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    POLIMERO ADECUADO PARA SU USO EN CULTIVO CELULAR.
    52.
    发明专利
    POLIMERO ADECUADO PARA SU USO EN CULTIVO CELULAR. 未知

    公开(公告)号：MX2016000612A

    公开(公告)日：2016-09-16

    申请号：MX2016000612

    申请日：2014-07-16

    Applicant: STICHTING KATHOLIEKE UNIV

    Inventor： ALAN EDWARD ROWAN ,  PETRUS JOHANNES GEUTJES ,  WOUTER F J FEITZ ,  EGBERT OOSTERWIJK ,  ZASKIA HILLET EKSTEEN AKEROYD ,  CHRISTOPHER WILSON

    IPC: A61K47/48 ,  C08G65/325 ,  C08G65/333 ,  C08G73/00

    Abstract: La invención se refiere a un procedimiento para preparar un copoliisocianopéptido funcionalizado con oligo (alquilenglicol), comprendiendo el procedimiento las etapas de: i) copolimerizar - un primer comonómero de un isocianopéptido funcionalizado con oligo (alquilenglicol) injertado con un grupo enlazante y - un segundo monómero de un isocianopéptido funcionalizado con oligo (alquilenglicol) sin injertar, en donde la proporción molar entre el primer comonómero y el segundo comonómero esde 1:500 y 1:30 y ii) añadir un reactante de una unidad espaciadora y un factor de adhesión celular al copolímero obtenido mediante la etapa i), en donde la unidad espaciadora se representa con la fórmula general A-L-B, en donde el grupo enlazante y el grupo A se eligen de modo que reaccionen y formen un primer acoplamiento y el factor de adhesión celular y el grupo B se eligen de modo que reaccionen y formen un segundo acoplamiento, en donde el primer acoplamiento y el segundo acoplamiento se seleccionan independientemente del grupo que consiste en acoplamiento alquino-azida, acoplamiento dibenzociclooctino-azida, acoplamientos de azida basada en oxanorbornad ieno, acoplamiento vinilsu Ifona-tiol, acoplamiento maleimida-tiol, acoplamiento metacrilato de metilo-tiol, acoplamiento de éter, acoplamiento de tioéter, acoplamiento biotina-estrepavidina, amina-ácido carboxílico resultante en enlaces de amidas, acoplamiento alcohol-ácido carboxílico resultante en enlaces de ésteres y acoplamiento de éster de NHS (éster de N-hidroxisuccinimida)-amina y en donde el grupo L es un segmento de cadena lineal que tiene 10-60 enlaces entre átomos seleccionados de C, N, O y S en la cadena principal.

    Polymer suitable for use in cell culture
    53.
    发明专利
    Polymer suitable for use in cell culture 未知

    公开(公告)号：AU2014292097A1

    公开(公告)日：2016-02-11

    申请号：AU2014292097

    申请日：2014-07-16

    Applicant: STICHTING KATHOLIEKE UNIV

    Inventor： ROWAN ALAN EDWARD ,  EKSTEEN AKEROYD ZASKIA HILLET ,  WILSON CHRISTOPHER ,  GEUTJES PETRUS JOHANNES ,  FEITZ WOUTER F J ,  OOSTERWIJK EGBERT

    IPC: A61K47/48 ,  C08G65/325 ,  C08G65/333 ,  C08G73/00

    Abstract: The invention relates to a process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process comprises the steps of: i) copolymerizing - a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and - a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is :500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula A-L-B, wherein the linking group and group A are chosen to react and form a first coupling and the cell adhesion factor and group B are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornadiene-based-azide couplings, vinylsulphone-thiol coupling, maleimide-thiol coupling, methyl methacrylate-thiol coupling, ether coupling, thioether coupling, biotin- strepavidin coupling, amine-carboxylic acid resulting in amides linkages, alcohol- carboxylic acid coupling resulting in esters linkages and NHS-Ester (N- Hydroxysuccinimide ester)-amine coupling and wherein group L is a linear chain segment having 10-60 bonds between atoms selected from C, N, O and S in the main chain.

    Anatomical Image Projection System.
    54.
    发明专利
    Anatomical Image Projection System. 未知

    公开(公告)号：NL2012416A

    公开(公告)日：2015-11-19

    申请号：NL2012416

    申请日：2014-03-12

    Applicant: STICHTING KATHOLIEKE UNIV

    Inventor： STEFAN LAURENTIUS MARIA HUMMELINK

    IPC: A61B6/00 ,  A61B8/08

    Abstract: Projection system for image projection of anatomical features on a subject. Intraoperative position markers (10) are disposed on a first body surface (6), and a moveable first detector (12) with a detection line of sight is provided. A control unit (14) is arranged for registering detected intraoperative position markers (10) with a plurality of preoperative position markers (4) in preoperative images. A movable projector (16) is provided for projecting an image representation (18) of the one or more anatomical features of interest. The projection line of sight is substantially parallel to the detection line of sight. The control unit (14) is in communication with the first detector (12) and projector (16) and arranged for real-time image projection of the image representation (18) on the second body surface (20) by the projector (16) independent from synchronized movement and varying detection/projection angles of the first detector (12) and the projector (16).

    SPECIFIC METHOD OF PROSTATE CANCER DETECTION BASED ON PCA3 GENE, AND KITS THEREFOR
    55.
    发明专利
    SPECIFIC METHOD OF PROSTATE CANCER DETECTION BASED ON PCA3 GENE, AND KITS THEREFOR 未知

    公开(公告)号：CA2530646C

    公开(公告)日：2015-11-03

    申请号：CA2530646

    申请日：2004-06-30

    Applicant: STICHTING KATHOLIEKE UNIV

    Inventor： SCHALKEN JACK A ,  VERHAEGH GERALD ,  HESSELS DAPHNE ,  SMIT FRANK

    IPC: C12Q1/68

    Abstract: The present invention relates, in general, to prostate cancer. More specifically, the present invention relates to a method to diagnose prostate cancer in a, patient by detecting a PCA3 sequence, and more particularly a PCA3 RNA, the PCA3 sequence detected in a sample from the patient being specifically associated with prostate cancer. In a particular embodiment the method and kit enables an amplification of a PCA3 RNA through an exon-exon junction of a spliced PCA3 mRNA. The invention also related to methods and kits to detect such an amplified PCA3 RNA, using a probe which spans the amplified exonexon junction. The invention also relates to kits containing nucleic acid primers and kits containing nucleic acid primers and nucleic acid probes to diagnose, assess, or prognose a human afflicted with prostate cancer. In particular the methods and kits are designed to detect a PCA3 RNA which lacks one intron or more, and in particular case is intron-less.

    METHOD OF ANALYSING DATA FROM, COMPUTER PROGRAM, COMPUTER READABLE MEDIUM AND DATA ANALYSIS SYSTEM.
    56.
    发明专利
    METHOD OF ANALYSING DATA FROM, COMPUTER PROGRAM, COMPUTER READABLE MEDIUM AND DATA ANALYSIS SYSTEM. 未知

    公开(公告)号：NL1040872C2

    公开(公告)日：2015-06-22

    申请号：NL1040872

    申请日：2014-06-29

    Applicant: STICHTING KATHOLIEKE UNIV ,  UNIV MEDICAL CT UTRECHT

    Inventor： JANSE JEROEN ,  BUYDENS LUTGARDE ,  KOENDERMAN LEO ,  HILVERING BART ,  BRINK OSCAR

    IPC: G01N15/14

    Abstract: The invention relates to a computer implemented method of analysing data comprising measured values of characteristics of objects in samples, the data comprising —a first set of data (Xireference)′ with measured values of characteristics of objects in reference samples; —a test set of data (Xitest) with measured values of the characteristics of objects in a test sample; characterised by the method comprising; —fitting a control model to the first set of data to determine control loadings (Pcontrol) each representing an independent correlation between characteristics; —projecting the first set of data (Xireference) onto the control loadings (Pcontrol) for determining a first set control scores (Tcontrol,ireference) and determining one or more confidence intervals for the first set of control scores (Tcontrol,ireference); —projecting the test data onto the control loadings (Pcontrol) for determining test control scores; —determining if the test control scores are within one or more the confidence intervals.

    CONTRAST AGENT AND ITS USE FOR IMAGING
    58.
    发明专利
    CONTRAST AGENT AND ITS USE FOR IMAGING 未知

    公开(公告)号：CA2884154A1

    公开(公告)日：2014-03-20

    申请号：CA2884154

    申请日：2013-09-14

    Applicant: STICHTING KATHOLIEKE UNIV

    Inventor： FIGDOR CARL GUSTAV ,  DE VRIES INGRID JOLANDA MONIQUE ,  SRINIVAS MANGALA ,  CRUZ RICONDO LUIS JAVIER

    IPC: A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61P9/00 ,  A61P35/00 ,  A61P37/00 ,  B82Y5/00 ,  B82Y15/00

    Abstract: The present invention relates to contrast agent enhanced medical ultrasound imaging. In particular, the contrast agents provided are useful for cell imaging and cell therapy, as well as in vivo targeting, drug delivery and perfusion or vascular imaging applications. More specifically, it provides a particle comprising a fluorinated organic compound and a metal. Such particles may be advantageously employed in qualitative or quantitative imaging such as acoustic imaging including photoacoustic and ultrasound imaging, MRI imaging, such as 19F imaging, 1H imaging including T1 and T2 weighted imaging, SPECT, PET, scintigraphy, fluorescence imaging and optical coherence imaging and tomographic applications. This may then be employed in cell labeling, microscopy, histology or for imaging vasculature or perfusion in vivo and in vitro.

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