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公开(公告)号：WO2019039937A8
公开(公告)日：2019-02-28
申请号：PCT/NL2018/050547
申请日：2018-08-20
Applicant: STICHTING VUMC
IPC: A61K31/195 , A61K31/216 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/47 , A61K31/505 , A61K45/06 , A61P35/00 , A61P35/02
Abstract: The invention relates to a composition comprising a statin and an aminopeptidase inhibitor. Said composition may be used as a medicament, including in a method of treating cancer, such as a hematological cancer. The invention further relates to methods of treating a cancer in an individual, and to a use of an aminopeptidase inhibitor in a method for the preparation of a medicament for the treatment of a cancer.
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公开(公告)号：WO2019039937A1
公开(公告)日：2019-02-28
申请号：PCT/NL2018/050547
申请日：2018-08-20
Applicant: STICHTING VUMC
Inventor： JANSEN, Gerrit , PETERS, Godefridus Johannes
IPC: A61K31/195 , A61K31/216 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/47 , A61K31/505 , A61K45/06 , A61P35/00 , A61P35/02
CPC classification number: A61K31/195 , A61K31/216 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/47 , A61K31/505 , A61K45/06 , A61K2300/00
Abstract: The invention relates to a composition comprising a statin and an aminopeptidase inhibitor. Said composition may be used as a medicament, including in a method of treating cancer, such as a hematological cancer. The invention further relates to methods of treating a cancer in an individual, and to a use of an aminopeptidase inhibitor in a method for the preparation of a medicament for the treatment of a cancer.
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公开(公告)号：WO2018203751A8
公开(公告)日：2018-11-08
申请号：PCT/NL2018/050293
申请日：2018-05-04
Applicant: STICHTING VUMC
IPC: A61K31/00 , A61K31/4168 , A61P25/28
Abstract: The invention relates to Guanabenz or an analogue thereof for use in the treatment and to methods of treatment of a subject that has vanishing white matter (VWM), comprising administering the compound Guanabenz or an analogue thereof to the subject in need thereof. Also provided are methods with which the success of a medical intervention in a subject with VWM can be determined. Such methods comprise quantifying the translocation of Bergmann glia into the molecular layer in the cerebellum in a suitable sample of the sub ject. The sample is typically a post mortem sample.
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公开(公告)号：WO2018111099A1
公开(公告)日：2018-06-21
申请号：PCT/NL2017/050831
申请日：2017-12-12
Applicant: STICHTING VUMC , STICHTING VU
Inventor： SMIT, August Benjamin , HOOZEMANS, Jeroen Joseph Maria , HONDIUS, David Carolus , KWAKKEL, Johanna Maria
CPC classification number: A61K51/1018 , G01N33/5088 , G01N33/6896 , G01N2800/2821 , G01N2800/50 , G01N2800/52
Abstract: The invention relates to biomarkers and diagnostic methods for determining the presence and/or risk of cerebral amyloid angiopathy (CAA) as well as to methods for screening for treatments for CAA.
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公开(公告)号：WO2016122320A1
公开(公告)日：2016-08-04
申请号：PCT/NL2016/050064
申请日：2016-01-27
Applicant: STICHTING VU-VUMC , STICHTING VUMC
Inventor： VAN DER VLIET, Johannes Jelle , DE GRUIJL, Tanja Denise , VERHEUL, Hendrik Marinus Willem , DE BRUIN, Renée Cornelia Gerarda , LAMERIS, Roland
IPC: C07K16/28
CPC classification number: C07K16/2809 , C07K16/2833 , C07K16/30 , C07K2317/565 , C07K2317/569 , C07K2317/75
Abstract: The invention relates to compounds, in particular polypeptides that specifically bind to the non-classical MHC protein CD1d and modulate CD1d-mediated biological functions. The invention in particular relates to such compounds and polypeptides comprising or consisting of at least one single domain antibody, and wherein at least one single domain antibody specifically binds to CD1d. Also provided is for methods and use employing such compounds, polypeptides and/or single-domain antibodies.
Abstract translation: 本发明涉及化合物，特别是与非经典MHC蛋白质CD1d特异性结合并调节CD1d介导的生物功能的多肽。 本发明特别涉及包含至少一个单结构域抗体或由至少一个单结构域抗体组成的这样的化合物和多肽，并且其中至少一个单结构域抗体特异性结合CD1d。 还提供了使用这种化合物，多肽和/或单域抗体的方法和用途。
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Patent Agency Ranking
公开(公告)号：AU2022245215A1
公开(公告)日：2023-10-12
申请号：AU2022245215
申请日：2022-03-22
Applicant: MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , MEMORIAL SLOAN KETTERING CANCER CENTER , SLOAN KETTERING INST CANCER RES , STICHTING VUMC
Inventor： SADELAIN MICHEL , THEMELI MARIA , SJÖSTRAND MARIA , KATSAROU AFRODITI
Abstract: The presently disclosed subject matter provides uses of a chimeric costimulatory receptor (CCR) targeting CD38, and cells comprising a CD38 CCR and an antigen-recognizing receptor, and uses of such cells.
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公开(公告)号：DOP2020000209A
公开(公告)日：2021-09-30
申请号：DO2020000209
申请日：2020-11-13
Applicant: JANSSEN BIOTECH INC , STICHTING VUMC
Inventor： FRANCOIS GAUDET , HOMER ADAMS , NIELS VAN DE DONK , CHRISTIE VERLEIJ , KRIS FRERICHS
Abstract: La descripción proporciona métodos para tratar un cáncer y/o destruir células tumorales en un sujeto, que comprende administrar una cantidad terapéuticamente eficaz de un anticuerpo anti-CD38 y un agente terapéutico para el redireccionamiento de células T al sujeto para tratar el cáncer. La presente descripción proporciona un método para potenciar la eficacia de un agente terapéutico para el redireccionamiento de células T en un sujeto que tiene un cáncer, que comprende administrar al sujeto un anticuerpo anti-CD38. La descripción también proporciona un método para tratar un mieloma múltiple en un sujeto, que comprende administrar una cantidad terapéuticamente eficaz de un anticuerpo biespecífico BCMAxCDS y un anticuerpo anti-CD38 al sujeto para tratar el mieloma múltiple. La descripción también proporciona una combinación farmacéutica que comprende un anticuerpo biespecífico GPRC5DxCD3. La descripción también proporciona un kit que comprende una composición farmacéutica que comprende un anticuerpo biespecífico BCMAxCD3 y un anticuerpo anti-CD38.
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公开(公告)号：BR112020023187A2
公开(公告)日：2021-04-20
申请号：BR112020023187
申请日：2019-05-15
Applicant: JANSSEN BIOTECH INC , STICHTING VUMC
Inventor： CHRISTIE VERLEIJ , FRANCOIS GAUDET , HOMER ADAMS , KRIS FRERICHS , NIELS VAN DE DONK
Abstract: métodos para tratamento de cânceres e de aumento da eficácia de agentes teraêuticos de redirecionamento de células . a presente invenção refere-se a métodos para tratamento de cânceres e aumento da eficácia de agentes terapêuticos de redirecionamento de células t.
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公开(公告)号：BR112020023264A2
公开(公告)日：2021-02-23
申请号：BR112020023264
申请日：2019-05-15
Applicant: JANSSEN BIOTECH INC , STICHTING VUMC
Inventor： CHRISTIE VERKLEIJ , FRANCOIS GAUDET , HOMER ADAMS , KRIS FRERICHS , NIELS VAN DE DONK
IPC: A61K39/395 , A61K39/00 , A61K45/06 , C07K16/28 , C07K16/30
Abstract: anticorpos biespecíficos de bcma/cd3 e gprdc5d/cd3 para uso em terapia de câncer. o presente pedido refere-se a anticorpos biespecíficos, bcma * cd3 ou grrc5d * cd3. os anticorpos biespecíficos devem ser usados no tratamento de cânceres refratário, especialmente após um tratamento anterior com um anticorpo anti-cd38.
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公开(公告)号：SG11202011306TA
公开(公告)日：2020-12-30
申请号：SG11202011306T
申请日：2019-05-15
Applicant: JANSSEN BIOTECH INC , STICHTING VUMC
Inventor： ADAMS HOMER , GAUDET FRANCOIS , FRERICHS KRIS , VAN DE DONK NIELS , VERKLEIJ CHRISTIE
IPC: A61K39/395 , A61K39/00 , A61K45/06 , C07K16/28 , C07K16/30
Abstract: Disclosed are methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics.
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