C12Q1/02 ,  C12M1/34 ,  C12M3/06 ,  C12N5/078 ,  G01N1/10 ,  G01N33/15 ,  G01N33/50

Abstract: The purpose of the present invention is to provide a method for isolating, removing and analyzing cells. Provided is a method for isolating, removing and analyzing cells by filtering a liquid specimen containing cells through a porous polyimide film, and subjecting the cells captured by the film which did not pass through the porous polyimide film, or the cells in the liquid specimen which did pass through the porous polyimide film, to an examination of one or more cell properties selected from a group consisting of cell number or type, internal or external cell structure, type or amount of cell surface antigen, type or amount of material secreted from cells, cell adhesion, and cell survival rate.

公开(公告)号：PL2003136T3

公开(公告)日：2017-06-30

申请号：PL07741221

申请日：2007-04-06

Applicant: DAIICHI SANKYO CO LTD ,  UBE INDUSTRIES

Inventor： INOUE TERUHIKO ,  NAKAMURA KAZUYOSHI ,  HAGIHARA MASAHIKO ,  MIYATA HIROYUKI ,  WADA YUKINORI ,  YOKOTA NAOYUKI

IPC: C07D495/04 ,  A61K31/4365 ,  A61P7/02

公开(公告)号：CA2969197A1

公开(公告)日：2016-08-04

申请号：CA2969197

申请日：2016-01-26

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  SHIMIZU MOTOHISA ,  WADA YUKINORI

IPC: C12N5/071 ,  C12M1/00 ,  C12M3/00 ,  C12N1/14 ,  C12N1/16 ,  C12N1/20 ,  C12N5/04

Abstract: The present invention pertains to a method for the mass cultivation of cells, and a cell cultivation device and kit. The present invention further pertains to a continuous cell cultivation method and a continuous cell cultivation device in which a carrier is used.

公开(公告)号：NZ579993A

公开(公告)日：2012-06-29

申请号：NZ57999308

申请日：2008-02-29

Applicant: DAIICHI SANKYO CO LTD ,  UBE INDUSTRIES

Inventor： MIYATA HIROYUKI ,  WADA YUKINORI ,  YOKOTA NAOYUKI

IPC: C07D495/04 ,  A61K31/4365 ,  A61P7/02

Abstract: Disclosed herein is a method of producing prasugrel hydrochloride (compound of formula (Ia)), comprising the steps of: i) chlorinating a compound represented by formula (III), by adding a chlorinating agent optionally dropwise thereto in a solvent; ii) reacting the resultant compound represented by formula (IV) with a compound represented by formula (V), wherein R represents a protecting group for a hydroxyl group, or a salt thereof in a solvent in the presence of a base; iii) acetylating the resultant compound represented by formula (II), wherein R has the same meaning as above, by reacting an acetylating agent therewith in a solvent in the presence of a base and an acylation catalyst; and iv) adding hydrochloric acid, optionally dropwise to the resultant compound of formula (I) in a solvent, thereby producing prasugrel hydrochloride as represented by formula (Ia); in which in step i), the temperature during the addition, optionally dropwise, of the chlorinating agent is -20°C to 5°C and the reacting temperature after the addition, optionally dropwise, of the chlorinating agent is -20°C to 5°C.

公开(公告)号：CA2500225C

公开(公告)日：2011-01-18

申请号：CA2500225

申请日：2003-09-25

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  SHIBAKAWA NOBUHIKO ,  NISHIHARA MASAMICHI ,  SHIRAI TOSHIYUKI ,  SHIMIZU MOTOHISA ,  HASEGAWA TOHRU ,  TOKUNAGA YASUNORI ,  SUZUKI NAOTO ,  WADA YUKINORI

IPC: C07D401/14 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P1/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D403/14 ,  C07D487/04

Abstract: The present invention relates to pyrazole compounds represented by the formula (I): (see formula I) wherein R1 represents phenyl which may be substituted, R2 represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R3 represents H, alkyl or amino, R4 represents the formula (II) to (V): (see formula II) (see formula III) (see formula IV) (see formula V) wherein R7 represents H or alkyl, R8 represents H, alkyl or substituted amino, R9 represents H or alkyl, R12 represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.

公开(公告)号：AU2008321770A1

公开(公告)日：2009-05-22

申请号：AU2008321770

申请日：2008-11-14

Applicant: UBE INDUSTRIES

Inventor： WADA YUKINORI ,  MARUYAMA MASAO ,  FUJII NOBUYOSHI ,  HAGIHARA MASAHIKO ,  SUZUKI NAOTO ,  YOSHIMURA KIMIHIKO ,  TSUZAKI YASUNORI ,  AGA YASUHIRO

IPC: C07D487/04 ,  A61K31/55 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/04 ,  A61P19/10 ,  A61P25/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00

Abstract: The present invention relates to a benzazepinone compound represented by the following formula (I): wherein R 1 represents a C 1 -C 6 alkyl group or halogeno C 1 -C 6 alkyl group, R 2 represents a carboxyl group which may be protected, and Y represents a group represented by the formula (II): wherein Z represents CH or a nitrogen atom, or a pharmaceutically acceptable salt thereof.

公开(公告)号：ES2891083T3

公开(公告)日：2022-01-26

申请号：ES15807453

申请日：2015-06-10

Applicant: UBE INDUSTRIES

Inventor： YAMAMOTO YASUHITO ,  OUE MASAYOSHI ,  WADA YUKINORI

IPC: C07D401/14

Abstract: Método para producir compuestos de sulfonamida N-sustituida, que comprende una etapa de hacer reaccionar un compuesto de sulfonamida de la fórmula general (4): **(Ver fórmula)** en la que R1a es un grupo alquilo, alquenilo, alquinilo, cicloalquilo, arilo, heteroarilo, aralquilo o heteroarilalquilo opcionalmente sustituido y R4 es un grupo arilo o heteroarilo opcionalmente sustituido, con un compuesto orgánico halogenado de la fórmula general (5): **(Ver fórmula)** en la que R5 es un grupo alquilo y X1 es un átomo de halógeno, en presencia de carbonato de cesio o carbonato de potasio en un disolvente orgánico para producir un compuesto de sulfonamida N-sustituida de la fórmula general (6): **(Ver fórmula)** en la que R1a, R4 y R5 son los mismos tal como se definieron anteriormente.

公开(公告)号：AU2021201479A1

公开(公告)日：2021-03-25

申请号：AU2021201479

申请日：2021-03-09

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  FUSE SHINSAKU ,  SHIMIZU MOTOHISA ,  WADA YUKINORI

IPC: C12M3/00

Abstract: The present invention provides a cell cultivation module comprising a polymer porous film and a casing that has two or more culture medium inflow/outflow ports and accommodates 5 the polymer porous film, wherein the polymer porous film is a polymer porous film with a three layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that 10 are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in communication with the macrovoids, and the polymer porous film is accommodated within the casing.