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公开(公告)号：KR1020090128677A
公开(公告)日：2009-12-16
申请号：KR1020080054540
申请日：2008-06-11
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/97 , A61K2800/80 , A61Q19/08
Abstract: PURPOSE: A cosmetic composition containing Cornus officinalis extract for antiaging is provided to suppress the collagenase expression and procollagen synthesis promotion. CONSTITUTION: A cosmetic composition for antiaging contains Cornus officinalis extract as an active ingredient. A method for processing Cornus officinalis: a process of boiling, roasting, steaming Cornus officinalis; and a step of extracting Cornus officinalis using water or organic solvent. The organic solvent is ethanol, methanol, butanol, ether, ethylacetate, chloroform or mixture solvent.
Abstract translation: 目的：提供含有枸杞提取物用于抗衰老的化妆品组合物，以抑制胶原酶表达和前胶原合成促进。 构成：抗衰老的化妆品组合物含有枸杞提取物作为活性成分。 一种加工枸杞的方法：一种沸腾，焙烧，蒸a的方法。 并使用水或有机溶剂提取枸杞子的步骤。 有机溶剂为乙醇，甲醇，丁醇，乙醚，乙酸乙酯，氯仿或混合溶剂。
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公开(公告)号：KR1020090115609A
公开(公告)日：2009-11-05
申请号：KR1020080041544
申请日：2008-05-02
Applicant: (주)아모레퍼시픽
IPC: A61K36/488 , A61K36/237 , A61K36/28 , A61K36/804
CPC classification number: A61K36/185 , A23L33/105 , A23V2002/00 , A61K36/232 , A61K36/28 , A61K36/287 , A61K36/428 , A61K36/45 , A61K36/732 , A61K36/78 , A61K36/8945
Abstract: PURPOSE: A skin external composition containing medicinal plant extract is provided to suppress oxidation of DPPH[1,1-diphenyl-2-picryl hydrazyl] and improve anti-oxidative efficiency. CONSTITUTION: A method for producing medicinal herb extract comprises: a step of processing through boiling, steaming, roasting, and baking medicinal plants; and a step of extracting medicinal plant extract using water or organic solvent. The organic solvent is ethanol, methanol, butanol, ether, ethylacetate or chloroform.
Abstract translation: 目的：提供含有药用植物提取物的皮肤外用组合物，以抑制DPPH [1,1-二苯基-2-苦基酰肼]的氧化，提高抗氧化效率。 构成：药用植物提取物的制造方法，包括：通过煮沸，蒸煮，焙烧，烘烤药用植物加工的步骤; 以及使用水或有机溶剂提取药用植物提取物的步骤。 有机溶剂为乙醇，甲醇，丁醇，乙醚，乙酸乙酯或氯仿。
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公开(公告)号：KR1020090054736A
公开(公告)日：2009-06-01
申请号：KR1020070121572
申请日：2007-11-27
Applicant: (주)아모레퍼시픽
IPC: A47J31/00
CPC classification number: A47J31/32
Abstract: An extractor and an extracting method using a pottery are provided to create high pressure inside the extractor body in order to prevent extracts from contacting the extractor body of metal material. An extractor(200) comprises a hollow body(210) made of metal, a cover(220) closing the body, a heating part(230) heating the body from the outside, a pottery(240) placed inside the body, and a gas valve(250) which injects gas into the body or discharges gas from the body.
Abstract translation: 提供使用陶器的提取器和提取方法以在提取器体内产生高压，以防止提取物与金属材料的提取体接触。 提取器（200）包括由金属制成的中空体（210），封闭主体的盖（220），从外部加热身体的加热部（230），放置在身体内的陶器（240），以及 气体阀（250），其将气体注入体内或从身体排出气体。
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公开(公告)号：KR100864677B1
公开(公告)日：2008-10-23
申请号：KR1020070029255
申请日：2007-03-26
Applicant: (주)아모레퍼시픽
IPC: C07C233/07 , C07C233/10
Abstract: 본 발명은 항비만 효과를 나타내는 하기 화학식 1로 표시되는 3,5-디히드록시벤조산 유도체 화합물 및 이의 제조방법에 관한 것이다:
[화학식 1]
상기 식 중, R은 아다만틸, 시클로헥실 또는 헥실이다.
3,5-디히드록시벤조산 유도체, 항비만, 루시퍼라아제, IDH3α, CPT1, 혈당-
公开(公告)号：KR100845511B1
公开(公告)日：2008-07-10
申请号：KR1020070029253
申请日：2007-03-26
Applicant: (주)아모레퍼시픽
IPC: C07D317/68 , A61K31/357
Abstract: A hydroxamic acid derivative is provided to induce the activity increase of each promoter of IDH3alpha and CPT1 involving with energy consumption metabolism, thereby being usefully used for preventing or treating diseases related to dyslipidemia such as obesity, hyperlipidemia and diabetes. A hydroxamic acid is represented by a formula(1), wherein R1 is CONH, NHCO, CONR4 or NR4CO(where R4 is H or C1-10 alkyl); R2 is -(CH2)n-(where n is 0 or 1); and R3 is H or C1-10 alkyl. A method for preparing the hydroxamic acid comprises the steps of: (a) reacting an anhydrous compound synthesized by reacting ethyl chloroformate with piperonic acid using pyridine or N-methyl morpholine as a solvent with methyl 4-amino benzoate or 4-amino phenyl acetic acid ethyl ester at a temperature of 10-20 deg.C using pyridine or N-methyl morpholine as a solvent to prepare a benzamide compound; (b) reacting the benzamide with an alkyl halide selected from the group consisting of bromomethane, bromoethane, bromopropane, bromo isopropane, bromo butane, and bromo tert-butane to substitute an amide bond of the benzamide with an alkyl group; (c) hydrolyzing methyl ester in the benzamide obtained from the step(a) or the benzamide compound obtained from the step(b) to prepare an acid and reacting the acid with ethyl chloroformate using pyridine or N-methyl morpholine as a solvent to covert the acid into an anhydrous compound; and (d) reacting the anhydrous compound with hydroxyl amine chloride or N-methyl hydroxyl amine chloride at a temperature of 0-10 deg.C using pyridine or N-methyl morpholine as a solvent to obtain the product of the formula(1). An agent for anti-obese, treating diabetes or hyperlipidemia comprises the hydroxamic acid.
Abstract translation: 提供异羟肟酸衍生物以诱导与能量代谢相关的IDH3α和CPT1的每种启动子的活性增加，从而有效地用于预防或治疗与脂肪血症如肥胖症，高脂血症和糖尿病有关的疾病。 异羟肟酸由式（1）表示，其中R1是CONH，NHCO，CONR4或NR4CO（其中R4是H或C1-10烷基）; R2是 - （CH2）n-（其中n是0或1）; 并且R 3是H或C 1-10烷基。 制备异羟肟酸的方法包括以下步骤：（a）使吡啶或N-甲基吗啉作为溶剂与4-氨基苯甲酸甲酯或4-氨基苯基乙酸反应，使氯甲酸乙酯与胡椒酸反应合成的无水化合物 乙酯，使用吡啶或N-甲基吗啉作为溶剂，在10-20℃的温度下制备苯甲酰胺化合物; （b）使苯甲酰胺与选自溴甲烷，溴乙烷，溴丙烷，溴异丙烷，溴丁烷和溴叔丁烷的烷基卤反应，以苯甲酰胺与烷基取代; （c）水解由步骤（a）获得的苯甲酰胺中的甲酯或由步骤（b）获得的苯甲酰胺化合物制备酸，并使用吡啶或N-甲基吗啉作为溶剂使酸与氯甲酸乙酯反应，从而使 将酸变成无水化合物; 和（d）使用吡啶或N-甲基吗啉作为溶剂，在0-10℃的温度下使无水化合物与羟胺或N-甲基羟胺氯化物反应，得到式（1）的产物。 用于抗肥胖，治疗糖尿病或高脂血症的药物包括异羟肟酸。
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Patent Agency Ranking
公开(公告)号：KR100837186B1
公开(公告)日：2008-06-13
申请号：KR1020060095279
申请日：2006-09-29
Applicant: (주)아모레퍼시픽
IPC: C07C233/11 , C07C233/21
Abstract: 본 발명은 하기 화학식 1로 표시되는 항노화 효과를 나타내는 레티노익산(Retinoic acid) 유도체 및 이의 제조방법에 관한 것이다:
[화학식 1]
[상기 화학식 1에서, R
1 은 수소, 직쇄 또는 분쇄의 (C
1 -C
7 )알킬 또는 (C
3 -C
7 )시클로알킬이고; R
2 는 히드록시, 1~4개의 히드록시기가 치환된 직쇄 또는 분쇄의 (C
1 -C
7 )알킬 또는 히드록시피라논이 치환된 직쇄 또는 분쇄의 (C
1 -C
5 )알킬이다.]
또한 본 발명은 상기 화학식 1의 레티노익산 유도체를 유효성분으로 함유하는 피부노화 방지용 피부 외용제 조성물에 관한 것이다.
레티노익산 * 레티노익산 수용체 * 항노화 * 콜라겐 * 콜라게나아제 발현억제 * 주름 개선 * 피부 외용제-
公开(公告)号：KR100829819B1
公开(公告)日：2008-05-16
申请号：KR1020070054863
申请日：2007-06-05
Abstract: A skin whitening cosmetic composition comprising a panduratin derivative or an extract of Kaempferia Pandurata is provided to be safely used to skin without side effects and show excellent pigmentation inhibitory effect by inhibiting melanogenesis, thereby improving liver spots or freckles and showing excellent skin whitening effect. A skin whitening cosmetic composition comprises 0.001-10 wt.% of at least one panduratin derivative selected from the group consisting of compounds represented by formulae(1) to (3), wherein the panduratin derivative is extracted from Kaempferia Pandurata. Further, the skin whitening cosmetic composition is cosmetic water, cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing form, cleansing water, pack, gel, powder, body lotion, body cream, body oil and body essence.
Abstract translation: 提供一种皮肤美白化妆品组合物，其包含潘多汀衍生物或山茶皮提取物以安全地用于皮肤而没有副作用，并通过抑制黑素生成显示出优异的色素沉着抑制作用，从而改善肝斑或雀斑并显示出优异的皮肤美白效果。 皮肤美白化妆品组合物包含0.001-10重量％的至少一种选自由式（1）至（3）表示的化合物的潘多肽衍生物，其中所述潘多汀衍生物从山茶中提取。 此外，皮肤美白化妆品组合物是化妆水，奶油，按摩霜，精华，眼霜，眼睛精华，清洁霜，清洁剂，清洁水，包装，凝胶，粉末，身体乳液，身体霜，身体油和身体精华 。
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公开(公告)号：KR100803577B1
公开(公告)日：2008-02-15
申请号：KR1020050115649
申请日：2005-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/498 , A61K8/602 , A61K2800/522 , A61Q19/02 , A61Q19/08
Abstract: 본 발명은 이카린의 가수분해물을 함유하는 화장료용 조성물에 관한 것으로, 보다 구체적으로는 이카린의 가수분해물인 이카리틴, 이카리시드 I 및 이카리시드 II를 함유하는 화장료에 관한 것이고, 상기 이카린(icariin)의 가수분해물은 (a) 식물로부터 물 또는 유기용매를 이용하여 이카린을 함유하는 식물 추출물을 수득하는 단계; 및 (b) 상기 수득된 식물 추출물을 산, 염기, 효소 또는 상기 효소를 생산하는 미생물을 이용하여 가수분해하는 단계를 포함하는 방법에 의해 제조될 수 있다.
본 발명에 따른 화장료용 조성물은 항산화, 항노화, 미백 또는 주름 개선용으로 적용될 수 있다.
에피메디움, 이카리틴, 이카리시드 I, 이카리시드 II, 이카린, 항산화, 미백, 주름 개선, 항노화, 화장료-
公开(公告)号：KR100787879B1
公开(公告)日：2007-12-27
申请号：KR1020020010512
申请日：2002-02-27
Applicant: (주)아모레퍼시픽
IPC: C07D311/72
Abstract: 본 발명은 항산화 효과를 나타내는, 하기 화학식 1로 표시되는 신규 토코페롤 유도체 및 이의 제조방법, 이를 함유하는 화장료 조성물에 관한 것이다.
[화학식 1]
상기 식 중에서
R
1 , R
2 , R
3 는 H 또는 메틸기로서, 토코페롤의 상기 5, 7 또는 8번 위치에 적어도 하나 이상의 메틸기를 가지며, A는 CH
2 -CH(CH
3 )- 또는 CH=C(CH
3 )-이다.
R
4 는 CH
2 -CH
2 , CH=CH, CH
2 -CH
2 -CH
2 , CH
2 -CH(CH
3 )-CH
2 또는 CH
2 -C(CH
3 )
2 -CH
2 이다.
R
5 는 디에탄올 아민, 트리스 히드록시 아민 또는 N-메틸 글루카민이다.
토코페롤 유도체 * 토코페롤숙신산 * 토코페롤말레인산 * 토코페롤 글루타르산 * 염화토코페롤숙신산 * 염화토코페롤말레인산 * 염화토코페롤글루타르산 * 화장료 조성물 * 항산화-
60.发明授权엘라스테아제 저해 효과를 갖는 3,5-디히드록시벤조산유도체 화합물과 그 제조방법 및 이를 함유하는 항노화화장료 조성물 有权,5-라스테아제저해효과를갖갖갖는,5- ,5- 3 3 3 3 3 3 3 3 3 3 3 3
公开(公告)号：KR100726280B1
公开(公告)日：2007-06-11
申请号：KR1020060035603
申请日：2006-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C233/65 , C07C235/64
Abstract: Provided is a 3,5-dihydroxybenzoic acid derivative, which shows an elastase inhibitory effect and an excellent effect of scavenging free radicals generated by UV irradiation, has an excellent anti-aging effect, and is useful for an anti-aging cosmetic composition. The 3,5-dihydroxybenzoic acid derivative is a compound represented by a formula 1, substituted with hydroxyl groups at 3,5-position thereof and the amide group being substituted with a bulky substituent. The 3,5-dihydroxybenzoic acid derivative is obtained by the method comprising the steps of: (A) reacting 3,5-dihydroxybenzoic acid with acetic anhydride to form 3,5-diacetyloxybenzoic acid; (B) forming an amide compound from the 3,5-diacetyloxybenzoic acid by using ethyl chloroformate and an oleophilic group; and (C) hydrolyzing the acetyl group of the amide compound to provide a 3,5-dihydroxybenzoic acid derivative.
Abstract translation: 本发明提供一种3,5-二羟基苯甲酸衍生物，其显示出弹性蛋白酶抑制作用，并且通过UV照射产生的清除自由基的优异效果，具有优异的抗老化作用，并且可用于抗老化化妆品组合物。 3,5-二羟基苯甲酸衍生物是由式3表示的化合物，其3,5-位被羟基取代且酰胺基被大体积取代基取代。 3,5-二羟基苯甲酸衍生物通过包括以下步骤的方法获得：（A）使3,5-二羟基苯甲酸与乙酸酐反应形成3,5-二乙酰氧基苯甲酸; （B）通过使用氯甲酸乙酯和亲油基团由3,5-二乙酰氧基苯甲酸形成酰胺化合物; 和（C）水解酰胺化合物的乙酰基得到3,5-二羟基苯甲酸衍生物。
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