公开(公告)号：WO2003004687A2

公开(公告)日：2003-01-16

申请号：PCT/US2002/021361

申请日：2002-07-03

Applicant: CURAGEN CORPORATION ,  ANDERSON, David, W. ,  BERGHS, Constance ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CATTERTON, Elina ,  EDINGER, Shlomit ,  EISEN, Andrew, J. ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GORMAN, Linda ,  GUO, Xiaojia ,  JEFFERS, Michael ,  KEKUDA, Ramesh ,  LI, Li ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  RASTELLI, Luca ,  SHENOY, Suresh ,  SHIMKETS, Richard, A. ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZHONG, Mei

Inventor： ANDERSON, David, W. ,  BERGHS, Constance ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CATTERTON, Elina ,  EDINGER, Shlomit ,  EISEN, Andrew, J. ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GORMAN, Linda ,  GUO, Xiaojia ,  JEFFERS, Michael ,  KEKUDA, Ramesh ,  LI, Li ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  RASTELLI, Luca ,  SHENOY, Suresh ,  SHIMKETS, Richard, A. ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZHONG, Mei

IPC: C12Q

CPC classification number: C07K14/47

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了与疾病相关的治疗性小分子。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2003000842A2

公开(公告)日：2003-01-03

申请号：PCT/US2002/017443

申请日：2002-06-04

Applicant: CURAGEN CORPORATION ,  AGEE, Michele, L. ,  ANDERSON, David, W. ,  BERGHS, Constance ,  CASMAN, Stacie, J. ,  CATTERTON, Elina ,  DIPIPPO, Vincent, A. ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  HERRMANN, John, L. ,  HJALT, Tord ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  VERNET, Corine, A., M. ,  ZHONG, Haihong ,  ZHONG, Mei ,  ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  LEPLEY, Denise, M.

Inventor： AGEE, Michele, L. ,  ANDERSON, David, W. ,  BERGHS, Constance ,  CASMAN, Stacie, J. ,  CATTERTON, Elina ,  DIPIPPO, Vincent, A. ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  HERRMANN, John, L. ,  HJALT, Tord ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  VERNET, Corine, A., M. ,  ZHONG, Haihong ,  ZHONG, Mei ,  ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  LEPLEY, Denise, M.

IPC: C12N

CPC classification number: C07K14/47

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.

公开(公告)号：WO2002090500A2

公开(公告)日：2002-11-14

申请号：PCT/US2002/014256

申请日：2002-05-02

Applicant: CURAGEN CORPORATION ,  SPYTEK, Kimberley, A. ,  LI, Li ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  GUO, Xiaojia ,  ANDERSON, David, W. ,  PATTURAJAN, Meera ,  GERLACH, Valerie, L. ,  TAUPIER, Raymond, J., Jr. ,  PENA, Carol, E., A. ,  PADIGARU, Muralidhara ,  KEKUDA, Ramesh ,  GORMAN, Linda ,  ZERHUSEN, Bryan, D. ,  SMITHSON, Glennda ,  MACDOUGALL, John, R. ,  MEZES, Peter, S. ,  PEYMAN, John, A. ,  ZHONG, Mei

Inventor： SPYTEK, Kimberley, A. ,  LI, Li ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  GUO, Xiaojia ,  ANDERSON, David, W. ,  PATTURAJAN, Meera ,  GERLACH, Valerie, L. ,  TAUPIER, Raymond, J., Jr. ,  PENA, Carol, E., A. ,  PADIGARU, Muralidhara ,  KEKUDA, Ramesh ,  GORMAN, Linda ,  ZERHUSEN, Bryan, D. ,  SMITHSON, Glennda ,  MACDOUGALL, John, R. ,  MEZES, Peter, S. ,  PEYMAN, John, A. ,  ZHONG, Mei

IPC: C12N

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/705

Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

Abstract translation: 公开了编码它们的多肽和核酸。 还公开了用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。

公开(公告)号：WO2002064791A3

公开(公告)日：2002-08-22

申请号：PCT/US2001/048369

申请日：2001-12-10

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BURGESS, Catherine, E. ,  BOLDOG, Ferenc, L. ,  CASMAN, Stacie, J. ,  COLMAN, Steven, D. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUO, Xiaojia ,  HERRMANN, John, L. ,  KEKUDA, Ramesh ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MILLET, Isabelle ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGEL, Danier, K. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Haihong ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BURGESS, Catherine, E. ,  BOLDOG, Ferenc, L. ,  CASMAN, Stacie, J. ,  COLMAN, Steven, D. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUO, Xiaojia ,  HERRMANN, John, L. ,  KEKUDA, Ramesh ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MILLET, Isabelle ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGEL, Danier, K. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Haihong ,  ZHONG, Mei

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further disclose therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these human nucleic acids and proteins.

公开(公告)号：WO2002059313A2

公开(公告)日：2002-08-01

申请号：PCT/US2001/049394

申请日：2001-12-18

Applicant: CURAGEN CORPORATION ,  LI, Li ,  BALLINGER, Robert, A. ,  PADIGARU, Muralidhara ,  KEKUDA, Ramesh ,  COLMAN, Steven, D. ,  SPYTEK, Kimberly, A. ,  CASMAN, Stacie, J. ,  VERNET, Corine, A., M. ,  SHENOY, Suresh, G. ,  GUSEV, Vladimir ,  MALYANKAR, Uriel, M. ,  EDINGER, Shlomit ,  GERLACH, Valerie ,  SMITHSON, Glennda ,  STONE, David, J. ,  SCIORE, Paul ,  MACDOUGALL, John, R. ,  GUNTHER, Erik ,  PEYMAN, John, A. ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  MILLET, Isabelle

Inventor： LI, Li ,  BALLINGER, Robert, A. ,  PADIGARU, Muralidhara ,  KEKUDA, Ramesh ,  COLMAN, Steven, D. ,  SPYTEK, Kimberly, A. ,  CASMAN, Stacie, J. ,  VERNET, Corine, A., M. ,  SHENOY, Suresh, G. ,  GUSEV, Vladimir ,  MALYANKAR, Uriel, M. ,  EDINGER, Shlomit ,  GERLACH, Valerie ,  SMITHSON, Glennda ,  STONE, David, J. ,  SCIORE, Paul ,  MACDOUGALL, John, R. ,  GUNTHER, Erik ,  PEYMAN, John, A. ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  MILLET, Isabelle

IPC: C12N15/12

CPC classification number: C07K14/705 ,  A61K38/00 ,  A61K2039/505

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2002053742A3

公开(公告)日：2002-07-11

申请号：PCT/US2002/000375

申请日：2002-01-07

Applicant: CURAGEN CORPORATION ,  KEKUDA, Ramesh ,  ALSOBROOK, John, P., II ,  TCHERNEV, Velizar, T. ,  LIU, Xiaohong ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  GROSSE, William, M. ,  LEPLEY, Denise, M. ,  BURGESS, Catherine, E. ,  VERNET, Corine, A., M. ,  LI, Li ,  GORMAN, Linda ,  EDINGER, Schlomit ,  SCIORE, Paul ,  ELLERMAN, Karen ,  MALYANKAR, Uriel ,  ROTHENBERG, Mark ,  STONE, David ,  BOLDOG, Ferenc ,  GUO, Xiaojia ,  SHENOY, Suresh ,  ANDERSON, David ,  PADIGARU, Muralidhara ,  TAUPIER, Raymond, J. ,  MILLER, Charles, E. ,  EISEN, Andrew

Inventor： KEKUDA, Ramesh ,  ALSOBROOK, John, P., II ,  TCHERNEV, Velizar, T. ,  LIU, Xiaohong ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  GROSSE, William, M. ,  LEPLEY, Denise, M. ,  BURGESS, Catherine, E. ,  VERNET, Corine, A., M. ,  LI, Li ,  GORMAN, Linda ,  EDINGER, Schlomit ,  SCIORE, Paul ,  ELLERMAN, Karen ,  MALYANKAR, Uriel ,  ROTHENBERG, Mark ,  STONE, David ,  BOLDOG, Ferenc ,  GUO, Xiaojia ,  SHENOY, Suresh ,  ANDERSON, David ,  PADIGARU, Muralidhara ,  TAUPIER, Raymond, J. ,  MILLER, Charles, E. ,  EISEN, Andrew

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these human nucleic acids and proteins.

公开(公告)号：WO0216600A2

公开(公告)日：2002-02-28

申请号：PCT/US0126518

申请日：2001-08-27

Applicant: CURAGEN CORP ,  GERLACH VALERIE ,  MACDOUGALL JOHN R ,  SMITHSON GLENNDA ,  STONE DAVID J ,  ELLERMAN KAREN ,  SPYTEK KIMBERLY A ,  ZERHUSEN BRYAN D ,  RASTELLI LUCA ,  VERNEY CORINE A M ,  PATTURAJAN MEERA ,  TCHERNEV VELIZAR T ,  PADIGARU MURALIDHARA ,  TAUPIER RAYMOND J

Inventor： GERLACH VALERIE ,  MACDOUGALL JOHN R ,  SMITHSON GLENNDA ,  STONE DAVID J ,  ELLERMAN KAREN ,  SPYTEK KIMBERLY A ,  ZERHUSEN BRYAN D ,  RASTELLI LUCA ,  VERNEY CORINE A M ,  PATTURAJAN MEERA ,  TCHERNEV VELIZAR T ,  PADIGARU MURALIDHARA ,  TAUPIER RAYMOND J

IPC: C07K14/47 ,  C07K14/705 ,  C12N15/12 ,  C12N15/00

CPC classification number: C07K14/705

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO0206345A2

公开(公告)日：2002-01-24

申请号：PCT/US0122637

申请日：2001-07-18

Applicant: CURAGEN CORP ,  ZERHUSEN BRYAN ,  PADIGARU MURALIDHARA ,  LI LI ,  BURGESS CATHERINE E ,  CASMAN STACIE J ,  SPYTEK KIMBERLY A ,  MISHRA VISHNU ,  TAYLOR SARAH ,  SHENOY SURESH ,  VERNET CORINE ,  GERLACH VALERIE ,  ELLERMAN KAREN ,  MACDOUGALL JOHN R ,  STONE DAVID ,  SMITHSON GLENNDA ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  TCHERNEV VELIZAR T ,  TAILLON BRUCE

Inventor： ZERHUSEN BRYAN ,  PADIGARU MURALIDHARA ,  LI LI ,  BURGESS CATHERINE E ,  CASMAN STACIE J ,  SPYTEK KIMBERLY A ,  MISHRA VISHNU ,  TAYLOR SARAH ,  SHENOY SURESH ,  VERNET CORINE ,  GERLACH VALERIE ,  ELLERMAN KAREN ,  MACDOUGALL JOHN R ,  STONE DAVID ,  SMITHSON GLENNDA ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  TCHERNEV VELIZAR T ,  TAILLON BRUCE

IPC: C07K14/705 ,  C12N15/12

CPC classification number: C07K14/705

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospeficically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human acids and proteins.

Abstract translation: 本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及与多肽免疫表面结合的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人酸和蛋白质中的任何一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2012170846A3

公开(公告)日：2013-03-14

申请号：PCT/US2012041598

申请日：2012-06-08

Applicant: ADC TELECOMMUNICATIONS INC ,  STONE DAVID ,  SYBESMA ERIC W ,  RESSLER KEVIN

Inventor： STONE DAVID ,  SYBESMA ERIC W ,  RESSLER KEVIN

IPC: H04W64/00 ,  G01S5/02

CPC classification number: H04W4/023 ,  H04L67/18 ,  H04W4/02 ,  H04W64/003

Abstract: One embodiment described herein includes a method of determining the location of a wireless device. The method includes capturing wired information about layer one and layer two used by wired components in a network; capturing wireless information about a wireless device communicatively coupled to the network; integrating at least some of the wired information and the wireless information; and using the integrated wired information and wireless information to locate the wireless device.

Abstract translation: 本文描述的一个实施例包括确定无线设备的位置的方法。 该方法包括捕获网络中有线组件使用的有关第一层和第二层的有线信息; 捕获关于通信地耦合到所述网络的无线设备的无线信息; 整合有线信息和无线信息中的至少一些; 并使用集成的有线信息和无线信息来定位无线设备。

公开(公告)号：WO2012099810A1

公开(公告)日：2012-07-26

申请号：PCT/US2012/021411

申请日：2012-01-16

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  LACROIX, Luke, D. ,  LAMOREY, Mark, C.H. ,  OAKLAND, Steven, F. ,  PATEL, Janak, G. ,  PFARR, Kerry, P. ,  SLOTA, Peter ,  STONE, David, B.

Inventor： LACROIX, Luke, D. ,  LAMOREY, Mark, C.H. ,  OAKLAND, Steven, F. ,  PATEL, Janak, G. ,  PFARR, Kerry, P. ,  SLOTA, Peter ,  STONE, David, B.

IPC: G01R31/00

CPC classification number: G01R31/2884 ,  G01R31/2896 ,  H01L21/76895 ,  H01L22/32

Abstract: Detection circuits, methods of use and manufacture and design structures are provided herein. The structure (25) includes at least one signal line (30) traversing one or more metal layers (20) of an integrated circuit. Circuitry (35) is coupled to the at least one signal line, which is structured to receive a signal with a known signal value (VDD) from the at least one signal line or a signal from a different potential (GND) and, based on which signal is received; determine whether there is a structural defect in the integrated circuit.

Abstract translation: 本文提供了检测电路，使用和制造方法以及设计结构。 结构（25）包括穿过集成电路的一个或多个金属层（20）的至少一个信号线（30）。 电路（35）耦合到所述至少一个信号线，其被构造为从所述至少一个信号线或来自不同电位（GND）的信号接收具有已知信号值（VDD）的信号，并且基于 接收哪个信号; 确定集成电路中是否存在结构缺陷。