DEVICE AND METHOD FOR MAKING SOLID BEADS
    41.
    发明申请
    DEVICE AND METHOD FOR MAKING SOLID BEADS 审中-公开
    制造固体珠的装置和方法

    公开(公告)号:WO2010004253A3

    公开(公告)日:2010-08-05

    申请号:PCT/GB2009001492

    申请日:2009-06-16

    CPC classification number: B01J2/08 A61K9/1647 A61K9/1694

    Abstract: A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.

    Abstract translation: 公开了一种制备固体珠粒的方法,所述方法包括:(i)提供微流体装置,其包括在连接区域相遇的载体流体导管和功能流体导管; (ii)提供功能流体的层流,其包括沿着功能流体导管的溶剂和溶质,并且沿着载体流体导管提供载体流体的层流,以便在载体流体流中形成功能流体液滴 ; (iii)冷却所述微流体装置的管道中的功能流体段以形成冷却(优选冷冻)的液滴; 和(iv)将液体与冷却的液滴紧密混合,以使所述溶剂离开所述冷却的液滴,从而形成固体珠粒。 还公开了一种用于这种方法的微流体装置。

    セラミックス微粒子の製造方法及びそれに用いられるセラミックス微粒子の製造装置
    42.
    发明申请
    セラミックス微粒子の製造方法及びそれに用いられるセラミックス微粒子の製造装置 审中-公开
    生产陶瓷微生物和陶瓷微生物的方法

    公开(公告)号:WO2009098795A1

    公开(公告)日:2009-08-13

    申请号:PCT/JP2008/065277

    申请日:2008-08-27

    Abstract:  微細流路構造体が煩雑化すること無く、真円に近い球状の形状を備え、かつ、単分散性に優れ、セラミックス単体の固体成分のみで構成されたセラミックス微粒子を容易に製造することができるセラミックス微粒子の製造方法及びそれに用いられるセラミックス微粒子の製造装置を提供する。  界面活性剤を含む油性液体で構成された連続相中に、冷却によりゲル化するゲル化剤とセラミックス原料とが含まれる水性液体で構成された分散相が送り込まれることによって微小液滴を生成する工程(S100)と、前記生成した微小液滴を回収し、冷却する工程(S110)と、前記冷却した微小液滴を洗浄する工程(S120)と、前記洗浄した微小液滴を乾燥する工程(S130)と、前記乾燥した微小液滴を焼成する工程(S140)とを備える。

    Abstract translation: 可以容易地制造陶瓷微粒的制造方法,其中仅由陶瓷元素的固体成分构成的陶瓷微粒不伴随微通道结构的并入,具有接近正圆的球形构造,并且单分散性优异; 和陶瓷微粒制造装置。 该方法包括进料由含有陶瓷原料的水性液体组成的分散相的步骤(S100)和当冷却成含有表面活性剂的油性液体的连续相时形成凝胶的胶凝剂,从而形成液体 微滴; 回收形成的液体微滴并冷却的步骤(S110) 洗涤被冷却的液体微滴的步骤(S120) 干燥洗涤过的液体微滴的步骤(S130) 以及烧制干燥的液体微滴的步骤(S140)。

    SYSTEM AND METHOD FOR PRODUCING BEADS
    43.
    发明申请
    SYSTEM AND METHOD FOR PRODUCING BEADS 审中-公开
    用于生产珠粒的系统和方法

    公开(公告)号:WO2009071560A1

    公开(公告)日:2009-06-11

    申请号:PCT/EP2008/066659

    申请日:2008-12-02

    CPC classification number: B01J2/08 B01J13/046

    Abstract: The present invention relates to a method for producing beads comprising a material capable of gelation, said method comprising the steps of: (i) combining (a) a liquid composition comprising a material capable of gelation; and (b) a first hydrophobic phase; (ii) subjecting the liquid composition and the first hydrophobic phase, to means for emulsification in a first reactor by addition of external mechanical energy creating an emulsion comprising individual droplets comprising the material capable of gelation in the first hydrophobic phase (wherein the material capable of gelation provides a discontinuous phase and the first hydrophobic phase provides a continuous phase); (iii) stabilising the droplets by transferring the emulsion from the first reactor to a stabilisation reactor wherein the emulsion obtained in step (ii) is subjected to means for gelation in order to obtain gelation within 5 minutes or less, and the beads are formed.

    Abstract translation: 本发明涉及包含能够凝胶化的材料的珠粒的制造方法,所述方法包括以下步骤:(i)将(a)包含能够凝胶化的材料的液体组合物组合; 和(b)第一疏水相; (ii)使液体组合物和第一疏水相经过添加外部机械能在第一反应器中进行乳化的装置,产生包含单个液滴的乳液,所述液滴包含能够在第一疏水相中凝胶化的材料(其中能够 凝胶化提供不连续相,第一疏水相提供连续相); (iii)通过将乳液从第一反应器转移到稳定反应器中来稳定液滴,其中在步骤(ii)中获得的乳液经历凝胶化手段以在5分钟或更短时间内获得凝胶化,并形成珠粒。

    MICROPARTICLE PRODUCTION PROCESS AND APPARATUS
    45.
    发明申请
    MICROPARTICLE PRODUCTION PROCESS AND APPARATUS 审中-公开
    微粒生产方法和设备

    公开(公告)号:WO2017103113A3

    公开(公告)日:2017-08-24

    申请号:PCT/EP2016081436

    申请日:2016-12-16

    CPC classification number: B01J2/04 B01J2/08 B01J2/18

    Abstract: Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid. Also provided is a process for producing solid microparticles, the process comprising: providing a first liquid comprising a solute and a solvent, the solute comprising a biocompatible polymer, the concentration of polymer in the first liquid being at least 10% w/v, 'w' being the weight of the polymer and 'ν' being the volume of the solvent, providing a plurality of liquid droplet generators operable to generate liquid droplets, providing a jet of a second liquid, causing the plurality of liquid droplet generators to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the jet of the second liquid so as to cause the solvent to exit the droplets, thus forming solid microparticles, the solubility of the solvent in the second liquid being at least 5g of solvent per 100ml of second liquid, the solvent being substantially miscible with the second liquid.

    Abstract translation: 本发明提供一种固体高分子微粒的制造装置,其特征在于,具备:形成第一液体的液滴的多个液滴生成器和形成第二液体的射流的喷嘴,其中,所述多个液滴生成器和所述喷嘴 彼此相对布置,使得在使用中,来自所述多个液滴发生器的液滴通过气体进入所述第二液体射流。 还提供了生产固体微粒的方法,所述方法包括:提供包含溶质和溶剂的第一液体,所述溶质包含生物相容性聚合物,第一液体中聚合物的浓度为至少10%w / v, w'为聚合物的重量,'v'为溶剂的体积,提供多个可操作以产生液滴的液滴发生器,提供第二液体的射流,使多个液滴发生器形成液体 使液滴通过气体与第二液体的射流接触以使溶剂离开液滴从而形成固体微粒,溶剂在第二液体中的溶解度至少为5g 的溶剂/ 100ml第二液体,该溶剂基本上与第二液体混溶。

    DEVICE AND METHOD FOR MAKING SOLID BEADS
    47.
    发明申请
    DEVICE AND METHOD FOR MAKING SOLID BEADS 审中-公开
    制造固体珠的装置和方法

    公开(公告)号:WO2010004253A2

    公开(公告)日:2010-01-14

    申请号:PCT/GB2009/001492

    申请日:2009-06-16

    CPC classification number: B01J2/08 A61K9/1647 A61K9/1694

    Abstract: A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid 'in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.

    Abstract translation: 公开了一种制备固体珠粒的方法,所述方法包括:(i)提供微流体装置,其包括在连接区域相遇的载体流体导管和功能流体导管; (ii)提供功能流体的层流,其包括沿着功能流体导管的溶剂和溶质,并且沿着载体流体导管提供载体流体的层流,以在载体流中形成功能流体的液滴 流体; (iii)冷却所述微流体装置的管道中的功能流体段以形成冷却(优选冷冻)的液滴; 和(iv)将液体与冷却的液滴紧密混合,以使所述溶剂离开所述冷却的液滴,从而形成固体珠粒。 还公开了一种用于这种方法的微流体装置。

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