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公开(公告)号：US10125222B2
公开(公告)日：2018-11-13
申请号：US15373424
申请日：2016-12-08
Inventor： Alan Edward Rowan , Roeland Johannes Maria Nolte , Jeroen Johannes Lambertus Maria Cornelissen , Heather Joy Kitto , Erik Schwartz , Matthieu Koepf
IPC: C08G18/08 , C08G69/40 , C09D177/04 , C08L77/04
Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol)-functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol-functionalized isocyanopeptides. Several isocyanopeptides may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably, the isocyanopeptides are functionalized with at least three ethylene glycol side chains. The peptides may comprise L-amino acids, D-amino acids or D, L-amino acids. The obtained oligoalkylene-functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.
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公开(公告)号：US10076417B2
公开(公告)日：2018-09-18
申请号：US15028042
申请日：2014-01-27
Applicant: Stichting Katholieke Universiteit
Inventor： Tony George Van Tienen
CPC classification number: A61F2/30756 , A61B17/562 , A61F2/30 , A61F2/3872 , A61F2220/0008
Abstract: A joint prosthesis assembly, includes a joint prosthesis body (1) made of a first biocompatible non-resorbable material and an anchoring element (2-5) made of a second biocompatible non-resorbable material. The anchoring element (2-5) is arranged to allow rotation of an end portion of the joint prosthesis body (1) with respect to the anchoring element (2-5) when in situ.
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公开(公告)号：US20180245049A1
公开(公告)日：2018-08-30
申请号：US15757218
申请日：2016-09-05
Applicant: STICHTING KATHOLIEKE UNIVERSITEIT
Inventor： Wouter Franciscus Joannes FEITZ , Egbert OOSTERWIJK , Silvia Maria MIHAILA , Alan Edward ROWAN
IPC: C12N5/0775 , C12N5/00
CPC classification number: C12N5/0663 , C08L71/02 , C12N5/0062 , C12N2506/1346 , C12N2513/00 , C12N2527/00 , C12N2533/30 , C12N2533/32 , C12N2533/40
Abstract: A cell culture including a cell culturing medium for growing stem cells, a three-dimensional (3D) cell growth matrix and stem cells, wherein the cell culture has a critical stress σc of 2-30 Pa, wherein the critical stress is a stress which marks an onset of strain stiffening and wherein the cell culture has a storage modulus G′ measured at 37° C. of 50-1000 Pa.
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54.发明申请公开(公告)号：US20180237749A1
公开(公告)日：2018-08-23
申请号：US15759878
申请日：2016-09-14
Applicant: Stichting Katholieke Universiteit
Inventor： Harmen Dolstra
IPC: C12N5/0783 , A61K35/17 , A61P35/00
CPC classification number: C12N5/0646 , A61K35/17 , A61P35/00 , C12N2500/46 , C12N2501/145 , C12N2501/20 , C12N2501/2307 , C12N2501/2312 , C12N2501/2315 , C12N2501/26 , C12N2501/60 , C12N2506/11
Abstract: The present invention relates to the field of medicine, specifically the field of treatment of cancer. More specifically, the invention relates to a method for the ex vivo production of a population of highly functional NK cells from CD34-positive cells, to a population of highly functional NK cells obtained and to the use of such population of highly functional NK cells for adoptive cell therapy.
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公开(公告)号：US09958463B2
公开(公告)日：2018-05-01
申请号：US15106727
申请日：2014-12-18
Inventor： Giacinto Scoles , Fabio Del Ben , Matteo Turetta , Wilhelm Huck , Aigars Piruska
IPC: G01N33/84
CPC classification number: G01N33/84 , G01N2800/7028
Abstract: The present invention relates to a method for detecting circulating tumor cells (CTCs) in body fluids, preferably in blood and lymph.In particular, the method for detecting circulating tumor cells in a body fluid comprises a step of detecting a change in pH and/or in a concentration of at least one molecule selected from lactic acid, lactate ions and protons within an isolated volume of said body fluid in which a cell has been encapsulated.
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Patent Agency Ranking
公开(公告)号：US20170342414A1
公开(公告)日：2017-11-30
申请号：US15656635
申请日：2017-07-21
Applicant: Stichting Katholieke Universiteit
Inventor： Robert Wilhelmus Johanna COLLIN , Franciscus Peter Maria CREMERS , Antonia Ingrid DEN HOLLANDER
IPC: C12N15/113
CPC classification number: C12N15/113 , C12N2310/11 , C12N2310/15 , C12N2310/321 , C12N2310/346 , C12N2320/33 , C12N2320/34 , C12N2310/3521
Abstract: The present invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Leber congenital amaurosis.
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公开(公告)号：US20170136162A1
公开(公告)日：2017-05-18
申请号：US15322459
申请日：2015-06-30
Applicant: STICHTING KATHOLIEKE UNIVERSITEIT
Inventor： Daniël Immanuel Michaël van Dort , Harry Suryapranata , Paul Frederik Gründeman , Jakob Roelf Lahpor
CPC classification number: A61M1/1074 , A61B2017/3425 , A61M1/1006 , A61M1/1008 , A61M1/106 , A61M1/107 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M2205/0216 , A61M2230/005 , A61M2230/06
Abstract: Heart support device for circulatory assistance, with an internal member (6) to be disposed inside a heart lumen (13) and having a dynamic volume body. The internal member (6) has a substantially stiff wall strengthening portion (8) arranged to engage an inner wall surface (12a) of the heart (10) in operation and a dynamic member (9) that is inflatable to assist pumping action of the heart (10).
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58.发明申请公开(公告)号：US20170088670A1
公开(公告)日：2017-03-30
申请号：US15373424
申请日：2016-12-08
Inventor： Alan Edward Rowan , Roeland Johannes Maria Nolte , Jeroen Johannes Lambertus Maria Cornelissen , Heather Joy Kitto , Erik Schwartz , Matthieu Koepf
IPC: C08G69/40 , C08L77/04 , C09D177/04
CPC classification number: C08G69/40 , C08G65/33348 , C08L77/04 , C08L2201/54 , C09D177/04
Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol)-functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol-functionalized isocyanopeptides. Several isocyanopeptides may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably, the isocyanopeptides are functionalized with at least three ethylene glycol side chains. The peptides may comprise L-amino acids, D-amino acids or D, L-amino acids. The obtained oligoalkylene-functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.
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公开(公告)号：US20170073776A1
公开(公告)日：2017-03-16
申请号：US15364962
申请日：2016-11-30
Applicant: Stichting Katholieke Universiteit, more particularly The University Medical Centre Nijmege , The Johns Hopkins University
Inventor： Marion J.G. Bussemakers , William B. Isaacs
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , A01K2217/05 , A61K38/00 , C07K14/47 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
Abstract: The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.
Abstract translation: 本发明一般涉及前列腺特异性抗原PCA3。 特别地，本发明涉及编码PCA3蛋白的核酸分子; 纯化的PCA3蛋白和多肽; 重组核酸分子; 含有重组核酸分子的细胞; 具有与PCA3蛋白和多肽特异性结合亲和力的抗体; 含有抗体的杂交瘤; 用于检测编码PCA3蛋白质的核酸的核酸探针; 检测样品中编码PCA3蛋白或多肽的核酸的方法; 含有核酸探针或抗体的试剂盒; 使用本发明的核酸序列，蛋白质或抗体的生物测定来诊断，评估或预测患有前列腺癌的哺乳动物; 治疗用途; 以及预防动物中前列腺癌的方法。
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公开(公告)号：US09259466B2
公开(公告)日：2016-02-16
申请号：US14471968
申请日：2014-08-28
Applicant: Stichting Katholieke Universiteit
Inventor： Timothy Ruben Dirk Jan Radstake
CPC classification number: A61M1/3618 , A61K38/17 , A61K39/39541 , A61K39/3955 , A61K2039/505 , C07K16/18 , C07K16/24 , C07K16/2851 , C07K2317/76
Abstract: The invention is in the field of molecular immunology, more in particular, in the field of the prevention or treatment of autoimmune diseases, more in particular, systemic sclerosis or scleroderma. The invention is based on the observation that SSC patients have an elevated plasma level of CXCL4. This was found to contribute to the pathogenesis of SSc, in particular, fibrosis. When CXCL4 was neutralized in in vitro experiments, the fibrotic effects could be neutralized. This led us to conclude that SSc may be cured by reducing the plasma level of CXCL4. The invention, therefore, relates to a method for treatment or prevention of fibrosis in patients with scleroderma, wherein the plasma level of CXCL4 is reduced.
Abstract translation: 本发明涉及分子免疫学领域，特别是在预防或治疗自身免疫性疾病领域，特别是系统性硬化症或硬皮病领域。 本发明是基于SSC患者血浆CXCL4水平升高的观察。 这被发现有助于SSc的发病机制，特别是纤维化。 当CXCL4在体外实验中被中和时，可以中和纤维化作用。 这导致我们得出结论，通过降低CXCL4的血浆水平可以治愈SSc。 因此，本发明涉及用于治疗或预防硬皮病患者纤维化的方法，其中CXCL4的血浆水平降低。
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