公开(公告)号：DK2663577T3

公开(公告)日：2017-07-17

申请号：DK12700433

申请日：2012-01-11

Applicant: UCB BIOPHARMA SPRL

Inventor： ADAMS RALPH ,  BAKER TERENCE SEWARD ,  LAWSON ALASTAIR DAVID GRIFFITHS

IPC: C07K16/24

公开(公告)号：ME02607B

公开(公告)日：2017-06-20

申请号：MEP3817

申请日：2010-03-10

Applicant: UCB BIOPHARMA SPRL

Inventor： GOZZARD NEIL ,  LAWSON ALASTAIR DAVID GRIFFITHS ,  LIGHTWOOD DANIEL JOHN ,  PALFRAMAN ROGER THOMAS ,  SMITH BRYAN JOHN ,  TYSON KERRY LOUISE

IPC: A61K39/395 ,  A61P11/06 ,  C07K16/24 ,  C07K16/46 ,  C12N15/13

公开(公告)号：HRP20170234T1

公开(公告)日：2017-04-07

申请号：HRP20170234

申请日：2017-02-13

Applicant: UCB BIOPHARMA SPRL

Inventor： GOZZARD NEIL ,  LAWSON ALASTAIR DAVID GRIFFITHS ,  LIGHTWOOD DANIEL JOHN ,  PALFRAMAN ROGER THOMAS ,  SMITH BRYAN JOHN ,  TYSON KERRY LOUISE

IPC: C07K16/24 ,  A61K39/395 ,  A61P11/06 ,  C07K16/46 ,  C12N15/13

公开(公告)号：LT2406283T

公开(公告)日：2017-02-27

申请号：LT10714046

申请日：2010-03-10

Applicant: UCB BIOPHARMA SPRL

Inventor： GOZZARD NEIL ,  LAWSON ALASTAIR DAVID GRIFFITHS ,  LIGHTWOOD DANIEL JOHN ,  PALFRAMAN ROGER THOMAS ,  SMITH BRYAN JOHN ,  TYSON KERRY LOUISE

IPC: C07K16/24 ,  A61K39/395 ,  A61P11/06 ,  C07K16/46 ,  C12N15/13

公开(公告)号：DK2406283T3

公开(公告)日：2017-02-27

申请号：DK10714046

申请日：2010-03-10

Applicant: UCB BIOPHARMA SPRL

Inventor： GOZZARD NEIL ,  LIGHTWOOD DANIEL JOHN ,  PALFRAMAN ROGER THOMAS ,  SMITH BRYAN JOHN ,  TYSON KERRY LOUISE ,  LAWSON ALASTAIR DAVID GRIFFITHS

IPC: C07K16/24 ,  A61K39/395 ,  A61P11/06 ,  C07K16/46 ,  C12N15/13

公开(公告)号：AU2010216152B2

公开(公告)日：2015-05-14

申请号：AU2010216152

申请日：2010-02-17

Applicant: UCB BIOPHARMA SPRL

Inventor： LAWSON ALASTAIR DAVID GRIFFITHS ,  NESBITT ANDREW MALCOLM ,  POPPLEWELL ANDREW GEORGE ,  SHAW STEVAN GRAHAM ,  SHPEKTOR DIANA ,  ZHANG YI

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/00

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：CA2914726A1

公开(公告)日：2014-12-18

申请号：CA2914726

申请日：2014-06-13

Applicant: UCB BIOPHARMA SPRL

Inventor： SHI JIYE ,  BAKER TERENCE SEWARD ,  LAWSON ALASTAIR DAVID GRIFFITHS ,  LIU XIAOFENG

IPC: G06F19/16 ,  A61K39/395 ,  C12Q1/68 ,  G01N33/15 ,  G06F19/28

Abstract: Methods and associated apparatus involving designing a ligand ab initio that will bind to a binding site of a macromolecular target, or of identifying a modification to a ligand for improving the affinity of the ligand to a binding site of a macromolecular target, comprising using information about non-bonding, intra-molecular or inter-molecular atom to atom contacts extracted from a database of biological macromolecules to identify favoured regions adjacent to the binding site for particular atom types and modifying a candidate ligand to increase the intersection between atoms of the candidate ligand and the favoured regions. One or more steps of the methods may be performed by a computer.