公开(公告)号：WO2010085537A2

公开(公告)日：2010-07-29

申请号：PCT/US2010/021605

申请日：2010-01-21

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA ,  GONG, Weiliang ,  LUTZE, Werner ,  PEGG, Ian

Inventor： GONG, Weiliang ,  LUTZE, Werner ,  PEGG, Ian

IPC: C04B18/08 ,  C04B28/24 ,  C04B22/00 ,  C04B18/14 ,  C04B103/44 ,  C04B103/14

CPC classification number: C04B28/006 ,  C04B7/243 ,  C04B12/005 ,  Y02P40/145 ,  Y02P40/165 ,  Y02W30/92 ,  Y02W30/94 ,  C04B2103/10 ,  C04B2103/14 ,  C04B2103/44 ,  C04B14/106 ,  C04B18/08 ,  C04B22/0013 ,  C04B22/062 ,  C04B12/04 ,  C04B14/047 ,  C04B18/141

Abstract: A geopolymer composite binder is provided herein, the composite binder including (i) at least one fly ash material having less than or equal to 15 wt% of calcium oxide; (ii) at least one gelation enhancer; and (iii) at least one hardening enhancer having a different composition from a composition of the at least one fly ash material.

Abstract translation: 本文提供了一种地质聚合物复合粘合剂，所述复合粘合剂包括（i）至少一种粉煤灰材料，其具有小于或等于15重量％的氧化钙; （ii）至少一个凝胶化促进剂; 并具有从所述至少一个飞灰材料的组合物不同的组合物（iii）至少一个硬化促进剂。

公开(公告)号：WO2008066509A2

公开(公告)日：2008-06-05

申请号：PCT/US2006/045491

申请日：2006-11-28

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA ,  LITOVITZ, Charlotte

IPC: A61B17/52

CPC classification number: A61N2/02

Abstract: The present invention provides a method and apparatus for delivering an electric field to a body, comprising delivering a polarized magnetic field in a first direction to a body and directed at a desired target within the body, and changing the delivery direction of the magnetic field to a second direction directed at the desired target to induce an electric field across the desired target.

Abstract translation: 本发明提供了一种用于将电场传送到人体的方法和装置，包括：将第一方向上的极化磁场传递到身体并且引导到身体内的期望目标，并且将磁场的输送方向改变为 指向期望目标的第二方向以诱导穿过期望目标的电场。

公开(公告)号：WO1997019647A1

公开(公告)日：1997-06-05

申请号：PCT/US1995014941

申请日：1995-11-28

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： THE CATHOLIC UNIVERSITY OF AMERICA ,  LITOVITZ, Theodore, A. ,  PENAFIEL, Luis, Miguel

IPC: A61B19/00

CPC classification number: A61N1/16 ,  A61B90/04 ,  A61N1/323 ,  A61N2/00 ,  A61N2/02 ,  A61N2/06

Abstract: Methods and apparatus for inhibiting the adverse effect of an ambient time varying field having an electric component and/or a magnetic component on a living system. To provide protection, the field to which the system is exposed is caused to be one wherein at least one of the characteristic parameters of said field to which the living system is exposed is changed within time intervals of less than 10 seconds. The strength of the field to which the living system is to be exposed is controlled as a function of the strength of the ambient field. Living systems which are benefitted include humans.

Abstract translation: 用于抑制具有电气部件和/或磁性部件的环境时变场对生物系统的不利影响的方法和装置。 为了提供保护，系统暴露的场被引导为其中暴露生物系统的所述场的特征参数中的至少一个在小于10秒的时间间隔内改变。 生活系统要暴露的领域的强度是作为环境场强度的函数来控制的。 受益的生活系统包括人类。

公开(公告)号：WO2021211680A1

公开(公告)日：2021-10-21

申请号：PCT/US2021/027226

申请日：2021-04-14

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： FORBES, Kevin F.

IPC: G01R22/00 ,  H02J3/06

Abstract: Systems and methods for improving load energy forecasting in the presence of distributed energy resources in which a revised load forecast is calculated based on forecasted meteorological conditions data, forecasted wind and solar energy, forecasted load data, time data and time-series variables determined based on an analysis of the historical data. In exemplary embodiments, the revised load forecast is provided to energy management computer systems to enable appropriate levels of generation of conventional and renewable energy generation within the electric power grid.

公开(公告)号：WO2021033082A1

公开(公告)日：2021-02-25

申请号：PCT/IB2020/057588

申请日：2020-08-12

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： RAO, Venigalla B. ,  ZHU, Jingen

IPC: C12N15/86 ,  A61K39/12 ,  A61K48/00

Abstract: Described is hybrid viral vector comprising: a first virus such as bacteriophage T4; one or more second virus such as adeno-associated virus (AAV) attached to the first virus through cross-bridges, such as avidin-biotin cross-bridges; one or more DNA molecules packaged in the first virus; one or more nucleic acid molecules packaged in the second virus; and one or more proteins displayed on the surface of the first virus. Also described are methods of making and using such a hybrid viral vector.

公开(公告)号：WO2017201427A1

公开(公告)日：2017-11-23

申请号：PCT/US2017/033577

申请日：2017-05-19

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： FORBES, Kevin, F. ,  ZAMPELLI, Ernest, M.

IPC: G06F17/30 ,  G06G7/10 ,  G06Q10/06 ,  G06Q30/02 ,  H02J3/38 ,  H02P9/04

Abstract: A computer system and method for improving the accuracy of predictions of the amount of renewable energy, such as solar energy and wind energy, available to an electric utility, and/or refine such predictions, by providing improved integration of meteorological forecasts. Coefficient values are calculated for a renewable energy generation model by performing a regression analysis with the forecasted level of renewable energy posted by the utility, forecasted weather conditions and measures of seasonality as explanatory variables. Accuracy is further enhanced through the inclusion of a large number of time series variables that reflect the systematic nature of the energy/weather system. The model also uses the original forecast posted by the system operator as well as variables to control for season.

Abstract translation: 通过提供改进的用于提高对电力公司可用的可再生能源（诸如太阳能和风能）的量的预测的准确性和/或改进这种预测的计算机系统和方法 气象预报的整合。 通过对公用事业公布的可再生能源预测水平，预测的天气条件和季节性度量作为解释变量进行回归分析，计算可再生能源发电模型的系数值。 通过纳入反映能源/天气系统系统性质的大量时间序列变量，进一步提高了准确性。 该模型还使用系统操作员发布的原始预测以及变量来控制季节。

公开(公告)号：WO2017013564A1

公开(公告)日：2017-01-26

申请号：PCT/IB2016/054250

申请日：2016-07-15

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： RAO, Venigalla B. ,  ALSALMI, Wadad

IPC: C07K14/005 ,  C12N15/63

CPC classification number: C07K14/005 ,  A61K9/7023 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/54 ,  A61K2039/627 ,  C07K1/22 ,  C07K1/36 ,  C07K14/162 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/40 ,  C07K2319/50 ,  C12N7/00 ,  C12N2740/16022 ,  C12N2740/16043 ,  C12N2740/16051 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16234

Abstract: An approach of producing recombinant trimers that mimic native HIV- 1 envelope trimers is developed. A recombinant protein forming the recombinant trimers encompasses a recombinant HIV-1 gp140 fused to a tag through a linker at C-terminus of the recombinant HIV - 1 gp140. The linker is sufficiently long so that the tag is accessible for binding by a binding molecule bound on a solid matrix. After expressed in a cell, the recombinant protein is secreted into the culture medium and assembles into recombinant trimers therein. The recombinant trimers may be directly purified from the culture medium. Cleaved and uncleaved trimers from different clade viruses are produced.

Abstract translation: 开发了生产模仿天然HIV-1包膜三聚体的重组三聚体的方法。 形成重组三聚体的重组蛋白包含通过重组HIV-1 gp140的C-末端的接头与标签融合的重组HIV-1 gp140。 接头足够长，使得标签可通过结合在固体基质上的结合分子进行结合。 在细胞中表达后，将重组蛋白分泌到培养基中并在其中组装成重组三聚体。 重组三聚体可以从培养基中直接纯化。 产生来自不同进化枝病毒的切割和未切割的三聚体。

公开(公告)号：WO2015004627A1

公开(公告)日：2015-01-15

申请号：PCT/IB2014/063005

申请日：2014-07-10

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： RAO, Venigalla B. ,  TAO, Pan

IPC: C07K14/24 ,  C07K19/00 ,  C12N15/09 ,  A61K39/02

CPC classification number: C07K14/24 ,  A61K39/0291 ,  A61K2039/5256 ,  C07K14/005 ,  C07K2319/21 ,  C07K2319/40 ,  C07K2319/735 ,  C12N2795/10123 ,  Y02A50/407

Abstract: Techniques from two basic approaches, structure-based immunogen design and phage T4 nanoparticle delivery, are developed to construct new plague vaccines. The NH 2 - terminal β-strand of F1 of Yersinia pestis is transplanted to the COOH-terminus of F1 of Yersinia pestis and the NH 2 -- terminus sequence flanking the β-strand of F1 of Yersinia pestis is duplicated to eliminate polymerization but to retain the T cell epitopes. The mutated F1 is fused to the V antigen of Yersinia pestis to thereby form a fusion protein F1mut-V mutant, which produces a completely soluble monomer. The fusion protein F1mut-V is then arrayed on phage T4 nanoparticles via a small outer capsid protein, Soc, from a T4 phage or a T4-related phage. Both the soluble and T4 decorated F1mut-V provided approximately 100% protection to mice and rats against pneumonic plague evoked by high doses of Yersinia pestis CO92.

Abstract translation: 开发了两种基本方法，基于结构的免疫原设计和噬菌体T4纳米颗粒递送的技术来构建新的疫苗疫苗。 将鼠疫耶尔森氏菌的F1的NH2-末端菌株移植到鼠疫耶尔森氏菌的F1的COOH-末端，并且重复鼠疫耶尔森氏菌的F1侧链的NH 2 - 末端序列，以消除聚合反应 保留T细胞表位。 突变的F1融合到鼠疫耶尔森氏菌的V抗原，从而形成融合蛋白F1mut-V突变体，其产生完全可溶的单体。 然后通过T4噬菌体或与T4相关的噬菌体的小外壳衣壳蛋白Soc，将融合蛋白F1mut-V排列在噬菌体T4纳米颗粒上。 可溶性和T4装饰的F1mut-V都能够对小鼠和大鼠提供大约100％的抗高剂量鼠疫耶尔森氏菌CO92诱发的肺炎瘟疫。

公开(公告)号：WO2014135998A1

公开(公告)日：2014-09-12

申请号：PCT/IB2014/058716

申请日：2014-01-31

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： RAO, Venigalla

IPC: C12N15/86 ,  C12N7/01

CPC classification number: C12N15/87 ,  C07K2319/10 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10122 ,  C12N2795/10123 ,  C12N2795/10142 ,  C12N2810/6009 ,  C12N2810/85 ,  C12N2810/859

Abstract: Described is T4 DNA packaging machine comprising: one or more DNA molecules packaged in a head of the T4 DNA packaging machine, one or more Hoc-fused proteins displayed on the head of the T4 DNA packaging machine, and one or more Soc-fused proteins displayed on the head of the T4 DNA packaging machine. Also described are methods of making and using such a T4 DNA packaging machine.

Abstract translation: 描述的是T4 DNA包装机，其包括：包装在T4 DNA包装机的头部中的一个或多个DNA分子，显示在T4 DNA包装机头部上的一种或多种Hoc融合蛋白，以及一种或多种Soc-融合蛋白 显示在T4 DNA包装机的头上。 还描述了制备和使用这种T4 DNA包装机的方法。

公开(公告)号：WO2011017531A1

公开(公告)日：2011-02-10

申请号：PCT/US2010/044566

申请日：2010-08-05

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA ,  GONG, Weiliang ,  LUTZE, Werner ,  CHEN, Chen ,  PEGG, Ian

Inventor： GONG, Weiliang ,  LUTZE, Werner ,  CHEN, Chen ,  PEGG, Ian

IPC: C04B14/00

CPC classification number: C04B28/006 ,  C04B18/08 ,  C04B20/12 ,  C04B28/04 ,  Y02P40/165 ,  Y02W30/92 ,  Y10T436/23 ,  C04B20/1066 ,  C04B20/1074 ,  C04B40/0096

Abstract: Provided in one embodiment is a method of charactering a fly ash composition, comprising determining a reactivity of the fly ash composition in a solution. The applicability of the findings to low water-to-solid ratios for the process of geopolymerization for the relationship between the amounts of fly ash reacted, and the compressive strength of a geopolymer cement is also described.

Abstract translation: 在一个实施方案中提供了表征飞灰组合物的方法，其包括测定溶液中飞灰组合物的反应性。 还描述了对于反应的飞灰的量与地质聚合物水泥的抗压强度之间的关系的地质聚合过程的研究结果对低水固比的适用性。