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    Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions
    41.
    发明授权
    Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions 有权

    公开(公告)号：US06780475B2

    公开(公告)日：2004-08-24

    申请号：US10156970

    申请日：2002-05-28

    Applicant: John L. Fulton ,  George Deverman

    Inventor： John L. Fulton ,  George Deverman

    IPC: B05D106

    CPC classification number: B05D1/025 ,  B05D1/04

    Abstract: A method for depositing a substance on a substrate that involves forming a supercritical fluid solution of at least one supercritical fluid solvent and at least one solute, discharging the supercritical fluid solution through an orifice under conditions sufficient to form solid particles of the solute that are substantially free of the supercritical fluid solvent, and electrostatically depositing the solid solute particles onto the substrate. The solid solute particles may be charged to a first electric potential and then deposited onto the substrate to form a film. The solute particles may have a mean particle size of less than 1 micron.

    Methods for producing films using supercritical fluid
    44.
    发明申请
    Methods for producing films using supercritical fluid 有权
    使用超临界流体生产膜的方法

    公开(公告)号：US20030222018A1

    公开(公告)日：2003-12-04

    申请号：US10157591

    申请日：2002-05-28

    Applicant: Battelle Memorial Institute

    Inventor： Clement R. Yonker ,  John L. Fulton

    IPC: B01D011/04

    CPC classification number: B05D1/025 ,  B05D5/083

    Abstract: A method for forming a continuous film on a substrate surface that involves depositing particles onto a substrate surface and contacting the particle-deposited substrate surface with a supercritical fluid under conditions sufficient for forming a continuous film from the deposited particles. The particles may have a mean particle size of less 1 micron. The method may be performed by providing a pressure vessel that can contain a compressible fluid. A particle-deposited substrate is provided in the pressure vessel and the compressible fluid is maintained at a supercritical or sub-critical state sufficient for forming a film from the deposited particles. The Tg of particles may be reduced by subjecting the particles to the methods detailed in the present disclosure.

    Abstract translation: 一种用于在基板表面上形成连续膜的方法，其包括在足以从沉积颗粒形成连续膜的条件下将颗粒沉积到基板表面上并使颗粒沉积的基板表面与超临界流体接触。 颗粒可以具有小于1微米的平均粒度。 该方法可以通过提供可容纳可压缩流体的压力容器来进行。 在压力容器中提供颗粒沉积的基底，并且可压缩流体保持在足以从沉积的颗粒形成膜的超临界或亚临界状态。 颗粒的Tg可以通过使颗粒经受本公开中详述的方法来降低。

    Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
    47.
    发明授权
    Methods for a particle precipitation and coating using near-critical and supercritical antisolvents 失效
    使用近临界和超临界反溶剂进行颗粒沉淀和涂层的方法

    公开(公告)号：US5833891A

    公开(公告)日：1998-11-10

    申请号：US805215

    申请日：1997-02-27

    Applicant: Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

    Inventor： Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

    IPC: A61K9/16 ,  A61K9/50 ,  B01J2/04 ,  B05D1/02 ,  B01D11/00

    CPC classification number: A61K9/1676 ,  A61K9/1688 ,  B01J2/04 ,  B05D1/025 ,  A61K9/1694 ,  A61K9/5089 ,  B05D2401/90

    Abstract: Improved methods and apparatus for particle precipitation and coating using near- or supercritical fluid conditions are described. A fluid dispersion having a continuous phase dispersant and at least one precipitatable substance therein is contacted with a supercritical fluid (SCF) antisolvent so as to generate focused high frequency antisolvent sonic waves, breaking up the dispersion into extremely small droplets; the enhanced mass transfer rates between the droplets and the antisolvent causes precipitation of very small particles on the order of 0.1-10 .mu.m. In coating processes, a turbulent fluidized flow of core particles is created using an SCF antisolvent in an enclosed zone. The core particles are contacted therein at near- or supercritical conditions by a fluid dispersion containing a dispersant together with a precipitatable substance. The antisolvent depletes the dispersant and the substance is precipitated onto the fluidized core particles. In another aspect of the invention, a process for preparing and administering a medicament using only a single container is provided. In such method, a fluid dispersion having a dispersant with the medicament therein is contacted with an antisolvent at near- or supercritical conditions within a use container, so as to directly precipitate small particles of the medicament in the container. The antisolvent is then removed and the use container is sealed with the medicament particles therein. Thereafter, dose(s) of the medicament can be withdrawn from the use container and administered to a patient.

    Abstract translation: 描述了使用近或超临界流体条件改进颗粒沉淀和涂层的方法和装置。 具有连续相分散剂和至少一种可沉淀物质的流体分散体与超临界流体（SCF）反溶剂接触，以产生聚焦的高频反溶剂声波，将分散体分解成极小的液滴; 液滴和抗溶剂之间的增强的传质速率导致非常小的颗粒的沉淀约0.1-10μm。 在涂覆过程中，使用封闭区域中的SCF反溶剂产生核心颗粒的湍流流化流。 核心颗粒在近或超临界条件下通过含有分散剂和可沉淀物质的流体分散体接触。 反溶剂消耗分散剂，物质沉淀在流化核心颗粒上。 在本发明的另一方面，提供了仅使用单一容器制备和施用药物的方法。 在这种方法中，将具有药物的分散剂的流体分散体与使用容器内的近临界或超临界条件下的反溶剂接触，从而将药物的小颗粒直接沉淀在容器中。 然后将抗溶剂除去，并将使用容器用其中的药物颗粒密封。 此后，药物的剂量可以从使用容器中取出并给予患者。

    Method of making fluoropolymers
    49.
    发明授权
    Method of making fluoropolymers 失效
    制备含氟聚合物的方法

    公开(公告)号：US5496901A

    公开(公告)日：1996-03-05

    申请号：US302642

    申请日：1994-09-27

    Applicant: Joseph M. DeSimone

    Inventor： Joseph M. DeSimone

    IPC: B05D1/02 ,  B05D5/08 ,  C08F2/00 ,  C08F2/02 ,  C08F2/04 ,  C08F2/06 ,  C08F12/00 ,  C08F12/14 ,  C08F12/20 ,  C08F14/18 ,  C08F16/14 ,  C08F16/22 ,  C08F16/24 ,  C08F20/22 ,  C08J3/02

    CPC classification number: C08J3/02 ,  B05D1/025 ,  B05D5/083 ,  C08F12/20 ,  C08F14/18 ,  C08F16/22 ,  C08F16/24 ,  C08F20/22 ,  C08J2327/12 ,  Y02P20/544 ,  Y10S526/942

    Abstract: A process for making a fluoropolymer is disclosed. The process comprises solubilizing a fluoromonomer in solvent comprising a carbon dioxide fluid, and then polymerizing the fluoromonomer to produce the fluoropolymer. A preferred solvent for carrying out the process is supercritical carbon dioxide; preferred fluoromonomers for carrying out the process are fluoroacrylate monomers such as 1,1-dihydroperfluorooctyl acrylate. The polymerization step is preferably carried out in the presence of an initiator such as azobisisobutyronitrile.

    Abstract translation: PCT No.PCT / US93 / 01626 Sec。 371日期：1994年9月27日 102（e）日期1994年9月27日PCT提交1993年2月26日PCT公布。 公开号WO93 / 20116 PCT 日期：10月14日，日本专利公开了一种制造含氟聚合物的方法。 该方法包括将含氟单体溶解在包含二氧化碳流体的溶剂中，然后使含氟单体聚合以制备含氟聚合物。 用于进行该方法的优选溶剂是超临界二氧化碳; 用于进行该方法的优选的氟单体是氟代丙烯酸酯单体，例如丙烯酸1,1-二氢双氟辛酯。 聚合步骤优选在引发剂如偶氮二异丁腈存在下进行。

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