公开(公告)号：WO2010083264A1

公开(公告)日：2010-07-22

申请号：PCT/US2010/020964

申请日：2010-01-14

Applicant: ABBOTT LABORATORIES ,  ZHANG, Qingwei ,  STEWART, Andrew, O. ,  XIA, Zhiren

Inventor： ZHANG, Qingwei ,  STEWART, Andrew, O. ,  XIA, Zhiren

IPC: C07D211/58 ,  C07D471/06 ,  C07D487/06 ,  A61K31/4985 ,  A61P25/04 ,  A61P25/28

CPC classification number: C07D487/04 ,  C07D211/58 ,  C07D401/04 ,  C07D471/04

Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Abstract translation: 本发明涉及包含式（I），式（II），式（III）或式（IV）的化合物的钙通道抑制剂，其中L 1，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R c 如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2009126484A3

公开(公告)日：2009-12-17

申请号：PCT/US2009039093

申请日：2009-04-01

Applicant: PALM INC ,  DATTA MAINAK ,  STEWART ANDREW ,  FAN JAMES JIANHUA ,  SHIRADWADE SATEESH K

Inventor： DATTA MAINAK ,  STEWART ANDREW ,  FAN JAMES JIANHUA ,  SHIRADWADE SATEESH K

IPC: H04W8/24 ,  G06F9/445 ,  H04W88/02

CPC classification number: H04L67/06 ,  G06F8/65 ,  H04L67/34 ,  H04M1/72525

Abstract: A system and method for updating a computer program on a mobile computing device comprises uploading of packages to a repository, wherein each package comprises update data for a different portion of the computer program, a server identifying portions of the computer program to be updated on a device based on comparing information reported by the device and metadata about packages in the repository and a download server configured to wirelessly download the packages to the mobile computing device. The device may report back installation status to a server.

Abstract translation: 一种用于在移动计算设备上更新计算机程序的系统和方法包括将包上传到存储库，其中每个包包括用于计算机程序的不同部分的更新数据，识别要更新的计算机程序的部分的服务器 设备，其基于所述设备报告的信息和所述存储库中的包的元数据以及被配置为将所述包无线地下载到所述移动计算设备的下载服务器。 设备可能会将安装状态报告给服务器。

公开(公告)号：WO2008083499A1

公开(公告)日：2008-07-17

申请号：PCT/CA2008/000059

申请日：2008-01-11

Applicant: SPORT MASKA INC. ,  STEWART, Andrew

Inventor： STEWART, Andrew

IPC: A43B5/16 ,  A63C1/42

CPC classification number: A43B5/16 ,  A43B5/1691 ,  A43B7/18 ,  A43B7/20 ,  A63C1/42

Abstract: A skate boot with a rear element that includes a tendon guard upwardly extending from an outsole of the boot is disclosed. The rear element covers at least a rear portion of an ankle received within the boot. The rear element has a base in connection with a heel portion of the outsole such that the rear element is displaceable relative a remainder of the boot in a forward and rearward direction about the connection. The rear element is an external element of the boot, and has a desired flexibility allowing the rear element to flex in the forward and rearward direction following a given forward and rearward flexion of the ankle.

Abstract translation: 公开了一种具有后部元件的滑冰靴，其包括从靴子的外底向上延伸的腱护罩。 后部元件覆盖在靴子内部接收的踝部的至少后部。 后部元件具有与鞋外底的后跟部分相连的基部，使得后部元件相对于围绕连接件的向前和向后方向的保护罩的其余部分可移动。 后部元件是护罩的外部元件，并且具有期望的柔性，允许后部元件在给定的脚踝的向前和向后弯曲之后沿前后方向弯曲。

公开(公告)号：WO2006033912B1

公开(公告)日：2006-09-08

申请号：PCT/US2005032706

申请日：2005-09-14

Applicant: OSTEOTROPHIN LLC ,  STEWART ANDREW F

Inventor： STEWART ANDREW F

IPC: A61K38/00

CPC classification number: A61K38/29

Abstract: Disclosed herein are methods for the prevention and treatment of a variety of mammalian conditions manifested by loss of bone mass, including osteoporosis. The present invention provides methods of using PTHrP, or analogs thereof, for the treatment of metabolic bone disorders that are both effective and have an increased safety.

Abstract translation: 本文公开了用于预防和治疗由骨量丧失（包括骨质疏松症）表现的多种哺乳动物病症的方法。 本发明提供了使用PTHrP或其类似物治疗既有效又具有增加的安全性的代谢性骨病症的方法。

公开(公告)号：WO2006081072A1

公开(公告)日：2006-08-03

申请号：PCT/US2006/000967

申请日：2006-01-12

Applicant: ABBOTT LABORATORIES ,  STEWART, Andrew, O. ,  ZHENG, Guo, Zhu ,  KOLASA, Teodozyj ,  BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  LATSHAW, Steven, P. ,  WANG, Xueqing

Inventor： STEWART, Andrew, O. ,  ZHENG, Guo, Zhu ,  KOLASA, Teodozyj ,  BHATIA, Pramila, A. ,  DAANEN, Jerome, F. ,  LATSHAW, Steven, P. ,  WANG, Xueqing

IPC: C07D493/14 ,  C07D495/14 ,  C07D495/04 ,  A61K31/519 ,  A61P25/04 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24

CPC classification number: C07D493/14 ,  C07D495/14

Abstract: The present invention discloses compounds of general formula (I) wherein X 1 -X 4 and R 1 -R 3 are as defined in the description. The present invention also discloses methods of treatment for pain, neurodegeneration and convulsive states in a host mammal in need thereof, and pharmaceutical compositions including those compounds.

Abstract translation: 本发明公开了通式（I）的化合物，其中X 1 -X 4 -X 3和R 1 -R 3 >如说明书中所定义。 本发明还公开了在有需要的宿主哺乳动物中治疗疼痛，神经变性和惊厥状态的方法，以及包括那些化合物的药物组合物。

公开(公告)号：WO2006033912A2

公开(公告)日：2006-03-30

申请号：PCT/US2005/032706

申请日：2005-09-14

Applicant: OSTEOTROPHIN LLC ,  STEWART, Andrew, F.

Inventor： STEWART, Andrew, F.

IPC: A61K38/18

CPC classification number: A61K38/29

Abstract: Disclosed herein are methods for the prevention and treatment of a variety of mammalian conditions manifested by loss of bone mass, including osteoporosis. The present invention provides methods of using PTHrP, or analogs thereof, for the treatment of metabolic bone disorders that are both effective and have an increased safety.

Abstract translation: 本文公开了用于预防和治疗由骨质量丢失（包括骨质疏松症）表现的多种哺乳动物疾病的方法。 本发明提供了使用PTHrP或其类似物治疗既有效又增加安全性的代谢性骨病的方法。

公开(公告)号：WO2003059291A3

公开(公告)日：2003-07-24

申请号：PCT/US2003/000770

申请日：2003-01-10

Applicant: OSTEOTROPHIN LLC ,  STEWART, Andrew, F.

Inventor： STEWART, Andrew, F.

IPC: A61K38/29

Abstract: Disclosed herein are methods for the prevention and treatment of a variety of mammalian conditions manifested by loss of bone mass, including osteoporosis. The present invention provides methods of using PTHrP, or analogs thereof, for the treatment of metabolic bone disorders that are both effective and have an increased safety.

公开(公告)号：WO1991002799A1

公开(公告)日：1991-03-07

申请号：PCT/AU1990000373

申请日：1990-08-24

Applicant: BIOTECHNOLOGY AUSTRALIA PTY LTD ,  RUSSELL-JONES, Gregory, John ,  STEWART, Andrew, George ,  TSONIS, Con, George

Inventor： BIOTECHNOLOGY AUSTRALIA PTY LTD

IPC: C12N15/62

CPC classification number: C07K7/23 ,  A61K38/00 ,  A61K39/00 ,  C07K14/245 ,  C07K2319/00 ,  C07K2319/035 ,  C07K2319/75 ,  Y10S424/811 ,  Y10S930/13

Abstract: This invention relates to the preparation of novel fusion proteins which comprise an analogue of LHRH and TraTp or an analogue of TraTp. The fusion proteins of the invention are useful as components of vaccines for the inhibition or control of reproductive functions in vertebrate hosts. The invention also relates to polynucleotide molecules encoding the fusion proteins, to transformant hosts expressing the fusion proteins and to methods of inhibiting or controlling reproductive function in vertebrate hosts using the fusion proteins or vaccines of the invention.

Abstract translation: 本发明涉及新型融合蛋白的制备，其包含LHRH和TraTp的类似物或TraTp的类似物。 本发明的融合蛋白可用作在脊椎动物宿主中抑制或控制生殖功能的疫苗的组分。 本发明还涉及编码融合蛋白的多核苷酸分子，表达融合蛋白的转化体宿主以及使用本发明的融合蛋白或疫苗在脊椎动物宿主中抑制或控制生殖功能的方法。

公开(公告)号：WO2012025701A1

公开(公告)日：2012-03-01

申请号：PCT/GB2010/001608

申请日：2010-08-25

Applicant: CHROMA THERAPEUTICS LTD. ,  DONALD, Alistair David Graham ,  MOFFAT, David Festus Charles ,  BELFIELD, Andrew James ,  NORTH, Carl Leslie ,  JONES, Stewart Andrew Wayne

Inventor： DONALD, Alistair David Graham ,  MOFFAT, David Festus Charles ,  BELFIELD, Andrew James ,  NORTH, Carl Leslie ,  JONES, Stewart Andrew Wayne

IPC: C07D213/56 ,  C07D307/20 ,  C07D309/14 ,  C07D405/12 ,  C07D405/14 ,  C07C259/06 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/165 ,  A61K31/341 ,  A61K31/351

CPC classification number: C07D213/56 ,  C07C259/06 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/16 ,  C07D307/20 ,  C07D309/14 ,  C07D405/12 ,  C07D405/14

Abstract: Compounds selected from the following group and their salts are inhibitors of HDAC activity, useful in the treatment of, inter alia, cell proliferative disease and inflammation: Cyclopentyl 1 -[({5-[(1 E )-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]pyridin-2- yl}methy)amino]cyclopropanecarboxylate; Cyclopentyl 1 -[({5-[(1 E )-3-(hydroxyamino)-3- oxoprop-1-en-1-yl]pyridin-2-yl}methy)amino]cyclobutanecarboxylate; Cyclopentyl 1-[({5- [(1 E )-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]pyridin-2yl}methyl)amino]- cyclopentanecarboxylate; Cyclopentyl 1-[({5-[(1 E )-3-(hydroxyamino)-3-oxoprop-1-en-1- yl]pyridin-2-yl}methyl)amino]cyclohexanecarboxylate; Cyclopentyl 4-[({5-[(1 E )-3- (hydroxyamino)-3-oxoprop-1 -en-1 -yl]pyridin-2-yl}methyl)amino]tetrahydro-2 H -pyran-4- carboxylate; Cyclopentyl 4-[({6-[(1 E )-3-{[1 -(2-methylpropoxy)ethoxy]amino}-3-oxoprop-1 - en-1 -yl]pyridin-3-yl}methyl)amino]tetrahydro-2H-pyran-4-carboxylate; Cyclopentyl 1 -({4- [(1 E )-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]-2-methylbenzyl}amino)- cyclohexanecarboxylate; Cyclopentyl 1-({4-[(1 E )-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]- 2-methylbenzyl}amino)cyclopentanecarboxylate; Cyclopentyl 1-({4-[(1 E )-3- (hydroxyamino)-3-oxoprop-1-en-1-yl]-2-methylbenzyl}amino)cyclobutanecarboxylate; Methylcyclopentyl 4-[({6-[(1 E )-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]pyridin-3- yl}methyl)amino]tetrahydro-2 H -pyran-4-carboxylate; Cyclopentyl 4-{[1 -({6-[(1 E )-3- (hydroxyamino)-3-oxoprop-1-en-1-yl]pyridin-3-yl}methyl)piperidin-4-yl]amino}tetrahydro- 2 H -pyran-4-carboxylate; Cyclopentyl 4-{[1-({5-[(1 E )-3-(hydroxyamino)-3-oxoprop-1-en-1- yl]pyridin-2-yl}methyl)piperidin-4-yl]amino}tetrahydro-2 H -pyran-4-carboxylate; Cyclopentyl 4-({4-[(1 E )-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]benzyl}amino)tetrahydro- 2 H -pyran-4-carboxylate; Cyclopentyl 4-({3-[(1 E )-3-(hydroxyamino)-3-oxoprop-1 -en-1 - yl]benzyl}amino)tetrahydro-2 H -pyran-4-carboxylate; and (3 R )-Tetrahydrofuran-3-yl N -{4- [(1 E )-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]benzyl}-2-methyl-D-leucinate.

Abstract translation: 选自下列组和其盐的化合物是HDAC活性的抑制剂，可用于治疗细胞增殖性疾病和炎症：环戊基1 - [（{5 - [（1E）-3-（羟基氨基）-3 - 氧代丙-1-烯-1-基]吡啶-2-基}甲基）氨基]环丙烷甲酸甲酯; 1 - [（{5 - [（1E）-3-（羟氨基）-3-氧代丙-1-烯-1-基]吡啶-2-基}甲基）氨基]环丁烷甲酸叔丁酯; 1 - [（{5 - [（1E）-3-（羟基氨基）-3-氧代丙-1-烯-1-基]吡啶-2-基}甲基）氨基] - 环戊烷甲酸甲酯; 1 - [（{5 - [（1E）-3-（羟基氨基）-3-氧代丙-1-烯-1-基]吡啶-2-基}甲基）氨基]环己烷羧酸酯; 4 - [（{5 - [（1E）-3-（羟基氨基）-3-氧代丙-1-烯-1-基]吡啶-2-基}甲基）氨基]四氢-2H-吡喃-4-羧酸 ; 环戊基4 - [（{6 - [（1E）-3 - {[1-（2-甲基丙氧基）乙氧基]氨基} -3-氧代丙-1-烯-1-基]吡啶-3-基}甲基）氨基 ]四氢-2H-吡喃-4-羧酸乙酯; 1 - （{4 - [（1E）-3-（羟基氨基）-3-氧代丙-1-烯-1-基] -2-甲基苄基}氨基） - 环己烷甲酸环戊酯; 1 - （{4 - [（1E）-3-（羟基氨基）-3-氧代丙-1-烯-1-基] -2-甲基苄基}氨基）环戊烷甲酸环戊酯; 1 - （{4 - [（1E）-3-（羟基氨基）-3-氧代丙-1-烯-1-基] -2-甲基苄基}氨基）环丁烷甲酸环戊酯; 甲基环戊基4 - [（{6 - [（1E）-3-（羟基氨基）-3-氧代丙-1-烯-1-基]吡啶-3-基}甲基）氨基]四氢-2H-吡喃-4-甲酸甲酯 ; 4 - {[1 - （{6 - [（1E）-3-（羟氨基）-3-氧代丙-1-烯-1-基]吡啶-3-基}甲基）哌啶-4-基]氨基} 四氢-2H-吡喃-4-羧酸乙酯; 4 - {[1 - （{5 - [（1E）-3-（羟基氨基）-3-氧代丙-1-烯-1-基]吡啶-2-基}甲基）哌啶-4-基]氨基} 四氢-2H-吡喃-4-羧酸乙酯; 4 - （{4 - [（1E）-3-（羟氨基）-3-氧代丙-1-烯-1-基]苄基}氨基）四氢-2H-吡喃-4-羧酸4- 4 - （{3 - [（1E）-3-（羟基氨基）-3-氧代丙-1-烯-1-基]苄基}氨基）四氢-2H-吡喃-4-羧酸4- 和（3R） - 四氢呋喃-3-基N- {4 - [（1E）-3-（羟基氨基）-3-氧代丙-1-烯基]苄基} -2-甲基-D-亮氨酸。

公开(公告)号：WO2010031995A3

公开(公告)日：2010-11-25

申请号：PCT/GB2009002184

申请日：2009-09-14

Applicant: MEDTRADE PRODUCTS LTD ,  HARDY CRAIG JULIAN ,  DARBY STEWART ANDREW

Inventor： HARDY CRAIG JULIAN ,  DARBY STEWART ANDREW

IPC: A61L15/60

CPC classification number: A61L15/60 ,  C08L5/00 ,  C08L1/00

Abstract: The present invention relates to an absorbent wound care device comprising two or more materials which individually do not gel when exposed to a fluid but do gel when brought together and exposed to a fluid. The device is particularly intended for haemostatic use and for absorbing bodily fluids being emitted from wounds and physiological target sites.

Abstract translation: 本发明涉及包含两种或更多种材料的吸收性伤口护理装置，所述两种或更多种材料在暴露于流体时单独地不凝胶，但当被放在一起并暴露于流体时凝胶化。 该装置特别用于止血用途和吸收从伤口和生理目标部位排出的体液。