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公开(公告)号:WO2010004253A3
公开(公告)日:2010-08-05
申请号:PCT/GB2009001492
申请日:2009-06-16
Applicant: Q CHIP LTD , PALMER DANIEL , CALDER RICHARD , SHADICK OWEN
Inventor: PALMER DANIEL , CALDER RICHARD , SHADICK OWEN
CPC classification number: B01J2/08 , A61K9/1647 , A61K9/1694
Abstract: A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.
Abstract translation: 公开了一种制备固体珠粒的方法,所述方法包括:(i)提供微流体装置,其包括在连接区域相遇的载体流体导管和功能流体导管; (ii)提供功能流体的层流,其包括沿着功能流体导管的溶剂和溶质,并且沿着载体流体导管提供载体流体的层流,以便在载体流体流中形成功能流体液滴 ; (iii)冷却所述微流体装置的管道中的功能流体段以形成冷却(优选冷冻)的液滴; 和(iv)将液体与冷却的液滴紧密混合,以使所述溶剂离开所述冷却的液滴,从而形成固体珠粒。 还公开了一种用于这种方法的微流体装置。
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公开(公告)号:WO2009098795A1
公开(公告)日:2009-08-13
申请号:PCT/JP2008/065277
申请日:2008-08-27
Applicant: コバレントマテリアル株式会社 , 後藤 浩之 , 上本 英雄 , 杉野 友紀
CPC classification number: C01B13/145 , B01J2/08 , B01J2/18 , C01P2004/03 , C01P2004/32 , C01P2004/52
Abstract: 微細流路構造体が煩雑化すること無く、真円に近い球状の形状を備え、かつ、単分散性に優れ、セラミックス単体の固体成分のみで構成されたセラミックス微粒子を容易に製造することができるセラミックス微粒子の製造方法及びそれに用いられるセラミックス微粒子の製造装置を提供する。 界面活性剤を含む油性液体で構成された連続相中に、冷却によりゲル化するゲル化剤とセラミックス原料とが含まれる水性液体で構成された分散相が送り込まれることによって微小液滴を生成する工程(S100)と、前記生成した微小液滴を回収し、冷却する工程(S110)と、前記冷却した微小液滴を洗浄する工程(S120)と、前記洗浄した微小液滴を乾燥する工程(S130)と、前記乾燥した微小液滴を焼成する工程(S140)とを備える。
Abstract translation: 可以容易地制造陶瓷微粒的制造方法,其中仅由陶瓷元素的固体成分构成的陶瓷微粒不伴随微通道结构的并入,具有接近正圆的球形构造,并且单分散性优异; 和陶瓷微粒制造装置。 该方法包括进料由含有陶瓷原料的水性液体组成的分散相的步骤(S100)和当冷却成含有表面活性剂的油性液体的连续相时形成凝胶的胶凝剂,从而形成液体 微滴; 回收形成的液体微滴并冷却的步骤(S110) 洗涤被冷却的液体微滴的步骤(S120) 干燥洗涤过的液体微滴的步骤(S130) 以及烧制干燥的液体微滴的步骤(S140)。
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公开(公告)号:WO2009071560A1
公开(公告)日:2009-06-11
申请号:PCT/EP2008/066659
申请日:2008-12-02
Applicant: UPFRONT CHROMATOGRAPHY A/S , LIHME, Allan Otto Fog , HANSEN, Marie Bendix , HOLTE, René Oehlenschlaeger , LARSEN, Brian
Inventor: LIHME, Allan Otto Fog , HANSEN, Marie Bendix , HOLTE, René Oehlenschlaeger , LARSEN, Brian
IPC: B01J13/04
CPC classification number: B01J2/08 , B01J13/046
Abstract: The present invention relates to a method for producing beads comprising a material capable of gelation, said method comprising the steps of: (i) combining (a) a liquid composition comprising a material capable of gelation; and (b) a first hydrophobic phase; (ii) subjecting the liquid composition and the first hydrophobic phase, to means for emulsification in a first reactor by addition of external mechanical energy creating an emulsion comprising individual droplets comprising the material capable of gelation in the first hydrophobic phase (wherein the material capable of gelation provides a discontinuous phase and the first hydrophobic phase provides a continuous phase); (iii) stabilising the droplets by transferring the emulsion from the first reactor to a stabilisation reactor wherein the emulsion obtained in step (ii) is subjected to means for gelation in order to obtain gelation within 5 minutes or less, and the beads are formed.
Abstract translation: 本发明涉及包含能够凝胶化的材料的珠粒的制造方法,所述方法包括以下步骤:(i)将(a)包含能够凝胶化的材料的液体组合物组合; 和(b)第一疏水相; (ii)使液体组合物和第一疏水相经过添加外部机械能在第一反应器中进行乳化的装置,产生包含单个液滴的乳液,所述液滴包含能够在第一疏水相中凝胶化的材料(其中能够 凝胶化提供不连续相,第一疏水相提供连续相); (iii)通过将乳液从第一反应器转移到稳定反应器中来稳定液滴,其中在步骤(ii)中获得的乳液经历凝胶化手段以在5分钟或更短时间内获得凝胶化,并形成珠粒。
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公开(公告)号:WO2009053885A2
公开(公告)日:2009-04-30
申请号:PCT/IB2008/054300
申请日:2008-10-20
Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. , BOHMER, Marcel, R. , STEENBAKKERS, Johannes, A., M. , DE WINTER, Suzanna, H., P., M.
CPC classification number: A61K9/1694 , A61K9/1647 , B01J2/06 , B01J2/08 , B01J2/18 , B01J13/04
Abstract: The present invention describes methods and tools for preparing a population of monodisperse polymer microparticles, which are of particular interest in the field of drug delivery.
Abstract translation: 本发明描述了用于制备单分散聚合物微粒群体的方法和工具,其在药物递送领域是特别有意义的。
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公开(公告)号:WO2017103113A3
公开(公告)日:2017-08-24
申请号:PCT/EP2016081436
申请日:2016-12-16
Applicant: MIDATECH PHARMA (WALES) LTD
Inventor: SEAMAN PAUL , JONES HUW , MCALEER LIAM
Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid. Also provided is a process for producing solid microparticles, the process comprising: providing a first liquid comprising a solute and a solvent, the solute comprising a biocompatible polymer, the concentration of polymer in the first liquid being at least 10% w/v, 'w' being the weight of the polymer and 'ν' being the volume of the solvent, providing a plurality of liquid droplet generators operable to generate liquid droplets, providing a jet of a second liquid, causing the plurality of liquid droplet generators to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the jet of the second liquid so as to cause the solvent to exit the droplets, thus forming solid microparticles, the solubility of the solvent in the second liquid being at least 5g of solvent per 100ml of second liquid, the solvent being substantially miscible with the second liquid.
Abstract translation: 本发明提供一种固体高分子微粒的制造装置,其特征在于,具备:形成第一液体的液滴的多个液滴生成器和形成第二液体的射流的喷嘴,其中,所述多个液滴生成器和所述喷嘴 彼此相对布置,使得在使用中,来自所述多个液滴发生器的液滴通过气体进入所述第二液体射流。 还提供了生产固体微粒的方法,所述方法包括:提供包含溶质和溶剂的第一液体,所述溶质包含生物相容性聚合物,第一液体中聚合物的浓度为至少10%w / v, w'为聚合物的重量,'v'为溶剂的体积,提供多个可操作以产生液滴的液滴发生器,提供第二液体的射流,使多个液滴发生器形成液体 使液滴通过气体与第二液体的射流接触以使溶剂离开液滴从而形成固体微粒,溶剂在第二液体中的溶解度至少为5g 的溶剂/ 100ml第二液体,该溶剂基本上与第二液体混溶。
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公开(公告)号:WO2017087431A1
公开(公告)日:2017-05-26
申请号:PCT/US2016/062119
申请日:2016-11-16
Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION , SCHLUMBERGER CANADA LIMITED , SERVICES PETROLIERS SCHLUMBERGER , SCHLUMBERGER TECHNOLOGY B.V.
CPC classification number: B29B9/16 , B01J2/06 , B01J2/08 , B01J2/18 , B29L2031/7734 , E21B43/267
Abstract: A method for forming spheroidal particles including inducing flow of a slurry of particles and a reactant through one or more orifices, detaching an amount of the slurry from the slurry flow following exit from the one or more orifices, the detached amount forming a slurry body, forming the slurry body into a spheroidal shape, contacting the spheroidally shaped slurry body with a coagulation solution to form a stabilized spheroidal particle and drying and/or sintering the stabilized spheroidal particle.
Abstract translation: 一种用于形成球形颗粒的方法,所述方法包括使颗粒和反应物的浆料通过一个或多个孔口流动,在离开所述一个或多个孔口之后从浆液流中分离一定量的浆料, 分离量形成浆体,将浆体形成球体形状,使球体形浆体与凝固溶液接触以形成稳定化的球形颗粒并干燥和/或烧结稳定的球形颗粒。 p>
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公开(公告)号:WO2010004253A2
公开(公告)日:2010-01-14
申请号:PCT/GB2009/001492
申请日:2009-06-16
Applicant: Q CHIP LIMITED , PALMER, Daniel , CALDER, Richard , SHADICK, Owen
Inventor: PALMER, Daniel , CALDER, Richard , SHADICK, Owen
IPC: B01J2/08
CPC classification number: B01J2/08 , A61K9/1647 , A61K9/1694
Abstract: A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid 'in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.
Abstract translation: 公开了一种制备固体珠粒的方法,所述方法包括:(i)提供微流体装置,其包括在连接区域相遇的载体流体导管和功能流体导管; (ii)提供功能流体的层流,其包括沿着功能流体导管的溶剂和溶质,并且沿着载体流体导管提供载体流体的层流,以在载体流中形成功能流体的液滴 流体; (iii)冷却所述微流体装置的管道中的功能流体段以形成冷却(优选冷冻)的液滴; 和(iv)将液体与冷却的液滴紧密混合,以使所述溶剂离开所述冷却的液滴,从而形成固体珠粒。 还公开了一种用于这种方法的微流体装置。
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公开(公告)号:WO2006066317A1
公开(公告)日:2006-06-29
申请号:PCT/AU2005/001915
申请日:2005-12-20
Applicant: AUSTRALIAN NUCLEAR SCIENCE & TECHNOLOGY ORGANISATION , FINNIE, Kim, Suzanne , JACQUES, David , BARBE, Christophe, Jean, Alexandre , KONG, Linggen
Inventor: FINNIE, Kim, Suzanne , JACQUES, David , BARBE, Christophe, Jean, Alexandre , KONG, Linggen
CPC classification number: A61K9/14 , A61K9/1611 , A61K9/1694 , A61K9/501 , A61K38/1709 , A61K38/465 , A61K38/482 , A61K38/4826 , A61K38/50 , B01J2/08 , B01J13/02 , C12Y304/21001 , C12Y304/21062 , C12Y305/01005 , A61K2300/00
Abstract: A process is provided for releasably encapsulating a biological entity. The process comprise combining a solution of a surfactant in a non-polar solvent with a precursor material and the biological entity to form an emulsion. The emulsion comprises a polar phase dispersed in a non- polar phase, wherein the polar phase comprises the biological entity. The particles comprising the biological entity are then formed from the polar phase.
Abstract translation: 提供了用于可释放地封装生物实体的过程。 该方法包括将表面活性剂在非极性溶剂中的溶液与前体材料和生物实体组合以形成乳液。 乳液包含分散在非极性相中的极性相,其中极性相包含生物实体。 然后由极性相形成包含生物实体的颗粒。 p>
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公开(公告)号:WO2005058472A3
公开(公告)日:2005-10-20
申请号:PCT/DK2004000888
申请日:2004-12-19
Applicant: SCF TECHNOLOGIES AS , IVERSEN STEEN BRUMMERSTEDT , FELSVANG KARSTEN , LARSEN TOMMY , LUETHJE VIGGO
Inventor: IVERSEN STEEN BRUMMERSTEDT , FELSVANG KARSTEN , LARSEN TOMMY , LUETHJE VIGGO
IPC: A61K9/14 , A61K9/51 , B01D9/00 , B01D11/00 , B01J2/00 , B01J2/08 , B01J3/00 , B01J8/00 , B01J13/00 , B01J19/00 , B01J19/10 , B01J19/24 , B01J19/30 , C01G1/02 , C01G49/00 , C01G51/00 , C01G53/00 , B01J2/04
CPC classification number: B01D9/005 , B01D9/0063 , B01J2/006 , B01J2/08 , B01J3/008 , B01J8/009 , B01J13/0091 , B01J19/10 , B01J19/2475 , B01J19/2495 , B01J19/30 , B01J2219/30261 , B01J2219/30276 , B01J2219/30416 , B01J2219/30433 , B01J2219/30475 , B01J2219/32286 , B01J2219/32416 , B01J2219/32425 , B01J2219/32441 , B01J2219/32466 , B01J2219/32491 , B82Y30/00 , C01G1/02 , C01G49/0018 , C01G51/00 , C01G53/00 , C01P2002/04 , C01P2004/10 , C01P2004/34 , C01P2004/50 , C01P2004/51 , C01P2004/62 , C01P2004/64 , C01P2006/12 , C01P2006/42 , Y02P20/544 , Y10T428/2438
Abstract: The invention relates to controlled preparation of fine particles such as nano-crystalline films and powders with at least one solvent being in a supercritical state. It provides methods, measures, apparatus and products produced by the methods. In other aspects the invention relates to further treatment of formed particles such as encapsulation of formed primary particles, and methods and measures for collection of formed substances in a batch wise, semi-continuous or continuous manner.
Abstract translation: 本发明涉及具有至少一种溶剂处于超临界状态的微粒例如纳米晶膜和粉末的受控制备。 它提供了方法,措施,仪器和产品的方法。 在其它方面,本发明涉及成形颗粒的进一步处理,例如形成的初级颗粒的包封,以及以分批,半连续或连续方式收集成形物质的方法和措施。
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公开(公告)号:WO2004103347A2
公开(公告)日:2004-12-02
申请号:PCT/NL2004000350
申请日:2004-05-19
Applicant: APPLIED NANOSYSTEMS BV , FRIGGERI ARIANNA , VAN BOMMEL KJELD JACOBUS CORNE , ROBILLARD GEORGE THOMAS
IPC: A61K9/51 , A61K9/14 , C07C275/40
CPC classification number: C07D215/38 , A61K9/14 , A61K9/1688 , B01J2/08 , Y10S977/906
Abstract: The present invention relates to a method for producing particles of a compound of interest. In a method according to the invention a solution is provided of the compound of interest in a solvent. This solution is thickened or gelled and particles are formed. The invention further relates to a particle that is obtainable by the invention.
Abstract translation: 本发明涉及一种生产目的化合物颗粒的方法。 在根据本发明的方法中,在溶剂中提供目标化合物的溶液。 该溶液变稠或凝胶化并形成颗粒。 本发明还涉及可通过本发明获得的颗粒。
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