公开(公告)号：WO1996026747A2

公开(公告)日：1996-09-06

申请号：PCT/US1996002588

申请日：1996-02-26

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  DASSANAYAKE, Nissanke, L. ,  SCHLITZER, Ronald, L. ,  PARK, Joonsup

IPC: A61L02/18

CPC classification number: A61K31/164 ,  A01N37/20 ,  A01N37/36 ,  A01N37/44 ,  A61L12/12 ,  Y10S514/84

Abstract: The use of certain amidoamines to disinfect contact lenses and preserve ophthalmic compositions is described. Ophthalmic compositions containing these compounds as disinfecting agents or preservatives are also described. The amidoamines utilized in the present invention have potent antibacterial and antifungal activity, and are chemically compatible with inorganic ions and other materials utilized in ophthalmic compositions.

Abstract translation: 描述使用某些酰氨基胺消毒隐形眼镜并保护眼用组合物。 还描述了含有这些化合物作为消毒剂或防腐剂的眼科组合物。 本发明中使用的酰氨基胺具有有效的抗细菌和抗真菌活性，并且与眼用组合物中所用的无机离子和其它材料化学相容。

公开(公告)号：WO1996010403A1

公开(公告)日：1996-04-11

申请号：PCT/US1995011314

申请日：1995-09-07

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  BHAGAT, Haresh, G. ,  AIRY, Subhash, C.

IPC: A61K31/20

CPC classification number: A61K31/7004 ,  A61K31/203 ,  A61K31/7012

Abstract: Certain stable analogues of retinoic acid are found to be useful in the treatment of dry eye and related aliments, and skin disorders such as acne, psoriasis, skin aging and wound healing. These compounds are much more soluble than retinoic acid, and may therefore be formulated in standard.

Abstract translation: 发现视黄酸的一些稳定的类似物可用于治疗干眼症和相关的营养物质，以及皮肤疾病如痤疮，牛皮癣，皮肤老化和伤口愈合。 这些化合物比视黄酸更易溶，因此可以配制成标准。

公开(公告)号：WO1995016435A2

公开(公告)日：1995-06-22

申请号：PCT/US1994014196

申请日：1994-12-13

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  CAGLE, Gerald, D. ,  LORENZETTI, Ole, J. ,  GAN, Owen

IPC: A61K09/08

CPC classification number: A61K9/0048

Abstract: Pharmaceutical compositions useful in ophthalmic surgery are described. The compositions include one or more non-steroidal antiinflammatory drugs, and are useful for preventing or treating ophthalmic inflammation and other conditions associated with ophthalmic surgery. Methods of using the compositions in connection with ophthalmic surgical procedures are also described.

Abstract translation: 描述了可用于眼科手术的药物组合物。 组合物包括一种或多种非甾体抗炎药，并且可用于预防或治疗眼科炎症和与眼科手术相关的其它病症。 还描述了使用组合物与眼科外科手术相关的方法。

公开(公告)号：WO1995003800A1

公开(公告)日：1995-02-09

申请号：PCT/US1994008521

申请日：1994-07-28

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  YORK, Billie, M.

IPC: A61K31/415

CPC classification number: A61K31/415 ,  Y10S514/866 ,  Y10S514/922

Abstract: Disclosed are novel compositions comprising mixtures useful to treat the metabolically impaired and to improve patient compliance. Included are non-racemic mixtures of certain chiral spirofluorenehydantoins. Methods of use to treat glucose toxicity and complications arising from diabetes mellitus are also disclosed.

Abstract translation: 公开了包含可用于治疗代谢障碍并改善患者依从性的混合物的新型组合物。 包括某些手性螺芴壬内酯的非外消旋混合物。 还公开了用于治疗葡萄糖毒性的方法和由糖尿病引起的并发症。

公开(公告)号：WO1994013299A1

公开(公告)日：1994-06-23

申请号：PCT/US1993011939

申请日：1993-12-08

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  YANNI, John, M. ,  ROBERTSON, Stella, M. ,  OKUMURA, Shigetoshi ,  TANAKA, Hitoshi ,  SAITO, Tadayuki

IPC: A61K31/55

CPC classification number: A61K31/55 ,  Y10S514/912

Abstract: Topical ophthalmic compositions comprising 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimidazole and its ophthalmically acceptable acid addition salts have been found to be useful in treating allergic conjunctivitis and related ailments.

Abstract translation: 已经发现包含1-（2-乙氧基乙基）-2-（4-甲基-1-高哌嗪基） - 苯并咪唑及其眼科可接受的酸加成盐的局部眼用组合物可用于治疗过敏性结膜炎和相关疾病。

公开(公告)号：WO1994008602A1

公开(公告)日：1994-04-28

申请号：PCT/US1993009912

申请日：1993-10-15

Applicant: ALCON LABORATORIES, INC. ,  GAN, Owen ,  DeFALLER, Joseph, M. ,  LORENZETTI, Ole, J. ,  DOSHI, Uday ,  LUTHY, Connie, L.

Inventor： ALCON LABORATORIES, INC.

IPC: A61K37/00

CPC classification number: A61K31/22 ,  A61K31/135 ,  A61K38/063 ,  A61K2300/00

Abstract: An improved pharmaceutical composition useful in ophthalmic surgery is described. The composition includes a mydriatic agent, such as epinephrine in an acidic solution. The acidic solution preferably also contains glutathione. The composition is preferably formulated as a two-part solution, with the mydriatic agent being included in a relatively small volume, acid solution, and one or more electrolytes being included in a neutral, buffered solution having a relatively large volume.

Abstract translation: 描述了可用于眼科手术的改进的药物组合物。 该组合物包括散瞳剂，例如在酸性溶液中的肾上腺素。 酸性溶液优选还含有谷胱甘肽。 组合物优选配制成两部分溶液，散瞳剂包括在相对小体积的酸溶液中，并且一种或多种电解质包含在具有相对较大体积的中性缓冲溶液中。

公开(公告)号：WO1994001086A1

公开(公告)日：1994-01-20

申请号：PCT/US1993005929

申请日：1993-06-21

Applicant: ALCON LABORATORIES, INC. ,  HECHT, Gerald ,  LUTHY, Connie, L.

Inventor： ALCON LABORATORIES, INC.

IPC: A61K09/00

CPC classification number: A61K38/26 ,  A61K9/0048 ,  A61K31/13 ,  A61K31/195 ,  A61K33/42 ,  A61K38/04 ,  Y10S514/912 ,  A61K2300/00 ,  A61K33/14 ,  A61K33/10 ,  A61K31/7004 ,  A61K31/19

Abstract: Irrigating solutions with thiol or disulfide containing compounds or precursors to cystine or cysteine in physiologically acceptable salt solutions are described. The irrigating solutions are useful during surgery, particularly ophthalmic, neural, cardiovascular or otic surgery, to stabilize the affected tissue. Methods for their preparation and use are described.

Abstract translation: 描述了在生理学上可接受的盐溶液中含有硫醇或二硫化物的化合物或胱氨酸或半胱氨酸的前体的冲洗溶液。 冲洗溶液在手术中是有用的，特别是眼科，神经，心血管或耳部手术，以稳定受影响的组织。 描述了其制备和使用方法。

公开(公告)号：WO1993017664A1

公开(公告)日：1993-09-16

申请号：PCT/US1993001565

申请日：1993-02-22

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  ALI, Yusuf ,  BHAGAT, Haresh, G.

IPC: A61K09/08

CPC classification number: A61K9/0048

Abstract: Combinations of at least one cellulosic polymer and at least one carboxy vinyl polymer have an unexpectedly high viscosity. Compositions containing these polymeric combinations have a number of applications, such as in pharmaceuticals, especially in the field of ophthalmics. Topical ophthalmic compositions containing these polymeric combinations are contemplated for the relief of the symptoms of dry eye syndrome.

Abstract translation: 至少一种纤维素聚合物和至少一种羧乙烯基聚合物的组合具有出乎意料的高粘度。 含有这些聚合物组合的组合物具有许多应用，例如在药物中，特别是在眼科领域。 预期含有这些聚合物组合物的局部眼用组合物用于缓解干眼综合征的症状。

公开(公告)号：WO1991018081A1

公开(公告)日：1991-11-28

申请号：PCT/US1991003237

申请日：1991-05-10

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  SCHLITZER, Ronald, L. ,  DASSANAYAKE, Nissanke, L. ,  BHATIA, Rajkumar, P.

IPC: C11D03/14

CPC classification number: A61L12/102 ,  A61L12/10 ,  A61L12/107 ,  A61L12/124 ,  C11D3/0078 ,  Y10S514/84

Abstract: An improved system for rapid disinfection of contact lenses in a convenient and reliable manner is disclosed in which a series of oxidation-reduction reactions are employed. This improved system includes compositions as well as methods of use.

公开(公告)号：WO1991003245A1

公开(公告)日：1991-03-21

申请号：PCT/US1990004071

申请日：1990-07-25

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  CLARK, Abbot, F.

IPC: A61K31/58

CPC classification number: A61K31/569 ,  A61K31/565 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  A61K31/665 ,  C07J3/00 ,  C07J5/0053 ,  C07J9/00 ,  C07J11/00 ,  C07J41/0005 ,  C07J41/0027 ,  C07J51/00 ,  A61K2300/00

Abstract: Pharmaceutical compositions useful in the treatment of ophthalmic inflammation and methods of treating ophthalmic inflammation with those compositions ar disclosed. The compositions contain a combination of a glucocorticoid and an angiostatic steroid. The angiostatic steroid substantially prevents any significant increases in intraocular pressure which might otherwise be experienced by the patient as a side effect of the glucocorticoid component of the compositions. The therapeutic interaction of the two components therefore allows the potent anti-inflammatory properties of the glucocorticoids to be utilized without fear of elevating intraocular pressure.

Abstract translation: 可用于治疗眼部炎症的药物组合物和所公开的那些组合物治疗眼部炎症的方法。 组合物含有糖皮质激素和血管抑制类固醇的组合。 血管抑制类固醇基本上防止了眼睛压力的任何显着增加，否则患者可能会经历该组合物的糖皮质激素成分的副作用。 因此，两种组分的治疗相互作用允许使用糖皮质激素的有效抗炎特性，而不用担心升高眼内压。