公开(公告)号：ES2396606T3

公开(公告)日：2013-02-22

申请号：ES03798497

申请日：2003-09-25

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  SHIBAKAWA NOBUHIKO ,  NISHIHARA MASAMICHI ,  SHIRAI TOSHIYUKI ,  SHIMIZU MOTOHISA ,  HASEGAWA TOHRU ,  TOKUNAGA YASUNORI ,  SUZUKI NAOTO ,  WADA YUKINORI

IPC: C07D401/14 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P1/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D403/14 ,  C07D487/04

Abstract: Un compuesto de pirazol representado por la fórmula (I): en la que R1 representa un grupo fenilo que puede estar sustituido con un grupo o grupos seleccionados del grupoque consiste en un átomo de halógeno, un grupo alquilo C1-C6, un grupo halógeno-alquilo C1-C6, un grupo alcoxiloC1-C6, un grupo halógeno-alcoxilo C1-C6 y un grupo alquiltio C1-C6, R2 representa un átomo de hidrógeno, unátomo de halógeno, un grupo alquilo C1-C6, un grupo alcoxilo C1-C6, un grupo alquiltio C1-C6, un grupoalquilsulfinilo C1-C6, un grupo alquilsulfonilo C1-C6 o un grupo: -NR5R6 en el que R5 y R6 pueden ser iguales o diferentes uno de otro, y cada uno representa un átomo de hidrógeno, ungrupo alquilo C1-C6, un grupo halógeno-alquilo C1-C6, un grupo cicloalquilo C3-C7, un grupo alquil-carbonilo C1-C6,un grupo cicloalquil-carbonilo C3-C7, un grupo formilo, un grupo alcoxi-carbonilo C1-C6 o un grupo alquilsulfoniloC1-C6, o un grupo aralquilo C7-C12 o un grupo benzoílo, cada uno de los cuales puede estar sustituido con un grupoo grupos seleccionados del grupo que consiste en un átomo de halógeno, un grupo alquilo C1-C6, un grupohalógeno-alquilo C1-C6, un grupo alcoxilo C1-C6 y un grupo halógeno-alcoxilo C1-C6, Q representa CH o un átomo de nitrógeno, R3 representa un átomo de hidrógeno, un grupo alquilo C1-C6 o un grupoamino, R4 representa la fórmula (II):

公开(公告)号：CA2500225C

公开(公告)日：2011-01-18

申请号：CA2500225

申请日：2003-09-25

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  SHIBAKAWA NOBUHIKO ,  NISHIHARA MASAMICHI ,  SHIRAI TOSHIYUKI ,  SHIMIZU MOTOHISA ,  HASEGAWA TOHRU ,  TOKUNAGA YASUNORI ,  SUZUKI NAOTO ,  WADA YUKINORI

IPC: C07D401/14 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P1/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D403/14 ,  C07D487/04

Abstract: The present invention relates to pyrazole compounds represented by the formula (I): (see formula I) wherein R1 represents phenyl which may be substituted, R2 represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R3 represents H, alkyl or amino, R4 represents the formula (II) to (V): (see formula II) (see formula III) (see formula IV) (see formula V) wherein R7 represents H or alkyl, R8 represents H, alkyl or substituted amino, R9 represents H or alkyl, R12 represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.

公开(公告)号：AU2003266617B2

公开(公告)日：2009-01-29

申请号：AU2003266617

申请日：2003-09-25

Applicant: UBE INDUSTRIES

Inventor： NISHIHARA MASAMICHI ,  SHIMIZU MOTOHISA ,  WADA YUKINORI ,  TOKUNAGA YASUNORI ,  SHIBAKAWA NOBUHIKO ,  HASEGAWA TOHRU ,  SHIRAI TOSHIYUKI ,  HAGIHARA MASAHIKO ,  SUZUKI NAOTO

IPC: C07D487/04 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P1/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention relates to pyrazole compounds represented by the formula (I): wherein R represents phenyl which may be substituted, R represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R represents H, alkyl or amino, R represents the formula (II) to (V): wherein R represents H or alkyl, R represents H, alkyl or substituted amino, R represents H or alkyl, R represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.

公开(公告)号：AU2003266617A1

公开(公告)日：2004-04-19

申请号：AU2003266617

申请日：2003-09-25

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  SHIBAKAWA NOBUHIKO ,  NISHIHARA MASAMICHI ,  SHIRAI TOSHIYUKI ,  SHIMIZU MOTOHISA ,  HASEGAWA TOHRU ,  TOKUNAGA YASUNORI ,  SUZUKI NAOTO ,  WADA YUKINORI

IPC: A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P1/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/14 ,  C07D403/14 ,  C07D487/04

Abstract: The present invention relates to pyrazole compounds represented by the formula (I): wherein R represents phenyl which may be substituted, R represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R represents H, alkyl or amino, R represents the formula (II) to (V): wherein R represents H or alkyl, R represents H, alkyl or substituted amino, R represents H or alkyl, R represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.

公开(公告)号：CA2500225A1

公开(公告)日：2004-04-08

申请号：CA2500225

申请日：2003-09-25

Applicant: UBE INDUSTRIES

Inventor： WADA YUKINORI ,  SHIBAKAWA NOBUHIKO ,  NISHIHARA MASAMICHI ,  SUZUKI NAOTO ,  HAGIHARA MASAHIKO ,  SHIRAI TOSHIYUKI ,  HASEGAWA TOHRU ,  TOKUNAGA YASUNORI ,  SHIMIZU MOTOHISA

IPC: A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P1/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/14 ,  C07D403/14 ,  C07D487/04

Abstract: Pyrazole compounds represented by the general formula (I) or pharmacological ly acceptable salts thereof, and pharmaceutical compositions containing the sam e as the active ingredient: (I) wherein R1 is optionally substituted phenyl; R 2 is H, halogeno, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, or substituted amino; Q is CH or N; R3 is H, alkyl, or amino; and R4 is a group represented by the general formula (II), (III), (IV), or (V): (II) (III) (II I) (V) (wherein R7 is H or alkyl; R8 is H, alkyl, or substituted amino; R9 is H or alkyl; and R12 is H, alkyl, halogenoalkyl, or substituted amino).

公开(公告)号：EP1553096A4

公开(公告)日：2008-05-28

申请号：EP03798497

申请日：2003-09-25

Applicant: UBE INDUSTRIES

Inventor： HAGIHARA MASAHIKO ,  SHIBAKAWA NOBUHIKO ,  NISHIHARA MASAMICHI ,  SHIRAI TOSHIYUKI ,  SHIMIZU MOTOHISA ,  HASEGAWA TOHRU ,  TOKUNAGA YASUNORI ,  SUZUKI NAOTO ,  WADA YUKINORI

IPC: A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61P1/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/14 ,  C07D403/14 ,  C07D487/04

CPC classification number: C07D401/14 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  C07D403/14 ,  C07D487/04

Abstract: Pyrazole compounds represented by the general formula (I) or pharmacologically acceptable salts thereof, and pharmaceutical compositions containing the same as the active ingredient: (I) wherein R1 is optionally substituted phenyl; R2 is H, halogeno, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, or substituted amino; Q is CH or N; R3 is H, alkyl, or amino; and R4 is a group represented by the general formula (II), (III), (IV), or (V): (II) (III) (III) (V) (wherein R7 is H or alkyl; R8 is H, alkyl, or substituted amino; R9 is H or alkyl; and R12 is H, alkyl, halogenoalkyl, or substituted amino).